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Clinical Edge Journal Scan Commentary: Multiple Sclerosis June 2022
https://www.mdedge.com/neurology/msresourcecenter/article/255056/multiple-sclerosis/clinical-edge-journal-scan-commentary
Mark Gudesblatt, MD

May 27th, 2022 - Mark Gudesblatt, MD Multiple sclerosis (MS) remains a complex disease with varied effects, some visible and clinically symptomatic and others invisible (eg, effects on cognition). However much we focus on the visible and uncovering the currently invisible effects, we must be aware of the effects of prior infection with SARS-CoV-2 (ie, post-acute COVID-19 syndrome, aka long COVID) in people with.

Psychological intervention looks promising in Crohn’s disease
https://www.mdedge.com/internalmedicine/article/255054/gastroenterology/psychological-intervention-looks-promising-crohns
Laird Harrison

May 27th, 2022 - SAN DIEGO – A combination of cognitive-behavioral therapy and mindfulness meditation could reduce pain and fatigue from Crohn’s disease, researchers say. Patients who followed the program not only felt better but were also more often able to show up for work and leisure activities, compared with a control group assigned to a wait list, said Shmuel Odes, MD, a professor of internal medicine at B.

Medical trauma an under-recognized trigger for PTSD
https://www.mdedge.com/psychiatry/article/255051/ptsd/medical-trauma-under-recognized-trigger-ptsd
Randy Dotinga

May 27th, 2022 - NEW ORLEANS – Recent studies have confirmed that posttraumatic stress disorder can be triggered by health-related stress such as stints in the ICU and life-threatening medical emergencies, but most psychiatrists may not be aware of the latest research, according to an expert in mental trauma. “This is true among children as well as adults, but it is not generally appreciated by psychiatrists an.

Race-, ethnicity-based clinical guidelines miss the mark: Study
https://www.mdedge.com/internalmedicine/article/255047/diversity-medicine/race-ethnicity-based-clinical-guidelines-miss
Jim Kling

May 27th, 2022 - SAN DIEGO – Race-based recommendations and clinical algorithms may be doing more harm than good, according to a systematic review of databases and guidelines. The study found examples of screening recommendations based on race or ethnicity that were likely misleading since these are social constructs that don’t reflect a patient’s individual risk, said Shazia Siddique, MD, who presented the stu.

Does taking isotretinoin worsen a patient’s baseline IBD symptoms?
https://www.mdedge.com/dermatology/article/255034/acne/does-taking-isotretinoin-worsen-patients-baseline-ibd-symptoms
Doug Brunk

May 27th, 2022 - A limited association exists between the use of isotretinoin for severe acne and worsening of a patient’s baseline inflammatory bowel disease, results from a small retrospective study suggests. “Early studies of isotretinoin for use in severe acne suggested the drug may serve as a trigger for new-onset inflammatory bowel disease (IBD),” researchers led by Christina G.

Urinating multiple times per night
https://www.mdedge.com/prostate-cancer-challenge-center/article/255032/prostate-cancer/urinating-multiple-times-night

May 27th, 2022 - On the basis of the patient's history and presentation, this is likely a case of adenocarcinoma of the prostate. Although most patients with prostate cancer are diagnosed on screening, when localized symptoms do occur, they may include urinary frequency, decreased urine stream, urinary urgency, and hematuria.

Sugar-sweetened beverage and sugar consumption tied with incidence of and mortality from proximal colon cancer
https://www.mdedge.com/hematology-oncology/article/255022/gastrointestinal-cancer/sugar-sweetened-beverage-and-sugar

May 27th, 2022 - Key clinical point: High sugar-sweetened beverage (SSB) and total fructose intake was associated with increased incidence of and mortality from proximal colon cancer, especially during the later stages of colorectal tumorigenesis. Major finding: SSB and total fructose consumption was associated with a significant increase in the incidence of (hazard ratio [HR] per 1-serving/d increment 1.

ctDNA: Strong prognostic biomarker but lacks true clinical utility in mCRC
https://www.mdedge.com/hematology-oncology/article/255021/gastrointestinal-cancer/ctdna-strong-prognostic-biomarker-lacks

May 27th, 2022 - Key clinical point: Circulating tumor DNA (ctDNA) has substantiated its role as a strong prognostic biomarker in patients with metastatic colorectal cancer (mCRC). However, uncovering its true clinical value for these patients calls for prospective clinical trials with standardized methodologies.

KRAS p.G12C mutations may have prognostic implications in mCRC
https://www.mdedge.com/hematology-oncology/article/255019/gastrointestinal-cancer/kras-pg12c-mutations-may-have-prognostic

May 27th, 2022 - Key clinical point: Patients with KRAS p. G12C-mutant metastatic colorectal cancer (mCRC) show poor treatment outcomes, which are numerically worse than those in patients without this mutation or with KRAS non-p.

Senegal Health Minister Sacked After Babies Die in Hospital Fire
https://www.medscape.com/viewarticle/974697

May 27th, 2022 - DAKAR (Reuters) - Senegal President Macky Sall on Thursday sacked his health minister, Abdoulaye Diouf Sarr, a government decree showed, after 11 babies were killed by a fire in a hospital neonatal ward. Sarr will be replaced by Marie Khemesse Ngom Ndiaye, the ministry's director general, according to the decree.

Breakthrough Infections May Be Less Contagious
https://www.medscape.com/viewarticle/974700

May 27th, 2022 - (Reuters) - Fully vaccinated individuals who get infected with the coronavirus spread the infection to fewer people and are contagious for less time compared to people who are partially vaccinated or unvaccinated, a small study from South Korea suggests. In 173 hospital workers with COVID-19, including 50 who had breakthrough infections, researchers found that the virus had been transmitted to ...

MRI Technique May Yield Clues to Long COVID Breathlessness
https://www.medscape.com/viewarticle/974705

May 27th, 2022 - (Reuters) - In people with lasting breathlessness after COVID-19, a special type of magnetic resonance imaging (MRI) reveals lung abnormalities that traditional imaging techniques do not detect, a small study shows. In 23 patients with shortness of breath lasting for months after COVID-19, including 11 who had not required hospitalization, the researchers performed hyperpolarized xenon 129MRI, ...

Elderly Still Make Up Most of the COVID-19 Deaths
https://www.medscape.com/viewarticle/974719

May 27th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. The number of daily COVID-19 deaths is dropping in the United States, but one fact has not changed in two-plus years of the pandemic: The elderly are still most at risk of dying from the virus. The seven-day moving average of COVID-related deaths is now 288, a number far lower than the peaks of ...

Telemedicine in Cancer Care: Not All Patients Can Access
https://www.medscape.com/viewarticle/974718

May 27th, 2022 - The COVID pandemic pushed telemedicine forward as a safe, accessible, and more widely reimbursed approach to care delivery for patients with cancer, but uptake of telemedicine was plagued by inequities, a retrospective study suggests. Before March 2020, only a very small percentage of patients with cancer used telemedicine services. By November 2021, nearly 16% of patients initiating cancer tre...

Don't Equate Mass Shootings With Mental Illness
https://www.medscape.com/viewarticle/974716

May 27th, 2022 - Here we go, again, and again, and again. There just aren't enough tears, and before the bodies of 19 small children are identified, the political noise starts up. Mass shootings are a part of the American landscape, but when they happen at schools, we all feel a distinct sense of violation and gaping grief. Those children are so innocent, so deserving of a right to live their lives, hold their ...

UCLA Reinstates Mask Mandate as California COVID Cases Surge
https://www.medscape.com/viewarticle/974729

May 27th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. LOS ANGELES (AP) — The University of California, Los Angeles said Thursday it will reinstate an indoor mask policy as coronavirus cases surge in the nation's most populous state, which now forecasts hospitalizations will nearly triple in the next month. UCLA's 45,000 students and all faculty, st...

Is Subfertility Linked With Postpartum Mental Illness?
https://www.medscape.com/viewarticle/974741

May 27th, 2022 - Mothers with previous subfertility have increased risk for postpartum mental illness, compared with mothers who conceived spontaneously, according to a new study. In a population-based cohort study that examined almost 800,000 births, the adjusted relative risk (RR) for postpartum mental illness was 1.14 in women with subfertility, compared with women without reproductive assistance. The magnit...

FDA Okays IN.PACT 018 Drug-Coated Balloon for PAD
https://www.medscape.com/viewarticle/974732

May 27th, 2022 - The US Food and Drug Administration has approved the IN.PACT 018 drug-coated balloon (DCB) for the treatment of peripheral arterial disease, Medtronic announced today. The paclitaxel-coated balloon is indicated for percutaneous transluminal angioplasty of de novo, restenotic, or in-stent restenotic lesions up to 360 mm in length with vessel diameters of 4 to 7 mm, located in the superficial fem...

'It's an Amazing Time to Be a Hemophilia Provider'
https://www.medscape.com/viewarticle/974738

May 27th, 2022 - New medications such as emicizumab (Hemlibra) are transforming the lives of patients with hemophilia A, and more treatments are in the pipeline. "It's an amazing time to be a hemophilia provider," Alice D. Ma, MD, University of North Carolina at Chapel Hill hematologist and bleeding disorder specialist, said in an interview. "There are real options, and it's very exciting." But the drugs come w...

After Texas School Shooting, Parents Search for New Answers
https://www.medscape.com/viewarticle/974753

May 27th, 2022 - Amy Chambers is planning a visit soon with the principal of her son's elementary school in Joplin, MO. The grade level of the 19 children killed in the Tuesday school shooting in Uvalde, TX, was not unnoticed by her. Her son, the youngest of her three, is also a fourth grader. Chambers, a church secretary in Joplin, thinks the security to get into her son's school is good, but she has questions...

Nutrients and Exercise Affect Tumor Development
https://www.medscape.com/viewarticle/974751

May 27th, 2022 - MADRID, Spain — Researchers discussed an update on the latest evidence regarding the cancer-lifestyle link as part of the Precision Health session: Oncology, held during the 7th International Congress of the Spanish Society of Precision Health (SESAP). The role that certain nutrients can have on tumor development was analyzed, along with the most recent data justifying the idea that the prescri...

Artificial Insemination Births Ebb in Women With Underweight
https://www.medscape.com/viewarticle/974744

May 27th, 2022 - Researchers published the study covered in this summary on researchsquare.com as a preprint that has not yet been peer reviewed. Key Takeaways In a large cohort of women with a body mass index (BMI) below 30 kg/m2 receiving up to four intrauterine insemination (IUI) infertility treatments in China, those with underweight were significantly less likely to become pregnant or have a live birth, wh...

Increased Social Services Spending Ups Cancer Survival of Blacks
https://www.medscape.com/viewarticle/974756

May 27th, 2022 - Increasing social services spending by 10% led to improved survival for non-Hispanic Black adults with cancer, according to new research. Five-year overall survival increased among non-Hispanic Black patients by 2.02% in conjunction with a 10% increase in spending. In addition, there was a decrease in racial disparities in survival between non-Hispanic Black patients and White patients for many...

ESG's Cardiometabolic Benefits Last 5 Years
https://www.medscape.com/viewarticle/974768

May 27th, 2022 - SAN DIEGO – Endoscopic sleeve gastroplasty (ESG) led to sustained weight loss and a reduction of cardiometabolic syndrome comorbidities at 5 years, according to a new retrospective analysis of prospectively collected data. Dr Donevan Westerveld Improved cardiometabolic outcomes following bariatric surgery have been well documented, but ESG is relatively new, so its outcomes haven't been as well...

'Unlimited' Cancer Costs: The Medicare Part D Dilemma
https://www.medscape.com/viewarticle/974754

May 27th, 2022 - Learning that a family member has cancer can be devastating enough. Waiting to find out whether a loved one can afford their treatment takes the concern to another level. That was the case for health policy expert Stacie B. Dusetzina, PhD, when her mother was diagnosed with metastatic breast cancer. "There is this period where you are waiting to learn more about the cancer type and treatment op...

Number of US Monkeypox Cases Grows to 10, CDC Says
https://www.medscape.com/viewarticle/974772

May 27th, 2022 - Ten monkeypox cases have been identified in eight states, according to the CDC. The CDC website said that as of 5 p.m. Thursday, health officials had identified two cases in Florida, two cases in Utah, and one case each in California, Colorado, Massachusetts, New York, Virginia, and Washington state. CDC Director Rochelle Walensky, MD, said Thursday that most of the cases "are within gay [and] ...

Double the Pleasure: Stim Patch Delays Early Ejaculation: Study
https://www.medscape.com/viewarticle/974773

May 27th, 2022 - A wearable patch that delivers electrical stimulation to the perineum may postpone premature ejaculation, according to research presented at the 2022 annual meeting of the American Urological Association. The disposable device appears to work by helping men contract the muscles in the pelvic floor, allowing them to postpone climax. Among 34 men with a lifelong history of premature ejaculation, ...

Interatrial Shunt in HF Hints at Heart Structural, Functional Benefits
https://www.medscape.com/viewarticle/974776

May 27th, 2022 - Transcatheter implants designed to alleviate high left atrial (LA) pressures — which, as a possible way to treat heart failure (HF) once seemed like a long shot — are emerging as new stars of heart failure research. Clinical trial results have been mixed but also seem to have dispelled most doubts about whether interatrial shunt devices may eventually prove an effective treatment for HF. That w...

H pylori Antibiotics Briefly Disrupt Gut Microbiome
https://www.medscape.com/viewarticle/974767

May 27th, 2022 - SAN DIEGO – Treatments to eradicate Helicobacter pylori (H. pylori) infections do increase the antibiotic resistance of the gut microbiota, but for only a few months, researchers reported at Digestive Disease Week® (DDW). The finding applies similarly to levofloxacin quadruple therapy and bismuth quadruple therapy, both of which are equally efficacious as second-line treatments, said Jyh-Ming L...

When Does an Elite Athlete Need Mental Health Treatment?
https://www.medscape.com/viewarticle/974777

May 27th, 2022 - MAR DEL PLATA, Argentina — Many athletes get the "jitters" — a feeling of anxiety — just prior to competing. For elite athletes, whether they're participating in an individual event or as part of a team, whether on a track, court, rink, or field, this feeling can affect performance. It is a well-known, and not unexpected, phenomenon that comes with the territory. Nevertheless, specialists shoul...

Distal Radial Access Does Not Impair Hand Function: RATATOUILLE
https://www.medscape.com/viewarticle/974771

May 27th, 2022 - A systematic battery of tests revealed no worsening of hand function out to 1 year following distal radial access (DRA) for percutaneous coronary procedures in the multicenter RATATOUILLE study. Further, patients experienced only modest access-site pain and very few complications. "This is reassuring, totally reassuring, because patients start at one level and they end exactly at the same level...

Eosinophilic Diseases Often Overlap, Raising Costs
https://www.medscape.com/viewarticle/974781

May 27th, 2022 - Eosinophilic GI diseases (EGIDs) often overlap with other eosinophil-associated diseases (EADs), which leads to greater health care costs, according to an analysis of the U.S. Optum Clinformatics claims database. EADs have gained increased attention in recent years. They include eosinophilic esophagitis (EoE), eosinophilic asthma, bullous pemphigoid, eosinophilic granulomatosis with polyangiiti...

New Test Might Transform Male Infertility
https://www.medscape.com/viewarticle/974757

May 27th, 2022 - A new study suggests that, at least for certain male patients, the answer to infertility might lie with epigenetics. According to the study, a commercially-available test of epigenetic anomalies — factors that affect how genes express themselves — can grade the likelihood that sperm are viable for conception. "The uniqueness of epigenetics is that some of the abnormalities detected have the pot...

Race-, Ethnicity-Based Clinical Guidelines Miss the Mark: Study
https://www.medscape.com/viewarticle/974783

May 27th, 2022 - SAN DIEGO, California — Race-based recommendations and clinical algorithms may be doing more harm than good, according to a systematic review of databases and guidelines. The study found examples of screening recommendations based on race or ethnicity that were likely misleading since these are social constructs that don't reflect a patient's individual risk, said Shazia Siddique, MD, who prese...

Psychological Intervention Looks Promising in Crohn's Disease
https://www.medscape.com/viewarticle/974780

May 27th, 2022 - SAN DIEGO — A combination of cognitive-behavioral therapy and mindfulness meditation could reduce pain and fatigue from Crohn's disease, researchers say. Patients who followed the program not only felt better but were also more often able to show up for work and leisure activities, compared with a control group assigned to a wait list, said Shmuel Odes, MD, a professor of internal medicine at B...

Steroid Use May Increase Relapse Risk in Some Patients With Ulcerative Colitis
https://www.medscape.com/viewarticle/974782

May 27th, 2022 - Patients who have histologically active ulcerative colitis (UC) with a Mayo endoscopic subscore (MES) of 1 and a history of steroid use may be at increased risk for clinical relapse, according to a new single-center, retrospective analysis. In recent years, treat-to-target approaches in UC have incorporated clinician and patient-reported outcomes, along with endoscopic remission, defined as MES...

Rapid Review Quiz: Nonalcoholic Fatty Liver Disease (NAFLD)
https://reference.medscape.com/viewarticle/973952

May 27th, 2022 - Approximately 25% of the global population has nonalcoholic fatty liver disease (NAFLD), a broad term that covers a range of conditions. NAFLD is defined by the presence of macrovesicular steatosis without secondary causes, such as chronic use of medications, significant alcohol consumption, or hereditary disorders. Several phases of progression are noted, including simple steatosis, fibrosis, ...

Update on Rabies, TBE, and Cholera Vaccines Before Travel
https://www.medscape.com/viewarticle/974443

May 27th, 2022 - Healthcare providers should be aware of important updates to vaccine recommendations that could affect patients preparing to travel internationally this summer. This includes information about: New rabies pre-exposure prophylaxis guidelines (PrEP); The new tick-borne encephalitis (TBE) vaccine; and Updated cholera vaccine recommendations and a restart of Vaxchora manufacturing and distribution....

The Next US Abortion Battle Is Over Pills, and It's Already Begun
https://www.medscape.com/viewarticle/974646

May 27th, 2022 - WASHINGTON (Reuters) - The U.S. Supreme Court has not yet released its decision that looks set to dramatically scale back abortion rights, but one of the next legal battles has already begun in a Mississippi court. That is where the manufacturer of a pill used to carry out medication abortions, Las Vegas-based GenBioPro Inc, has filed a federal lawsuit challenging the conservative state's restr...

Acupoint Hot Compress May Be Helpful After Vaginal Delivery
https://www.medscape.com/viewarticle/974680

May 27th, 2022 - NEW YORK (Reuters Health) - Following vaginal birth, acupoint hot compress involving the abdominal, lumbosacral and plantar regions appears to lessen postpartum urinary retention, uterine contraction pain and depressive symptoms, while promoting lactation, a randomized controlled trial has found. "Findings of this trial suggest that acupoint hot compress could be considered as an adjunctive int...

WHO Asks Countries to Increase Surveillance for Monkeypox
https://www.medscape.com/viewarticle/974685

May 27th, 2022 - (Reuters) - About 200 confirmed and more than 100 suspected cases of Monkeypox have been detected so far outside of the countries where it usually spreads, a World Health Organization official said on Thursday, urging countries to increase surveillance for the infectious disease. Monkeypox, a mild viral infection, is endemic in the African countries of Cameroon, Central African Republic, Democr...

Early Liver Transplant Outcomes Not Impacted by New US Allocation System
https://www.medscape.com/viewarticle/974702

May 27th, 2022 - NEW YORK (Reuters Health) - A new system for allocating liver allografts in the United States, implemented in 2020, has been associated with procurement-related delays but has had no adverse impact on early transplant outcomes, a new study shows. To assess the effect of Liver Acuity Circle Allocation (AC), researchers compared data from the Organ Procurement and Transplantation Network (OPTN) o...

Disparities Exist in Diabetes-Related ED Visits
https://www.medscape.com/viewarticle/974720

May 27th, 2022 - Wide disparities exist in diabetes-related emergency department (ED) use between racial and ethnic groups, rural and urban patients, and Medicare and Medicaid-insured adults versus those who were privately insured between 2008 and 2017, a serial cross-sectional study indicates. All-cause ED visits increased by over 50% during the same period even though substantial health reforms were made duri...

Baby Formula Shortage Highlights Racial Disparities
https://www.medscape.com/viewarticle/974731

May 27th, 2022 - COLUMBIA, Md. (AP) — Capri Isidoro broke down in tears in the office of a lactation consultant. The mother of two had been struggling to breastfeed her 1-month-old daughter ever since she was born, when the hospital gave the baby formula first without consulting her on her desire to breastfeed. Now, with massive safety recall and supply disruptions causing formula shortages across the United St...

Gout App Improves Treat to Target, Reduces Flares
https://www.medscape.com/viewarticle/974721

May 27th, 2022 - Self-management of gout using a smartphone app to record self-test urate levels and flares, and communicate those results to clinicians, could see more patients reaching target urate levels and even reducing flare frequency, a study has found. Writing in The Lancet Rheumatology, Philip Riches, PhD, of the rheumatic disease unit at Western General Hospital in Edinburgh, and coauthors presented t...

Study Addresses Whether Isotretinoin Precipitates IBD Flares
https://www.medscape.com/viewarticle/974735

May 27th, 2022 - A limited association exists between the use of isotretinoin for severe acne and worsening of a patient's baseline inflammatory bowel disease, results from a small retrospective study suggests. "Early studies of isotretinoin for use in severe acne suggested the drug may serve as a trigger for new-onset inflammatory bowel disease (IBD)," researchers led by Christina G. Lopez, MD, of the Lewis Ka...

Overlooked: Black Woman Doctor's Key Role in Oncology History 
https://www.medscape.com/viewarticle/974724

May 27th, 2022 - When Jane Cooke Wright, MD, entered the medical profession in 1945, the notion that toxic drugs could target tumors struck many physicians and patients as outlandish. How could one poison be weaponized against another poison — a cancerous tumor — without creating more havoc? Let alone a combination of two or more chemicals? Yet by the time Wright retired in 1987, chemotherapy treatments that sh...

Screening Finds Albuminuria in 3% of Community Adults
https://www.medscape.com/viewarticle/974739

May 27th, 2022 - Roughly 3% of adults in the general population of The Netherlands have microalbuminuria or macroalbuminuria, and in nearly two thirds of this subgroup — roughly 2% of the general population — kidney disease had previously gone unidentified, based on screening results in a study of about 15,000 adults. "This is the first study to prospectively investigate population screening for albuminuria," s...

Betting on 'Golden Age' of Colonoscopies, Private Equity Invests in Gastro Docs
https://www.medscape.com/viewarticle/974747

May 27th, 2022 - Mariel needed a new gastroenterologist. Having just moved back to San Antonio, the 30-something searched for a doctor to manage her Crohn's disease, an inflammatory bowel condition that is successfully managed with medications and lifelong monitoring — including regular colonoscopies. Mariel booked an appointment and learned she would be on the hook for a $1,100 colonoscopy — about three times ...

Index Cholecystectomy Cuts Readmissions After Acute Cholangitis
https://www.medscape.com/viewarticle/974779

May 27th, 2022 - Patients with acute cholangitis are twice as likely to be readmitted within 30 days if they don't get a cholecystectomy in the same hospital admission for which they get biliary decompression, researchers say. The readmissions result mostly from sepsis and recurrence of the acute cholangitis, said Ahmad Khan, MD, MS, a gastroenterology fellow at Case Western Reserve University in Cleveland, at ...

COVID-19 Vaccines Work Better and for Longer Than Expected Across Populations, Including Immunocompromised Individuals
https://www.medscape.com/viewarticle/974363

May 27th, 2022 - The mRNA vaccines are powerful in terms of preventing severe disease with COVID-19 across populations because of the multifaceted immune response they generate, a redundancy that can help among patients on agents which cause immunocompromise. Although antibodies from the vaccines will wane over time, or these antibodies can be less effective against new variants like Omicron, the vaccines do no...

Patent Foramen Ovale Clinical Practice Guidelines (SCAI, 2022)
https://www.medscape.com/viewarticle/974545

May 27th, 2022 - Clinical practice guidelines on the management of patent foramen ovale (PFO) from the Society for Cardiovascular Angiography and Interventions (SCAI) were published in May 2022 in  JSCAI.[1] In patients aged 18-60 years who have had a PFO-related stroke, PFO closure is strongly recommended instead of antiplatelet therapy alone. For patients aged 60 years and older with a history of PFO-related ...

New method allows easy, versatile synthesis of lactone molecules
https://www.eurekalert.org/news-releases/954194

May 27th, 2022 - LA JOLLA, CA—Chemists at Scripps Research have unveiled a method for turning cheap and widely available chemicals known as dicarboxylic acids into potentially very valuable molecules called lactones. Lactone structures are common in biologically active natural molecules; they can be found, for example, in vitamin C and in the bacterial-derived antibiotic erythromycin. Chemists have long had tec...

Hennepin Healthcare investigators study game to help people quit smoking
https://www.eurekalert.org/news-releases/954228

May 27th, 2022 - Minneapolis, Minn. - Hennepin Healthcare Research Institute is testing an innovative way to help people quit smoking – by letting them bet on themselves and win real money. It’s part of a new game called QuitBet and it’s being funded by a National Institutes of Health (NIH) research grant administered by researchers at Hennepin Healthcare. Players commit to quit smoking over four weeks and bet ...

Social media data show language related to depression didn’t spike after initial pandemic wave
https://www.eurekalert.org/news-releases/954190

May 27th, 2022 - Researchers who analyzed language related to depression on social media during the pandemic say the data suggest people learned to cope as the waves wore on. University of Alberta researcher Alona Fyshe and her collaborators at the University of Western Ontario hypothesized that depression-related language would spike during each wave of COVID-19. But their study shows that wasn’t the case. “Th...

MSK scientists identify new — and very common — subtype of prostate cancer
https://www.eurekalert.org/news-releases/954169

May 27th, 2022 - A previously unknown subtype of hormone-resistant prostate cancer accounts for about 30% of all cases, according to a new study from a team of scientists at Memorial Sloan Kettering Cancer Center (MSK) and Weill Cornell Medicine, published May 27, 2022, in the journal Science. The results could pave the way for targeted therapies for people with this subtype of prostate cancer. Prior to this re...

New liver and kidney disease identified
https://www.eurekalert.org/news-releases/954166

May 27th, 2022 - Scientists have identified a new disease in a ground-breaking discovery that could help patients with unexplained liver and kidney problems. Experts at Newcastle University, UK, have established the inherited condition, called TULP3-related ciliopathy that causes kidney and liver failure in children and adults. There are numerous reasons for kidney and liver organ failure, which if left untreat...

MU study finds health benefits of ‘aging in place’ at TigerPlace
https://www.eurekalert.org/news-releases/954168

May 27th, 2022 - COLUMBIA, Mo. -- The American Association of Retired Persons (AARP) found the majority of older adults want to stay in their own home as they age. However, given the natural decline in health that comes with aging, some older adults may have to move into a nursing home or assisted-living facility to receive more intensive levels of care. To help older adults live independently as they ‘age in p...

Previous COVID-19 or MIS-C does not protect kids from Omicron
https://www.eurekalert.org/news-releases/954167

May 27th, 2022 - Research drawing on the national Overcoming COVID-19 study, led by Boston Children’s Hospital, and the hospital’s own Taking On COVID-19 Together Group provides evidence that children who previously had COVID-19 (or the inflammatory condition MIS-C) are not protected against the newer Omicron variant. Vaccination, however, does afford protection, the study found. The findings, published in Natu...

Follow-up data further support the superior efficacy of cabozantinib in patients with progressive differentiated thyroid cancer
https://www.eurekalert.org/news-releases/954173

May 27th, 2022 - The most common subtype of thyroid cancer is differentiated thyroid cancer (DTC), which has a good prognosis and a survival rate of over 85%. The initial treatment approach is surgery followed, in some cases, by adjuvant radioactive iodine (RAI) therapy. A subset of patients develop RAI-refractory progressive disease, and, until the advent of multikinase inhibitors, lenvatinib and sorafenib, tr...

New gels could help the medicine go down
https://www.eurekalert.org/news-releases/953883

May 27th, 2022 - CAMBRIDGE, MA -- For most children and even some adults, swallowing pills or tablets is difficult. To make it easier to give those medicines, researchers at MIT and Brigham and Women’s Hospital have created a drug-delivering gel that is much easier to swallow and could be used to administer a variety of different kinds of drugs. The gels, made from plant-based oils such as sesame oil, can be pr...

Critical race theory at center of UW study of unequal access to treatment for opioid addiction
https://www.eurekalert.org/news-releases/954237

May 27th, 2022 - Opioid use disorder is an addiction crisis in the United States that has become increasingly lethal during the COVID-19 pandemic. To preserve access to life-saving treatment during the pandemic, federal drug agencies loosened requirements on physicians for treating these patients, including moving patient evaluations away from in-person exams to telemedicine. This federal policy change focused ...

Watching video feed of hospitalized baby improves pumping experience
https://www.eurekalert.org/news-releases/954221

May 27th, 2022 - Parents who used videoconferencing technology to view their hospitalized baby reported an improved pumping experience while expressing milk for their premature infant. Videoconferencing also helped the whole family connect to their infant in the Neonatal Intensive Care Unit (NICU). These findings were published in Breastfeeding Medicine this month. “Breast milk feeding is an essential component...

Biomedical engineers design drug-delivery solution for low-resource settings
https://www.eurekalert.org/news-releases/953430

May 27th, 2022 - Administering medications to children poses unique challenges, especially in resource-limited countries with high infant and child mortality rates. Many drugs are solids or tablets, which are not easily swallowed by children and difficult to dose according to a child’s weight. While liquid and semi-solid alternatives exist for some drugs, many medications lack this option, or become unstable wi...

Chung-Ang University researchers unravel role of cohesins in embryonic stem cell division
https://www.eurekalert.org/news-releases/954143

May 27th, 2022 - Chromosomes undergo precise structural changes at a molecular level during the different phases of cell division. These changes occur at a high level of accuracy to prevent genome instability. Genome instability resulting from broken, missing, or rearranged chromosomes has been found to be the root cause of cell death, carcinogenesis, and congenital disorders. Studying genomic instability helps...

ECOG-ACRIN research highlights at ASCO 2022
https://www.eurekalert.org/news-releases/954124

May 27th, 2022 - Philadelphia, May 27, 2022—Researchers with the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) will present a wide range of study results at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago and online June 3-7. The data include evaluations of new approaches to cancer treatment, control, care delivery, and health equity. The National Cancer Institute, part of the Na...

Same symptom – different cause?
https://www.eurekalert.org/news-releases/954150

May 27th, 2022 - Nowadays doctors define and diagnose most diseases on the basis of symptoms. However, that does not necessarily mean that the illnesses of patients with similar symptoms will have identical causes or demonstrate the same molecular changes. In biomedicine, one often speaks of the molecular mechanisms of a disease. This refers to changes in the regulation of genes, proteins or metabolic pathways ...

Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA
https://www.eurekalert.org/news-releases/954152

May 27th, 2022 - This study is led by Prof. Wei Xiong (Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University) and Prof. Fuyan Wang (Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University). Nasopharyngeal carcinoma (NPC) is the most commo...

Lack of affordable childcare is still a burden for plastic surgery residents – Especially women
https://www.eurekalert.org/news-releases/954171

May 27th, 2022 - May 27, 2022 – Plastic surgery residents face persistent barriers accessing affordable childcare, with high costs and a major impact on surgical training – with most of the burden falling on women residents, reports a paper in the June issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). Plastic and Reconstructive Surgery...

Study reveals potential target for treatment of diseases associated with mitochondrial DNA mutations
https://www.eurekalert.org/news-releases/954172

May 27th, 2022 - A study by Brazilian scientists points to the probable biological mechanism that modulates the accumulation of mutant mitochondrial DNA in cells during aging, especially in the liver. The mechanism is called autophagy, a process of cellular cleansing that destroys organelles, including mitochondria, and recycles their components. The findings resolve a paradigm in the field and raise a hypothes...

Scientists identify beetle that triggers production of red propolis in Brazil
https://www.eurekalert.org/news-releases/954174

May 27th, 2022 - Jairo Kenupp Bastos first heard about the insect while visiting Canavieiras on the south coast of Bahia, a state in the Northeast of Brazil. “Local beekeepers told me about a tiny beetle that made holes in a plant called Dalbergia ecastaphyllum [Coinvine], a member of the pea family, and that the holes leaked a resin used by bees to make red propolis,” said Bastos, a professor of pharmacognosy ...

Association of zip code vaccination rate with COVID-19 mortality in Chicago
https://www.eurekalert.org/news-releases/953996

May 27th, 2022 - About The Study: The findings in this study of 2.6 million Chicago residents suggest that zip codes with low vaccination rates were associated with more deaths during the Alpha and Delta waves of COVID-19 and that inequitable vaccination coverage exacerbated existing racial and ethnic disparities in COVID-19 deaths. Authors: William F. Parker, M.D., Ph.D., of the University of Chicago, is the c...

On the way to smart hearing aids
https://www.eurekalert.org/news-releases/954127

May 27th, 2022 - Smart hearing aids that adapt to the individual needs of the user: for the last four years, the researchers of the Collaborative Research Centre (CRC) Hearing Acoustics have been working towards this goal. Now the German Research Foundation (DFG) has extended the funding of the project. Led by Prof. Dr. Volker Hohmann, a hearing researcher at the University of Oldenburg, the CRC will receive up...

Easy, flexible access to produce, resources boosts healthy eating for central Texas kids
https://www.eurekalert.org/news-releases/954036

May 27th, 2022 - Austin, TX— What children eat affects their lifelong health. But influencing their habits can be difficult, especially for underserved families with fewer resources. However, providing caregivers easy access to produce and flexible resources can lead to improvements in kids’ diets in a short time, according to a new study from researchers at Dell Medical School at The University of Texas at Aus...

Comparing cancer-related spending, mortality rates in high-income countries
https://www.eurekalert.org/news-releases/953997

May 27th, 2022 - About The Study: Researchers found in this study of 22 high-income countries that cancer care spending in 2020 was not associated with age-standardized cancer mortality rates, and that although the United States spent more on cancer care than any other country, this expenditure was not associated with substantially lower cancer mortality rates. Authors: Cary P. Gross, M.D., of the Yale School o...

Analysis of household catastrophic health care expenditures associated with chronic disease
https://www.eurekalert.org/news-releases/953999

May 27th, 2022 - About The Study: Changes in catastrophic health care expenditures associated with chronic diseases in U.S. households from 2008 to 2018 were evaluated in this study. Authors: Young-Rock Hong, Ph.D., M.P.H., of the University of Florida in Gainesville, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1...

Autistic individuals have poorer health and healthcare
https://www.eurekalert.org/news-releases/954138

May 27th, 2022 - Autistic individuals are more likely to have chronic mental and physical health conditions, suggests new research from the University of Cambridge. Autistic individuals also report lower quality healthcare than others. These findings, published in Molecular Autism, have important implications for the healthcare and support of autistic individuals. Many studies indicate that autistic people are ...

Ancient viral elements embedded in human genome not from fossil retrovirus
https://www.eurekalert.org/news-releases/954134

May 27th, 2022 - Using a next generation sequencing analysis to examine human endogenous retrovirus (HERV) integration sites, researchers from Kumamoto University, the National Institute of Genetics (Japan), and the University of Michigan (USA) have discovered that these ancient retroviruses can undergo retrotransposition (DNA sequence insertion with RNA mediation) into iPS cells. The team believes that their d...

Examining association of registered nurse staffing with mortality risk of older patients with sepsis
https://www.eurekalert.org/news-releases/954002

May 27th, 2022 - About The Study: The results of this analysis of 1,958 acute care hospitals and 702,000 patients suggest that hospitals that provide more registered nurse hours of care could likely decrease the likelihood of mortality in Medicare patients with sepsis. Authors: Jeannie P. Cimiotti, Ph.D., of Emory University in Atlanta, is the corresponding author. To access the embargoed study: Visit our For T...

Meta-analysis shows targeted radiation therapy may be as effective as standard care for small cell lung cancer patients with brain metastases
https://www.eurekalert.org/news-releases/954104

May 27th, 2022 - A study published in The Lancet Oncology suggests that a targeted radiation therapy is equitable to the current standard of care for patients whose lung cancer has metastasized to the brain. The work, led by researchers at St. Michael’s Hospital, a site of Unity Health Toronto, suggests that implementation of this targeted approach, which is known to result in fewer negative cognitive consequen...

New cancer subtype may illuminate treatment strategy
https://www.eurekalert.org/news-releases/954184

May 27th, 2022 - Researchers at Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center have identified a previously unrecognized form of hormone therapy-resistant prostate cancer, as well as a set of molecules that drive its growth. This discovery opens the door to the development of therapies that treat this specific disease. In the study, published May 27 in Science, the researchers examined the mo...

Exercise response divides COPD patients into four groups
https://www.mdedge.com/chestphysician/article/255009/copd/exercise-response-divides-copd-patients-four-groups
Pam Harrison, MDedge News

May 26th, 2022 - Not all patients with chronic obstructive pulmonary disease (COPD) respond equally well to pulmonary rehabilitation (PR). Now, physicians can better categorize which patients will do well with PR and which ones less well or not well at all based on a new system of clustering of COPD patients according to their response to exercise therapy.

Airway injuries ‘devastating’ after battery ingestions: Review
https://www.mdedge.com/pediatrics/article/255004/injuries/airway-injuries-devastating-after-battery-ingestions-review
Marcia Frellick

May 26th, 2022 - Severe airway injuries are a “not infrequent” consequence after children swallow button batteries, which are commonly found in many household electronics, according to a systematic review published online in JAMA Otolaryngology–Head & Neck Surgery. Most literature has focused on esophageal injury, but “the direct apposition of the esophagus to the trachea and recurrent laryngeal nerves also pla.

Eosinophilic diseases often overlap, raising costs
https://www.mdedge.com/internalmedicine/article/255002/gastroenterology/eosinophilic-diseases-often-overlap-raising-costs
Jim Kling

May 26th, 2022 - Eosinophilic GI diseases (EGIDs) often overlap with other eosinophil-associated diseases (EADs), which leads to greater health care costs, according to an analysis of the U. S.

Climate change and air pollution seen through the cancer lens
https://www.mdedge.com/hematology-oncology/article/255001/lung-cancer/climate-change-and-air-pollution-seen-through-cancer
Joan H. Schiller, MD

May 26th, 2022 - Air pollution is a well-established cause of morbidity and mortality. It largely comes from manmade sources such as particulate matter that arises from burning fossil fuels, which is a major contributor of greenhouse gas emissions.

ESG’s cardiometabolic benefits last 5 years
https://www.mdedge.com/internalmedicine/article/255000/gastroenterology/esgs-cardiometabolic-benefits-last-5-years
Jim Kling

May 26th, 2022 - SAN DIEGO – Endoscopic sleeve gastroplasty (ESG) led to sustained weight loss and a reduction of cardiometabolic syndrome comorbidities at 5 years, according to a new retrospective analysis of prospectively collected data. Improved cardiometabolic outcomes following bariatric surgery have been well documented, but ESG is relatively new, so its outcomes haven’t been as well described.

H. pylori antibiotics briefly disrupt gut microbiome
https://www.mdedge.com/internalmedicine/article/254997/gastroenterology/h-pylori-antibiotics-briefly-disrupt-gut-microbiome
Laird Harrison

May 26th, 2022 - SAN DIEGO – Treatments to eradicate Helicobacter pylori (H. pylori) infections do increase the antibiotic resistance of the gut microbiota, but for only a few months, researchers reported at Digestive Disease Week® (DDW).

Does Viagra reduce mortality in pulmonary fibrosis?
https://www.mdedge.com/chestphysician/article/254988/pulmonology/does-viagra-reduce-mortality-pulmonary-fibrosis
Pam Harrison, MDedge News

May 26th, 2022 - Sildenafil (Viagra, Pfizer), a phosphodieterase-5 (PDE-5) inhibitor and a pulmonary-selective vasodilator, may reduce mortality in patients with idiopathic pulmonary fibrosis (IPF), compared with placebo or standard of care but it does not reduce hospitalizations or acute exacerbations from the disorder, a small meta-analysis suggests. “There have only been four trials investigating sildenafil.

Video game addiction: Definitions and best treatments remain elusive
https://www.mdedge.com/psychiatry/article/254987/addiction-medicine/video-game-addiction-definitions-and-best-treatments
Randy Dotinga

May 26th, 2022 - NEW ORLEANS – Research into video game addiction is turning up new insights, and some treatments seem to make a difference, according to addiction psychiatry experts speaking at the annual meeting of the American Psychiatric Association. Still, understanding remains limited amid a general lack of clarity about definitions, measurements, and the most effective treatment strategies.

‘Cool’ way of eradicating fat a promising therapy for many medical conditions
https://www.mdedge.com/dermatology/article/254986/aesthetic-dermatology/cool-way-eradicating-fat-promising-therapy-many
Doug Brunk

May 26th, 2022 - SAN DIEGO – During her third year in the combined Harvard/Massachusetts General Hospital dermatology residency program in 2011, Lilit Garibyan, MD, PhD, attended a lecture presented by R. Rox Anderson, MD, director of the Wellman Center for Photomedicine at MGH.

Gout app improves treat to target, reduces flares
https://www.mdedge.com/rheumatology/article/254981/gout/gout-app-improves-treat-target-reduces-flares
Bianca Nogrady

May 26th, 2022 - Self-management of gout using a smartphone app to record self-test urate levels and flares, and communicate those results to clinicians, could see more patients reaching target urate levels and even reducing flare frequency, a study has found. Writing in The Lancet Rheumatology, Philip Riches, PhD, of the rheumatic disease unit at Western General Hospital in Edinburgh, and coauthors presented t.

Crohn’s disease research goes to the dogs
https://www.mdedge.com/internalmedicine/article/254980/lotme/crohns-disease-research-goes-dogs
Lucas Franki, Richard Franki et. al.

May 26th, 2022 - Why it might be better to be a dog person Here’s that old debate again: Dogs or cats? You probably have your own opinion, but research presented at this year’s Digestive Disease Week may have tipped the scale by showing that children who lived with dogs may be less likely to have Crohn’s disease as adults. The research was done by having approximately 4,300 people closely related to patients wi.

Depressed patients respond faster to IV ketamine than intranasal ketamine
https://www.mdedge.com/psychiatry/article/254979/depression/depressed-patients-respond-faster-iv-ketamine-intranasal
Nancy A. Melville

May 26th, 2022 - NEW ORLEANS – New research reveals that patients with treatment-resistant depression who were treated with repeated intravenous ketamine show no significant differences in achieving response or remission, compared with those receiving the intranasal formulation of the drug, esketamine – although fewer treatments appear necessary with the intravenous formulation. “This is one of the first studie.

Ulcer on knuckle
https://www.mdedge.com/familymedicine/article/254791/dermatology/ulcer-knuckle
MDedge Family Medicine;

May 26th, 2022 - Since the papules were worrisome for vasculitis, 2 punch biopsies were performed on smaller, younger lesions on the hand and 1 was submitted for direct immunofluorescence. Findings revealed a leukocytoclastic vasculitis (LCV) with prominent immunoglobulin A (IgA) deposits around the vessel wall.

Texas School Killing, Deadliest in a Decade, Prompts Biden Call for Action
https://www.medscape.com/viewarticle/974578

May 26th, 2022 - UVALDE, Texas (Reuters) - The murder of 19 children and two teachers at a South Texas elementary school has prompted a call to action from U.S. President Joe Biden, who urged Americans to confront the country's gun lobby and pressure Congress to tighten gun laws. In the deadliest school shooting in nearly a decade, Salvador Ramos, 18, began his rampage on Tuesday when he shot his grandmother, t...

As Hunger Spreads in Somalia, Babies Start to Die
https://www.medscape.com/viewarticle/974584

May 26th, 2022 - DOLLOW, Somalia (Reuters) - Hacked-off thorn branches encircle two mounds of earth heaped over the tiny bodies of Halima Hassan Abdullahi's twin granddaughters. Babies Ebla and Abdia lived only a day. Weakened by hunger, their mother gave birth to the twins a month early, eight weeks after their exhausted family walked into a camp for displaced families in the Somali town of Dollow. "She is mal...

Healthy Habits Tied to Lower Dementia Risk in Genetically High-Risk Patients
https://www.medscape.com/viewarticle/974639

May 26th, 2022 - Higher scores regarding seven modifiable cardiovascular and brain health factors are linked to lower dementia risk in middle-aged individuals at high genetic risk for the disorder, new research shows. Investigators found that individuals with the APOE ε4 variant who scored high on the American Heart Association's (AHA 's) Life's Simple 7 (LS7) modifiable health factors had a significantly lower...

Faster Response to IV vs Intranasal Ketamine in Depression
https://www.medscape.com/viewarticle/974687

May 26th, 2022 - NEW ORLEANS – New research reveals that patients with treatment-resistant depression who were treated with repeated intravenous ketamine show no significant differences in achieving response or remission, compared with those receiving the intranasal formulation of the drug, esketamine – although fewer treatments appear necessary with the intravenous formulation. Dr Balwinder Singh "This is one ...

Oklahoma Gov. Signs Bill That Bans Nearly All Abortions
https://www.medscape.com/viewarticle/974690

May 26th, 2022 - Oklahoma Gov. Kevin Stitt signed a bill into law on Wednesday that bans almost all abortions in the state, starting at fertilization. The new law is the most restrictive abortion ban in the U.S., making exceptions only when an abortion is necessary to save the mother's life or in cases of rape or incest if they have been reported to police. It takes effect immediately. "From the moment life beg...

C. diff: How Did a Community Hospital Cut Infections by 77%?
https://www.medscape.com/viewarticle/974686

May 26th, 2022 - Teamwork by a wide range of professional staff, coupled with support from leadership, enabled one academic community hospital to cut its rate of hospital-onset Clostridioides difficile infections (HO-CDIs) by almost two thirds in 1 year and by over three quarters in 3 years, a study published in the American Journal of Infection Control reports. C. difficile is a major health threat. According ...