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Cyberattack, Overworked Doctors, Travel Restrictions: COVID-19 Global Weekly Highlights
https://www.medscape.com/viewarticle/950712

May 6th, 2021 - These are the global coronavirus stories you need to know about this week. India reported 3780 deaths on May 5, the highest daily death toll since the beginning of the pandemic. In the past week, India accounted for 46% of total COVID-19 cases and 1 in 4 COVID-19 deaths worldwide. On May 1, India widened its COVID-19 vaccination programme to include all adults aged 18 and over. However, several...

 COVID-19 Vaccine Coverage and Effectiveness among Healthcare Workers in England
https://www.medscape.com/viewarticle/950713

May 6th, 2021 - Takeaway In a cohort of healthcare workers in England, vaccine coverage was very high 2 months after the roll-out of approved COVID-19 vaccines in the UK.

FDA In Brief: FDA Issues Procedural Notice on Potential Plans to Conduct Research About Use of ‘Healthy’ Symbols on Food Products | FDA
https://www.fda.gov/news-events/press-announcements/fda-brief-fda-issues-procedural-notice-potential-plans-conduct-research-about-use-healthy-symbols

May 6th, 2021 - For Immediate Release: May 06, 2021 The following quote is attributed to Conrad Choiniere, Ph.D., director of the Office of Analytics and Outreach, Center for Food Safety and Applied Nutrition "The FDA understands that consumers want healthy choices when it comes to food and nutrition. Today, we are issuing a procedural notice on preliminary consumer research we are planning on the use of symbo...

FDA Committee Votes to Withdraw Two Accelerated Approvals of Cancer Treatments
https://www.ashclinicalnews.org/online-exclusives/fda-committee-votes-withdraw-two-accelerated-approvals-cancer-treatments/

May 5th, 2021 - The U.S. Food and Drug Administration’s (FDA’s) Oncologic Drugs Advisory Committee (ODAC) recommended withdrawing two of six accelerated approvals of cancer treatments that it reevaluated in a recent meeting, citing the failure to verify benefit in follow-up trials. The committee voted 6-2 to withdraw the accelerated approval of pembrolizumab for the treatment of patients with recurrent locally...

Pipette Tip Shortage Hinders Scientific Work Worldwide
https://www.ashclinicalnews.org/online-exclusives/pipette-tip-shortage-hinders-scientific-work-worldwide/

May 5th, 2021 - An ongoing pipette tip shortage caused by the COVID-19 pandemic, blackouts in Texas, and a manufacturing plant fire is hindering scientific work around the world, from newborn screening to drug development to basic research. While COVID-19 diagnostic tests’ reliance on pipette tips has contributed to the shortage, several other issues further up the supply chain have also played a role. Winter ...

Will the FDA Crack Down on Clinical Trial Reporting Noncompliance?
https://www.ashclinicalnews.org/online-exclusives/will-fda-crack-clinical-trial-reporting-noncompliance/

May 5th, 2021 - The U.S. Food and Drug Administration (FDA) has issued its first notice of noncompliance to Acceleron Pharma for failing to submit clinical trial results to ClinicalTrials.gov, the federal government’s database of privately and publicly funded clinical studies. If the pharmaceutical company does not submit the required data within 30 days, the agency is authorized to seek civil monetary penalti...

UK COVID-19 Update: Strong Protection from Pfizer Jab and Vaccine Confidence Remains High
https://www.medscape.com/viewarticle/950654

May 5th, 2021 - These are the UK coronavirus stories you need to know about today. A supplementary analysis showed that a single dose of the vaccine was associated with moderate protection against infection, hospitalisation, and death, emphasising the importance of fully vaccinating adults, the researchers said. They acknowledged remaining uncertainties about the duration of immunity, and the possible emergenc...

Web-Based Patient Education Cuts Down Upper GI Endoscopy for Dyspepsia
https://www.medscape.com/viewarticle/950605

May 5th, 2021 - (Reuters Health) - Patients with uninvestigated dyspepsia may be less likely to require an upper gastrointestinal tract endoscopy if they participate in web-based patient education, a small clinical trial suggests. Researchers followed 119 patients with uninvestigated symptoms of dyspepsia who had been referred by general practitioners for an upper gastrointestinal (GI) tract endoscopy without ...

COVID Delay of Treatment of Neovascular Age-Related Macular Degeneration Less Harmful Than Expected
https://www.medscape.com/viewarticle/950709

May 5th, 2021 - Many people with neovascular age-related macular degeneration (nAMD) lost less vision than expected during treatment delays imposed by COVID-19, researchers say. The finding suggests that physicians may be overtreating these patients, said James Talks, MB BChir, a consultant ophthalmologist at the Royal Victoria Infirmary in Newcastle upon Tyne, United Kingdom. But many patients with nAMD decid...

Should COVID Shots for Teens Go to Developing Countries?
https://www.medscape.com/viewarticle/950683

May 5th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. U. S The administration announced plans in late April to send 60 million doses of the AstraZeneca vaccine to countries in need. But that won't be enough to help resolve the humanitarian crisis, he says. Spencer is just one of many voices in the public health realm pushing for more international ...

School-Based Asthma Program Improves Care for Kids
https://www.medscape.com/viewarticle/950672

May 5th, 2021 - Asthma care coordination for children can be improved through a school-based asthma program involving the child's school, their family, and clinicians, according to a recent presentation at the annual meeting of the American Academy of Allergy, Asthma, and Immunology, held virtually this year. "Partnerships among schools, families, and clinicians can be powerful agents to improve the recognitio...

Look Beyond Liver Biopsy for NAFLD Diagnosis
https://www.medscape.com/viewarticle/950690

May 5th, 2021 - Nonalcoholic fatty liver disease (NAFLD) was present in approximately two-thirds of patients who did not undergo a liver biopsy. These patients were more likely to be non-White and older, as well as have normal ALT levels, which shows potential gaps in knowledge about this population. Data from studies of patients diagnosed with NAFLD that require biopsy among their inclusion criteria may be su...

Prioritize Goals of Older Patients With Multimorbidities
https://www.medscape.com/viewarticle/950670

May 5th, 2021 - When caring for older adults with multiple chronic conditions, prioritizing patient goals is more effective and efficient than trying to address each condition in isolation, said Mary Tinetti, MD, Gladys Phillips Crofoot Professor of Medicine and Public Health and chief of geriatrics at Yale University, New Haven, Conn. During a virtual presentation at the American College of Physicians annual ...

Vaping Linked to Visual Impairment
https://www.medscape.com/viewarticle/950633

May 5th, 2021 - People who use e-cigarettes have a high rate of visual impairment, researchers say, and that association is independent of and in addition to traditional cigarette use. The statistical correlation doesn't prove that vaping causes visual impairment. But it parallels earlier studies that link tobacco smoking to visual impairment, and vaping to lung damage. And it raises new questions about whethe...

Reduced Kidney Function Tied to Increased Dementia Risk
https://www.medscape.com/viewarticle/950612

May 5th, 2021 - NEW YORK (Reuters Health) - Older adults with reduced kidney function may be an increased risk of developing dementia, according to a large population-based study from Sweden. "Even a mild reduction in kidney function has been linked to an increased risk of cardiovascular disease and infections, and there is growing evidence of a relationship between the kidneys and the brain," Dr. Hong Xu of t...

Preventing Endoscopist Injuries Starts With Ergonomics
https://www.medscape.com/viewarticle/950634

May 5th, 2021 - Endoscopists are at high risk of musculoskeletal issues, and a multifaceted strategy is needed to reduce rates of injury, including better body posture and endoscopic suite layout, according to leading experts. Latha Alaparthi, MD, director of committee operations at Gastroenterology Center of Connecticut, Hamden, and assistant clinical professor at Yale University, New Haven, Conn. , noted tha...

COVID Impact on Breast Cancer: Upfront Endocrine Rx Increased
https://www.medscape.com/viewarticle/950624

May 5th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. The use of neoadjuvant endocrine therapy (NET) increased significantly during the first 8 months of the COVID-19 pandemic for women with estrogen receptor–positive (ER+) breast cancer. These patients would normally undergo surgery first, but because of operating room restrictions, those surgerie...

No Extra Drop in AF Burden from Postablation Weight-Loss Program: SORT-AF
https://www.medscape.com/viewarticle/950629

May 5th, 2021 - Obesity is well known to promote atrial fibrillation (AF), and catheter ablation can dramatically cut back on AF prevalence. But assigning patients to a structured obesity-reduction program after AF ablation may not enhance the treatment's effect on AF burden, a novel randomized trial suggests. Of 133 patients with symptomatic persistent or paroxysmal AF with a body mass index (BMI) in the 30 t...

Heart Retrieval Technique May Boost Organs for Transplant by 20%
https://www.medscape.com/viewarticle/950639

May 5th, 2021 - In a small observational study that tested normothermic regional perfusion (NRP) for donation after cardiac death (DCD), posttransplant cardiac function was "excellent" in 8 of 8 transplant recipients, and survival after a mean of 237 days was 100%. Seven recipients of isolated heart transplants required minimal inotropic support. The eighth patient, a heart-lung recipient, required venoarteria...

COVID Restrictions Tough for Individuals With Autism and Their Caregivers
https://www.medscape.com/viewarticle/950542

May 5th, 2021 - NEW YORK (Reuters Health) - COVID-19 restrictions greatly impacted young people with neurodevelopmental disorders and their caregivers, according to results of a large survey released at the International Society for Autism Research (INSAR) annual meeting. Overall, the survey results highlight the fact that COVID-19 restrictions "disrupted access to medical and therapeutic services and created ...

Pediatric Cancer Survivors at Risk for Opioid Misuse
https://www.medscape.com/viewarticle/950642

May 5th, 2021 - Survivors of childhood cancers are at increased risk for prescription opioid misuse compared with their peers, a review of a claims database revealed. Among more than 8,000 patients age 21 or younger who had completed treatment for hematologic, central nervous system, bone, or gonadal cancers, survivors were significantly more likely than were their peers to have an opioid prescription, longer ...

 Sleep Disorders Linked to an Increased Risk of Osteoarthritis
https://www.medscape.com/viewarticle/950625

May 5th, 2021 - Takeaway Sleep disorders were significantly associated with an increased risk of osteoarthritis (OA). The association was significant across all sex, age and OA type subgroups, with the exception of patients aged >80 years and those with knee OA. Why this matters Findings highlight the importance of improving the diagnosis and management of sleep disorders to mitigate their potentially deleteri...

AGA Clinical Practice Update: Management of Bleeding Gastric Varices
https://www.medscape.com/viewarticle/950632

May 5th, 2021 - When classifying gastric varices during endoscopy, experts suggest not only describing their location but also their size and whether any high-risk stigmata, such as discolorations and platelet plugs, are present. In a clinical practice update from the American Gastroenterological Association, Zachary Henry, MD, of the University of Virginia, Charlottesville, and associates also proposed an alt...

Jimmy Kimmel Urges People to Get COVID-19 Vaccine
https://www.medscape.com/viewarticle/950661

May 5th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. On Tuesday's episode of Jimmy Kimmel Live, host Jimmy Kimmel encouraged people to get a COVID-19 vaccine and featured a video of doctors and nurses across the country who talked about their experiences.

CVST With AZ COVID Vaccine: 1 in 40,000 'More Reliable' Estimate
https://www.medscape.com/viewarticle/950646

May 5th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. A new study that systematically monitored rates of vascular and thromboembolic events in people receiving the AstraZeneca COVID-19 vaccine has found it to be associated with a rate of cerebral venous sinus thrombosis (CVST) of 1 in 40,000. "Early on, we thought CVST was a very rare occurrence — ...

Is Potentially Inappropriate Prescribing Common in Chronic Kidney Disease?
https://www.medscape.com/viewarticle/950620

May 5th, 2021 - Potentially inappropriate prescribing is common in patients with chronic kidney disease (CKD) in primary care, according to a new retrospective Scottish population-based analysis. High-risk prescribing in CKD contributes to adverse drug reactions and drug-related acute kidney injury (AKI)—people with CKD have the poorest health outcomes after drug-related AKI, specifically being most likely to ...

Would You Get a Vaccine Passport to Travel?
https://www.medscape.com/viewarticle/950622

May 5th, 2021 - As some companies, venues, and governments form plans to implement "vaccine passports" (and others pledge to prohibit them), individuals may soon face choices about whether to get such proof of vaccination to travel or participate in certain events. What will you do? You must Log In to answer this question

Bill Would Make Employers Pay for Any Required COVID-19 Test
https://www.medscape.com/viewarticle/950647

May 5th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. CONCORD, N. H

In Interactions With Law Enforcement, Black Males More Likely to Suffer Severe Injury
https://www.medscape.com/viewarticle/950604

May 5th, 2021 - (Reuters Health) - Black males are more likely than whites to be hospitalized with gunshot wounds and other severe injuries suffered during law enforcement interactions, a new study suggests. The analysis of data from the American College of Surgeons Trauma Quality Improvement Program (TQIP) found that the number of white individuals who sustained firearm injuries was about twice that of Black ...

Dexamethasone for Nausea Does Not Raise Risk of Surgical-Site Infections
https://www.medscape.com/viewarticle/950607

May 5th, 2021 - NEW YORK (Reuters Health) - Fears that dexamethasone may increase the risk of surgical-site infection when given to prevent nausea and vomiting after an operation appear to be unfounded. A new noninferiority study of 8,725 volunteers who received the drug or placebo for their nonurgent, noncardiac surgery found an infection rate of 8. 1% over 30 days with intravenous dexamethasone and 9 More im...

Going Viral: Social Media May Be Increasing Cases of New-Onset Tics
https://www.medscape.com/viewarticle/949882

May 5th, 2021 - This transcript has been edited for clarity. Kathrin LaFaver, MD: Hello. I'm Dr Kathrin LaFaver, a movement disorders specialist at Northwestern University here in Chicago. It is my great pleasure today to interview Dr Tamara Pringsheim on the topic of acute-onset explosive tic-like behaviors. Dr Pringsheim is an associate professor in the Department of Clinical Neurosciences, Psychiatry, Pedia...

Suicide Risk Prediction Tools Fail Racialized Patients
https://www.medscape.com/viewarticle/950631

May 5th, 2021 - Current models used to predict suicide risk fall short for racialized populations including Black, Indigenous, and People of Color (BIPOC), new research shows. Investigators developed two suicide prediction models to examine whether these types of tools are accurate in their predictive abilities, or whether they are flawed. Table 2. Area Under the Curve (AUC) Sensitivity for Predication Models ...

Military Leader Shows Hospitalists a Way Out of Pandemic 'Combat'
https://www.medscape.com/viewarticle/950655

May 5th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Whether they realize it or not, hospitalists treating patients during the COVID-19 pandemic have been in a combat-like situation, with challenges and stresses similar to those faced by soldiers in a war zone. Lt. Gen. Hertling described several issues – mirroring those seen in combat – that clin...

Shorter Tuberculosis Regimen With Moxifloxacin Not Inferior to 6-Month Treatment
https://www.medscape.com/viewarticle/950608

May 5th, 2021 - NEW YORK (Reuters Health) - A new rifapentine-based regimen with moxifloxacin can shorten the treatment time for drug-susceptible pulmonary tuberculosis, the authors behind a new phase-3 test report. "This is the first time in 40 years wherein treatment shortening has been feasible for drug-susceptible TB, so this is a landmark event," coauthor Dr. Payam Nahid, director of the Center for Tuberc...

Moderna Announces First Data Showing Efficacy of COVID-19 Vaccine Booster in Development
https://www.medscape.com/viewarticle/950650

May 5th, 2021 - Find the latest COVID-19 news and guidance in Medscape's  Coronavirus Resource Center. The Moderna SARS-CoV-2 vaccine booster developed specifically with variant B. 1

Majority of Parents Will Wait on Kids' COVID Vaccine
https://www.medscape.com/viewarticle/950697

May 5th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Three-quarters of parents don't plan to vaccinate their kids against COVID-19 when the FDA gives the go-ahead for younger children, according to a new survey. Many said they'd wait a few months, but a full third said they don't plan to vaccinate their kids at all Gretchen Schaeffer's 14-year-old...

Ventilated COVID Patient Gets Ivermectin After Court Order
https://www.medscape.com/viewarticle/950686

May 5th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. A 68-year-old woman with COVID-19, who has been in intensive care in an Illinois hospital for a month, started receiving the controversial drug ivermectin (Stromectol) this week after her family sued the hospital to have someone administer it, according to a report in the Chicago Tribune. In a f...

Evidence or Anecdote: Clinical Judgment in COVID Care
https://www.medscape.com/viewarticle/950665

May 5th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. As the COVID-19 pandemic continues and evidence evolves, clinical judgment is the bottom line for clinical care, according to Adarsh Bhimraj, MD, of the Cleveland Clinic, and James Walter, MD, of Northwestern Medicine, Chicago. In a debate/discussion presented at SHM Converge, the annual confere...

COVID-Related Mental Illness Rises, Capacity to Treat Falls
https://www.medscape.com/viewarticle/950688

May 5th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. During the COVID-19 pandemic, the percentage of Americans reporting symptoms of mental illness has increased, and the capacity to treat these disorders has decreased, a new report from the Government Accountability Office (GAO) shows. The GAO report did not explain why so many organizations that...

New Pediatric Advanced Life Support Guidelines Raise Questions
https://www.medscape.com/viewarticle/950200

May 5th, 2021 - This transcript has been edited for clarity. Robert D. Glatter, MD: Hi. I'm Dr Robert Glatter, medical advisor for Medscape Emergency Medicine. More than 20,000 pediatric cardiac arrests occur annually in the US, but the outcomes for about 7000 annual pediatric out-of-hospital cardiac arrests have remained poor, with no significant improvement for decades in overall survival and neurologically ...

Breast Cancer Survivors Have Specific Gynecological Needs
https://www.medscape.com/viewarticle/950630

May 5th, 2021 - Sexual dysfunction is a common problem among breast cancer survivors, but it's also an issue inadequately addressed by either ob/gyns. or hematologists and oncologists, according to Erin Keyser, MD, the program director of the San Antonio Uniformed Services Health Education Consortium. Keyser discussed management of sexual dysfunction and a variety of other issues frequently faced by women who ...

Obesity Is Deadlier in Men With COVID-19 Than in Women
https://www.medscape.com/viewarticle/950662

May 5th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. The association between obesity and poor outcomes in COVID-19 are worse in men than women, with increased rates of in-hospital death, shows the largest study to date exploring the different impact of obesity between the sexes on COVID-19.   As a primary outcome, researchers looked at which class...

Don't Pass the Salt: WHO Issues Benchmarks for Sodium Content in Food
https://www.medscape.com/viewarticle/950551

May 5th, 2021 - GENEVA (Reuters) - Excessive salt in food and beverages is putting people at greater risk of potentially fatal heart disease and strokes, the World Health Organization (WHO) said on Wednesday, issuing fresh guidelines for limiting sodium content. An estimated 11 million deaths globally are associated with poor diet each year, including 3 million attributable to high sodium intake, it said in a ...

Bar Owner Accused of Selling Fake Vaccination Cards
https://www.medscape.com/viewarticle/950684

May 5th, 2021 - A bar owner in California was arrested after being accused of making and selling fake COVID-19 vaccination cards, according to ABC News. Todd Anderson, 59, owner of the Old Corner Saloon in Clements, was arrested on Wednesday by the California Department of Alcoholic Beverage Control and charged with falsifying a medical record, falsifying an official government seal, and several counts of iden...

Improving Health Disparities Starts With Acknowledging Structural Racism
https://www.medscape.com/viewarticle/950673

May 5th, 2021 - Earlier this spring, Kimberly D. Manning, MD, FACP, FAAP, was caring for an elderly Black man with multiple comorbidities at Grady Memorial Hospital in Atlanta, assembling an order for medications and a discharge plan. "It was very challenging," Manning, professor of medicine and associate vice chair of diversity, equity, and inclusion at Emory University, Atlanta, recalled during a May 4 sessi...

Pediatric Topics Cross Continuum of COVID-19
https://www.medscape.com/viewarticle/950674

May 5th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. A year into the COVID-19 pandemic, it is fair to say that children do transmit the virus, but at lower rates, Philip Zachariah, MD, of Columbia University, New York City, said in a presentation at SHM Converge, the annual conference of the Society of Hospital Medicine. Supportive care remains a ...

Endoscopic Device Could Expand Treatment for GERD, Reduce PPI Use
https://www.medscape.com/viewarticle/950689

May 5th, 2021 - In patients with proton pump inhibitor (PPI)–dependent gastroesophageal reflux disease (GERD), a procedure known as endoscopic full-thickness plication (EFTP) — performed with the novel GERD-X device — improved both symptoms and quality of life, compared with a sham procedure. It also had few side effects and a short procedure time, according to a new randomized, controlled trial. "It seems lik...

Telemedicine Is a Tool — Not a Replacement for a Doctor's Touch
https://www.medscape.com/viewarticle/950667

May 5th, 2021 - Earlier in the pandemic it was vital to see doctors over platforms like Zoom or FaceTime when in-person appointments posed risks of coronavirus exposure. Insurers were forced — often for the first time — to reimburse for all sorts of virtual medical visits and generally at the same price as in-person consultations. By April 2020, one national study found, telemedicine visits already accounted f...

FDA OKs Upfront Pembro for Advanced HER2+ Gastric Cancer
https://www.medscape.com/viewarticle/950679

May 5th, 2021 - This week, the US Food and Drug Administration (FDA) granted accelerated approval to pembrolizumab (Keytruda) in combination with other agents for the first-line treatment of patients with locally advanced unresectable or metastatic HER2-positive gastric or gastroesophageal junction (GEJ) adenocarcinoma. The checkpoint inhibitor is to be used in conjunction with trastuzumab (Herceptin) and fluo...

Infective Endocarditis With Stroke After TAVR Has 'Dismal' Prognosis
https://www.medscape.com/viewarticle/950702

May 5th, 2021 - Patients who suffer a stroke during hospitalization for infective endocarditis (IE) after transcatheter aortic valve replacement (TAVR) have a dismal prognosis, with more than half dying during the index hospitalization and two thirds within the first year, a new study shows. The study — the first to evaluate stroke as an IE-related complication following TAVR in a large multicenter cohort — is...

DHHS: Fully Vaccinated Nebraska Woman Dies of COVID-19
https://www.medscape.com/viewarticle/950651

May 5th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. KEARNEY, Neb. (AP) — A south-central Nebraska woman who had been fully vaccinated against COVID-19 recently died of the disease, state health officials said Wednesday. The Nebraska Department of Health and Human Services said in a news release that the woman was in her 80s and had underlying hea...

What's New for UK Cardiology Practice from EHRA 2021?
https://www.medscape.com/viewarticle/950621

May 5th, 2021 - Dr Sukh Nijjer and Dr Afzal Sohaib discuss the key developments from the European Heart Rhythm Association (EHRA) Congress. This transcript has been edited for clarity. Welcome to this Medscape UK video. Today we're going to be talking about the Heart Rhythm Congress from the European Society of Cardiology (EHRA). I'm Dr Sukh Nijjer. I'm a consultant cardiologist working in London, and today I'...

COVID-19 Confinement May Have Caused Myopia in Kids
https://www.medscape.com/viewarticle/950711

May 5th, 2021 - The COVID-19 pandemic may have increased the prevalence of myopia by confining young children indoors, researchers say. Spending more time inside focused on computer screens appears to have most affected the eyesight of the youngest school children, said Xuehan Qian, MD, PhD, of Tianjin Medical University Eye Hospital in Tianjin, China. "We should be worried about the eye problems of COVID-19, ...

Nighttime Asthma Predicts Poor Outcomes in Teens
https://www.medscape.com/viewarticle/950658

May 5th, 2021 - Teens with persistent nocturnal asthma symptoms were significantly more likely than were those without nighttime asthma to report poor functional health independent of daytime asthma, based on data from 430 adolescents aged 12-16 years. Approximately half of children with severe asthma experience at least one night of inadequate sleep per week, and lost sleep among young children with asthma ha...

CDC Sets Rules for Trial Cruises With Volunteer Passengers
https://www.medscape.com/viewarticle/950669

May 5th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Cruise lines can soon begin trial voyages in U. S

Coronavirus (COVID-19) Update: FDA Outlines Inspection and Assessment Activities During Pandemic, Roadmap for Future State of Operations | FDA
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-outlines-inspection-and-assessment-activities-during-pandemic

May 5th, 2021 - For Immediate Release: May 05, 2021 Today, the U.S. Food and Drug Administration issued a new report titled, “Resiliency Roadmap for FDA Inspectional Oversight,” outlining the agency’s inspectional activities during the COVID-19 pandemic and its detailed plan to move toward a more consistent state of operations, including the FDA’s priorities related to this work going forward. “Like most organ...

NHS England to Introduce 3D Heart Scans for Quicker Diagnosis of CAD
https://www.medscape.com/viewarticle/950531

May 4th, 2021 - NHS England is to introduce a pioneering technology called HeartFlow for quicker diagnosis and treatment of suspected heart disease. HeartFlow transforms a regular cardiac computerised tomography (CT) scan into a three-dimensional (3D) image, enabling physicians to diagnose coronary heart disease (CAD) within 20 minutes. The technology could potentially cut the need for invasive and laborious a...

Ohio Surgeon Who Wrote His Own Colorful Obituary Dead at 48
https://www.medscape.com/viewarticle/950540

May 4th, 2021 - The family of Ohio surgeon Thomas Lee Flanigan, 48, who died last week, made public the obituary he wrote himself, self-eulogizing his "shocking and unexpected, yet fabulous, exit." Flanigan, who referred to himself as the "Ginger God of Surgery and Shenanigans," wrote, "Yes, I have joined the likes of Princess Diana, John Belushi, and Steve Irwin the Crocodile Hunter in leaving while still at ...

In-Hospital Glucose Management Program Gives Dramatic Savings
https://www.medscape.com/viewarticle/950563

May 4th, 2021 - Initiatives targeting hypoglycemia and insulin pen wastage could lead to dramatic cost savings in small community hospitals, new data suggest. The two projects are part of a dedicated inpatient glucose management service led by Mihail ("Misha") Zilbermint, MD, one of the few full-time endocrine hospitalists in the United States and one of even fewer who work at a small community hospital. Regar...

FDA Reviewers: Why We Are Against Approval of Aducanumab for Alzheimer's
https://www.medscape.com/viewarticle/950565

May 4th, 2021 - Three members of a US Food and Drug Administration (FDA) advisory committee are explaining why they do not support approval of the drug aducanumab (Biogen, Eisai) for the treatment of Alzheimer's disease (AD). G. Caleb Alexander, MD, Scott Emerson, MD, PhD, and Aaron Kesselheim, MD, JD, MPH, all serve on the FDA's Peripheral and Central Nervous System Advisory Committee and participated in the ...

Progress Stalling on Malaria Elimination
https://www.medscape.com/viewarticle/950546

May 4th, 2021 - In its final report on the E-2020 initiative, the World Health Organization (WHO) touted its progress on its goal of eliminating malaria throughout the world. But critics are charging that progress has stalled. The E-2020 initiative supported the efforts of twenty-one countries in eliminating malaria. In a remarkable achievement, especially during the COVID-19 pandemic, eight E-2020 member coun...

Novel Drug Offers Rapid Relief From Agitation in Serious Mental Illness
https://www.medscape.com/viewarticle/950613

May 4th, 2021 - An investigational, orally dissolving film formulation of dexmedetomidine (BXCL501, BioXcel Therapeutics) may offer rapid relief from acute agitation related to schizophrenia or bipolar disorder (BD), results of two phase 3, randomized, placebo-controlled trials show. Dr Leslie Citrome For both disorders, BXCL501 showed "superiority over placebo" by meeting the primary endpoint of reduction of ...

Docs Mobilize Help For Indian Colleagues Overwhelmed With COVID-19 Surge
https://www.medscape.com/viewarticle/950603

May 4th, 2021 - Clinicians from across the world are banding together to mobilize help for their colleagues in India, where more than 300,000 new cases of COVID-19 have been reported daily for the past 2 weeks. Some are working hotlines and disseminating critical public health information; others are crowdfunding for equipment, training young doctors, or supporting vaccine registration.  In the last 2 weeks, a...

Insomnia? Referral, Drugs Not Usually Needed
https://www.medscape.com/viewarticle/950539

May 4th, 2021 - Chronic insomnia is often underrecognized and misunderstood in primary care, sleep expert Christopher Lettieri, MD, told attendees at the American College of Physicians (ACP) Internal Medicine Meeting 2021. Too often, medications are the treatment of choice, and when used long term they can perpetuate a problematic cycle, said Lettieri, professor in pulmonary, critical care, and sleep medicine ...

Female Physicians More Likely Than Other Women to Delay Childbearing
https://www.medscape.com/viewarticle/950436

May 4th, 2021 - (Reuters Health) - Compared to women in the general public, female physicians in Canada are less likely to have children overall, less likely to have babies when they are in their twenties, and far more likely to delay childbearing until they are in their late thirties, a new study finds. An analysis of data from 5,328 female doctors and 26,640 non-physician women revealed that the physicians w...

COVID-19 Severity Starts in Normal BMI Range, Especially in Young
https://www.medscape.com/viewarticle/950568

May 4th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. The risk of severe outcomes with COVID-19 increases with excess weight in a linear manner beginning in normal body mass index ranges, with the effect apparently independent of obesity-related diseases such as diabetes and stronger among younger people and Black persons, new research shows. Risk ...

Exclusive: Guidance on Talking to Patients About COVID-19 Vaccines
https://www.medscape.com/viewarticle/950569

May 4th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Physicians remain one of the most trusted sources of nonjudgmental information for patients ― including on vaccinations ― and this could come in handy as the daily pace at which people receive COVID-19 vaccines nationwide continues to slow. "Anytime you have a new disease, new procedure, or a ne...

After Hundreds of Interviews, Here's John Whyte's View of COVID
https://www.medscape.com/viewarticle/950180

May 4th, 2021 - This transcript has been edited for clarity. Eric J. Topol, MD: This is Eric Topol for Medscape and the Medicine and the Machine podcast. It is a special privilege for me today to welcome Dr John Whyte, who is the chief medical officer at WebMD. Welcome, John. John Whyte, MD, MPH: Thanks, Eric. It's great to be with you. Topol: We're flipping the script because John has interviewed me several t...

COVID and False Beliefs: How Social Media Exploits Cognitive Bias
https://www.medscape.com/viewarticle/950367

May 4th, 2021 - Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. This transcript has been edited for clarity. Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I'm Dr F. Perry Wilson of the Yale School of Medicine. Medical misinformation is nothing new, but I think we can all agree that the coronavirus pandemic has added fuel to the misinforma...

Big Three Drug Distributors Blame Doctors, Regulators in Trial Over Opioid Epidemic
https://www.medscape.com/viewarticle/950438

May 4th, 2021 - (Reuters) - The three largest U.S. drug distributors, facing their first trial over claims that they fueled the opioid crisis, said responsibility for ballooning painkiller sales lies with doctors, drugmakers and regulators. AmerisourceBergen Corp, McKesson Corp and Cardinal Health Inc are defending themselves against a lawsuit brought by the city of Huntington and Cabell County in West Virginia.

New Federal Program Reimburses Vaccine Administration Fees for Underinsured Patients
https://www.medscape.com/viewarticle/950544

May 4th, 2021 - A new federal program will cover physicians' costs of administering COVID-19 vaccines to patients enrolled in health plans that either do not cover vaccination fees or cover them with patient cost-sharing. Physicians will be compensated for vaccine administration at national Medicare rates, which were raised in March. The new COVID-19 Coverage Assistance Fund (CAF), which the Department of Heal...

Formal Geriatric Assessment Should Be Routine
https://www.medscape.com/viewarticle/950609

May 4th, 2021 - As the number of elderly patients with cancer continues to rise — and geriatricians remain in short supply — primary care providers and community oncologists need to incorporate formal geriatric assessment into routine practice, a geriatric oncologist said during a presentation at the American College of Physicians annual Internal Medicine meeting. A 2020 ASCO survey, which the speaker, Grant R...

With RA in Remission, Tapering of Conventional DMARDs May Lead to Disease Flares for Some Patients
https://www.medscape.com/viewarticle/950455

May 4th, 2021 - NEW YORK (Reuters Health) - In patients with rheumatoid arthritis (RA) in remission taking conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), cutting the drug dose in half could lead to more disease flares, according to a randomized controlled trial. Sustained remission is now achievable for RA patients receiving csDMARDs, but how to best manage patients in clinical remiss...

COVID Shot in the Arm Not Enough to Keep Pharmacies in Business
https://www.medscape.com/viewarticle/950584

May 4th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Joe Moose, co-owner of Moose Pharmacies in the Charlotte, North Carolina, area, is trying to adapt to the changes dealt by COVID. The chain expanded curbside services, hired additional drivers and tripled home deliveries Most pharmacies, he said, saw a decline in prescriptions last year as custo...

Tofacitinib: Small Study Shows Big Cutaneous Sarcoidosis Response
https://www.medscape.com/viewarticle/950598

May 4th, 2021 - Researchers are reporting impressive results in a small, open-label trial of the JAK inhibitor tofacitinib in cutaneous sarcoidosis: 6 of 10 patients improved so much that they reached a disease activity level of zero, and all patients improved by an average of 83% via a scoring system. "Not only did patients get better, but they were in many cases able to come off their baseline immunosuppress...

EU Regulator Begins Real-time Review of First Chinese COVID-19 Vaccine
https://www.medscape.com/viewarticle/950441

May 4th, 2021 - (Reuters) - Europe's medicines regulator said on Tuesday it has started a real-time review of Sinovac's COVID-19 vaccine, based on preliminary results from animal and human trials that suggested the vaccine produces an immune response against the coronavirus. Data on the vaccine, COVID-19 Vaccine (Vero Cell) Inactivated, will be assessed as they are made available to help speed up potential app...

When to Refer Patients With New Memory Loss
https://www.medscape.com/viewarticle/950534

May 4th, 2021 - Asking a patient who has concerns about memory loss particular questions can guide referral decisions, according to new research. Initial questions should zero in on what the patient is forgetting, said Megan Richie, MD, a neurohospitalist at the University of California, San Francisco, who spoke to a virtual audience at the American College of Physicians (ACP) Internal Medicine Meeting. Is the...

Checkpoint Inhibitor Skin Side Effects More Common in Women
https://www.medscape.com/viewarticle/950535

May 4th, 2021 - Women had about a twofold higher risk than men of developing dermatologic adverse events while taking immune checkpoint inhibitors for metastatic melanoma in a review of 235 patients at Dana Farber Cancer Center, Boston, Massachusetts. Overall, 62. 4% of the 93 women in the review and 48 "This suggests that factors beyond sex hormones are likely contributory" to the difference in risk between m...

Metformin Use During Pregnancy and Maternal Outcomes
https://www.medscape.com/viewarticle/950077

May 4th, 2021 - Takeaway Use of metformin for any indication during pregnancy was associated with a reduction in gestational weight gain (GWG) and a modest reduction in the risk of pre-eclampsia, but an increased risk of gastrointestinal (GI) side effects compared with other treatments. No significant effects were observed on other maternal outcomes. Why this matters Despite the widespread use of metformin dur...

Fast Five Quiz: Squamous Cell Non-Small Cell Lung Cancer
https://reference.medscape.com/viewarticle/928233

May 4th, 2021 - Lung cancer continues to be the leading cause of cancer-related deaths worldwide. Non–small cell lung cancer (NSCLC), which accounts for 85% of all lung cancers, is divided histologically into adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. In the United States, Canada, and many European countries, squamous cell carcinoma is the second most common histologic subtype of lung c...

RUC Alternative Might Address Lagging Primary-Care Pay: Report
https://www.medscape.com/viewarticle/950532

May 4th, 2021 - Tucked within a new National Academies report on the future of primary care is a challenge to an influential panel whose approach to valuing US physician pay has been criticized for being skewed toward specialists. The Centers for Medicare & Medicaid Services (CMS) should independently value physicians' services, given the limits of the existing Relative Value Scale Update Committee (RUC) of th...

Who Can Call Themselves 'Doctor'? The Debate Heats Up
https://www.medscape.com/viewarticle/950556

May 4th, 2021 - Physicians and non-physicians clearly differ in whether or not a PhD or EdD should be able to call themselves 'doctor,' a new Medscape poll Who Should Get to Be Called 'Doctor'? shows. The topic has clearly struck a nerve, since a record number of respondents — over 12,000 — voted in the poll. Most physicians think it's appropriate for people with other doctorate degrees such as a PhD or EdD to...

For Diagnosing Skin Lesions, AI Risks Failing in Skin of Color
https://www.medscape.com/viewarticle/950572

May 4th, 2021 - In the analysis of images for detecting potential pathology, artificial intelligence (AI) is showing enormous promise across multiple fields of medicine. But the technology in dermatology is bound to fail in skin of color if training does not specifically address these skin types, according to Adewole S. Adamson, MD, who outlined this issue at the American Academy of Dermatology Virtual Meeting...

Neonatal Nurses, Doctor Help Woman Who Delivered Baby on Plane
https://www.medscape.com/viewarticle/950575

May 4th, 2021 - Three neonatal intensive care nurses and a family physician were in the right place ― on an airliner traveling to Hawaii ― at the right time ― when a woman unexpectedly delivered a baby prematurely on the flight. The medical professionals sprang into action to keep baby Raymond, who came into the world at 29 weeks, healthy until the flight got to Honolulu, according to a news release from Hawai...

UK COVID-19 Update: 'Significant' Pandemic Burden on Female Staff, Porton Down Investment
https://www.medscape.com/viewarticle/950537

May 4th, 2021 - These are the UK coronavirus stories you need to know about today. Vaccines minister Nadhim Zahawi again confirmed today that plans are being formed for autumn booster jabs for some people, possibly over-50s. "We want them [CMOs] to be able, if they need to, from September onwards to boost those that are most vulnerable," he told Sky News. Deaths The number of deaths registered in England and W...

Delays a Major Cause of Transfusion-related Deaths
https://www.medscape.com/viewarticle/950553

May 4th, 2021 - Transfusion-related circulatory overload (TACO) remains the most common cause of transfusion-related death, although deaths due to delays are increasing year-on-year, shows an analysis of reports to the UK’s transfusion safety body. "Communication is a major, major issue" when it comes to delays, which account for over one in four deaths, explained lead author Simon Carter-Graham, clinical inci...

'Malicious Peer Review' Destroyed Doc's Career, He Says
https://www.medscape.com/viewarticle/950564

May 4th, 2021 - Cardiothoracic surgeon J. Marvin Smith III, MD, had always thrived on a busy practice schedule, often performing 20 to 30 surgeries a week. A practicing surgeon for more than 40 years, Smith says he had no plans to slow down anytime soon. But Smith says his career was derailed when leaders at Methodist Healthcare System of San Antonio initiated a sudden peer review proceeding against him. The h...

Nutritional Support May Be Lifesaving in Heart Failure
https://www.medscape.com/viewarticle/950599

May 4th, 2021 - Personalized nutritional support for adults hospitalized with chronic heart failure and deemed to be at high nutritional risk reduced the risk of dying or suffering adverse cardiovascular events compared with standard hospital food, new research indicates. The Swiss EFFORT trial focused on patients with chronic heart failure and high risk of malnutrition defined by low body mass index (BMI), we...

Therapeutic Drug Monitoring Has Little Value During Infliximab Induction
https://www.medscape.com/viewarticle/950456

May 4th, 2021 - NEW YORK (Reuters Health) - Results of a randomized controlled trial do not support routine use of proactive therapeutic drug monitoring (TDM) during infliximab induction for improving disease remission rates in patients with rheumatoid arthritis (RA) and other chronic immune-mediated inflammatory diseases. Proactive TDM tailors biologic therapy to individual patients by measuring serum drug le...

India Virus Variant Identified in Two Southeast Iowa People
https://www.medscape.com/viewarticle/950600

May 4th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. DES MOINES, Iowa (AP) — A third coronavirus variant that was first identified in hard-hit India has been uncovered in Iowa, state public health officials said Tuesday.

N Carolina GOP Advances Bill to Ban Down Syndrome Abortions
https://www.medscape.com/viewarticle/950573

May 4th, 2021 - RALEIGH, NC (AP) — North Carolina lawmakers on Tuesday advanced a bill to make it illegal for physicians to perform abortions because of the fetus' race or a prenatal diagnosis of Down syndrome. A physician would be subject to monetary damages if he or she performed an abortion despite being aware that the pregnant woman's decision to get the procedure was influenced by either of those two conc...

Pharma Company to Pay $12.6M to Settle Kickback Allegations
https://www.medscape.com/viewarticle/950585

May 4th, 2021 - DOVER, Del. (AP) — A Delaware pharmaceutical company has agreed to pay $12.6 million to resolve allegations that it violated the federal False Claims Act by paying kickbacks. Department of Justice officials said in a news release Tuesday that the settlement resolves allegations that Incyte Corp. improperly used an independent foundation to cover the copays of certain people taking the company's...

Biden Wants 70% of the US Vaccinated by July 4
https://www.medscape.com/viewarticle/950597

May 4th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. President Joe Biden has announced new strategies for the national COVID-19 vaccination program as demand for vaccinations drops. He also set a new goal for getting shots into people's arms Pfizer and Moderna are developing adolescent vaccines. Health experts say vaccinating children is crucial t...

'Last Resort': Desperate for Oxygen, Indian Hospitals Go to Court
https://www.medscape.com/viewarticle/950439

May 4th, 2021 - NEW DELHI (Reuters) - A court in India's capital New Delhi has become the last hope for many hospitals struggling to get oxygen for COVID-19 patients as supplies run dangerously short while government officials bicker over who is responsible. A two-judge bench of the Delhi High Court has been holding almost daily video conferences to hear petitions from hospitals invoking India's constitutional...

Montana Tribe Gifts Vaccines to Neighbors Across the Border
https://www.medscape.com/viewarticle/950591

May 4th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. BABB, Montana (AP) — On a cloudy spring day, hundreds lined up in their cars on the Canadian side of the border crossing that separates Alberta and Montana. They had driven for hours and camped out in their vehicles in hopes of receiving the season's hottest commodity — a COVID-19 vaccine — from...

Pfizer Bets on COVID-19 Vaccine Demand for Years, Sees Sales of $26 Bln in 2021
https://www.medscape.com/viewarticle/950462

May 4th, 2021 - (Reuters) - Pfizer Inc on Tuesday raised its forecast for 2021 COVID-19 vaccine sales by more than 70% to $26 billion and said demand from governments around the world trying to halt the pandemic could contribute to its growth for years to come. The company said it expects by the end of this month to file for full approval of the vaccine for people over the age of 16 in the United States, where...

Marijuana Vaping More Common Among Hispanic Teens
https://www.medscape.com/viewarticle/950571

May 4th, 2021 - Hispanic adolescents were more likely to use e-cigarettes to vape marijuana than were their Black and White counterparts in 2020, according to a recent study conducted by the Centers for Disease Control and Prevention and published in JAMA Pediatrics. Researchers found that 25.6% of Hispanic students reported vaping marijuana, compared to 19.4% of Black students and 18.2% of White students. The...

Corticosteroid Bursts May Increase GI Bleeding, Sepsis Risk in Children
https://www.medscape.com/viewarticle/950567

May 4th, 2021 - Oral corticosteroid bursts are associated with an increased risk of gastrointestinal bleeding, sepsis, and pneumonia during the month after treatment initiation, according to a nationwide cohort study of children in Taiwan. The adverse events are rare, and the risk attenuates in subsequent months, the analysis shows. Still, the study "provides evidence that corticosteroid bursts are not innocuo...

Peloton, Feds Agree to Treadmill Recall
https://www.medscape.com/viewarticle/950587

May 4th, 2021 - Exercise giant Peloton has agreed to recall its popular and pricey treadmill after at least one child was killed after becoming caught underneath the machine's belt. Peloton has also agreed to recall its limited-edition Tread, after 18 reports of the touchscreen loosening and six reports of the screen detaching and falling off. No injuries have been reported for the Tread Among the 72 reports o...

Hit by Higher Prices for Gear, Doctors and Dentists Want Insurers to Pay
https://www.medscape.com/viewarticle/950579

May 4th, 2021 - SACRAMENTO — Treating patients has become more expensive during the pandemic, and doctors and dentists don't want to be on the hook for all the new costs. For instance, the box of 100 gloves that cost $2. 39 in February 2020 costs $30 now, said Dr Reimbursing the cost of nonmedical supplies isn't typically the responsibility of insurers, said Mary Ellen Grant, spokesperson for the California As...