About 383,095 results

‘Superior’ CLL regimen cuts chemo in half
Nancy A. Melville

Jun 28th, 2022 - VIENNA – Ibrutinib and obinutuzumab combined with a three-cycle regimen of chemotherapy as a first-line treatment for fit patients with chronic lymphocytic leukemia (CLL) shows progression-free and overall survival rates that are comparable, if not higher, than those commonly reported with six-cycle regimens, new research shows. “Overall, our data suggests that [the chemoimmunotherapy] regimen.

Simultaneous Cases of Carfilzomib-Induced Thrombotic Microangiopathy in 2 Patients With Multiple Myeloma
Nathaniel J. Myall, MD, Samantha X. Wang, MD et. al.

Jun 28th, 2022 - As a class of drugs, proteasome inhibitors are known to rarely cause drug-induced thrombotic microangiopathy (DITMA). In particular, carfilzomib is a second-generation, irreversible proteasome inhibitor approved for the treatment of relapsed, refractory multiple myeloma (MM) in combination with other therapeutic agents.

Chronic Retiform Purpura of the Abdomen and Thighs: A Fatal Case of Intravascular Large Cell Lymphoma
Nelson Ugwu, MD, Nour Kibbi, MD et. al.

Jun 28th, 2022 - To the Editor: Intravascular large cell lymphoma (ILCL) is a rare B-cell lymphoma that is defined by the presence of large neoplastic B cells in the lumen of blood vessels. 1 At least 3 variants of ILCL have been described based on case reports and a small case series: classic, cutaneous, and hemophagocytic.

Tumor Necrosis Factor α Inhibitor–Induced Lupuslike Syndrome in a Patient Prescribed Certolizumab Pegol
David Walton Crasto Jr, DO, Loren Touma, DO et. al.

Jun 28th, 2022 - To the Editor: Tumor necrosis factor α (TNF-α) inhibitor–induced lupuslike syndrome (TAILS) is a newly described entity that refers to the onset of subacute cutaneous lupus erythematosus (SCLE) during drug therapy with TNF-α antagonists. The condition is unique because it is thought to occur via a separate pathophysiologic mechanism than all other agents implicated in the development of drug-in.

Hard-won medical advances versus miracle cures
Allan M. Block, MD

Jun 28th, 2022 - I’m not hiding anything. Occasionally I deal with patients and families who seem to think I have some miracle cure for a condition that I’m not telling them about.

Monkeypox and COVID: Public Health Has to Increase Trust

Jun 28th, 2022 - As a long-standing HIV doctor (where we use harm reduction messaging as a matter of course), I have watched with interest the excellent messaging by the Centers for Disease Control and Prevention (CDC) on monkeypox and contrasted that with the "abstinence only" messaging that occurred with COVID-19. Harm reduction messaging — which incorporates the needs of individuals while working to minimize...

Novel liver-targeting drug offers hope for AAT deficiency
Sara Freeman

Jun 27th, 2022 - LONDON – The novel liver-targeting agent fazirsiran has fared well in a small, but significant, study looking at its ability to improve liver histology in adults with alpha-1 antitrypsin (AAT) deficiency. Not only were serum and liver levels of the aberrant Z-AAT protein decreased, but also reductions in key liver enzymes were observed.

Treat-to-target strategy with tapering proves effective in PsA and axSpA
Thomas R. Collins

Jun 27th, 2022 - Aiming for a disease activity target while reducing biologic therapy could be a winning approach for patients with psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA), according to the results of a new study presented at the annual European Congress of Rheumatology. The findings show that a treat-to-target (T2T) strategy with tapering using a tumor necrosis factor (TNF) inhibitor prod.

Stroke risk rises for women with history of infertility, miscarriage, stillbirth
Heidi Splete

Jun 27th, 2022 - Infertility, pregnancy loss, and stillbirth increased women’s later risk of both nonfatal and fatal stroke, based on data from more than 600,000 women. “To date, multiple studies have generated an expanding body of evidence on the association between pregnancy complications (e.

FDA approves liso-cel as second-line therapy for LBCL
Sharon Worcester

Jun 27th, 2022 - Lisocabtagene maraleucel, also known as liso-cel (Breyanzi), has been approved by the Food and Drug Administration for the second-line treatment of adult patients with relapsed or refractory large B-cell lymphoma (r/r LBCL). This expanded indication is based on findings from the pivotal phase 3 TRANSFORM study, which showed significant and clinically meaningful improvements with CD19-directed c.

ECG Challenge: Uncontrolled COPD or Something Else?

Jun 27th, 2022 - A 70-year-old man with a history of chronic obstructive pulmonary disease (COPD), treated with inhalers, presents to his pulmonologist with worsening shortness of breath which he thinks is related to COPD. He has noted intermittent palpitations. His physician checks his blood pressure, which is 100/70 mm Hg, and notes a rapid heart rate, prompting an ECG. Figure 1. Courtesy of Philip J. Podrid,...

Rhabdomyosarcoma Outcomes in Adolescents and Young Adults Worse Than in Children

Jun 27th, 2022 - NEW YORK (Reuters Health) - New data from rhabdomyosarcoma patients confirm poorer outcomes in adolescents and young adults compared with those in children, despite similar treatment, suggesting that a "tailored and intensive" treatment strategy might be warranted in adolescents and young adults, researchers say. While rare, rhabdomyosarcoma is the most common soft-tissue sarcoma in children an...

The Next COVID Booster Shots Will Likely Be Updated for Omicron

Jun 27th, 2022 - NEW YORK (Reuters) - COVID-19 vaccines this fall are likely to be based on the Omicron variant of the coronavirus rather than the original strain, although some experts suggest they may only offer significant benefits for older and immunocompromised people. Moderna, Pfizer and Novavax have been testing vaccines based on the first Omicron variant that became dominant last winter, BA.1, driving a...

Another Public Health Crisis Originating From Gun Violence

Jun 27th, 2022 - The number of mass shootings in the US has jumped from 272 annually in 2014 to 692 annually in 2021. As these attacks have increased in frequency, averaging more than once daily since 2019, we've slowly become accustomed to their occurrence. Now, guns only reenter the national conversation when there is a particularly devastating event. Most recently, a shooting in an elementary school in Uvald...

Some Long COVID Patients Still Have Virus in Blood

Jun 27th, 2022 - (Reuters) - Some cases of long COVID may be the immune system's response to a SARS-CoV-2 infection lurking somewhere in the body, new findings from a small study suggest. Researchers analyzed multiple plasma samples collected over time from 63 patients with COVID-19, including 37 who went on to develop long COVID. In the majority of those with long COVID, the spike protein from the surface of t...

COVID-19 Tied to Increased Risk for Alzheimer's, Parkinson's Disease

Jun 27th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. COVID-19 has been associated with a threefold increased risk of Alzheimer's disease (AD) and a doubling of Parkinson's disease (PD) risk, a new study suggests. However, the research also showed there was no excess risk of these neurologic disorders following COVID than other respiratory infectio...

2-Year Faricimab Results: 'Visual Gains With Fewer Injections'

Jun 27th, 2022 - The efficacy, durability, and safety of faricimab (Vabysmo, Genentech/Roche) for diabetic macular edema (DME) seen at 1 year extends to 2 years, according to results of two pivotal trials. As previously reported, in January 2022, the US Food and Drug Administration (FDA) approved faricimab for DME and for age-related macular degeneration based on 1-year outcomes from the phase 3 YOSEMITE and RH...

Stroke Risk Rises for Women With History of Infertility, Miscarriage, Stillbirth

Jun 27th, 2022 - Infertility, pregnancy loss, and stillbirth increased women's later risk of both nonfatal and fatal stroke, based on data from more than 600,000 women. "To date, multiple studies have generated an expanding body of evidence on the association between pregnancy complications (e.g., gestational diabetes and preeclampsia) and the long-term risk of stroke, but studies on associations with infertili...

ACC/AHA Issue Clinical Lexicon for Complications of COVID-19

Jun 27th, 2022 - The American College of Cardiology (ACC) and the American Heart Association (AHA) have jointly issued a comprehensive set of data standards to help clarify definitions of the cardiovascular (CV) and non-CV complications of COVID-19. It's the work of the ACC/AHA Task Force on Clinical Data Standards and has been endorsed by the Heart Failure Society of America and Society for Cardiac Angiography...

Better Breast Support Lessens ACL Risk in Female Athletes

Jun 27th, 2022 - SAN DIEGO — Greater breast support was associated with reduction in impact factors contributing to traumatic knee injuries including ACL rupture, based on data from 14 female college athletes. "We know that female athletes have a higher risk of ACL injury compared to males in the same sport, with the highest risk between ages 15 and 18," Hailey Fong, MS, a PhD student at the University of Memph...