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COVID-19 Science Update released: October 22, 2021 Edition 110

The COVID-19 Science Update summarizes new and emerging scientific data for public health professionals to meet the challenges of this fast-moving pandemic. Weekly, staff from the CDC COVID-19 Response and the CDC Library systematically review literature in the WHO COVID-19 database, and select publications and preprints for public health priority topics in the CDC Science Agenda for COVID-19 a...

A 70-year-old man presents with firm papules on his hand and fingers
Donna Bilu Martin, MD, Susannah Berke, MD

Oct 21st, 2021 - Granuloma annulare (GA) is a benign cutaneous disorder with an unknown cause. All races and ages may be affected, although women are more often affected than men.

Rare Aggressive Bladder Cancer Treated Successfully in Elderly Man

Oct 21st, 2021 - A 71-year-old man presented to hospital in November 2014 upon referral after reporting pain and evidence of blood on urination. Imaging and cystoscopy assessments identified a vegetative lesion of the bladder wall. The patient reported being a heavy smoker for the past 30 years. His medical history over the past 3 decades included high blood pressure, elevated cholesterol, and psoriasis. His su...

On improving DLBCL outcomes, single-agent regimens fall short
Sharon Worcester

Oct 20th, 2021 - Targeted agents for the treatment of diffuse large B-cell lymphoma (DLBCL) should be used in the context of oncogenic addictions within the lymphoma cells, and a thorough molecular analysis should be conducted prior to using specific agents, a review of the relevant literature suggests. “In addition.

Investigators Seek to Preserve Fertility in Ovarian Malignant Germ Cell Tumors

Oct 19th, 2021 - Germ cell tumors of the ovary are aggressive tumors derived from the primitive germ cells of the embryonic gonad and appear most often in young women or adolescent girls. These tumors are frequently unilateral and generally curable if found and treated early. Germ cell tumors constitute 20% to 25% of all ovarian neoplasms. The vast majority of these tumors are benign mature cystic teratomas;...

UGN-102 May Provide Alternative to Repetitive Surgery in Low-Grade Intermediate-Risk NMIBC

Oct 19th, 2021 - Non-surgical primary chemoablation using mitomycin-containing reverse thermal gel UGN-102 produced significant, durable responses in those with low-grade intermediate-risk non–muscle invasive bladder cancer (NMIBC), according to data from the phase 2b OPTIMA II trial (NCT03558503) published in The Journal of Urology.1 Results showed that among 63 patients who received 1 or more installation of...

Guideline Recommendations for CIN Prophylaxis

Oct 19th, 2021 - Hope S. Rugo, MD, FASCO: It’s really important: the whole concept of why we worry about this and how we treat it and also prophylax. We’ll talk more about that later. Tiffany, there are clear risk factors, as Bill and Rita pointed out. Can you tell us a little more about the risk factors, how you monitor patients, and if the risk factors change either the chemotherapy you choose, the doses, or ...

Toward Cholera Elimination, Haiti

Oct 19th, 2021 - After cholera was reintroduced into Haiti in 2010 (1), the country experienced an epidemic of unparalleled magnitude: the 9,789 recorded casualties represent the largest number for a single epidemic in the past 20 years (https://apps.who.int/gho/data/node.main.174). Unfortunately, vulnerabilities of people in Haiti to fecal–oral diseases such as cholera have barely been reduced over the past de...

Policy Review and Modeling Analysis of Mitigation Measures for Coronavirus Disease Epidemic Control, Health System, and Disease Burden, South Korea

Oct 19th, 2021 - Since the first reported outbreak in Wuhan, China, on December 31, 2019, severe acute respiratory syndrome coronavirus 2 has infected >210 million persons and resulted in nearly 4.4 million deaths worldwide as of August 2021 (1). Many countries have responded to the coronavirus disease (COVID-19) pandemic with unprecedented large-scale anticontagion policies, including closure of nonessential b...

Right-Sided CRC Metastases Call for 'More Aggressive' Approach

Oct 18th, 2021 - Colorectal cancer (CRC) metastases from right-sided primary tumors and CRC liver metastases had higher rates of local failure following stereotactic ablative radiotherapy (SABR), a single-institution retrospective study found. Among 130 patients with oligometastatic CRC, lesions stemming from right-sided CRCs were more than twice as likely to recur locally following SABR, as compared with left-...

COVID-19 Science Update released: October 15, 2021 Edition 109

The COVID-19 Science Update summarizes new and emerging scientific data for public health professionals to meet the challenges of this fast-moving pandemic. Weekly, staff from the CDC COVID-19 Response and the CDC Library systematically review literature in the WHO COVID-19 database, and select publications and preprints for public health priority topics in the CDC Science Agenda for COVID-19 a...

COVID Toes and Seasonal Chilblains Share Similar Immune Responses

Oct 15th, 2021 - NEW YORK (Reuters Health) - Chilblain-like lesions (CLLS), also known as "COVID toes," are histologically similar to seasonal chilblains (SCs), with high levels of certain autoantibodies as well as type 1 interferon, an observational study shows. "Both immune system and vascular alterations take part in the pathogenesis of COVID toe," Dr. Charles Cassius of AP-HP Hopital Saint-Louis in Paris to...

Case Report: Lung Cancer Shrinks in Patient Using CBD Oil

Oct 15th, 2021 - A case report describes the dramatic shrinkage of a tumor to a quarter of its original size in a patient with non–small cell lung cancer (NSCLC) who had declined conventional treatment, continued smoking, and who later revealed that she was ingesting cannabidiol (CBD) oil. The patient was an 80-year-old woman. At diagnosis, the tumor measured 41 mm, and there was no evidence of local or further...

Oncologist Recounts Difficulty of Mid-Career Move

Oct 15th, 2021 - After 18 years at his first and only employer, the Cleveland Clinic, in Ohio, Mikkael Sekeres, MD, decided it was time to move on. Dr Mikkael Sekeres The hematologist-oncologist said that his opportunities for career advancement had plateaued and, with the burden of additional clinic hours in recent years, his work as a researcher and mentor was pinched. So Sekeres set out on a mission to find ...

FDA Panel Backs Second Shot for Those Who Got J&J Vaccine 

Oct 15th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. A US Food and Drug Administration (FDA) advisory committee on Friday voted 19-0 to authorize second doses of the Johnson & Johnson COVID-19 vaccine in an effort to boost immunity. It was the second vote in as many days to back a change to a COVID vaccine timeline. In its vote, the committee said...

Precedex in Abdominal Surgery May Speed Up GI Function Recovery

Oct 14th, 2021 - Older adults who received a low-dose of intravenous dexmedetomidine (Precedex) while undergoing abdominal surgery saw a quicker return to normal gastrointestinal function and shorter hospital stays, a randomized trial conducted in China found. The study met its primary endpoint, with those administered intraoperative dexmedetomidine during anesthesia reporting a shorter time to first flatus ver...

Guillain-Barré Syndrome Associated with COVID-19 Vaccination

Oct 14th, 2021 - Guillain-Barré syndrome (GBS), an immune-mediated polyradiculoneuropathy with a ≈5% mortality rate, has an incidence worldwide of 0.81–1.91 cases/100,000 person-years (1). GBS has been reported to be associated with coronavirus disease (COVID-19) vaccination, but a comprehensive summary regarding this rare adverse event is still lacking. To determine clinical features of GBS associated with COV...

Subclinical Burkholderia pseudomallei Infection Associated with Travel to the British Virgin Islands

Oct 14th, 2021 - Burkholderia pseudomallei is a gram-negative aerobic bacillus and the etiologic agent of melioidosis (1). The clinical signs and symptoms of melioidosis are varied, and subclinical infection can occur with or without latent clinical manifestation (1–3). Infection with B. pseudomallei typically is associated with environmental exposure through inhalation or direct contact with contaminated soil ...

Telehealth Has Pros and Cons for Addiction Treatment

Oct 13th, 2021 - When it comes to substance use disorders, treatment via telehealth may not measure up to the efficacy of in-person treatment in all areas, but it may improve access and convenience during the COVID-19 pandemic, according to a recent literature review and survey study. Four of eight studies that compared individual counseling delivered through telehealth versus in-person counseling found no sign...

Analysis Examines Real-World Survival Outcomes With Frontline Combos in Metastatic RCC

Oct 13th, 2021 - The 18-month survival rates observed with axitinib (Inlyta) plus pembrolizumab (Keytruda) vs ipilimumab (Yervoy) plus nivolumab (Opdivo) in the frontline treatment of patients with metastatic renal cell carcinoma (RCC) were not found to be statistically different, according to findings from a real-world analysis presented during the 2021 Kidney Cancer Research Summit (KCRS).1 The median prog...