Jan 30th, 2023 - Supervised moderate and vigorous aerobic activity helped stave off type 2 diabetes in at-risk individuals with central obesity and nonalcoholic fatty liver disease, according to 10-year follow-up of a randomized trial from China. Compared with adults who did not exercise, the risk of diabetes was reduced by 49% in the vigorous exercise group (relative risk [RR] 0.51, 95% CI 0.27-0.94, P=0.01) a...

Jan 24th, 2023 - In this video, Amanda Calhoun, MD, MPH, of the Yale Child Study Center in New Haven, Connecticut, discusses the new American Academy of Pediatrics (AAP) Clinical Practice Guideline for the Evaluation and Treatment of Children and Adolescents with Obesity. The following is a transcript of her remarks: Essentially, the American Academy of Pediatrics released a series of guidelines that are meant ...

Jan 24th, 2023 - The FDA is reviewing a potential new indication for empagliflozin (Jardiance) for risk reduction of kidney disease progression and cardiovascular death in adults with chronic kidney disease (CKD) based on the EMPA-KIDNEY phase III trial, Boehringer Ingelheim and Eli Lilly announced. Why did NYU Langone Health abruptly withdraw from a study testing the bacillus Calmette-Guerin vaccine for adoles...

Jan 17th, 2023 - Oral semaglutide (Rybelsus) received an expanded label to include first-line treatment for adults with type 2 diabetes as an adjunct to diet and exercise, Novo Nordisk announced. The Obesity Society and Obesity Action Coalition lent support to the American Academy of Pediatrics' new childhood obesity guidelines in a statement, emphasizing that pediatric obesity is a disease and that early inter...

Jan 17th, 2023 - Weight may be linked to a modified response to vitamin D supplementation, according to a post-hoc analysis of the Vitamin D and Omega-3 Trial (VITAL). While supplementation with vitamin D 2,000 IU/day was associated with an increase in serum total 25-hydroxyvitamin D (25-OHD) levels compared with placebo at 2-year follow-up, increases were significantly lower with higher body mass index (BMI; P...

Jan 13th, 2023 - HealthDay News — In a clinical practice guideline issued by the American Academy of Pediatrics and published online in Pediatrics, key action statements and consensus recommendations are presented for the evaluation and treatment of children with overweight and obesity. Sarah E. Hampl, MD, from the Children’s Mercy Kansas City Center for Children’s Healthy Lifestyles & Nutrition at the Universi...

Jan 11th, 2023 - Once-weekly treatment with semaglutide 2.4 mg in adolescents with obesity, along with lifestyle intervention, is associated with a substantial reduction in body mass index (BMI) compared with the use of lifestyle intervention alone, according to study findings that were published in The New England Journal of Medicine. Investigators conducted the STEP TEENS trial (Semaglutide Treatment Effect i...

Jan 11th, 2023 - Undergoing bariatric surgery for severe obesity was linked to a decreased incidence of esophageal and gastric cancer and overall in-hospital mortality, a French cohort study showed. Among mostly women, the incidence rates of these cancers were 4.9 per 100,000 population per year for the group who underwent bariatric surgery versus 6.9 per 100,000 population per year for those who did not underg...

Jan 10th, 2023 - Among pregnant women with type 1 diabetes, using insulin degludec was noninferior to insulin detemir for glucose control and safety. (The Lancet Diabetes & Endocrinology) Even the lowest dose (3 mg/kg) of the investigational thyroid eye disease drug VRDN-001 significantly reduced proptosis in 67% of patients in an ongoing phase I/II trial, said developer Viridian Therapeutics. A school-based ga...

Jan 9th, 2023 - In contrast to previous recommendations, pediatricians and other pediatric healthcare providers are advised to provide "immediate, intensive obesity treatment to each patient" as soon as they receive a diagnosis, according to new guidance from the American Academy of Pediatrics (AAP). The guidance, published in Pediatrics, marks the AAP's first clinical practice guideline outlining evidence-bas...

Jan 4th, 2023 - The Food and Drug Administration (FDA) has approved Wegovy® (semaglutide injection) as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in pediatric patients aged 12 years and older with an initial body mass index (BMI) at the 95th percentile or greater for age and sex (obesity). Wegovy contains semaglutide, a glucagon-like peptide-1 (GLP-1) rec...

Jan 3rd, 2023 - Use bisphosphonates for the initial pharmacologic treatment of primary osteoporosis in men and postmenopausal women, the American College of Physicians recommended in its updated guidelines. (Annals of Internal Medicine) Detection of elevated uric acid levels prior to 24 weeks gestation was linked with a higher risk of gestational diabetes development, an observational study found. (Journal of ...

Dec 29th, 2022 - The FDA approved injectable semaglutide 2.4 mg (Wegovy) for people with obesity ages 12 and up, maker Novo Nordisk announced. When paired with diet and exercise, it's now indicated for use in adolescents with an initial BMI at or above the 95th percentile for age and sex based on CDC growth charts. This new indication for the GLP-1 receptor agonist marks the first anti-obesity medicine for teen...

Dec 28th, 2022 - In May, MedPage Today reported on the FDA approval of the first-in-class tirzepatide (Mounjaro) for type 2 diabetes. In this report, we follow up on what's happened since this approval and what's next. The FDA green-lit tirzepatide (Mounjaro), a once-weekly injectable glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide (GLP-1/GIP) agonist, in three dose levels (5 mg, 10 mg,...

Dec 27th, 2022 - The Endocrine Society released new guidelines for treating hypercalcemia of malignancy in adults. (The Journal of Clinical Endocrinology & Metabolism) Childhood cancer survivors -- especially females -- may carry an increased risk for fractures. (The Lancet Diabetes & Endocrinology) The American Thyroid Association, along with the European Thyroid Association, released a new consensus statement...

Dec 20th, 2022 - The FDA added Eli Lilly's tirzepatide (Mounjaro) and dulaglutide (Trulicity) to its shortage list this week. (Reuters) The decision to go ahead with bariatric surgery was closely tied with patient satisfaction in their patient-physician relationship, regardless of race and ethnicity. (JAMA Network Open) The FDA approved a new indication for the parathyroid hormone-related peptide analog abalopa...

Dec 19th, 2022 - In SPRINT, intensive systolic blood pressure lowering decreased natriuretic peptide levels but increased high-sensitivity cardiac troponin T (cTn). (Circulation) The medical community braces for harmful messaging about COVID-19 vaccines after Florida Surgeon General Joseph Ladapo, MD, PhD, announced plans for another study on their links to myocarditis. (Orlando Sentinel) As an alternative to h...

Dec 16th, 2022 - Fecal microbiota transplantation (FMT) had no effect on weight loss, body composition, or metabolic markers in obese individuals who underwent bariatric surgery, said authors of a small clinical trial. In 41 adults with severe obesity, total weight loss at 12 months post-surgery was not significantly different in those who received FMT beforehand compared with those who received a placebo trans...

Dec 15th, 2022 - Among kids with type 2 diabetes (T2D), obesity was common but far from universal in a look at the condition worldwide. In fact, only 75% of pediatric cases were found to also have obesity, with a rate of 77% at the time of diagnosis, according to a systematic review and meta-analysis of nearly 9,000 kids with T2D published in JAMA Network Open. Although only 4.2% of children with type 2 diabete...

Dec 15th, 2022 - The CDC released new extended BMI-for-age growth charts on Thursday to include children and adolescents with severe obesity. Charts now extend to a BMI of 60, and severe obesity is defined as 120% of the 95th percentile, to reflect the higher prevalence of obesity among kids and teens, rates of which have tripled over the past three decades. These new curves were added to the pre-existing 2000 ...