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About 41,253 results

CRC Screening: Blood Test Accuracy Compared to Colonoscopy
https://www.medscape.com/viewarticle/974402

May 21st, 2022 - The first prospective study to evaluate the accuracy of a blood test for people being screened for colorectal cancer (CRC) revealed a high sensitivity and specificity. At 90% specificity, the blood assay (Guardant Health) was 100% sensitive for detecting CRC. At 95% specificity, sensitivity was 88%. The blood assay detects circulating tumor DNA from cancer in the bloodstream, which is then anal...

H pylori May Undermine Immunotherapy Response in Gastric Cancer
https://www.medscape.com/viewarticle/974351

May 20th, 2022 - The study was published on researchsquare.com as a preprint and has not yet been peer reviewed. Key Takeaways Patients with advanced gastric cancer who have active Helicobacter pylori infections were less likely to respond to anti-PD-1 antibody therapy than H pylori–negative patients. Those with active H pylori infections also demonstrated shorter progression-free survival (PFS) and overall sur...

Gynecologic Cancer Studies: What to Look for at ASCO 2022
https://www.medscape.com/viewarticle/973898

May 20th, 2022 - This transcript has been edited for clarity. I'm Maurie Markman from Cancer Treatment Centers of America. I would like to briefly comment on the abstracts that have been released for the American Society of Clinical Oncology (ASCO) meeting coming up next month in Chicago and specifically the gynecologic oncology track. It's going to be a very interesting series of sessions. There's an oral abst...

Prostate Cancer Survival: Enzalutamide Edges Out Abiraterone
https://www.medscape.com/viewarticle/974344

May 20th, 2022 - The study was published on researchsquare.com as a preprint and has not yet been peer reviewed. Key Takeaways Men with metastatic castration-resistant prostate cancer (mCRPC) who began treatment on enzalutamide instead of abiraterone remained on treatment longer and lived a few more months. Older men and those with diabetes or cardiovascular disease also benefited more from enzalutamide. Why Th...

Experts Urge Stopping Melanoma Trial Because of Failure and Harm
https://www.medscape.com/viewarticle/974244

May 19th, 2022 - New results from a phase 3 clinical trial may shut the door on the addition of progressive death–1 or PD–ligand 1 inhibitors to the combination of BRAF and MEK inhibitors for the treatment of BRAF V600–mutated melanoma. The approach seemed promising, given the efficacy of PD-1 and PD-L1 inhibitors in metastatic melanoma, and the relatively short response times to BRAF and MEK inhibitors could p...

NeoChemo Preserves Rectum in Half of Patients With Rectal Cancer
https://www.medscape.com/viewarticle/974243

May 19th, 2022 - Among patients with stage II or stage III rectal adenocarcinoma, organ preservation is achievable in up to half of patients who undergo total neoadjuvant chemotherapy (TNT), according to the results from a new randomized phase 2 trial. The study included 324 patients from 18 centers who were randomized into one of two groups: induction chemotherapy followed by chemoradiotherapy (INCT-CRT) or ch...

AUA 2022: A Report From the Trenches
https://www.medscape.com/viewarticle/974295

May 19th, 2022 - The American Urological Association (AUA) 2022 Annual Meeting took place recently at the Ernest N. Morial Convention Center in New Orleans. A common theme among attendees was that although Zoom is a wonderful tool to disseminate information, something about physically attending a conference makes the meeting more rewarding and productive. Hundreds of talks and abstracts were presented over the ...

Shift to HPV Testing Will Require Public Education
https://www.medscape.com/viewarticle/974261

May 19th, 2022 - The shift from Papanicolaou (Pap) cytology to direct testing for the human papillomavirus (HPV) represents a major advance in cervical cancer screening. Nevertheless, some experts like Emily Delpero, MD, of Mount Sinai Hospital in Toronto, Canada, expect significant initial pushback from patients and physicians alike. Others like Marc Steben, MD, co-director of HPV Global Action, and professor ...

New Image-Based Risk Model Helps Predict Future Breast Cancers
https://www.medscape.com/viewarticle/974266

May 19th, 2022 - Researchers have created and validated a risk model based on digital breast tomosynthesis (DBT) images that can predict a woman's chance of developing breast cancer within a year of a negative or benign mammography screening exam. This model could potentially lead to earlier detection and improved prognosis. "The DBT risk model is fully automated and provides the clinician with a risk category ...

What Is the Optimal Treatment for Multifocal Intrahepatic Cholangiocarcinoma?
https://www.medscape.com/viewarticle/974146

May 18th, 2022 - NEW YORK (Reuters Health) - In patients with multifocal intrahepatic cholangiocarcinoma (iCCA), hepatic arterial infusion pump (HAIP) floxuridine chemotherapy may be an effective alternative to surgery, a cohort study suggests. "We believe that these findings are practice-changing," Stijn Franssen and Dr. Bas Groot Koerkamp, both of Erasmus MC Cancer Institute in Rotterdam, told Reuters Health ...

Liquid Biopsy Predicts Resistance to Neoadjuvant Therapy in Esophageal Cancer
https://www.medscape.com/viewarticle/974120

May 18th, 2022 - NEW YORK (Reuters Health) - Researchers have developed and validated a liquid biopsy assay that can predict response to neoadjuvant therapy (NAT) in patients with esophageal squamous-cell carcinoma (ESCC), which may lead to more-personalized treatment decisions. ESCC is one of the most aggressive and lethal subtypes of esophageal cancer and response to NAT is mixed. Predicting NAT resistance is...

Doctor Accused of 'Fraudulent Concealment' Can't Be Held Liable
https://www.medscape.com/viewarticle/974174

May 18th, 2022 - In April, the Iowa Supreme Court dismissed a knotty claim against a local doctor and hospital accused of concealing a woman's renal cancer, according to a story in the Iowa Capital Dispatch, among other news outlets. In 2004, Linda Berry visited Mercy Medical Center in Cedar Rapids for an unspecified ailment. At the hospital, Berry underwent a CT scan, which revealed a benign cyst on her right ...

Studies Address Ibrutinib Bleeding Risk in Patients With CLL Receiving Mohs Surgery
https://www.medscape.com/viewarticle/974234

May 18th, 2022 - Patients receiving treatment with ibrutinib for chronic lymphocytic leukemia (CLL) show significant increases in the risk for bleeding when undergoing Mohs micrographic surgery for skin cancer, indicating the need for temporary treatment interruptions, new research shows. Dr Kelsey E. Hirotsu "Our cohort of CLL patients on ibrutinib had a two-times greater risk of bleeding complications relativ...

Medicine, AI, and Bias: Will Bad Data Undermine Good Tech?
https://www.medscape.com/viewarticle/974242

May 18th, 2022 - Imagine walking into the Library of Congress, with its millions of books, and having the goal of reading them all. Impossible, right? Even if you could read every word of every work, you wouldn't be able to retain or comprehend everything — even if you spent a lifetime trying.  Now let's say you somehow had a super-powered brain capable of reading and understanding all that information. You wou...

Improved Cancer Survival in States with ACA Medicaid Expansion
https://www.medscape.com/viewarticle/974180

May 18th, 2022 - In states that adopted Medicaid expansion following the implementation of the Affordable Care Act (ACA), patients with cancer have improved 2-year overall survival rates when compared with patients in states that did not adopt the expansion. The finding comes from an American Cancer Society study, published online today in the Journal of the National Cancer Institute, of more than 2 million pat...

Sexual Minorities Less Likely to Receive Pap Screening
https://www.medscape.com/viewarticle/974028

May 17th, 2022 - NEW YORK (Reuters Health) - Sexual minorities who have a cervix are less likely than heterosexual women to be screened for cervical cancer, a new study suggest. An analysis of data from more than 18,000 people who were assigned female sex at birth and who participated in a national health survey revealed that sexual minorities (SM) were half as likely as heterosexual women to ever undergo Pap s...

Treatment and Follow-up Care for Premenopausal Women With Breast Cancer
https://www.medscape.com/viewarticle/963169

May 17th, 2022 - This transcript has been edited for clarity. Lidia Schapira, MD: Hello. I'm Dr Lidia Schapira, and I want to welcome you to Medscape InDiscussion: Breast Cancer. Today, we'll be talking about treatment and follow-up care for premenopausal women with breast cancer, a topic that is challenging for all clinicians — not only oncologists but also obstetricians, gynecologists, primary care clinicians...

Sarcopenia Nearly Doubles Risk Women Will Quit Endocrine Therapy
https://www.medscape.com/viewarticle/974106

May 17th, 2022 - The study was published on researchsquare.com as a preprint and has not yet been peer reviewed. Key Takeaway Having sarcopenia almost doubles the risk that women with hormone receptor (HR)–positive breast cancer will stop receiving endocrine therapy early owing to side effects. Why This Matters It is known that sarcopenia is associated with a reduction in chemotherapy adherence and is predictiv...

Mastectomy May Not Be Necessary for Young Breast Cancer Patients
https://www.medscape.com/viewarticle/974134

May 17th, 2022 - Mastectomies among younger women with nonmetastatic invasive breast cancer may not always be necessary, according to a new study that shows survival outcomes are similar to those of women who had a lumpectomy. The results come as an increasing number of women under 40 choose mastectomy. "A lot of times, there's this assumption that removal of the entire breast is going to prevent cancer from re...

Rapid Review Quiz: Carcinogens
https://www.medscape.com/viewarticle/973380

May 16th, 2022 - The US National Institute of Environmental Health Sciences and National Toxicology Program has cited the identification of carcinogens as a key step in cancer prevention and the improvement of public health, and this is in line with the view of the World Health Organization. Review the latest research into physical, chemical, and biological carcinogens, including newly recognized substances, wi...