About 107,020 results

Rural Residence Tied to Higher Risk for Heart Failure for Women, Black Men
Clinical Advisor

Jan 30th, 2023 - HealthDay News — Rural residence is associated with an increased risk for heart failure among women and Black men, according to a study published online in JAMA Cardiology. Sarah E. Turecamo, from the US National Institutes of Health in Bethesda, Maryland, and colleagues assessed whether rurality is associated with an increased risk for heart failure. The analysis included data from 27,115 part...

Noninvasive liver test may help select asymptomatic candidates for heart failure tests
Carolyn Crist

Jan 30th, 2023 - A noninvasive test for liver disease may be a useful, low-cost screening tool to select asymptomatic candidates for a detailed examination of heart failure with preserved ejection fraction (HFpEF), say authors of a report published in Gastro Hep Advances. The fibrosis-4 (FIB-4) index was a significant predictor of high HFpEF risk, wrote Chisato Okamoto, MD, of the department of medical biochemi.

JAK Inhibitor Improves Symptoms, Anemia in Myelofibrosis

Jan 30th, 2023 - Myelofibrosis treatment with the Janus kinase (JAK) inhibitor momelotinib resulted in clinically significant improvements in symptoms and spleen response compared with danazol for symptomatic, JAK inhibitor-exposed patients with anemia and intermediate- or high-risk disease, the phase III MOMENTUM trial showed. A significantly greater proportion of patients in the momelotinib group reported a ≥...

Enriched ICU Nutrition Strategy Spoiled in Randomized Trial

Jan 30th, 2023 - Higher protein doses did not improve critically ill patient outcomes, and may even be detrimental to patients with high organ failure and acute kidney injury, the EFFORT trial found. In nutritionally high-risk adults undergoing mechanical ventilation, alive hospital discharge for those who received higher doses of protein reached 46.1% by 60 days after randomization, compared with the 50.2% rat...

Gut enzymes fingered in some 5-ASA treatment failures
Neil Osterweil

Jan 27th, 2023 - AURORA, COLO. – The therapeutic action of 5-aminosalicylic acid (5-ASA), one of the most frequently prescribed drugs for inflammatory bowel disease (IBD), can be defeated by enzymes that reside in the very gut that the drug is designed to treat.

Population-Based Strategies Needed to Reduce US Salt Intake

Approximately 90% of Americans eat too much sodium. This practice leads to increased blood pressure, which increases the risk for stroke, coronary heart disease, heart failure, and renal disease. Population-based strategies to reduce sodium intake can be effective and are needed at national, state, and community levels. This article describes the role of communities and environments in influenc...

Early achievement of minimal disease activity important for long-term benefits in PsA

Jan 26th, 2023 - Key clinical point: The failure to achieve minimal disease activity (MDA) in the first year after the diagnosis of psoriatic arthritis (PsA) was associated with worse health-related quality of life and health status, functional impairment, fatigue, pain, and higher anxiety and depression. Major finding: Compared with patients who achieved sustained MDA in the first year after diagnosis, those w.

HER2+ metastatic BC: Meta-analysis demonstrates superior efficacy of pyrotinib over lapatinib

Jan 26th, 2023 - Key clinical point: Pyrotinib plus chemotherapy outperformed lapatinib plus chemotherapy in terms of improving survival outcomes in patients with human epidermal growth factor receptor 2-positive (HER2+) metastatic breast cancer (BC) but showed a worse toxicity profile. Major finding: Progression-free survival was significantly improved with pyrotinib vs lapatinib in patients who had received p.

False confidence in blood pressure knowledge undermines intentions to seek care

Jan 26th, 2023 - The majority of Americans do not know the threshold for normal/healthy blood pressure — yet they are confident that they do, according to a new USC study published this week in the journal Medical Decision Making. Nearly half of adults in the U.S. have high blood pressure (hypertension). In the long run, high blood pressure damages blood vessels, increases risk of heart failure, and leads to ot...

Hope for patients with a severe rare disease

Jan 26th, 2023 - Methylmalonic aciduria (MMA) is a metabolic disorder that affects approximately one in 90,000 newborns; both parents must carry a genetic predisposition to the disease. This means the disease is rare. The consequences are also severe: an enzyme these young patients need for energy metabolism is left defective. As a result, a specific metabolite, which is usually broken down to create energy, in...

CDC: Bivalent COVID Vaccines Stop Illness From XBB.1.5

Jan 25th, 2023 - Currently authorized bivalent COVID-19 boosters demonstrated similar protection against symptomatic illness from the XBB/XBB.1.5 Omicron subvariants as from BA.5-related subvariants, according to a CDC study. From December 2022 to January 2023, the bivalent boosters' vaccine effectiveness (VE) against symptomatic infection was a similar 48% versus XBB/XBB.1.5-related strains and 52% versus BA.5...

Early CVD Linked to Accelerated Cognitive Decline

Jan 25th, 2023 - Premature cardiovascular disease (CVD) was associated with accelerated decline in cognition and white matter health in midlife, a large prospective cohort study showed. On a composite cognitive score, those with CVD events before age 60 were more than three times as likely to drop by at least 1.5 standard deviation more than the race-specific average over 5 years (OR 3.07, 95% CI 1.65-5.71), Kr...

Emzahh Gets FDA Approval for Pregnancy Prevention
Clinical Advisor

Jan 25th, 2023 - The Food and Drug Administration has approved Emzahh (norethindrone tablets) for the prevention of pregnancy. Emzahh is an AB-rated generic equivalent of Ortho Micronor®. The progestin-only contraceptive is supplied as 0.35 mg tablets in a pack of 28 tablets. One tablet is taken daily at the same time; administration is continuous with no interruption between pill packs. The first-year failure ...

Is it time to unionize?
William G. Wilkoff, MD

Jan 25th, 2023 - According to an article in the Wall Street Journal (Mosbergen D. 2023 Jan 16), physicians-in-training in several parts of the country are attempting to unionize.

Risk of Maternal Morbidity After C-Section No Different Based on Surgeon Gender

Jan 25th, 2023 - Risk of maternal morbidity, including postpartum hemorrhage, after cesarean deliveries did not differ by surgeon gender, according to a prospective cohort study from France. Among over 4,000 women, maternal morbidity was 14.2% with male surgeons versus 16.3% with female surgeons (adjusted risk ratio [RR] 0.92, 95% CI 0.74-1.13, P=0.46), reported Loïc Sentilhes, MD, PhD, of Bordeaux University H...

Association of rurality with risk of heart failure

Jan 25th, 2023 - About The Study: Among predominantly low-income individuals in the southeastern United States, rurality was associated with an increased risk of heart failure among women and Black men, which persisted after adjustment for cardiovascular risk factors and socioeconomic status. This inequity points to a need for additional emphasis on primary prevention of heart failure among rural populations. A...

Early cardiovascular disease linked to worse brain health in middle age

Jan 25th, 2023 - EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, JANUARY 25, 2023 MINNEAPOLIS – People with early cardiovascular disease may be more likely to have memory and thinking problems and worse brain health in middle age, according to new research published in the January 25, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. “Cardiovascular diseases such as h...

Risk of developing heart failure much higher in rural areas vs. urban

Jan 25th, 2023 - Adults living in rural areas of the United States have a 19% higher risk of developing heart failure compared to their urban counterparts, and Black men living in rural areas have an especially higher risk – 34%, according to a large observational study supported by the National Institutes of Health. The study, one of the first to look at the link between living in rural America and first-time ...

Heart failure risk higher in rural areas

Jan 25th, 2023 - Heart failure risk is 19% higher for adults living in rural areas of the U.S., as compared to urban areas, and 34% higher for Black men living in rural areas, according to a large, observational study supported by the National Institutes of Health (NIH) and co-led by Vanderbilt University Medical Center (VUMC) researchers. The study, one of the first to look at the link between first-time case...

Brodalumab Promising for the Treatment of Plaque Psoriasis in a Real-World Setting
Clinical Advisor

Jan 24th, 2023 - Brodalumab was highly effective and associated with a tolerable safety profile for the treatment of moderate to severe chronic plaque psoriasis (PsO) in a real-world setting, according to study data published in the Journal of the European Academy of Dermatology & Venerology. Patients (N=91) with moderate to severe chronic plaque PsO who received brodalumab treatment at the National and Kapodis...