Nov 30th, 2022 - More patients with granulomatosis with polyangiitis (GPA) were in remission at 6 months if they had received rituximab (Rituxan) rather than cyclophosphamide (Cytoxan) as induction therapy, according to a target trial emulation performed by the French Vasculitis Study Group (FVSG). Remission, which was defined as a score of zero on the validated Birmingham Vasculitis Activity Score (BVAS) and u...

Nov 30th, 2022 - Using buprenorphine for opioid use disorder in pregnancy was linked with a lower risk of neonatal side effects than using methadone, but the risk of adverse maternal outcomes was similar between the two treatments, according to new research. Elizabeth A. Suarez, PhD, MPH, with Brigham and Women's Hospital in Boston, led the study published online in the New England Journal of Medicine. Opioid u...

Nov 29th, 2022 - After reading a paper published in The Annals of the Royal College of Surgeons of England last March, Andrew Thomas, an orthopedic surgeon in the UK, noticed that it was very similar to an article published the previous December in another journal. He wrote a letter to the editor of Annals, notifying the journal of the similarity between its paper, "The possible effect of different types of ven...

Nov 28th, 2022 - "Have you considered tissue donation?" These "five simple words" could have profound impact for pediatric brain cancer research — and for children with brain cancer and their families, according to pediatric neuro-oncologist Vijay Ramaswamy, MD, PhD, at The Hospital for Sick Children in Toronto, Canada. However, families who have lost a child to brain cancer often aren't made aware of the optio...

Nov 28th, 2022 - A 58-year-old man with a history of hypertension (treated with amlodipine and hydrochlorothiazide) and coronary artery disease (treated with a beta-blocker and isosorbide mononitrate) visits his cardiologist for a routine physical examination. His pulse is noted to be irregular, and a 12-lead ECG is obtained. Figure 1.

Nov 28th, 2022 - 1. There's a lot of flu out there. According to the Centers for Disease Control and Prevention's FluView report, flu activity is elevated across the country, and flu hospitalization rates are the highest we have seen at this time in a decade. Hospitalization rates are highest among adults 65 years or older (18.6 per 100,000), followed by children younger than 5 years (13.6 per 100,000). Indicat...

Nov 28th, 2022 - The study covered in this summary was published on researchsquare.com as a preprint and has not yet been peer reviewed. Key Takeaways The hypothalamic-pituitary-adrenal (HPA) axis recovered in nearly three quarters of patients with Cushing disease (CD) within 2 years after successful trans-sphenoidal surgery (TSS), with a median recovery time of 12 months. Preoperative total triiodothyronine (T...

Nov 28th, 2022 - From the moment you walk into the massive kitchen at Northern Westchester Hospital, you quickly realize that bland, processed food isn't on the menu for patients at this Mount Kisco, NY, hospital that's part of Northwell Health, the largest health care system in New York state. The first indication is the smell of apple and pear crumble that begins to waft through the massive space that resembl...

Nov 28th, 2022 - Mood stabilizers protect against suicide and all-cause mortality in patients with bipolar disorder (BD), including natural mortality, with lithium emerging as the most protective agent, new research suggests. Investigators led by Pao-Huan Chen, MD, of the Department of Psychiatry, Taipei Medical University Hospital, Taiwan, evaluated the association between the use of mood stabilizers and the r...

Nov 28th, 2022 - The study covered in this summary was published on MedRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaways Participants with premanifest Huntington's disease (HD) demonstrated speech timing deficits with syllable repetition tests and during cognitively demanding tasks. Speech tasks coupled with cognitive and motor demands differentiated participants with early HD from matche...

Nov 28th, 2022 - Pau, France — How can we care for women considering another pregnancy after a stillbirth? At the Infogyn 2022 conference, Christophe Vayssière, MD, PhD, of the Department of Obstetrics and Gynecology at Toulouse University Hospital in France, reported on the need to establish a personalized care plan, with psychologic support if necessary, without having to go through the avalanche of additiona...

Nov 28th, 2022 - Many more people are at risk for early cardiovascular events because of raised Lp(a) levels than from having familial hypercholesterolemia (FH), a new study suggests. The Danish study set out to try and establish a level of Lp(a) that would be associated with a cardiovascular risk similar to that seen with FH. As there are many different definitions of FH, results showed a large range of Lp(a) ...

Nov 23rd, 2022 - Brain indicators of motor impairment were distinct among children with autism spectrum disorder (ASD), those with developmental coordination disorder (DCD), and controls, in a new study. Previous research suggests that individuals with ASD overlap in motor impairment with those with DCD. But these two conditions may differ significantly in some areas, as children with ASD tend to show weaker sk...

Nov 23rd, 2022 - France — In light of the French International Prison Observatory's (OIP) report published last summer on the findings of a months-long inquiry concerning access to specialist care in prison, we interviewed 54-year-old Béatrice Carton, MD, chair of the French association of healthcare professionals working in the prison service (APSEP), on her experience working in a detention center. Having a w...

Nov 23rd, 2022 - The calendar year 2022 has been especially good for advancing acne-focused laser and light devices, most recently with the Food and Drug Administration clearance of the Accure Laser System in late November, for the treatment of mild to severe inflammatory acne vulgaris. This was preceded by the FDA clearance of AviClear, marketed by Cutera, in March, and the commercial launch of TheraClearX, ma...

Nov 22nd, 2022 - Results of a new study indicate that opt-out HIV testing, in particular "notional consent testing" where a patient is not asked or counseled before conducting the test, is an effective tool for identifying undiagnosed HIV cases in populations with an HIV positivity rate greater than 0.2%. On implementation of opt-out testing of patients aged 18-59 admitted to the emergency room at St. George's ...

Nov 22nd, 2022 -   Emergencies happen anywhere, anytime, and sometimes physicians find themselves in situations in which they are the only ones who can help. Is There a Doctor in the House? is a new Medscape series telling these stories. Dr Govani: We were lucky. In 2021, the NFL had chosen some healthcare workers to go to the Super Bowl. We're Rams season ticket holders, and we were chosen. We had an amazing t...

Nov 22nd, 2022 - PHILADELPHIA — A draft update of criteria for classifying antiphospholipid syndrome (APS) incorporates a much broader spectrum of disease signs and symptoms, such as kidney disease and more variables for pregnancy, and meets a higher level of specificity than the existing Sapporo criteria, although at the expense of lower sensitivity. Members of the ACR/EULAR core planning group, (left to right...

Nov 22nd, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. The overall risk of developing myocarditis after COVID-19 vaccination is low, according to a new report from British Columbia, Canada. Because of certain risk factors, however, researchers recommended preferential use of the Pfizer–BioNTech vaccine over the Moderna vaccine for patients aged 18-2...

Nov 22nd, 2022 - Using irrigation warmed to body temperature during burr hole evacuation for chronic subdural hematoma (cSDH) cuts the risk for recurrence by more than half compared and should become the standard of care, new research suggests. Results from the multicenter randomized controlled trial found that irrigation at 37° C (body temperature) offered better clinical outcomes than surgery with irrigation ...