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About 1,343,933 results

Elevated PCSK9 levels associated with psoriasis suggest new treatment target
https://www.mdedge.com/dermatology/article/260931/psoriasis/elevated-pcsk9-levels-associated-psoriasis-suggest-new
Ted Bosworth

Jan 30th, 2023 - A Mendelian randomization study employing data from nearly 300,000 individuals has linked elevated levels of the PCSK9 enzyme with an increased risk of psoriasis, suggesting it might be targetable as an intervention. Independent of low-density lipoprotein cholesterol (LDL-C), which is reduced when PCSK9 is inhibited, a reduction in PCSK9 levels appears to have a direct impact on lowering psoria.

The ongoing search for answers
https://www.mdedge.com/neurology/article/260930/business-medicine/ongoing-search-answers
Allan M. Block, MD

Jan 30th, 2023 - Hidden in the Dec. 1, 2022, issue of the New England Journal of Medicine was a small article on using deferiprone for Parkinson’s disease.

Novel nomogram distinguishes pneumonias
https://www.mdedge.com/chestphysician/article/260924/infectious-diseases/novel-nomogram-distinguishes-pneumonias
Heidi Splete, MDedge News

Jan 30th, 2023 - A model incorporating factors such as lymphocytes and lung lesions differentiated adenovirus pneumonias from Chlamydia psittaci (CPP) in a multicenter study of nearly 200 individuals. Symptoms of pneumonia caused by CPP are often confused with other respiratory infections, particularly adenovirus pneumonia (AVP), which can delay correct diagnosis and impact treatment, Yi Li, MD, of Xiangya Hosp.

Dermatologists address cultural competence and unconscious biases in the specialty
https://www.mdedge.com/dermatology/article/260923/diversity-medicine/dermatologists-address-cultural-competence-and
Thomas R. Collins

Jan 30th, 2023 - ORLANDO – When he was applying for residency, Omar N. Qutub, MD, eagerly arrived at his first interview of the day.

Two AI optical diagnosis systems appear clinically comparable for small colorectal polyps
https://www.mdedge.com/internalmedicine/article/260922/gastroenterology/two-ai-optical-diagnosis-systems-appear-clinically
Carolyn Crist

Jan 30th, 2023 - In a head-to-head comparison, two commercially available computer-aided diagnosis systems appeared clinically equivalent for the optical diagnosis of small colorectal polyps, according to a research letter published in Gastroenterology. For the optical diagnosis of diminutive colorectal polyps, the comparable performances of both CAD-EYE (Fujifilm Co.

Rural Residence Tied to Higher Risk for Heart Failure for Women, Black Men
https://www.clinicaladvisor.com/home/topics/cardiovascular-disease-information-center/rural-residence-tied-higher-risk-heart-failure-women-black-men/
Clinical Advisor

Jan 30th, 2023 - HealthDay News — Rural residence is associated with an increased risk for heart failure among women and Black men, according to a study published online in JAMA Cardiology. Sarah E. Turecamo, from the US National Institutes of Health in Bethesda, Maryland, and colleagues assessed whether rurality is associated with an increased risk for heart failure. The analysis included data from 27,115 part...

Noninvasive liver test may help select asymptomatic candidates for heart failure tests
https://www.mdedge.com/internalmedicine/article/260919/cardiology/noninvasive-liver-test-may-help-select-asymptomatic
Carolyn Crist

Jan 30th, 2023 - A noninvasive test for liver disease may be a useful, low-cost screening tool to select asymptomatic candidates for a detailed examination of heart failure with preserved ejection fraction (HFpEF), say authors of a report published in Gastro Hep Advances. The fibrosis-4 (FIB-4) index was a significant predictor of high HFpEF risk, wrote Chisato Okamoto, MD, of the department of medical biochemi.

Polypill Tested for Cognitive, Functional Benefits
https://www.medpagetoday.com/neurology/dementia/102884

Jan 30th, 2023 - Reducing blood pressure and cholesterol in the TIPS-3 trial with a polypill, with or without aspirin, showed no protective effect on cognition in older adults with cardiovascular disease risk factors, a secondary analysis showed. During a 5-year follow-up, about the same number of trial participants in TIPS-3 experienced substantive cognitive decline in both the treatment and placebo groups, ac...

JAK Inhibitor Improves Symptoms, Anemia in Myelofibrosis
https://www.medpagetoday.com/hematologyoncology/othercancers/102883

Jan 30th, 2023 - Myelofibrosis treatment with the Janus kinase (JAK) inhibitor momelotinib resulted in clinically significant improvements in symptoms and spleen response compared with danazol for symptomatic, JAK inhibitor-exposed patients with anemia and intermediate- or high-risk disease, the phase III MOMENTUM trial showed. A significantly greater proportion of patients in the momelotinib group reported a ≥...

Commentary: Early Diagnosis of PsA, February 2023
https://www.mdedge.com/rheumatology/article/260916/psoriatic-arthritis/commentary-early-diagnosis-psa-february-2023
Vinod Chandran, MBBS, MD, DM, PhD

Jan 30th, 2023 - Vinod Chandran, MBBS, MD, DM, PhD Most patients develop psoriatic arthritis (PsA) after the onset of cutaneous psoriasis. The path toward long-term remission of PsA may be by early diagnosis and effective treatment prior to the onset of joint damage.

Dermatopathologist reflects on the early history of melanoma
https://www.mdedge.com/dermatology/article/260915/melanoma/dermatopathologist-reflects-early-history-melanoma
Doug Brunk

Jan 30th, 2023 - SAN DIEGO – Evidence of melanoma in the ancient past is rare, but according to James W. Patterson, MD, signs of melanoma with cutaneous lesions and diffuse bony metastases have been discovered in Peruvian Inca mummies.

Cardiometabolic Risk With Autism: Vigilance Urged
https://www.medpagetoday.com/neurology/autism/102882

Jan 30th, 2023 - People with autism had an elevated risk of cardiometabolic conditions across several dozen studies, researchers confirmed in a meta-analysis. Among children and adults in the analyzed studies, autism was associated with greater likelihood of concomitant: Yet, there was no significantly associated increased risk of hypertension and stroke with autism across all age groups, according to investiga...

High School Alcohol Use Can Quickly Escalate
https://www.medpagetoday.com/pediatrics/generalpediatrics/102881

Jan 30th, 2023 - Heavy binge drinking isn't just a college problem, researchers affirmed, finding that most teen alcohol use that escalated to having 10 or more drinks in a row reached that level rapidly during the high school years. Among a sample of youth who reported drinking in the prior 30 days when surveyed in the 12th grade and who said they engaged in high-intensity drinking (HID, 10 or more in a row) w...

14-year-old boy • aching midsternal pain following a basketball injury • worsening pain with direct pressure and when the patient sneezed • Dx?
https://www.mdedge.com/familymedicine/article/260914/pediatrics
MDedge Family Medicine; Catherine Romaine, BS, Alyssa Heinrich, MD et. al.

Jan 30th, 2023 - THE CASE A 14-year-old boy sought care at our clinic for persistent chest pain after being hit in the chest with a teammate’s shoulder during a basketball game 3 weeks earlier. He had aching midsternal chest pain that worsened with direct pressure and when he sneezed, twisted, or bent forward.

Consider this tool to reduce antibiotic-associated adverse events in patients with sepsis
https://www.mdedge.com/familymedicine/article/260913/infectious-diseases/consider-tool-reduce-antibiotic-associated-adverse
MDedge Family Medicine; Timothy Mott, MD, FAAFP, Zachary Orme, DO

Jan 30th, 2023 - ILLUSTRATIVE CASE A 52-year-old woman presents to the emergency department complaining of dysuria and a fever. Her work-up yields a diagnosis of sepsis secondary to pyelonephritis and bacteremia.

Does regular walking improve lipid levels in adults?
https://www.mdedge.com/familymedicine/article/260912/cardiology/does-regular-walking-improve-lipid-levels-adults
MDedge Family Medicine; Kayla Hatchell, MD, Emily Chin, DO et. al.

Jan 30th, 2023 - Evidence summary Walking’s impact on cholesterol levels is modest, inconsistent A 2022 systematic review and meta-analysis of 21 studies (n = 1129) evaluated the effects of walking on lipids and lipoproteins in women older than 18 years who were overweight or obese and were not taking any lipid-lowering medications. Median TC was 206 mg/dL and median LDL was 126 mg/dL.

Acute hepatic porphyrias no longer as rare as previously thought
https://www.mdedge.com/internalmedicine/article/260911/gastroenterology/acute-hepatic-porphyrias-no-longer-rare-previously
Carolyn Crist

Jan 30th, 2023 - Although rare, acute hepatic porphyrias (AHPs) may be more common than previously thought, particularly among women between ages 15 and 50, according to a new clinical practice update from the American Gastroenterological Association. For acute attacks, treatment should include intravenous hemin, and for patients with recurrent attacks, a newly-approved therapy called givosiran should be consid.

FDA Greenlights First Drug for ESR1-Mutated Breast Cancer
https://www.medpagetoday.com/hematologyoncology/breastcancer/102880

Jan 30th, 2023 - The FDA approved the selective estrogen receptor (ER) degrader elacestrant (Orserdu) for the treatment of postmenopausal women or adult men with ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer with disease progression following at least one line of endocrine therapy. The FDA also approved the Guardant360 CDx assay as a companion diagnostic test to identify patients...

Early Return to School After Concussion Linked to Lower Symptom Burden
https://www.clinicaladvisor.com/home/topics/neurology-information-center/early-return-school-after-concussion-linked-lower-symptom-burden/
Clinical Advisor

Jan 30th, 2023 - Children with a concussion may no longer have to sit quietly in a dark room for days. New research suggests that prolonged absence from school and other activities may hinder recovery from a concussion. Returning to school earlier than previously recommended may be associated with lower symptom burden, leading to a faster recovery, according to an published online in JAMA Network Open. The anal...

Physician group issues 31 treatment recommendations for early-onset colorectal cancer
https://www.mdedge.com/internalmedicine/article/260906/oncology/physician-group-issues-31-treatment-recommendations-early
Jim Kling

Jan 30th, 2023 - An international group of physicians has issued consensus recommendations for the diagnosis and management of patients with early-onset colorectal cancer (eoCRC). Led by Giulia Martina Cavestro, MD, PhD, a gastroenterologist with the University Vita Salute San Raffaele Hospital, Milan, the Delphi Initiative for Early-Onset Colorectal Cancer group penned 31 recommendations for treating patients.