About 95,018 results

Oral antiviral drug effective against respiratory syncytial virus (RSV) identified by Biomedical Sciences researchers

Jun 24th, 2022 - ATLANTA—An oral antiviral drug that targets a key part of the respiratory syncytial virus (RSV) polymerase and inhibits the synthesis of viral genetic material has been identified, a finding that could provide an effective treatment against RSV disease, according to researchers in the Center for Translational Antiviral Research at Georgia State University. The findings, published in the journal...

'Can I Survive Without Payments From Insurers?'

Jun 24th, 2022 - It took Michael Golden, MD, 5 years to decide to switch to a concierge practice, in which patients pay a monthly or annual fee for more personalized care. Golden, an internist in Beverly, Massachusetts, changed course in 2021, during the COVID-19 pandemic. "I'm not sure why I hesitated for so long," said Golden. Once they take the plunge into concierge practice or direct primary care (DPC) ― a ...

Retained Motor Skills Linked to Single-Neuron Activity

Jun 24th, 2022 - The study covered in this summary was published bioRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaways Analysis of stereotyped behavior patterns with recordings of single-neuron activity in the motor cortex and dorsolateral striatum reveal that neural circuit dynamics are highly stable at the level of single neurons. Stable single-unit activity in motor circuits is involved...

Henry Ford Health participated in novel clinical trial without in-person patient involvement

Jun 23rd, 2022 - DETROIT (June 22, 2022) – Henry Ford Health was part of a multi-institutional heart failure study that was launched and executed completely virtual during the COVID-19 pandemic. The novel study design could serve as a model for future research. Unlike traditional clinical trials that involve in-person clinic visits, researchers in this study engaged directly with more than 400 patients through ...

Women's heart attacks are often missed. This gene may help explain why.

Jun 23rd, 2022 - When diagnostic tests for the heart were first created, scientists at the time did not fully consider that no two bodies are the same, especially between the sexes. According to University of Florida College of Nursing associate professor Jennifer Dungan, many of the current symptom profiles and lab tests for heart disease do not accurately reflect known differences in women’s heart disease. Th...

Promising New Tool for Better Migraine Management in Primary Care

Jun 23rd, 2022 - A new tool can help streamline diagnosis and treatment of migraine in the primary care setting, new research suggests. Early results from a small pilot study showed that the tool, essentially a medical record "best-practice alert," reduces specialist referrals and MRI studies. Dr Scott Friedenberg The idea behind the tool is to give primary care physicians "fingertip access" to prompts on patie...

Marathons Aren't Madness, They're Mindfulness for Me

Jun 23rd, 2022 - I often get asked how I have time for marathon training while doing residency training or why I want to fill my free time with running up to 20 miles at a time. For me, running and racing has been a way to cope with the demands of residency. Running is like a free hour of therapy for me. Sometimes, my mind is a blank slate, but other times, my racing thoughts seem to calm themselves by the end ...

After Cancer, Text Messages Up Exercise and Reduce Late Effects

Jun 23rd, 2022 - Sending a text with a brief motivational intervention (MI) to parents of childhood cancer survivors substantially increased their child's physical activity level compared with control persons and also reduced treatment-related late effects. The findings come from a randomized trial of 161 children (median age, 12.4 years) who had recovered after leukemia, lymphoma, or brain tumors. "Physical ac...

‘Travel therapy’: Could holidays help mental health and wellbeing?

Jun 23rd, 2022 - Many of us will have likely heard of music therapy and art therapy — but what about ‘travel therapy’? A new cross-disciplinary paper from Edith Cowan University (ECU) proposes we change the way we view tourism, seeing it not just as a recreational experience but as an industry that can provide real health benefits. The collaboration between ECU’s Centre for Precision Health and School of Busine...

Intensified chemotherapy confers no additional benefits with panitumumab in RAS and BRAF wt mCRC

Jun 22nd, 2022 - Key clinical point: The modified triplet (modified fluorouracil, leucovorin, oxaliplatin, and irinotecan [mFOLFOXIRI]) + panitumumab vs. the doublet (fluorouracil, leucovorin, and oxaliplatin [FOLFOX]) + panitumumab does not show improved activity as initial therapy for RAS and BRAF wild-type (wt) metastatic colorectal cancer (mCRC).

Presence of crystals in synovial fluid tied with higher disease burden in PsA

Jun 22nd, 2022 - Key clinical point: The prevalence of crystals in the synovial fluid was higher in patients with psoriatic arthritis (PsA) than in those with gonarthrosis and indicated increased disease activity and declining physical abilities in patients with PsA. Major finding: Synovial fluid crystals were present in a significantly higher proportion of patients with PsA vs.

Current psoriatic lesions or a personal history of psoriasis correlates with PsA disease activity

Jun 22nd, 2022 - Key clinical point: Patients with psoriatic arthritis (PsA) who had a personal history of psoriasis (pPsA) or a family history of psoriasis and current psoriatic lesions (fPsA/PSO) showed a higher disease activity (DA) and more severe axial joint destruction than those with merely a family history of psoriasis (fPsA). Major finding: Patients with fPsA/PSO vs.

Identifying clinical characteristics of difficult-to-treat PsA

Jun 22nd, 2022 - Key clinical point: Difficult-to-treat (D2T) patients with psoriatic arthritis (PsA) have a higher prevalence of fibromyalgia, higher body mass index (BMI), and more comorbidities than non-D2T patients with PsA. Major finding: The potential D2T vs.

Real-world study confirms benefits of golimumab on work productivity and QoL in PsA

Jun 22nd, 2022 - Key clinical point: Golimumab reduced disease activity and improved work productivity, activity, and the quality of life (QoL) in patients with psoriatic arthritis (PsA). Major finding: At 24 months after golimumab initiation, there was significant decrease in mean Clinical Disease Activity Index (−21.

Upadacitinib offers effective disease control in PsA

Jun 22nd, 2022 - Key clinical point: A higher proportion of patients with psoriatic arthritis (PsA) receiving 15 mg upadacitinib achieved low disease activity (LDA) or remission after the first 6 months of treatment, with the difference being visible even after 1 year of treatment, compared to those who received a placebo. Major finding: At week 24, a higher proportion of patients receiving 15 mg upadacitinib v.

Enthesitis resolves regardless of medication used in PsA

Jun 22nd, 2022 - Key clinical point: A substantial proportion of patients with psoriatic arthritis (PsA) achieved resolution of enthesitis within a year of initiating nonsteroidal anti-inflammatory drugs (NSAID) or disease-modifying antirheumatic drugs (DMARD), although the odds were lower in patients with high joint disease activity at baseline. Major finding: Complete resolution of enthesitis was achieved by.

Bone density loss in lean male runners parallels similar issue in women
Ted Bosworth

Jun 22nd, 2022 - Similar to a phenomenon already well documented in women, inadequate nutrition appears to be linked to hormonal abnormalities and potentially preventable tibial cortical bone density loss in athletic men, according to results of a small, prospective study. Based on these findings, “we suspect that a subset of male runners might not be fueling their bodies with enough nutrition and calories for.

Biomarkers found that could be drug targets against a deadly form of brain cancer

Jun 22nd, 2022 - WASHINGTON – Biomarkers that could be targets for novel drugs to treat glioblastoma brain tumors have been identified by investigators at Georgetown Lombardi Comprehensive Cancer Center, providing hope for a cancer that is highly lethal. Currently, the drug most often used to treat glioblastoma, temozolomide, is uniquely able to cross the blood/brain barrier to attack the tumor but resistance d...

UNH research finds repurposed drug inhibits enzyme related to COVID-19

Jun 22nd, 2022 - DURHAM, N.H.—With the end of the pandemic seemingly nowhere in sight, scientists are still very focused on finding new or alternative drugs to treat and stop the spread of COVID-19. In a first-of-its-kind study, researchers at the University of New Hampshire have found that using an already existing drug compound in a new way, known as drug repurposing, could be successful in blocking the activ...

Can acupuncture reduce headaches?

Jun 22nd, 2022 - EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, JUNE 22, 2022 MINNEAPOLIS – Acupuncture may reduce headaches for people who have chronic tension-type headaches, according to a study published in the June 22, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology. Tension-type headaches most often involve a pressing or tightening feeling on both sides of th...