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About 15 results

FDA Panel Votes Against Two Cancer Indications but Backs 4 of 6
https://www.medscape.com/viewarticle/950247

Apr 29th, 2021 - Federal advisers this week supported the efforts of pharmaceutical companies in 4 of 6 cases in which these firms are fighting to maintain cancer indications for approved drugs. They voted against them in two cases. The staff of the US Food and Drug Administration (FDA) will now consider these votes as they decide what to do regarding the six cases of what they have termed "dangling" accelerate...

FDA Approvals, Highlights, and Summaries: Oncology
https://reference.staging.medscape.com/viewarticle/925363

Feb 26th, 2020 - Rozlytrek (entrectinib) Entrectinib is an inhibitor of tropomyosin receptor tyrosine kinases (TRKs) TRKA, TRKB, and TRKC (encoded by the neurotrophic tyrosine receptor kinase [NTRK] genes NTRK1, NTRK2, and NTRK3, respectively), proto-oncogene tyrosine-protein kinase ROS1 (ROS1), and anaplastic lymphoma kinase (ALK). It is indicated in adults for metastatic non–small cell lung cancer (NSCLC) wit...

FDA Approvals, Highlights, and Summaries: Oncology
https://reference.medscape.com/viewarticle/925363

Feb 26th, 2020 - Rozlytrek (entrectinib) Entrectinib is an inhibitor of tropomyosin receptor tyrosine kinases (TRKs) TRKA, TRKB, and TRKC (encoded by the neurotrophic tyrosine receptor kinase [NTRK] genes NTRK1, NTRK2, and NTRK3, respectively), proto-oncogene tyrosine-protein kinase ROS1 (ROS1), and anaplastic lymphoma kinase (ALK). It is indicated in adults for metastatic non–small cell lung cancer (NSCLC) wit...

Pediatric Lymphoma Joins Family of BRCA2 Cancers
https://www.medscape.com/viewarticle/916083

Jul 25th, 2019 - For the first time, a pediatric cancer has been added to the "BRCA2 family." Researchers at St. Jude Children's Research Hospital in Memphis, Tennessee, revealed that BRCA2 mutations were five times more common in children with non-Hodgkin lymphoma compared to a control group. The study was published online on July 25 in JAMA Oncology. Although this may seem like bad news, in fact it provides m...

Ominous Symptoms in an Elderly Cancer Survivor
https://reference.medscape.com/viewarticle/748780_5

Jan 31st, 2018 - Currently, patients with a presentation and history much like those encountered in this case are likely to undergo a fluorodeoxyglucose (FDG) positron emission tomography (PET) scan. “Hot spots” on the image—ie, bright spots created by the absorption of large amounts of FDG by cancer cells—would indicate the presence of one or more small bowel tumors. In many cases of gastrointestinal imaging, ...

Ominous Symptoms in an Elderly Cancer Survivor
https://reference.medscape.com/viewarticle/748780

Jan 31st, 2018 - Editor's Note: The Case Challenge series includes difficult-to-diagnose conditions, some of which are not frequently encountered by most clinicians but are nonetheless important to accurately recognize. Test your diagnostic and treatment skills using the following patient scenario and corresponding questions. If you have a case that you would like to suggest for a future Case Challenge, please ...

Good Gut Microbes May Help Immunotherapy Drugs Shrink Tumors
https://www.medscape.com/viewarticle/887965

Nov 2nd, 2017 - LONDON (Reuters) - Cancer patients with high levels of good gut bacteria appear more likely to respond to immunotherapy, potentially opening up a new way to optimize the use of modern medicines that are highly effective but only work in some people. The finding, reported in two scientific papers on Thursday, suggests patients may in future be told to actively nurture their good bugs when taking...

Robotic Surgery: No Clinical Benefit Over Laparoscopy
https://www.medscape.com/viewarticle/887786

Oct 29th, 2017 - Robotic-assisted minimally invasive surgery does not appear to offer any clinical benefits over conventional laparoscopic techniques in terms of outcomes and complication rates but is associated with significantly higher costs, two new studies of cancers indicate. The first study is a retrospective analysis of more 23,000 patients treated with radical nephrectomy for a renal mass over a 12-year...

Pancreatic Cancer Patients 'Going the Extra Mile' for Improved Survival
https://www.medscape.com/viewarticle/886096

Oct 11th, 2017 - Is it worthwhile for patients with pancreatic cancer to seek care at a high-volume institution? The authors of a study published in Annals of Surgery[1] analyzed this problem using data from patients (N = 7086) obtained from 1998 to 2012 from the National Cancer Database. The main analysis was restricted to patients undergoing a pancreaticoduodenectomy at either a local facility performing fewe...

Are Race and Socioeconomic Status Related to Outcomes in Thyroid Cancer?
https://www.medscape.com/viewarticle/820042

Feb 4th, 2014 - Racial and Socioeconomic Disparities in Presentation and Outcomes of Well-Differentiated Thyroid Cancer Harari A, Li N, Yeh MW J Clin Endocrinol Metab. 2014;99:133-141 Article Summary Thyroid cancer is common and is increasing in frequency at an alarming rate. The purpose of this study was to assess disparities in the outcomes of thyroid cancer patients on the basis of racial and socioeconomic ...

Robotic Surgery: No Clinical Benefit Over Laparoscopy
https://emedicine.medscape.com/viewarticle/887786

Robotic-assisted minimally invasive surgery does not appear to offer any clinical benefits over conventional laparoscopic techniques in terms of outcomes and complication rates but is associated with significantly higher costs, two new studies of cancers indicate. The first study is a retrospective analysis of more 23,000 patients treated with radical nephrectomy for a renal mass over a 12-year...

FDA Approvals, Highlights, and Summaries: Oncology
https://emedicine.medscape.com/viewarticle/925363

Rozlytrek (entrectinib) Entrectinib is an inhibitor of tropomyosin receptor tyrosine kinases (TRKs) TRKA, TRKB, and TRKC (encoded by the neurotrophic tyrosine receptor kinase [NTRK] genes NTRK1, NTRK2, and NTRK3, respectively), proto-oncogene tyrosine-protein kinase ROS1 (ROS1), and anaplastic lymphoma kinase (ALK). It is indicated in adults for metastatic non–small cell lung cancer (NSCLC) wit...

NICE Recommends Digital CBT for Mild Depression in Children
https://emedicine.medscape.com/viewarticle/908310

Offering children and teenagers digital CBT for treating mild depression could result in faster access to therapy, the National Institute for Health and Care Excellence (NICE) said. There was guidance last week on drugs for prostate cancer and melanoma, and a recommendation for a treatment option for back and leg pain. Digital CBT for Young People Children aged 5 to 18 should be offered digital...

Pediatric Lymphoma Joins Family of BRCA2 Cancers
https://emedicine.medscape.com/viewarticle/916083

For the first time, a pediatric cancer has been added to the "BRCA2 family." Researchers at St. Jude Children's Research Hospital in Memphis, Tennessee, revealed that BRCA2 mutations were five times more common in children with non-Hodgkin lymphoma compared to a control group. The study was published online on July 25 in JAMA Oncology. Although this may seem like bad news, in fact it provides m...

Pancreatic Cancer Patients 'Going the Extra Mile' for Improved Survival
https://emedicine.medscape.com/viewarticle/886096

Is it worthwhile for patients with pancreatic cancer to seek care at a high-volume institution? The authors of a study published in Annals of Surgery[1] analyzed this problem using data from patients (N = 7086) obtained from 1998 to 2012 from the National Cancer Database. The main analysis was restricted to patients undergoing a pancreaticoduodenectomy at either a local facility performing fewe...