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About 13,368 results

The New Obesity Breakthrough Drugs
https://www.medscape.com/viewarticle/985549

Dec 14th, 2022 - This article was originally published December 10 on Medscape editor-in-chief Eric Topol's substack "Ground Truths." There are many holy grails in medicine, with failure after failure, like finding a way to prevent Alzheimer's disease or a non-invasive means for accurately measuring ambulatory blood pressure. But one of the biggest and most daunting has been finding drugs that can tackle obesit...

Bariatric Surgery Effective for Class l Obesity Over Long Term
https://www.medscape.com/viewarticle/985448

Dec 12th, 2022 - Patients with Class I obesity can be treated effectively with bariatric surgery, which reduces BMI and comorbidities over 5 years, according to a single-center study. In a retrospective analysis of patients who underwent bariatric surgery for Class I obesity, 35 patients achieved a mean BMI of 25.6 and excess weight loss of close to 90%. About half of the patients also achieved remission of com...

New 'Almanac' Details Global Burden, Drivers of Cardiovascular Disease
https://www.medscape.com/viewarticle/985461

Dec 12th, 2022 - A new multinational report details the substantial burden of cardiovascular disease (CVD) worldwide and spotlights the importance of collective action to address the modifiable risk factors driving these diseases. Published today in a special issue of the Journal of the American College of Cardiology, the report uses a graphic-rich, almanac style to present data on 18 specific CV conditions and...

Bariatric Surgery Reduces Obesity-Related Cancer Risk
https://www.medscape.com/viewarticle/981929

Dec 12th, 2022 - This transcript has been edited for clarity. I'm Dr Maurie Markman from Cancer Treatment Centers of America. I’m going to briefly discuss a component of a very complex and somewhat controversial topic. This relates to the long-term value of bariatric surgery in individuals who have very high BMI. The specific issue I'm addressing is the impact of bariatric surgery on subsequent cancer risk. The...

Does Paying People to Lose Weight Work?
https://www.medscape.com/viewarticle/985269

Dec 12th, 2022 - The notion that the reason people with obesity are not losing weight is that they aren't sufficiently incentivized to do so is toxic. It denies the impact of the thousands of genes and dozens of hormones involved in our individual levels of hunger, cravings, and fullness. It denies the torrential current of our ultraprocessed and calorific food environment. It denies the constant push of food a...

The Whale: Is This New Movie Fat-Phobic or Fat-Friendly?
https://www.medscape.com/viewarticle/985113

Dec 9th, 2022 - "I could relate to many, many, many of the experiences and emotions that Charlie, which is Brendan Fraser's character, was portraying," Patricia Nece recalls after watching the soon-to-be-released movie The Whale. Much of the movie "rang true and hit home for me as things that I, too, had experienced," Nece, the board of directors' chair of the Obesity Action Coalition (OAC) and a person living...

Teen's Undisclosed Dieting May Precede an Anorexia Nervosa Diagnosis
https://www.medscape.com/viewarticle/985353

Dec 9th, 2022 - Adolescents later diagnosed with anorexia nervosa (AN) likely embark on the trajectory to AN with undisclosed dieting for weight loss at about age 14, a study of teens and parents found. In the interview-based study, both adolescents and their parents described a similar prediagnosis sequence of behavioral changes occurring over roughly 1 year to 18 months, but parents lagged some 6 months behi...

Obesity Linked to Higher Risk for Adverse Events From Nivolumab
https://www.medscape.com/viewarticle/985325

Dec 9th, 2022 - Obese patients with advanced cancer treated with nivolumab monotherapy face a higher risk for immune-related adverse events, a new retrospective analysis suggests. However, only obese women receiving the nivolumab monotherapy appeared to have a higher risk for grade 3 or 4 events, according to the pooled analysis of data from 3772 patients with advanced cancer across eight tumor types. "Obesity...

New Indications for Bariatric Surgery: My Reservations
https://www.medscape.com/viewarticle/984177

Dec 8th, 2022 - This transcript has been edited for clarity. I'm Dr Neil Skolnik, and today we are going to talk about the American Society for Metabolic and Bariatric Surgery (ASMBS) "Indications for Metabolic and Bariatric Surgery." These are the first new guidelines to address this issue since the National Institutes of Health (NIH) consensus statement in 1991, so this is a much-needed update. I'm going sha...

Cold Water Immersion Can Have Benefits
https://www.medscape.com/viewarticle/985260

Dec 8th, 2022 - Bathing in cold water or ice may cut "bad" body fat and reduce the risk of disorders such as diabetes, but other claims of health benefits are less defined, according to researchers from the Arctic University of Norway and the University Hospital of North Norway. What to Know Immersion in cold water has a major impact on the body. It elevates the heart rate and has positive effects on brown adi...

Remission From Type 2 Diabetes: Myth or Reality?
https://www.medscape.com/viewarticle/985111

Dec 6th, 2022 - Stockholm, Sweden — Because half of patients with type 2 diabetes (T2D) in France have blood glucose levels that are outside of their target range, the idea of remission from the condition is not at the forefront of doctors' minds. It takes second place to glycemic control. Yet, an international consensus suggests that modern-day medicines now make remission possible in those recently diagnosed...

Amgen Says Experimental Obesity Drug Has Promising Durability
https://www.medscape.com/viewarticle/984965

Dec 5th, 2022 - LOS ANGELES (Reuters) - Amgen Inc's experimental obesity drug demonstrated promising durability trends in an early trial, paving the way for a larger mid-stage study early next year, company officials said ahead of a data presentation on Saturday. The small Phase I trial found that patients maintained their weight loss for 70 days after receiving the highest tested dose of the injected drug, cu...

Higher BMI May Dampen Steroid Response in Eosinophilic Esophagitis
https://www.medscape.com/viewarticle/984983

Dec 5th, 2022 - New research suggests that body mass index (BMI) may influence response to topical corticosteroid (tCS) therapy for eosinophilic esophagitis (EoE). The higher the patient's BMI level, the lower the individual's response to tCS therapy from a symptomatic, endoscopic, and histologic perspective, researchers observed in a retrospective study. Because there are few clinical predictors of response t...

Are Children With Atopic Dermatitis More Likely to Fracture Bones?
https://www.medscape.com/viewarticle/984999

Dec 5th, 2022 - Children with atopic dermatitis (AD) may be at increased risk for broken bones, results of a national cohort study in Korea suggest. "In this nationally representative cohort study, we observed that AD development was associated with an increased risk of subsequent fracture," and fracture risk increased with AD severity, lead author Seung Won Lee, MD, PhD, of the Department of Precision Medicin...

Joint Replacements: Should There Be BMI Cutoffs?
https://www.medscape.com/viewarticle/985023

Dec 5th, 2022 - For patients with severe arthritis, joint replacement is considered when more conservative treatments have failed. Because patients with obesity have a higher risk of complications during and after surgery, some surgeons, hospitals, and insurance companies have adopted body mass index (BMI) cutoffs as a basis for deciding whether to offer patients these elective surgeries. But some experts argu...

Lecanemab a Game-Changer for Alzheimer's? Not So Fast
https://www.medscape.com/viewarticle/985024

Dec 5th, 2022 - Full findings from the CLARITY AD trial released last week show that treatment with the monoclonal antibody lecanemab led to modest cognitive benefit in patients with early Alzheimer's disease (AD) — but at a cost of increased risk of amyloid-related edema and effusions. Yet, the modest benefit got lost in some mainstream news coverage; one headline hailed lecanemab as a "momentous breakthrough...

Trending Clinical Topic: Weight Loss Drugs
https://www.medscape.com/viewarticle/984313

Dec 2nd, 2022 - Each week, we identify one top search term, speculate about what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what's trending and why, share them with us on Twitter or Facebook.  Excitement about "unprecedented" weight loss associated with tirzepatide, news about other injectable medications, and updated antiobesity recommendations resulte...

How Much Exercise Will It Take to Burn Off?
https://www.medscape.com/viewarticle/984791

Dec 2nd, 2022 - One of the least helpful but most pervasive misconceptions in weight management is that exercise is a primary driver of weight loss, which in turn leads to the unhealthy corollary that calories burned are the primary reason to exercise. Yoni Freedhoff, MD Perhaps it's consequent to that misperception that some have suggested that posting messages like how long you'd need to run to burn off this...

Gestational Hypertension-Diabetes Combo Signals CVD Risk
https://www.medscape.com/viewarticle/984932

Dec 2nd, 2022 - Women who develop transient hypertensive disorders during their pregnancy are at risk for developing subsequent cardiovascular disease (CVD), particularly if this experienced at the same time as gestational diabetes. In a large population-based study, the adjusted hazard ratios for developing CVD following a gestational hypertensive disorder (GHTD) alone were 1.90 (95% confidence interval, 1.15...

Green Mediterranean Diet Lowers Visceral Adipose Tissue
https://www.medscape.com/viewarticle/984931

Dec 2nd, 2022 - Visceral adipose tissue is significantly reduced with the green Mediterranean diet (MED), which consists of polyphenols and reduced red meat intake, according to a new analysis of the 18-month Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed (DIRECT-PLUS) trial. The new results indicate that the green Mediterranean diet lowered visceral fat by twice as much as the standa...