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About 672,735 results

Highlights in Early Breast Cancer From the 2022 American Society of Clinical Oncology Annual Meeting
https://www.mdedge.com/hematology-oncology/article/255784/highlights-early-breast-cancer-2022-american-society-clinical
Ann H. Partridge, MD, MPH

Jun 29th, 2022 - Dr Ann Partridge from the Dana-Farber Cancer Institute in Boston, Massachusetts, highlights important new data in early breast cancer presented at American Society of Clinical Oncology (ASCO) 2022. Dr Partridge begins with promising results from the NeoSTAR study, which looked at the use of the novel antibody-drug conjugate (ADC) sacituzumab govitecan in the neoadjuvant setting.

Key Abstracts in Metastatic Breast Cancer From the 2022 American Society of Clinical Oncology Annual Meeting
https://www.mdedge.com/hematology-oncology/article/255775/key-abstracts-metastatic-breast-cancer-2022-american-society
Harold J. Burstein, MD, PhD

Jun 29th, 2022 - Dr Harold J. Burstein, from the Dana-Farber Cancer Institute in Boston, Massachusetts, reports on important abstracts in the management of metastatic breast cancer from the 2022 American Society of Clinical Oncology (ASCO) annual meeting.

Simultaneous Cases of Carfilzomib-Induced Thrombotic Microangiopathy in 2 Patients With Multiple Myeloma
https://www.mdedge.com/fedprac/avaho/article/255829/multiple-myeloma/simultaneous-cases-carfilzomib-induced-thrombotic
Nathaniel J. Myall, MD, Samantha X. Wang, MD et. al.

Jun 28th, 2022 - As a class of drugs, proteasome inhibitors are known to rarely cause drug-induced thrombotic microangiopathy (DITMA). In particular, carfilzomib is a second-generation, irreversible proteasome inhibitor approved for the treatment of relapsed, refractory multiple myeloma (MM) in combination with other therapeutic agents.

Abortion pills over the counter? Experts see major hurdles in widening U.S. access
https://www.mdedge.com/obgyn/article/255808/business-medicine/abortion-pills-over-counter-experts-see-major-hurdles
Ahmed Aboulenein

Jun 28th, 2022 - WASHINGTON (Reuters) – A pill used to terminate early pregnancies is unlikely to become available without a prescription for years, if ever, experts told Reuters, as the conservative-leaning U. S.

Chronic Retiform Purpura of the Abdomen and Thighs: A Fatal Case of Intravascular Large Cell Lymphoma
https://www.mdedge.com/dermatology/article/255804/dermatopathology/chronic-retiform-purpura-abdomen-and-thighs-fatal-case
Nelson Ugwu, MD, Nour Kibbi, MD et. al.

Jun 28th, 2022 - To the Editor: Intravascular large cell lymphoma (ILCL) is a rare B-cell lymphoma that is defined by the presence of large neoplastic B cells in the lumen of blood vessels. 1 At least 3 variants of ILCL have been described based on case reports and a small case series: classic, cutaneous, and hemophagocytic.

Tumor Necrosis Factor α Inhibitor–Induced Lupuslike Syndrome in a Patient Prescribed Certolizumab Pegol
https://www.mdedge.com/dermatology/article/255803/dermatopathology/tumor-necrosis-factor-inhibitor-induced-lupuslike
David Walton Crasto Jr, DO, Loren Touma, DO et. al.

Jun 28th, 2022 - To the Editor: Tumor necrosis factor α (TNF-α) inhibitor–induced lupuslike syndrome (TAILS) is a newly described entity that refers to the onset of subacute cutaneous lupus erythematosus (SCLE) during drug therapy with TNF-α antagonists. The condition is unique because it is thought to occur via a separate pathophysiologic mechanism than all other agents implicated in the development of drug-in.

Hard-won medical advances versus miracle cures
https://www.mdedge.com/neurology/article/255802/business-medicine/hard-won-medical-advances-versus-miracle-cures
Allan M. Block, MD

Jun 28th, 2022 - I’m not hiding anything. Occasionally I deal with patients and families who seem to think I have some miracle cure for a condition that I’m not telling them about.

Twin study offers new insight into genetics of migraine
https://www.mdedge.com/neurology/article/255800/headache-migraine/twin-study-offers-new-insight-genetics-migraine
Randy Dotinga

Jun 28th, 2022 - DENVER – A new study finds that females with male twins are more likely to suffer from migraines without aura than are those with female twins, even though testosterone is thought to be protective. The findings, presented at the annual meeting of the American Headache Society, also hint at a possible role played by the prenatal environment.

Highlights in Early-Stage Non–Small Cell Lung Cancer From ASCO 2022
https://www.mdedge.com/hematology-oncology/article/255791/asco-lung-cancer/highlights-early-stage-non-small-cell-lung
Howard (Jack) West, MD

Jun 28th, 2022 - Highlights in early-stage non–small lung cancer (NSCLC) from the 2022 American Society of Clinical Oncology Annual Meeting are discussed by Dr Jack West of City of Hope Comprehensive Cancer Center in Duarte, California. He opens with a post hoc analysis of CheckMate 816, which showed that achieving a pathologic complete response with adjuvant nivolumab plus chemotherapy was highly associated wi.

Highlights in Early-Stage Non–Small Cell Lung Cancer From ASCO 2022
https://www.mdedge.com/hematology-oncology/article/255791/conference-recap/highlights-early-stage-non-small-cell-lung
Howard (Jack) West, MD

Jun 28th, 2022 - Highlights in early-stage non–small lung cancer (NSCLC) from the 2022 American Society of Clinical Oncology Annual Meeting are discussed by Dr Jack West of City of Hope Comprehensive Cancer Center in Duarte, California. He opens with a post hoc analysis of CheckMate 816, which showed that achieving a pathologic complete response with adjuvant nivolumab plus chemotherapy was highly associated wi.

Monkeypox and COVID: Public Health Has to Increase Trust
https://www.medscape.com/viewarticle/976081

Jun 28th, 2022 - As a long-standing HIV doctor (where we use harm reduction messaging as a matter of course), I have watched with interest the excellent messaging by the Centers for Disease Control and Prevention (CDC) on monkeypox and contrasted that with the "abstinence only" messaging that occurred with COVID-19. Harm reduction messaging — which incorporates the needs of individuals while working to minimize...

Novel liver-targeting drug offers hope for AAT deficiency
https://www.mdedge.com/internalmedicine/article/255786/hepatology/novel-liver-targeting-drug-offers-hope-aat-deficiency
Sara Freeman

Jun 27th, 2022 - LONDON – The novel liver-targeting agent fazirsiran has fared well in a small, but significant, study looking at its ability to improve liver histology in adults with alpha-1 antitrypsin (AAT) deficiency. Not only were serum and liver levels of the aberrant Z-AAT protein decreased, but also reductions in key liver enzymes were observed.

Adjuvant vs. neoadjuvant? What has ASCO 2022 taught us regarding resectable NSCLC?
https://www.mdedge.com/hematology-oncology/article/255779/lung-cancer/adjuvant-vs-neoadjuvant-what-has-asco-2022-taught-us
Joan H. Schiller, MD

Jun 27th, 2022 - We’ve still got some work to do before we can say with authority whether concurrent neoadjuvant chemotherapy and immunotherapy is better than concurrent adjuvant chemotherapy with immunotherapy for non–small cell lung cancer (NSCLC). While there has been some notable progress in this area, we need phase 3 trials that compare the two therapeutic approaches.

Establishing a formalized mentorship program in a community practice
https://www.mdedge.com/gihepnews/article/255776/practice-management/establishing-formalized-mentorship-program-community
Marc Sonenshine, MD

Jun 27th, 2022 - Most GI physicians will tell you that we didn’t get where we are without help along the way. Each of us can point to one – or in most cases, several – specific mentors who provided invaluable guidance when we were in medical school, fellowship, and starting our careers.

Treat-to-target strategy with tapering proves effective in PsA and axSpA
https://www.mdedge.com/rheumatology/article/255773/psoriatic-arthritis/treat-target-strategy-tapering-proves-effective-psa
Thomas R. Collins

Jun 27th, 2022 - Aiming for a disease activity target while reducing biologic therapy could be a winning approach for patients with psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA), according to the results of a new study presented at the annual European Congress of Rheumatology. The findings show that a treat-to-target (T2T) strategy with tapering using a tumor necrosis factor (TNF) inhibitor prod.

Stroke risk rises for women with history of infertility, miscarriage, stillbirth
https://www.mdedge.com/obgyn/article/255770/stroke/stroke-risk-rises-women-history-infertility-miscarriage-stillbirth
Heidi Splete

Jun 27th, 2022 - Infertility, pregnancy loss, and stillbirth increased women’s later risk of both nonfatal and fatal stroke, based on data from more than 600,000 women. “To date, multiple studies have generated an expanding body of evidence on the association between pregnancy complications (e.

Low-protein Nordic diet promotes healthy eating in infants
https://www.mdedge.com/familymedicine/article/255766/pediatrics/low-protein-nordic-diet-promotes-healthy-eating-infants
MDedge Family Medicine; Heidi Splete

Jun 27th, 2022 - Infants who were introduced to a low-protein diet – high in fruit, vegetables, and roots – ate more fruits and vegetables at 12 and 18 months of age, compared with those who ate a conventional diet, in a new study. The “Nordic diet” has shown health benefits in children and adults, but has not been studied in infants, said Ulrica Johansson, MD, of Umeå (Sweden) University, in a presentation on.

Fast Five Quiz: Advanced and Metastatic Prostate Cancer Presentation and Diagnosis
https://www.medscape.com/viewarticle/921119

Jun 27th, 2022 - Despite improvements in detection and treatment, prostate cancer remains a significant cause of morbidity and mortality worldwide, and its incidence is increasing. Globally, over 1.4 million cases of prostate cancer were diagnosed in 2020. Although prostate cancer is often asymptomatic in its early stages, symptoms may arise as the disease progresses. Are you familiar with key aspects of the pr...

Fast Five Quiz: Metastatic Hormone-Sensitive Prostate Cancer Treatment
https://www.medscape.com/viewarticle/921254

Jun 27th, 2022 - The incidence of metastatic hormone-sensitive prostate cancer (mHSPC) has significantly increased in recent years, in part due to advancements in imaging technology. Men with metastatic prostate cancer who have not received prior treatment with androgen deprivation therapy (ADT) or who are still sensitive to ADT and do not have castration-resistant cancer are defined as having mHSPC, a lethal d...

ECG Challenge: Uncontrolled COPD or Something Else?
https://www.medscape.com/viewarticle/975590

Jun 27th, 2022 - A 70-year-old man with a history of chronic obstructive pulmonary disease (COPD), treated with inhalers, presents to his pulmonologist with worsening shortness of breath which he thinks is related to COPD. He has noted intermittent palpitations. His physician checks his blood pressure, which is 100/70 mm Hg, and notes a rapid heart rate, prompting an ECG. Figure 1. Courtesy of Philip J. Podrid,...