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About 1,343,933 results

Elevated PCSK9 levels associated with psoriasis suggest new treatment target
https://www.mdedge.com/dermatology/article/260931/psoriasis/elevated-pcsk9-levels-associated-psoriasis-suggest-new
Ted Bosworth

Jan 30th, 2023 - A Mendelian randomization study employing data from nearly 300,000 individuals has linked elevated levels of the PCSK9 enzyme with an increased risk of psoriasis, suggesting it might be targetable as an intervention. Independent of low-density lipoprotein cholesterol (LDL-C), which is reduced when PCSK9 is inhibited, a reduction in PCSK9 levels appears to have a direct impact on lowering psoria.

The ongoing search for answers
https://www.mdedge.com/neurology/article/260930/business-medicine/ongoing-search-answers
Allan M. Block, MD

Jan 30th, 2023 - Hidden in the Dec. 1, 2022, issue of the New England Journal of Medicine was a small article on using deferiprone for Parkinson’s disease.

Novel nomogram distinguishes pneumonias
https://www.mdedge.com/chestphysician/article/260924/infectious-diseases/novel-nomogram-distinguishes-pneumonias
Heidi Splete, MDedge News

Jan 30th, 2023 - A model incorporating factors such as lymphocytes and lung lesions differentiated adenovirus pneumonias from Chlamydia psittaci (CPP) in a multicenter study of nearly 200 individuals. Symptoms of pneumonia caused by CPP are often confused with other respiratory infections, particularly adenovirus pneumonia (AVP), which can delay correct diagnosis and impact treatment, Yi Li, MD, of Xiangya Hosp.

Dermatologists address cultural competence and unconscious biases in the specialty
https://www.mdedge.com/dermatology/article/260923/diversity-medicine/dermatologists-address-cultural-competence-and
Thomas R. Collins

Jan 30th, 2023 - ORLANDO – When he was applying for residency, Omar N. Qutub, MD, eagerly arrived at his first interview of the day.

Two AI optical diagnosis systems appear clinically comparable for small colorectal polyps
https://www.mdedge.com/internalmedicine/article/260922/gastroenterology/two-ai-optical-diagnosis-systems-appear-clinically
Carolyn Crist

Jan 30th, 2023 - In a head-to-head comparison, two commercially available computer-aided diagnosis systems appeared clinically equivalent for the optical diagnosis of small colorectal polyps, according to a research letter published in Gastroenterology. For the optical diagnosis of diminutive colorectal polyps, the comparable performances of both CAD-EYE (Fujifilm Co.

Rural Residence Tied to Higher Risk for Heart Failure for Women, Black Men
https://www.clinicaladvisor.com/home/topics/cardiovascular-disease-information-center/rural-residence-tied-higher-risk-heart-failure-women-black-men/
Clinical Advisor

Jan 30th, 2023 - HealthDay News — Rural residence is associated with an increased risk for heart failure among women and Black men, according to a study published online in JAMA Cardiology. Sarah E. Turecamo, from the US National Institutes of Health in Bethesda, Maryland, and colleagues assessed whether rurality is associated with an increased risk for heart failure. The analysis included data from 27,115 part...

Noninvasive liver test may help select asymptomatic candidates for heart failure tests
https://www.mdedge.com/internalmedicine/article/260919/cardiology/noninvasive-liver-test-may-help-select-asymptomatic
Carolyn Crist

Jan 30th, 2023 - A noninvasive test for liver disease may be a useful, low-cost screening tool to select asymptomatic candidates for a detailed examination of heart failure with preserved ejection fraction (HFpEF), say authors of a report published in Gastro Hep Advances. The fibrosis-4 (FIB-4) index was a significant predictor of high HFpEF risk, wrote Chisato Okamoto, MD, of the department of medical biochemi.

Polypill Tested for Cognitive, Functional Benefits
https://www.medpagetoday.com/neurology/dementia/102884

Jan 30th, 2023 - Reducing blood pressure and cholesterol in the TIPS-3 trial with a polypill, with or without aspirin, showed no protective effect on cognition in older adults with cardiovascular disease risk factors, a secondary analysis showed. During a 5-year follow-up, about the same number of trial participants in TIPS-3 experienced substantive cognitive decline in both the treatment and placebo groups, ac...

JAK Inhibitor Improves Symptoms, Anemia in Myelofibrosis
https://www.medpagetoday.com/hematologyoncology/othercancers/102883

Jan 30th, 2023 - Myelofibrosis treatment with the Janus kinase (JAK) inhibitor momelotinib resulted in clinically significant improvements in symptoms and spleen response compared with danazol for symptomatic, JAK inhibitor-exposed patients with anemia and intermediate- or high-risk disease, the phase III MOMENTUM trial showed. A significantly greater proportion of patients in the momelotinib group reported a ≥...

Commentary: Early Diagnosis of PsA, February 2023
https://www.mdedge.com/rheumatology/article/260916/psoriatic-arthritis/commentary-early-diagnosis-psa-february-2023
Vinod Chandran, MBBS, MD, DM, PhD

Jan 30th, 2023 - Vinod Chandran, MBBS, MD, DM, PhD Most patients develop psoriatic arthritis (PsA) after the onset of cutaneous psoriasis. The path toward long-term remission of PsA may be by early diagnosis and effective treatment prior to the onset of joint damage.

Dermatopathologist reflects on the early history of melanoma
https://www.mdedge.com/dermatology/article/260915/melanoma/dermatopathologist-reflects-early-history-melanoma
Doug Brunk

Jan 30th, 2023 - SAN DIEGO – Evidence of melanoma in the ancient past is rare, but according to James W. Patterson, MD, signs of melanoma with cutaneous lesions and diffuse bony metastases have been discovered in Peruvian Inca mummies.

Cardiometabolic Risk With Autism: Vigilance Urged
https://www.medpagetoday.com/neurology/autism/102882

Jan 30th, 2023 - People with autism had an elevated risk of cardiometabolic conditions across several dozen studies, researchers confirmed in a meta-analysis. Among children and adults in the analyzed studies, autism was associated with greater likelihood of concomitant: Yet, there was no significantly associated increased risk of hypertension and stroke with autism across all age groups, according to investiga...

High School Alcohol Use Can Quickly Escalate
https://www.medpagetoday.com/pediatrics/generalpediatrics/102881

Jan 30th, 2023 - Heavy binge drinking isn't just a college problem, researchers affirmed, finding that most teen alcohol use that escalated to having 10 or more drinks in a row reached that level rapidly during the high school years. Among a sample of youth who reported drinking in the prior 30 days when surveyed in the 12th grade and who said they engaged in high-intensity drinking (HID, 10 or more in a row) w...

14-year-old boy • aching midsternal pain following a basketball injury • worsening pain with direct pressure and when the patient sneezed • Dx?
https://www.mdedge.com/familymedicine/article/260914/pediatrics
MDedge Family Medicine; Catherine Romaine, BS, Alyssa Heinrich, MD et. al.

Jan 30th, 2023 - THE CASE A 14-year-old boy sought care at our clinic for persistent chest pain after being hit in the chest with a teammate’s shoulder during a basketball game 3 weeks earlier. He had aching midsternal chest pain that worsened with direct pressure and when he sneezed, twisted, or bent forward.

Consider this tool to reduce antibiotic-associated adverse events in patients with sepsis
https://www.mdedge.com/familymedicine/article/260913/infectious-diseases/consider-tool-reduce-antibiotic-associated-adverse
MDedge Family Medicine; Timothy Mott, MD, FAAFP, Zachary Orme, DO

Jan 30th, 2023 - ILLUSTRATIVE CASE A 52-year-old woman presents to the emergency department complaining of dysuria and a fever. Her work-up yields a diagnosis of sepsis secondary to pyelonephritis and bacteremia.

Does regular walking improve lipid levels in adults?
https://www.mdedge.com/familymedicine/article/260912/cardiology/does-regular-walking-improve-lipid-levels-adults
MDedge Family Medicine; Kayla Hatchell, MD, Emily Chin, DO et. al.

Jan 30th, 2023 - Evidence summary Walking’s impact on cholesterol levels is modest, inconsistent A 2022 systematic review and meta-analysis of 21 studies (n = 1129) evaluated the effects of walking on lipids and lipoproteins in women older than 18 years who were overweight or obese and were not taking any lipid-lowering medications. Median TC was 206 mg/dL and median LDL was 126 mg/dL.

Acute hepatic porphyrias no longer as rare as previously thought
https://www.mdedge.com/internalmedicine/article/260911/gastroenterology/acute-hepatic-porphyrias-no-longer-rare-previously
Carolyn Crist

Jan 30th, 2023 - Although rare, acute hepatic porphyrias (AHPs) may be more common than previously thought, particularly among women between ages 15 and 50, according to a new clinical practice update from the American Gastroenterological Association. For acute attacks, treatment should include intravenous hemin, and for patients with recurrent attacks, a newly-approved therapy called givosiran should be consid.

FDA Greenlights First Drug for ESR1-Mutated Breast Cancer
https://www.medpagetoday.com/hematologyoncology/breastcancer/102880

Jan 30th, 2023 - The FDA approved the selective estrogen receptor (ER) degrader elacestrant (Orserdu) for the treatment of postmenopausal women or adult men with ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer with disease progression following at least one line of endocrine therapy. The FDA also approved the Guardant360 CDx assay as a companion diagnostic test to identify patients...

Early Return to School After Concussion Linked to Lower Symptom Burden
https://www.clinicaladvisor.com/home/topics/neurology-information-center/early-return-school-after-concussion-linked-lower-symptom-burden/
Clinical Advisor

Jan 30th, 2023 - Children with a concussion may no longer have to sit quietly in a dark room for days. New research suggests that prolonged absence from school and other activities may hinder recovery from a concussion. Returning to school earlier than previously recommended may be associated with lower symptom burden, leading to a faster recovery, according to an published online in JAMA Network Open. The anal...

Physician group issues 31 treatment recommendations for early-onset colorectal cancer
https://www.mdedge.com/internalmedicine/article/260906/oncology/physician-group-issues-31-treatment-recommendations-early
Jim Kling

Jan 30th, 2023 - An international group of physicians has issued consensus recommendations for the diagnosis and management of patients with early-onset colorectal cancer (eoCRC). Led by Giulia Martina Cavestro, MD, PhD, a gastroenterologist with the University Vita Salute San Raffaele Hospital, Milan, the Delphi Initiative for Early-Onset Colorectal Cancer group penned 31 recommendations for treating patients.

Study: Diminished COVID Vaccine Response in Lupus
https://www.medpagetoday.com/rheumatology/lupus/102876

Jan 30th, 2023 - Patients with systemic lupus erythematosus (SLE) showed reduced antibody responses following COVID-19 vaccination, with drugs for the condition such as belimumab (Benlysta) and mycophenolate mofetil (MMF) likely to blame, researchers said. Immunoglobulin G (IgG) titers measured 2 weeks after the second dose of mRNA COVID vaccines were lower by about 20% among 342 lupus patients compared with th...

Reversible BTK Inhibitor Gets FDA Nod for Mantle Cell Lymphoma
https://www.medpagetoday.com/hematologyoncology/lymphoma/102874

Jan 30th, 2023 - The FDA has granted accelerated approval to pirtobrutinib (Jaypirca), a non-covalent or reversible Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of relapsed or refractory mantle cell lymphoma (MCL) after at least two prior lines of systemic therapy, including a BTK inhibitor. Pirtobrutinib is the first BTK inhibitor of any kind specifically approved for patients with MCL that has ...

Viruses Tied to Subsequent Dementia, Other Neurodegenerative Diseases
https://www.medpagetoday.com/neurology/generalneurology/102872

Jan 30th, 2023 - At least 22 viral illnesses were linked with an increased risk of subsequent neurodegenerative disease, NIH researchers found. Using data from the U.K. and Finland, Mike Nalls, PhD, of the NIH Center for Alzheimer's and Related Dementias, and co-authors identified 45 viral exposures that were tied to an increased risk of dementia or other neurodegenerative diseases and replicated 22 of these as...

Supervised Exercise Keeps Diabetes at Bay a Decade Later
https://www.medpagetoday.com/endocrinology/diabetes/102871

Jan 30th, 2023 - Supervised moderate and vigorous aerobic activity helped stave off type 2 diabetes in at-risk individuals with central obesity and nonalcoholic fatty liver disease, according to 10-year follow-up of a randomized trial from China. Compared with adults who did not exercise, the risk of diabetes was reduced by 49% in the vigorous exercise group (relative risk [RR] 0.51, 95% CI 0.27-0.94, P=0.01) a...

EMTs After Tyre Nichols Beating Suspended; Long COVID Declining; Damar Hamlin Speaks
https://www.medpagetoday.com/emergencymedicine/emergencymedicine/102870

Jan 30th, 2023 - Note that some links may require subscriptions. The medical response following the beating of Tyre Nichols by Memphis police is being questioned; now two emergency medical technicians (EMTs) have been suspended pending an investigation. (New York Times) COVID-19 is still a global health emergency, the World Health Organization said, though it may be reaching a turning point. (AP) Meanwhile, the...

Enriched ICU Nutrition Strategy Spoiled in Randomized Trial
https://www.medpagetoday.com/criticalcare/generalcriticalcare/102875

Jan 30th, 2023 - Higher protein doses did not improve critically ill patient outcomes, and may even be detrimental to patients with high organ failure and acute kidney injury, the EFFORT trial found. In nutritionally high-risk adults undergoing mechanical ventilation, alive hospital discharge for those who received higher doses of protein reached 46.1% by 60 days after randomization, compared with the 50.2% rat...

Woman Seeks Answers After 3 Years of Painful Genital Ulcers
https://www.medpagetoday.com/dermatology/generaldermatology/102873

Jan 30th, 2023 - A woman in her late 40s presented with painful ulcers in her groin and armpits that hadn't healed in 3 years, an Indian group reported in JAMA Dermatology. The woman explained that when the sores first appeared, they were just itchy, oozing, reddish bumps; over time, they worsened to form painful, pus-filled oozing ulcers. She had been treated with numerous courses of antibiotics, antifungals, ...

Sovos Brands Intermediate, Inc. Issues Allergy Alert on Undeclared Egg in Rao's Slow Simmered Soup, Labeled as Chicken & Gnocchi but Containing Vegetable Minestrone
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/733665

Sovos Brands Intermediate, Inc. ("Sovos") is voluntarily recalling a limited number of 16-ounce jars of Rao's Made for Home Slow Simmered Soup, Chicken & Gnocchi, because the affected jars may contain undeclared egg.

Ameripack Foods LLC Announces Allergy Alert for Undeclared Soy and Egg in H-E-B Meal Simple Chocolate Chunk Brownie
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/733429

Ameripack Foods LLC of Hughes Springs, TX is issuing a recall for 976lbs. of brownies for H-E-B Meal Simple Chocolate Chunk Brownie 13 Oz due to an undeclared - Soy & Egg. People who have an allergy or severe sensitivity to soy or egg run the risk of serious or life-threatening allergic reaction if

Daiso Issues Allergy Alert on Undeclared Milk in Tohato Nagewa Snack
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/733304

Daiso California LLC of La Mirada, CA is recalling Tohato Nagewa Snack (skus 4901940112036 & 4901940112005) because it contains an undeclared milk derivative ingredient. People who have an allergy or severe sensitivity to milk run the risk of serious or life-threatening allergic reaction if they co

Caesar's Pasta, LLC Recalls Frozen Manicotti Because of Possible Health Risk
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/733291

Caesar's Pasta, LLC of Blackwood, NJ is recalling 5,610 lbs. of frozen manicotti, because it has the potential to be contaminated with Listeria monocytogenes, an organism which can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immun

Perineal leiomyoma after 4th degree laceration
https://www.mdedge.com/obgyn/article/260905/perineal-leiomyoma-after-4th-degree-laceration
Mary K. Collins, DO, G. William Stone, MD et. al.

Jan 29th, 2023 - Additional videos from SGS are available here, including these recent offerings: Tips and tricks for a successful rollerball endometrial ablation Resection of infected sacrohysteropexy mesh Surgical techniques for excision of juvenile cystic adenomyoma.

Volume 29, Number 2-February 2023
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/733530

Table of Contents for Volume 29, Number 2-February 2023

Research Letter - Orthopoxvirus Infections in Rodents, Nigeria, 2018-2019
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/733531

Research Letter — Orthopoxvirus Infections in Rodents, Nigeria, 2018–2019

Dispatch - Nipah Virus Exposure in Domestic and Peridomestic Animals Living in Human Outbreak Sites, Bangladesh, 2013-2015
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/733533

Dispatch — Nipah Virus Exposure in Domestic and Peridomestic Animals Living in Human Outbreak Sites, Bangladesh, 2013–2015

Dispatch - (Mis)perception and Use of Unsterile Water in Home Medical Devices, PN View 360+ Survey, United States, August 2021
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/733532

Dispatch — (Mis)perception and Use of Unsterile Water in Home Medical Devices, PN View 360+ Survey, United States, August 2021

Synopsis - Infant Botulism, Israel, 2007-2021
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/733534

cases indicate a stronger link to soil transmission, possible seasonal variation, and a milder course of disease.

ASL - 10 Things You Can do to Manage COVID-19 at Home
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/733599

10 Things You Can do to Manage COVID-19 at Home presented in American Sign Language This video can also be viewed at https://www.cdc.gov/video/socialmedia/316025_10ThingstoManageCOVIDatHome-low-res.wmv

Sovos Brands Intermediate, Inc. Issues Allergy Alert on Undeclared Egg in Rao's Slow Simmered Soup, Labeled as Chicken & Gnocchi but Containing Vegetable Minestrone
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/733666

Sovos Brands Intermediate, Inc. ("Sovos") is voluntarily recalling a limited number of 16-ounce jars of Rao's Made for Home Slow Simmered Soup, Chicken & Gnocchi, because the affected jars may contain undeclared egg.

People with Certain Medical Conditions
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/733663

People with Certain Medical Conditions

Commentary: HER2+-targeted therapy, ovarian suppression, and adjuvant therapy in breast cancer, February 2023
https://www.mdedge.com/hematology-oncology/article/260902/breast-cancer/commentary-her2-targeted-therapy-ovarian
Erin Roesch, MD

Jan 27th, 2023 - Erin Roesch, MD Standard first-line therapy for human epidermal growth factor receptor 2 positive (HER2+, ERBB2+) metastatic breast cancer (MBC) includes dual-HER2 blockade (trastuzumab + pertuzumab) in combination with a taxane. 1,2 Differences according to hormone receptor status within HER2+ MBC have been demonstrated in clinicopathologic features, survival, and treatment response.

Commentary: A New Drug, and Pediatric Concerns, February 2023
https://www.mdedge.com/dermatology/article/260900/atopic-dermatitis/commentary-new-drug-and-pediatric-concerns-february
Steven R. Feldman, MD, PhD

Jan 27th, 2023 - Steven R. Feldman, MD, PhD I suspect lebrikizumab is going to be another excellent atopic dermatitis (AD) treatment option.

Fluorescence-optical imaging may detect preclinical PsA
https://www.mdedge.com/rheumatology/article/260899/psoriatic-arthritis/fluorescence-optical-imaging-may-detect-preclinical
Heidi Splete

Jan 27th, 2023 - Fluorescence-optical imaging (FOI) identified early signs of psoriatic arthritis, based on data from 2 years of follow-up of a cohort of 389 adults at 14 rheumatology centers. Approximately 25% of individuals with psoriasis go on to develop psoriatic arthritis (PsA), but there are no validated biomarkers to identify patients at risk for progression to PsA, Michaela Koehm, MD, of Goethe Universi.

Infant with red eyelid lesion
https://www.mdedge.com/familymedicine/article/260897/pediatrics/infant-red-eyelid-lesion
MDedge Family Medicine; Jimena G. Cervantes, MD, Richard P. Usatine, MD

Jan 27th, 2023 - A 4-MONTH-OLD HISPANIC INFANT was brought to her pediatrician by her parents for evaluation of a dark red lesion over her right eyelid. The mother said that the lesion appeared when the child was 4 weeks old and started as a small red dot.

Metabolic syndromes worsen outcomes in BC patients treated with neoadjuvant chemotherapy
https://www.mdedge.com/breast-cancer-icymi/article/260893/breast-cancer/metabolic-syndromes-worsen-outcomes-bc-patients

Jan 27th, 2023 - Key clinical point: The presence of metabolic syndromes (MetS) worsened survival outcomes and increased disease recurrence risk in patients with breast cancer (BC) who received neoadjuvant chemotherapy (NAC). Major finding: The MetS group had a significantly lower likelihood of achieving pathological complete response than the non-MetS group (odds ratio [ OR] 0.

Metastatic BC: Not worth changing the 4-weekly schedule of pegylated liposomal doxorubicin
https://www.mdedge.com/breast-cancer-icymi/article/260892/breast-cancer/metastatic-bc-not-worth-changing-4-weekly-schedule

Jan 27th, 2023 - Key clinical point: Recent phase 2 trials have recommended a 2-weekly schedule of pegylated liposomal doxorubicin (PLD) in patients with heavily treated metastatic breast cancer (BC); however, it failed to demonstrate any advantage in terms of efficacy or safety over the registered 4-weekly regimen of PLD. Major finding: The median progression-free survival was 3.

Early autologous fat grafting associated with increased BC recurrence risk
https://www.mdedge.com/breast-cancer-icymi/article/260891/breast-cancer/early-autologous-fat-grafting-associated-increased

Jan 27th, 2023 - Key clinical point: Autologous fat grafting (AFG) in the second stage of a 2-stage prosthetic breast reconstruction was linked to a higher risk for breast cancer (BC) recurrence when performed within a year after mastectomy. Major finding: Patients who did vs did not undergo AFG within 1 year after the primary operation had a significantly increased risk for disease recurrence (hazard ratio 5.

Meta-analysis compares adjuvant chemotherapy regimens for resected early-stage TNBC
https://www.mdedge.com/breast-cancer-icymi/article/260890/breast-cancer/meta-analysis-compares-adjuvant-chemotherapy

Jan 27th, 2023 - Key clinical point: In patients with early-stage triple-negative breast cancer (TNBC), adding capecitabine to classic anthracycline/taxane-based adjuvant chemotherapy improved overall survival (OS) and carboplatin/paclitaxel was the most effective regimen for improving disease-free survival (DFS). Major finding: Adjuvant chemotherapy with anthracyclines/taxanes plus capecitabine vs anthracyclin.

Overall survival improved with chemotherapy in ER-negative/HER2-negative, T1abN0 BC
https://www.mdedge.com/breast-cancer-icymi/article/260889/breast-cancer/overall-survival-improved-chemotherapy-er-negative

Jan 27th, 2023 - Key clinical point: Treatment with adjuvant chemotherapy significantly improved overall survival (OS) outcomes in patients with estrogen receptor-negative (ER−)/human epidermal growth factor receptor 2-negative (HER2−), T1abN0 breast cancer (BC). Major finding: After a median follow-up of 7.

ERBB2 mRNA expression predicts prognosis in trastuzumab emtansine-treated advanced HER2+ BC patients
https://www.mdedge.com/breast-cancer-icymi/article/260888/breast-cancer/erbb2-mrna-expression-predicts-prognosis

Jan 27th, 2023 - Key clinical point: In patients with advanced human epidermal growth factor receptor 2-positive ( HER2+ or ERBB2+) breast cancer (BC) treated with trastuzumab emtansine, the pre-established levels of ERBB2 mRNA expression according to the HER2DX standardized assay served as an important prognostic biomarker in predicting survival outcomes. Major finding: High, medium, and low levels of ERBB2 mR.

Addition of atezolizumab to carboplatin+paclitaxel improves pCR in stage II-III TNBC
https://www.mdedge.com/breast-cancer-icymi/article/260887/breast-cancer/addition-atezolizumab-carboplatinpaclitaxel

Jan 27th, 2023 - Key clinical point: Addition of atezolizumab to carboplatin+paclitaxel in the neoadjuvant setting improved the pathological complete response (pCR) rate in patients with stage II-III triple-negative breast cancer (TNBC). Major finding: After a median follow-up of 6.

Gut enzymes fingered in some 5-ASA treatment failures
https://www.mdedge.com/internalmedicine/article/260886/gastroenterology/gut-enzymes-fingered-some-5-asa-treatment-failures
Neil Osterweil

Jan 27th, 2023 - AURORA, COLO. – The therapeutic action of 5-aminosalicylic acid (5-ASA), one of the most frequently prescribed drugs for inflammatory bowel disease (IBD), can be defeated by enzymes that reside in the very gut that the drug is designed to treat.

ER/PgR+ BC: Adjuvant exemestane+ovarian suppression reduces recurrence risk
https://www.mdedge.com/breast-cancer-icymi/article/260885/breast-cancer/er/pgr-bc-adjuvant-exemestaneovarian-suppression

Jan 27th, 2023 - Key clinical point: Exemestane plus ovarian function suppression (OFS) led to a greater reduction in recurrence risk than tamoxifen+OFS in premenopausal women with estrogen or progesterone receptor-positive (ER/PgR+) early breast cancer (BC). Major finding: There was a significant improvement in 12-year disease-free survival (hazard ratio [ HR] 0.

Adding SBRT to sorafenib boosts survival in liver cancer
https://www.mdedge.com/hematology-oncology/article/260884/gastrointestinal-cancer/adding-sbrt-sorafenib-boosts-survival
Roxanne Nelson, RN, BSN

Jan 27th, 2023 - SAN FRANCISCO – Adding stereotactic body radiation therapy (SBRT) to sorafenib produced better outcomes among patients with hepatocellular carcinoma (HCC) than sorafenib alone, according to new findings. The use of SBRT in this setting improved both overall survival and progression-free survival (PFS).

Reported Human Infections with Avian Influenza A Viruses
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/639466

Human infections with avian influenza A viruses are uncommon but have occurred sporadically in many countries.

Tips and tools to help you manage ADHD in children, adolescents
https://www.mdedge.com/familymedicine/article/260883/pediatrics/tips-and-tools-help-you-manage-adhd-children-adolescents
MDedge Family Medicine; Sundania Wonnum, PhD, LCSW, Jamie Krassow, MD

Jan 27th, 2023 - THE CASE James B* is a 7-year-old Black child who presented to his primary care physician (PCP) for a well-child visit. During preventive health screening, James’ mother expressed concerns about his behavior, characterizing him as immature, aggressive, destructive, and occasionally self-loathing.

Does physical exercise reduce dementia-associated agitation?
https://www.mdedge.com/familymedicine/article/260882/neurology/does-physical-exercise-reduce-dementia-associated-agitation
MDedge Family Medicine; Katarzyna Jabbour, PharmD, BCPS, Lynn M. Wilson, DO, FACOFP, FAAFP et. al.

Jan 27th, 2023 - Evidence summary Mixed results on exercise’s effect on neuropsychiatric symptoms A 2020 systematic review and meta-analysis of 18 RCTs investigated the effect of home-based physical activity on several markers of behavioral and psychological symptoms of dementia (BPSD). These symptoms were measured using the caregiver-completed neuropsychiatric inventory (NPI), which includes agitation.

Adding veliparib to cisplatin improves PFS in BRCA-like metastatic TNBC
https://www.mdedge.com/breast-cancer-icymi/article/260881/breast-cancer/adding-veliparib-cisplatin-improves-pfs-brca

Jan 27th, 2023 - Key clinical point: In patients with germline BRCA1/2-wildtype metastatic triple-negative breast cancer (TNBC) with a BRCA-like phenotype, cisplatin plus veliparib significantly improved progression-free survival (PFS) without causing any unprecedented adverse events. Major finding: PFS was significantly improved with cisplatin+veliparib vs cisplatin+placebo (hazard ratio 0.

For Public Health Veterinarians and Animal Health Officials
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/730319

Mpox - Guide for Public Health Veterinarians and Animal Health Officials

COVID Risk Up to 50% Higher for Nursing Home Residents Behind on Vaccination
https://www.medpagetoday.com/infectiousdisease/covid19vaccine/102865

Jan 27th, 2023 - Nursing home residents who were not up to date with their COVID-19 vaccines had a 30% to 50% higher risk of getting infected compared with those who were up to date, CDC researchers said. From Oct. 10, 2022 to Jan. 8, 2023, weekly COVID incidence rates ranged from 7.2 to 15.6 per 1,000 nursing home residents among those who were up to date with vaccinations compared with rates of 9.5 to 18.8 pe...

How should PRAME be used to evaluate melanocytic lesions?
https://www.mdedge.com/dermatology/article/260874/melanoma/how-should-prame-be-used-evaluate-melanocytic-lesions
Doug Brunk

Jan 27th, 2023 - SAN DIEGO – As with many markers for the evaluation of challenging melanocytic lesions, preferentially expressed antigen in melanoma (PRAME) has its benefits and drawbacks, according to Cora Humberson, MD. “I’m a fan, but there are issues with it,” Dr.

Analysis of ctDNA Pinpoints Responders to Second-Line GIST Therapy
https://www.medpagetoday.com/hematologyoncology/othercancers/102862

Jan 27th, 2023 - Circulating tumor DNA (ctDNA) analysis of KIT mutational status may be able to guide second-line treatment in patients with imatinib-resistant gastrointestinal stromal tumors (GIST), according to an exploratory analysis from the INTRIGUE trial. Specifically, patients with KIT exon 11 plus 17/18 (activation loop) mutations had superior responses and better survival outcomes with ripretinib (Qinl...

Are Boiled Peanuts the Answer to Peanut Allergy?
https://www.clinicaladvisor.com/home/topics/allergy-and-immunology-information-center/boiled-peanuts-immunotherapy-peanut-allergy/
Clinical Advisor

Jan 27th, 2023 - Children with peanut allergies may benefit from an unusual oral immunotherapy regimen: boiled peanuts. Use of a boiled peanut regimen led to desensitization in 80% of children with peanut allergies enrolled in an open-label, phase 2 trial, which was published in Clinical & Experimental Allergy. Few children withdrew from the trial because of adverse events. “Small and increasing doses of boiled...

How Racial and Ethnic Disparities in Alzheimer Disease Affect Diagnosis, Quality of Care
https://www.clinicaladvisor.com/home/topics/neurology-information-center/racial-ethnic-disparities-adrd-impact-diagnosis-quality-of-care/
Clinical Advisor

Jan 27th, 2023 - As researchers continue to seek insights to improve the understanding, prevention, and treatment of Alzheimer disease and related dementias (ADRD), a growing body of research highlights significant racial and ethnic disparities in various aspects of these diseases.1 “In Blacks and Hispanics, the prevalence of ADRD is 1.5 to 2 times higher compared to non-Hispanic Whites,” said Timothy S. Chang,...

Factors That Affect Your Risk of Getting Very Sick from COVID-19
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/731463

Factors That Affect Your Risk of Getting Very Sick from COVID-19

ODAC to Review Lymphoma Drug; Tobacco Control; Artificial Skin Aids Cancer Studies
https://www.medpagetoday.com/hematologyoncology/lymphoma/102854

Jan 27th, 2023 - The FDA announced that the Oncologic Drugs Advisory Committee (ODAC) will meet March 9 to review the accelerated approval of polatuzumab vedotin (Polivy) plus rituximab (Rituxan) and chemotherapy for untreated diffuse large B-cell lymphoma. Janssen and Legend Biotech announced early termination of a phase III trial after an interim analysis showed that ciltacabtagene autoleucel (cilta-cel, Carv...

FDA Panel Backs Plan to Only Use Omicron-Containing COVID Vaccines
https://www.medpagetoday.com/infectiousdisease/covid19vaccine/102852

Jan 27th, 2023 - The FDA's vaccine advisors unanimously backed the agency's proposal to harmonize COVID-19 primary and booster vaccines to contain a single bivalent composition with components targeting BA.4/5 and the original SARS-CoV-2 strain. With a 21-0 vote on Thursday, members of the Vaccines and Related Biological Products Advisory Committee (VRBPAC) supported FDA's plan, which aims to offer better prote...

Joy Joy's Bakery Issues Allergy Alert on Undeclared Wheat in Ube Spanish Bread, Ube Ensaymada, and Ube Roll
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/733637

January 26, 2023, Joy Joy's Bakery Lakewood, Washington is recalling Ube Spanish Bread, Ube Ensaymada, and Ube Roll because it may contain undeclared wheat. People who have an allergy or severe sensitivity to wheat run the risk of serious or life-threatening allergic reaction if they consume this p

Joy Joy's Bakery Issues Allergy Alert on Undeclared Wheat in Ube Spanish Bread, Ube Ensaymada, and Ube Roll
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/733636

January 26, 2023, Joy Joy's Bakery Lakewood, Washington is recalling Ube Spanish Bread, Ube Ensaymada, and Ube Roll because it may contain undeclared wheat. People who have an allergy or severe sensitivity to wheat run the risk of serious or life-threatening allergic reaction if they consume this p

FDA OKs Adjuvant Pembrolizumab for NSCLC
https://www.medpagetoday.com/hematologyoncology/lungcancer/102849

Jan 27th, 2023 - The FDA has approved pembrolizumab (Keytruda) as an adjuvant therapy following surgical resection and platinum-based chemotherapy for patients with stage IB, II, or IIIA non-small cell lung cancer (NSCLC), Merck announced. The approval makes pembrolizumab the only immunotherapy to be approved for NSCLC regardless of PD-L1 expression in both the adjuvant and metastatic settings, the company note...

Small, convenient mosquito repellent device passes test to protect military personnel
https://www.eurekalert.org/news-releases/978005

Jan 27th, 2023 - A device developed at the University of Florida for the U.S. military provides protection from mosquitos for an extended period and requires no heat, electricity or skin contact. Funded by the Department of Defense Deployed Warfighter Protection program, the controlled-release passive device was designed by Nagarajan Rajagopal, a PhD candidate and Dr. Christopher Batich in UF’s Department of Ma...

Measles virus 'cooperates' with itself to cause fatal encephalitis
https://www.eurekalert.org/news-releases/977624

Jan 27th, 2023 - Fukuoka, Japan—Researchers in Japan have uncovered the mechanism for how the measles virus can cause subacute sclerosing panencephalitis, or SSPE, a rare but fatal neurological disorder that can occur several years after a measles infection. Although the normal form of the measles virus cannot infect the nervous system, the team found that viruses that persist in the body can develop mutations ...

Dr. Katerina Mastovska named AOAC INTERNATIONAL Deputy Executive Director and Chief Science Officer
https://www.eurekalert.org/news-releases/977974

Jan 27th, 2023 - AOAC INTERNATIONAL Executive Director David B. Schmidt is pleased to announce that Dr. Katerina (Kate) Mastovska has been named Deputy Executive Director and Chief Science Officer. Two current staff members, each with almost 20 years of experience at AOAC, Dawn L. Frazier and Deborah McKenzie, have been promoted to new roles at the nonprofit organization which ensures the safety and integrity o...

Testing a immunological drug as a new treatment for early type 1 diabetes
https://www.eurekalert.org/news-releases/977926

Jan 27th, 2023 - A large clinical study is now beginning on an approved drug for treating psoriasis. The drug will be tested on patients who were recently diagnosed with type 1 diabetes. The theory is that the drug could preserve the patient’s remaining insulin production. A large number of hospitals throughout Sweden are participating in this large project, which is funded by the Swedish Research Council withi...

Study shows FDA-approved TB regimen may not work against the deadliest form of TB due to multidrug-resistant strains
https://www.eurekalert.org/news-releases/977942

Jan 27th, 2023 - FOR IMMEDIATE RELEASE Findings from a Johns Hopkins Children’s Center study in animal models show that a U.S. Food and Drug Administration (FDA)-approved antibiotic regimen for multidrug-resistant (MDR) tuberculosis (TB) may not work for TB meningitis. Studies in a small number of people also provide evidence that a new combination of drugs is needed to develop effective treatments for TB menin...

Development, validation of a deep learning algorithm to differentiate colon carcinoma from diverticulitis in CT images
https://www.eurekalert.org/news-releases/977766

Jan 27th, 2023 - About The Study: The results of this study suggest that a deep learning model able to distinguish colon carcinoma and acute diverticulitis in computed tomography (CT) images as a support system may significantly improve the diagnostic performance of radiologists, which may improve patient care. As an artificial intelligence support system, the model significantly improved the sensitivity and sp...

Non-invasive neurotechnology reduces symptoms of insomnia and improves autonomic nervous system function
https://www.eurekalert.org/news-releases/977947

Jan 27th, 2023 - WINSTON-SALEM, N.C. – Jan. 27, 2023 – A good night’s sleep is crucial to health and well-being. Numerous research studies have shown that insomnia can increase the risk of cardiovascular events, obesity, diabetes and other illnesses. Now, a new study from researchers at Wake Forest University School of Medicine shows significant improvements in not only sleep quality, but also in improved auton...

New study debunks the assumption that menstrual cycles disqualify women from exercise research
https://www.eurekalert.org/news-releases/977913

Jan 27th, 2023 - Peruse any women’s magazine, and you’ll likely find advice on how to boost workouts. But what many don’t realize is that the research behind most exercise advice is based almost entirely on men. Female subjects are excluded from over 90% of studies on exercise performance and fatigability because hormonal changes during the menstrual cycle were thought to affect exercise capability — which, if ...

COVID by the numbers at UCLA Health: A million tests; 300,000 vaccines; 55,000 patients
https://www.eurekalert.org/news-releases/977968

Jan 27th, 2023 - Three years ago this month, the first case of COVID was diagnosed in the United States. Here are the latest figures on the pandemic, collected by UCLA Health hospitals and clinics. Clinical care Testing and vaccination Telehealth Also see: A bird’s-eye view of the COVID-19 pandemic from 2020 to now.

From AI software to surgical robots
https://www.eurekalert.org/news-releases/977933

Jan 27th, 2023 - A doctor needs a great deal of experience, knowledge and years of training to be able to expertly analyze an ECG. Automated procedures based on AI can offer effective support here. And an AI system in this field also has to be trained. This is namely undertaken (in this case) with very large amounts of high-quality ECG data. Such training means that, for instance, even the smallest abnormalitie...

Fresh questions about oxytocin as the ‘love hormone’ behind pair bonding
https://www.eurekalert.org/news-releases/977709

Jan 27th, 2023 - Removing the Oxytocin Receptor Does Not Interfere with Monogamy or Giving Birth Turning a decades-old dogma on its head, new research from scientists at UC San Francisco and Stanford Medicine shows that the receptor for oxytocin, a hormone considered essential to forming social bonds, may not play the critical role that scientists have assigned to it for the past 30 years. In the study, appeari...

Incorrectly recorded anesthesia start times cost medical centers and anesthesia practices significant revenue
https://www.eurekalert.org/news-releases/977828

Jan 27th, 2023 - ORLANDO, Fla. — Inaccurately recording the start of anesthesia care during a procedure is common and results in significant lost billing time for anesthesia practices and medical centers, suggests a study being presented at the American Society of Anesthesiologists’ ADVANCE 2023, the Anesthesiology Business Event. The anesthesia start time (AST) must be documented from a computer logged into th...

Researchers map the effects of dietary nutrients on disease
https://www.eurekalert.org/news-releases/977930

Jan 27th, 2023 - Francis Crick Institute press release For immediate release Peer reviewed Experimental study / Modelling Animals Researchers at the Francis Crick Institute and King’s College London have created a tool to predict the effects of different diets on both cancerous cells and healthy cells. Their work could help disentangle the subtle metabolic changes associated with different types of nutrients, a...

Additional anesthesiology residency positions may help hospitals save costs, address projected workforce shortages of anesthesia care professionals
https://www.eurekalert.org/news-releases/977848

Jan 27th, 2023 - ORLANDO, Fla. — Expanding anesthesiology residency programs — even in the absence of federal funding — may help medical institutions save staffing costs and address projected shortages of anesthesia care professionals, suggests a first-of-its-kind study being presented at the American Society of Anesthesiologists’ ADVANCE 2023, the Anesthesiology Business Event. In the wake of the COVID-19 pand...

Carlos del Rio to serve as interim dean for Emory University School of Medicine
https://www.eurekalert.org/news-releases/977979

Jan 27th, 2023 - Emory University has appointed Carlos del Rio, MD, an internationally known clinician and epidemiologist, as interim dean for the Emory University School of Medicine. He will also serve as interim chief academic officer for Emory Healthcare. He will begin his role on March 1, when Vikas Sukhatme, MD, ScD, steps down as dean to return to the Emory faculty. “Dr. Carlos Del Rio is an eminent globa...

$2 million grant will help rural Missouri schools detect possible threats to school safety
https://www.eurekalert.org/news-releases/977978

Jan 27th, 2023 - COLUMBIA, Mo. -- As school safety remains a critical issue for students, teachers and families, researchers at the University of Missouri are using a $2 million grant from the Department of Justice to help identify and avert threats students or others may make on school grounds involving potential harm to themselves or others. The project, which will partner with up to 26 rural school districts...

Day in the Life of a Doctor: Shadowing a Flight Paramedic
https://www.medpagetoday.com/emergencymedicine/emergencymedicine/102846

Jan 27th, 2023 - Join internal medicine and rheumatology specialist Siobhan Deshauer, MD, as she spends a second day on call with helicopter flight paramedics. Following is a partial transcript (note that errors are possible): Deshauer: Hey, guys. I'm Siobhan an internal medicine and rheumatology specialist. The last time I spent the day with the flight paramedics up in the helicopter I had such a good time. Ba...

Pediatricians, specialists largely agree on ASD diagnoses
https://www.mdedge.com/pediatrics/article/260868/neurology/pediatricians-specialists-largely-agree-asd-diagnoses
Marcia Frellick

Jan 26th, 2023 - General pediatricians and a multidisciplinary team of specialists agreed most of the time on which children should be diagnosed with autism spectrum disorder (ASD), data from a new study suggest. But when it came to ruling out ASD, the agreement rate was much lower.

Emergency Department Screening Detects Prediabetes, Type 2 Diabetes
https://www.clinicaladvisor.com/home/topics/diabetes-information-center/emergency-department-screening-program-can-id-undiagnosed-prediabetes-t2dm/
Clinical Advisor

Jan 26th, 2023 - HealthDay News — An emergency department type 2 diabetes screening program can identify patients with undiagnosed prediabetes and diabetes, according to a research letter published online in JAMA Network Open. Kirstie K. Danielson, PhD, from the University of Illinois Chicago, and colleagues developed and piloted an type 2 diabetes screening program. Patients at risk for type 2 diabetes were fl...

Suicides Among American Indian/Alaska Natives - National Violent Death Reporting System, 18 states, 2003-2014
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/359396

Suicide disproportionately affects American Indians/Alaska Natives (AI/AN). The suicide rate among AI/AN has been increasing since 2003 (1), and in 2015, AI/AN suicide rates in the 18 states participating in the National Violent Death Reporting System (NVDRS) were 21.5 per 100,000, more than 3.5 times higher than those among racial/ethnic groups with the lowest rates.* To study completed suicid...

Notes from the Field: Brucella abortus Vaccine Strain RB51 Exposures Associated with Raw Milk Consumption - Wise County, Texas, 2017
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/359395

In July 2017, the Texas Department of State Health Services (DSHS) Region 2/3 office reported a human case of brucellosis associated with the consumption of raw (unpasteurized) cow's milk purchased from a dairy in Paradise, Texas. CDC's Bacterial Special Pathogens Branch (BSPB) confirmed the isolate as Brucella abortus vaccine strain RB51 (RB51).

Vital Signs: Trends in Emergency Department Visits for Suspected Opioid Overdoses - United States, July 2016-September 2017
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/359394

From 2015 to 2016, opioid overdose deaths increased 27.7%, indicating a worsening of the opioid overdose epidemic and highlighting the importance of rapid data collection, analysis, and dissemination.

Update: Dura Mater Graft-Associated Creutzfeldt-Jakob Disease - Japan, 1975-2017
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/359393

Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disorder that, according to the most well accepted hypothesis (1), is caused by replicating, transmissible, abnormal forms of a host-encoded prion protein (prions). Most CJD cases occur spontaneously (sporadic CJD) or are inherited (genetic CJD). Iatrogenic CJD can occur after exposure to prion-contaminated instruments or products in ...

Dental Personnel Treated for Idiopathic Pulmonary Fibrosis at a Tertiary Care Center - Virginia, 2000-2015
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/359392

In April 2016, a Virginia dentist who had recently received a diagnosis of idiopathic pulmonary fibrosis (IPF) and was undergoing treatment at a specialty clinic at a Virginia tertiary care center contacted CDC to report concerns that IPF had been diagnosed in multiple Virginia dentists who had sought treatment at the same specialty clinic. IPF is a chronic, progressive lung disease of unknown ...

Update: Noncongenital Zika Virus Disease Cases - 50 States and the District of Columbia, 2016
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/359391

Zika virus is a flavivirus primarily transmitted to humans by Aedes aegypti mosquitoes (1). Zika virus infections also have been documented through intrauterine transmission resulting in congenital infection; intrapartum transmission from a viremic mother to her newborn; sexual transmission; blood transfusion; and laboratory exposure (1-3). Most Zika virus infections are asymptomatic or result ...

Notes from the Field: Assessing Rabies Risk After a Mass Bat Exposure at a Research Facility in a National Park - Wyoming, 2017
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/359390

On August 2, 2017, the Wyoming Department of Health (WDH) was notified by local public health nursing of a group of 20 persons who had slept in a national park research facility and reported contact with bats and bat excrement. Four of the 20 persons had already received rabies postexposure prophylaxis (PEP)* when WDH notified the National Park Service (NPS) and requested assistance from CDC fo...

Notes from the Field: False Negative Hepatitis B Surface Antigen Test Result in a Hemodialysis Patient - Nebraska, 2017
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/359389

In March 2017, the Nebraska Department of Health and Human Services (NDHHS) was contacted by a hemodialysis clinic regarding a patient who had tested negative for hepatitis B virus (HBV) surface antigen (HBsAg) after vaccination in 2010 and who later tested positive for HBsAg. A public health investigation subsequently determined that the false-negative results were caused by a surface antigen ...

Emergence of Monkeypox - West and Central Africa, 1970-2017
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/359388

The recent apparent increase in human monkeypox cases across a wide geographic area, the potential for further spread, and the lack of reliable surveillance have raised the level of concern for this emerging zoonosis. In November 2017, the World Health Organization (WHO), in collaboration with CDC, hosted an informal consultation on monkeypox with researchers, global health partners, ministries...

Vaccine-Derived Polioviruses - Three Provinces, Democratic Republic of the Congo, 2017
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/359387

The last confirmed wild poliovirus (WPV) case in Democratic Republic of the Congo (DRC) had paralysis onset in December 2011 (1). DRC has had cases of vaccine-derived polioviruses (VDPVs) documented since 2004 (Table 1) (1-6). After an outbreak of 30 circulating VDPV type 2 (cVDPV2) cases during 2011-2012, only five VDPV2 cases were reported during 2013-2016 (Table 1) (1-6). VDPVs can emerge fr...

Exposure to Electronic Cigarette Advertising Among Middle and High School Students - United States, 2014-2016
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/359386

Electronic cigarettes (e-cigarettes) are the most commonly used tobacco product among U.S. middle and high school students (1). Exposure to e-cigarette advertisements is associated with higher odds of current e-cigarette use among middle and high school students (2-4). To assess patterns of self-reported exposure to four e-cigarette advertising sources (retail stores, the Internet, television, ...