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About 39,223 results

Younger, African American Women, and Men, Get Breast Cancer Too
https://www.medscape.com/viewarticle/960808

Oct 15th, 2021 - There is a time in a nurse's career when we need to step up, even though we may feel overwhelmed. For me, that day arrived early in my career. I had promised to be available for an IV start for a friend with late-stage breast cancer. She had extreme peripheral lymphedema, which made vein selection impossible. Her port had failed. My IV skills were decent, but I could not fail her. A promise is ...

Case Report: Lung Cancer Shrinks in Patient Using CBD Oil
https://www.medscape.com/viewarticle/960949

Oct 15th, 2021 - A case report describes the dramatic shrinkage of a tumor to a quarter of its original size in a patient with non–small cell lung cancer (NSCLC) who had declined conventional treatment, continued smoking, and who later revealed that she was ingesting cannabidiol (CBD) oil. The patient was an 80-year-old woman. At diagnosis, the tumor measured 41 mm, and there was no evidence of local or further...

Detection of Lung Cancer in Primary Care 'Inadequate and Leading to Delayed Diagnoses'
https://www.medscape.com/viewarticle/960944

Oct 15th, 2021 - The diagnosis of lung cancer following symptomatic patient presentation to primary care is inadequate and needs to improve, according to the latest safety investigation report by the Healthcare Safety Investigation Branch (HSIB). HSIB research shows that estimated five-year survival rates in the UK are among the lowest in Europe, reflecting the fact that that two thirds of patients are diagnose...

House Committee: Racial Bias in Clinical Decision Support 'Unacceptable'
https://www.medscape.com/viewarticle/960979

Oct 15th, 2021 - As a rising chorus of healthcare experts decries the harmful racial bias in clinical decision support tools (CDSTs), the House Ways and Means Committee has released a report spelling out in detail what the problem is, how it affects health equity, and how healthcare stakeholders can address it. Among the issues described in the report is the widespread practice of applying "racial correction" m...

FDA OKs Adjuvant Atezolizumab for Early-Stage Lung Cancer
https://www.medscape.com/viewarticle/960998

Oct 15th, 2021 - The US Food and Drug Administration has approved a new indication for the immunotherapy drug atezolizumab (Tecentriq) — the adjuvant treatment following resection and platinum-based chemotherapy in patients with stage II to IIIA non-small cell lung cancer (NSCLC) whose tumors have PD-L1 expression ≥ 1%. The agency also approved the Ventana PD-L1 (SP263) Assay (Ventana Medical Systems) as the co...

Gut Bacteria May Fuel Prostate Cancer Treatment Resistance
https://www.medscape.com/viewarticle/961025

Oct 15th, 2021 - A mainstay of treatment for prostate cancer is to deprive it of androgens, the hormones that make it grow. The testes are the main source of these hormones, so treatment can consist of either surgical removal of these organs or use of drugs to block their hormone production. Over time, some prostate cancers become resistant to these treatments and begin to expand again. As with many cancers tha...

Could Your Patient Benefit? New Trials in Lung Cancer
https://www.medscape.com/viewarticle/960851

Oct 14th, 2021 - Untreated PD-L1 non–small cell lung cancer (NSCLC). Patients with previously untreated, PD-L1-selected, locally advanced, unresectable, or metastatic NSCLC are sought for a phase 3 trial comparing pembrolizumab to the investigational immunotherapies ociperlimab (an anti-TIGIT antibody) and tislelizumab (an anti-PD-1 checkpoint inhibitor). Participants will be treated until death or progression ...

Henrietta Lacks Honored With WHO Director-General Award
https://www.medscape.com/viewarticle/960903

Oct 14th, 2021 - Henrietta Lacks, the Black woman whose cells were infamously taken without her knowledge for scientific research, was honored this week by the World Heath Organization as her family continues the fight to protect her legacy. Henrietta Lacks Lacks's cells, commonly known as "HeLa," are the only known human cells that continue to stay alive and reproduce outside of the human body. When a person d...

PsA Prevention Study With Biologics Contradicts Prior Findings
https://www.medscape.com/viewarticle/960843

Oct 14th, 2021 - A new study has found that patients with psoriasis who were treated with biologics were more likely to develop psoriatic arthritis (PsA) than those treated with phototherapy, oral therapy, or no therapy at all, although the authors cautioned readers to consider potential biases when reviewing their findings. "We do not suggest that these results should be interpreted causally; in other words, b...

CKD and Cancer Risk: What's the Link?
https://www.medscape.com/viewarticle/960849

Oct 14th, 2021 - Takeaway Chronic kidney disease (CKD) diagnosed using estimated glomerular filtration rate cystatin C (eGFRcys) was associated with an increased risk of cancer incidence and cancer death. Why this matters Findings warrant future studies to evaluate the association between kidney function, urinary albumin:creatinine ratio (uACR) and cancer death. Study design This study included 431,263 particip...

Failure to Communicate 'Doc-to-Doc' Blamed for Patient's Death
https://www.medscape.com/viewarticle/960857

Oct 14th, 2021 - The family of a man who died from a rare and feared complication of head and neck cancer has filed a $34 million lawsuit against the medical center where he was treated, alleging that his death would have been avoided had there been better communication between the surgical oncologist and the treatment team. The patient was a 49-year-old man who was experiencing chronic pain in his right ear. H...

Ultrasound Enhances Drug Delivery to Treat Brain Metastases
https://www.medscape.com/viewarticle/960876

Oct 14th, 2021 - Enhanced delivery of drugs to the brain could improve the outcomes for patients who develop brain metastases: that is the hope from an early proof-of-concept study.   "Failure of promising therapies to cross the blood­­–brain barrier (BBB) is an important cause of poor clinical response for a broad range of brain pathologies including cancer," note the researchers, led by Ying Meng, PhD, Sunnyb...

Soft Nodule on the Forearm
https://www.mdedge.com/dermatology/article/247327/dermatopathology/soft-nodule-forearm
Syeda F. Absar, MD, MPH, Tammie C. Ferringer, MD

Oct 13th, 2021 - The Diagnosis: Schwannoma Schwannoma, also known as neurilemmoma, is a benign encapsulated neoplasm of the peripheral nerve sheath that presents as a subcutaneous nodule. 1 It also may present in the retroperitoneum, mediastinum, and viscera (eg, gastrointestinal tract, bone, upper respiratory tract, lymph nodes).

New Approval in Early Breast Cancer: First Advance in 20 Years
https://www.medscape.com/viewarticle/960784

Oct 13th, 2021 - The CDK4/6 inhibitor abemaciclib (Verzenio) has been approved for use in early breast cancer for certain patients. One expert has described the drug as the first advance for this patient population in 20 years. Abemaciclib had already been approved for use in the treatment of HR+, HER2- advanced or metastatic breast cancer. Now it is also approved for use in HR+, HER2- early breast cancer for p...

FDA Approves Pembrolizumab Plus Chemo as First-Line Therapy for Advanced, Recurrent Cervical Cancer
https://www.medscape.com/viewarticle/960819

Oct 13th, 2021 - The US Food and Drug Administration (FDA) has approved the checkpoint inhibitor pembrolizumab (Keytruda, Merck) alongside standard chemotherapy — with or without bevacizumab — as first-line therapy for patients with persistent, recurrent, or metastatic PD-L1-expressing cervical cancer. The first-line approval comes on the heels of the phase 3 results from the KEYNOTE-826 trial, presented last m...

Advanced Kidney Cancer Patients in Scotland to Be Among First to Access New Treatment 
https://www.medscape.com/viewarticle/960756

Oct 13th, 2021 - Patients with advanced renal cell carcinoma (RCC) in Scotland are to be among the first in the world to access a new combination treatment. The Scottish Medicines Consortium (SMC) has recommended cabozantinib (Cabometyx, Ipsen) in combination with nivolumab (Opdivo, Bristol Myers Squibb) for the first-line treatment of advanced RCC in adults, for use by NHS Scotland. Cabozantinib offers an addi...

FDA Lifts Hold on Rusfertide Clinical Development Program
https://www.onclive.com/view/fda-lifts-hold-on-rusfertide-clinical-development-program

Oct 12th, 2021 - The FDA has removed the full clinical hold that had previously been placed on trials evaluating rusfertide (PTG-300), according to an announcement from Protagonist Therapeutics, Inc.1 With this decision, dosing on all studies evaluating the agent is permitted to resume. The regulatory agency placed the hold on the trials in September 2021 following a notification from the pharmaceutical comp...

HPV Vaccine Hesitancy Remains High Among US Parents
https://www.medscape.com/viewarticle/960602

Oct 12th, 2021 - NEW YORK (Reuters Health) - Hesitancy over the human papillomavirus (HPV) vaccine remains high among parents in the United States, with almost two-thirds of parents on the fence about getting their child vaccinated, according to a new study. The HPV vaccine was approved in the U.S. in 2006. Two doses of the vaccine are recommended for most adolescents, with the first dose given before age 15 ye...

Genes Related to Osteosarcoma Survival Identified
https://www.medscape.com/viewarticle/960703

Oct 12th, 2021 - Investigators in China have identified 14 immune-related genes associated with survival in osteosarcoma. When they combined them into a risk score and added one additional factor – metastases at diagnosis – the model was an "excellent" predictor of 1-year survival, the team said (area under the curve, 0.947; 95% confidence interval, 0.832-0.972). "The survival-associated" immune-related genes (...

A Mail Carrier With Gross Hematuria Whose Sister Has Lupus
https://www.medscape.com/viewarticle/960397

Oct 12th, 2021 - Editor's Note: The Case Challenge series includes difficult-to-diagnose conditions, some of which are not frequently encountered by most clinicians but are nonetheless important to accurately recognize. Test your diagnostic and treatment skills using the following patient scenario and corresponding questions. If you have a case that you would like to suggest for a future Case Challenge, please ...