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Clinical Edge Journal Scan Commentary: Multiple Sclerosis June 2022
Mark Gudesblatt, MD

May 27th, 2022 - Mark Gudesblatt, MD Multiple sclerosis (MS) remains a complex disease with varied effects, some visible and clinically symptomatic and others invisible (eg, effects on cognition). However much we focus on the visible and uncovering the currently invisible effects, we must be aware of the effects of prior infection with SARS-CoV-2 (ie, post-acute COVID-19 syndrome, aka long COVID) in people with.

Psychological intervention looks promising in Crohn’s disease
Laird Harrison

May 27th, 2022 - SAN DIEGO – A combination of cognitive-behavioral therapy and mindfulness meditation could reduce pain and fatigue from Crohn’s disease, researchers say. Patients who followed the program not only felt better but were also more often able to show up for work and leisure activities, compared with a control group assigned to a wait list, said Shmuel Odes, MD, a professor of internal medicine at B.

Medical trauma an under-recognized trigger for PTSD
Randy Dotinga

May 27th, 2022 - NEW ORLEANS – Recent studies have confirmed that posttraumatic stress disorder can be triggered by health-related stress such as stints in the ICU and life-threatening medical emergencies, but most psychiatrists may not be aware of the latest research, according to an expert in mental trauma. “This is true among children as well as adults, but it is not generally appreciated by psychiatrists an.

Race-, ethnicity-based clinical guidelines miss the mark: Study
Jim Kling

May 27th, 2022 - SAN DIEGO – Race-based recommendations and clinical algorithms may be doing more harm than good, according to a systematic review of databases and guidelines. The study found examples of screening recommendations based on race or ethnicity that were likely misleading since these are social constructs that don’t reflect a patient’s individual risk, said Shazia Siddique, MD, who presented the stu.

Does taking isotretinoin worsen a patient’s baseline IBD symptoms?
Doug Brunk

May 27th, 2022 - A limited association exists between the use of isotretinoin for severe acne and worsening of a patient’s baseline inflammatory bowel disease, results from a small retrospective study suggests. “Early studies of isotretinoin for use in severe acne suggested the drug may serve as a trigger for new-onset inflammatory bowel disease (IBD),” researchers led by Christina G.

Urinating multiple times per night

May 27th, 2022 - On the basis of the patient's history and presentation, this is likely a case of adenocarcinoma of the prostate. Although most patients with prostate cancer are diagnosed on screening, when localized symptoms do occur, they may include urinary frequency, decreased urine stream, urinary urgency, and hematuria.

Sugar-sweetened beverage and sugar consumption tied with incidence of and mortality from proximal colon cancer

May 27th, 2022 - Key clinical point: High sugar-sweetened beverage (SSB) and total fructose intake was associated with increased incidence of and mortality from proximal colon cancer, especially during the later stages of colorectal tumorigenesis. Major finding: SSB and total fructose consumption was associated with a significant increase in the incidence of (hazard ratio [HR] per 1-serving/d increment 1.

ctDNA: Strong prognostic biomarker but lacks true clinical utility in mCRC

May 27th, 2022 - Key clinical point: Circulating tumor DNA (ctDNA) has substantiated its role as a strong prognostic biomarker in patients with metastatic colorectal cancer (mCRC). However, uncovering its true clinical value for these patients calls for prospective clinical trials with standardized methodologies.

KRAS p.G12C mutations may have prognostic implications in mCRC

May 27th, 2022 - Key clinical point: Patients with KRAS p. G12C-mutant metastatic colorectal cancer (mCRC) show poor treatment outcomes, which are numerically worse than those in patients without this mutation or with KRAS non-p.

Senegal Health Minister Sacked After Babies Die in Hospital Fire

May 27th, 2022 - DAKAR (Reuters) - Senegal President Macky Sall on Thursday sacked his health minister, Abdoulaye Diouf Sarr, a government decree showed, after 11 babies were killed by a fire in a hospital neonatal ward. Sarr will be replaced by Marie Khemesse Ngom Ndiaye, the ministry's director general, according to the decree.

Breakthrough Infections May Be Less Contagious

May 27th, 2022 - (Reuters) - Fully vaccinated individuals who get infected with the coronavirus spread the infection to fewer people and are contagious for less time compared to people who are partially vaccinated or unvaccinated, a small study from South Korea suggests. In 173 hospital workers with COVID-19, including 50 who had breakthrough infections, researchers found that the virus had been transmitted to ...

MRI Technique May Yield Clues to Long COVID Breathlessness

May 27th, 2022 - (Reuters) - In people with lasting breathlessness after COVID-19, a special type of magnetic resonance imaging (MRI) reveals lung abnormalities that traditional imaging techniques do not detect, a small study shows. In 23 patients with shortness of breath lasting for months after COVID-19, including 11 who had not required hospitalization, the researchers performed hyperpolarized xenon 129MRI, ...

Elderly Still Make Up Most of the COVID-19 Deaths

May 27th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. The number of daily COVID-19 deaths is dropping in the United States, but one fact has not changed in two-plus years of the pandemic: The elderly are still most at risk of dying from the virus. The seven-day moving average of COVID-related deaths is now 288, a number far lower than the peaks of ...

Telemedicine in Cancer Care: Not All Patients Can Access

May 27th, 2022 - The COVID pandemic pushed telemedicine forward as a safe, accessible, and more widely reimbursed approach to care delivery for patients with cancer, but uptake of telemedicine was plagued by inequities, a retrospective study suggests. Before March 2020, only a very small percentage of patients with cancer used telemedicine services. By November 2021, nearly 16% of patients initiating cancer tre...

Don't Equate Mass Shootings With Mental Illness

May 27th, 2022 - Here we go, again, and again, and again. There just aren't enough tears, and before the bodies of 19 small children are identified, the political noise starts up. Mass shootings are a part of the American landscape, but when they happen at schools, we all feel a distinct sense of violation and gaping grief. Those children are so innocent, so deserving of a right to live their lives, hold their ...

UCLA Reinstates Mask Mandate as California COVID Cases Surge

May 27th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. LOS ANGELES (AP) — The University of California, Los Angeles said Thursday it will reinstate an indoor mask policy as coronavirus cases surge in the nation's most populous state, which now forecasts hospitalizations will nearly triple in the next month. UCLA's 45,000 students and all faculty, st...

Is Subfertility Linked With Postpartum Mental Illness?

May 27th, 2022 - Mothers with previous subfertility have increased risk for postpartum mental illness, compared with mothers who conceived spontaneously, according to a new study. In a population-based cohort study that examined almost 800,000 births, the adjusted relative risk (RR) for postpartum mental illness was 1.14 in women with subfertility, compared with women without reproductive assistance. The magnit...

FDA Okays IN.PACT 018 Drug-Coated Balloon for PAD

May 27th, 2022 - The US Food and Drug Administration has approved the IN.PACT 018 drug-coated balloon (DCB) for the treatment of peripheral arterial disease, Medtronic announced today. The paclitaxel-coated balloon is indicated for percutaneous transluminal angioplasty of de novo, restenotic, or in-stent restenotic lesions up to 360 mm in length with vessel diameters of 4 to 7 mm, located in the superficial fem...

'It's an Amazing Time to Be a Hemophilia Provider'

May 27th, 2022 - New medications such as emicizumab (Hemlibra) are transforming the lives of patients with hemophilia A, and more treatments are in the pipeline. "It's an amazing time to be a hemophilia provider," Alice D. Ma, MD, University of North Carolina at Chapel Hill hematologist and bleeding disorder specialist, said in an interview. "There are real options, and it's very exciting." But the drugs come w...

After Texas School Shooting, Parents Search for New Answers

May 27th, 2022 - Amy Chambers is planning a visit soon with the principal of her son's elementary school in Joplin, MO. The grade level of the 19 children killed in the Tuesday school shooting in Uvalde, TX, was not unnoticed by her. Her son, the youngest of her three, is also a fourth grader. Chambers, a church secretary in Joplin, thinks the security to get into her son's school is good, but she has questions...