About 1,306,158 results

Antifibrotic shows mixed results in RA-ILD
Pam Harrison, MDedge News

Oct 3rd, 2022 - The antifibrotic pirfenidone (Esbriet) did not change the decline in forced vital capacity percentage (FVC%) from baseline of 10% or more or the risk of death compared with placebo in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). However, the drug appeared to slow the rate of decline in lung function, a phase 2 study indicated.

Instagram: Cosmetic procedures discussed without cosmetic experts
Richard Franki

Oct 3rd, 2022 - Instagram’s lack of high-quality educational content on nonsurgical cosmetic procedures puts the onus on dermatologists and plastic surgeons to increase their social media presence, according to analysis of related posts on the photo-sharing service. “Given that there is little to no oversight on social networking sites, unqualified sources can widely disseminate misinformation resulting in mis.

What’s the true role of Demodex mites in the development of papulopustular rosacea?
Doug Brunk

Oct 3rd, 2022 - Mounting evidence suggests that a higher density of Demodex mites on the skin may play a role in the development of papules and pustules associated with rosacea, a narrative review proposes. According to the author, Fabienne Forton, MD, PhD, a dermatologist based in Brussels, recent studies suggest that Demodex induces two opposite actions on host immunity: A defensive immune response aimed at.

High Risk of Long COVID Neurologic Sequelae in Veterans
Jan Dyer

Oct 3rd, 2022 - We now know that the effects of COVID-19 don’t always end when the infection seems over. Long COVID—the postacute sequelae—can encompass a wide range of extrapulmonary organ dysfunctions.

Sotatercept May Have Long Term Benefit in Pulmonary Arterial Hypertension
Pulmonology Advisor

Oct 3rd, 2022 - Long-term use of sotatercept may allow patients with pulmonary arterial hypertension (PAH) to maintain significantly reduced pulmonary vascular resistance, according to results of an 18- to 24- month open-label extension trial published in The European Respiratory Journal. The previously conducted 24-week, placebo-controlled, phase 2 PULSAR clinical trial (ClinicalTrials.gov Identifier: NCT0349...

Asthma Outcomes Improved With Use of Mindfulness-Based Stress Reduction
Pulmonology Advisor

Oct 3rd, 2022 - Training patients with asthma in mindfulness-based stress reduction (MBSR) improves clinically relevant outcomes and may therefore enhance asthma management, especially among those with comorbid psychopathology, according to study findings published in Brain, Behavior, and Immunity – Health. Asthma exacerbation risk is elevated in individuals with psychological distress and comorbid psychopatho...

Vaccine-Associated Aluminum Linked to Persistent Asthma in Young Children
Clinical Advisor

Oct 3rd, 2022 - HealthDay News — There is an association between vaccine-associated aluminum and persistent asthma among children with and without eczema, according to a study published online in Academic Pediatrics. Matthew F. Daley, MD, from Kaiser Permanente Colorado in Aurora, and colleagues conducted a retrospective cohort study in the Vaccine Safety Datalink to examine the association between cumulative ...

Self-Reported Lung-Related Comorbidities Have No Impact on LCS Outcomes
Pulmonology Advisor

Oct 3rd, 2022 - Patients undergoing lung cancer screening (LCS) who self-reported lung-related comorbidities did not have differing outcomes compared with those not reporting conditions. These findings were published in JAMA Network Open. Current guideline recommendations indicate people aged 50 to 80 years who had a 20 pack-year smoking history should undergo annual LCS. These recommendations do not specify w...

The dubious value of online reviews
Allan M. Block, MD

Oct 3rd, 2022 - I hear other doctors talk about online reviews, both good and bad. I recently read a piece where a practice gave doctors a bonus for getting 5-star reviews, though it doesn’t say if they were penalized for getting bad reviews.

Psychiatric Risks Subside Before Neurologic Risks After COVID-19
Pulmonology Advisor

Oct 3rd, 2022 - Following COVID-19 infection, the risk for developing neurological disorders remains high after 2 years, while the risk for psychiatric disorders subsides earlier. These are the findings of a study published in Lancet Psychiatry. Researchers analyzed outcome data in a multinational, retrospective cohort study. They obtained data from the TriNetX electronic health records network between January...

Risk-adapted screening strategy could reduce colonoscopy use
Carolyn Crist

Oct 3rd, 2022 - The Asia-Pacific Colorectal Screening (APCS) scoring system, combined with a stool DNA test, could improve the detection of advanced colorectal neoplasms and limit colonoscopy use, according to a new study published in Clinical Gastroenterology and Hepatology. Although a colonoscopy can detect both colorectal cancer and precancerous lesions, using it as the primary screening tool can cause barr.

Holding Methotrexate in RA/PsA After Second Dose of COVID-19 Vaccine Improves Antibody Response
Rheumatology Advisor

Oct 3rd, 2022 - In patients with rheumatoid arthritis (RA)/psoriatic arthritis (PsA), holding vs continuing methotrexate (MTX) after the second dose of the ChAdOx1 nCov-19 (Oxford-AstraZeneca) vaccine results in a higher antibody response, according to the results of a study published in The Lancet Rheumatology. The researchers sought to evaluate the impact of holding MTX for 2 weeks after each dose of the COV...

Cancer as a full contact sport
Sarah F. D’Ambruoso, NP

Oct 3rd, 2022 - John worked as a handyman and lived on a small sailboat in a marina. When he was diagnosed with metastatic kidney cancer at age 48, he quickly fell through the cracks.

APP Leaders Discuss What Keeps Them Up at Night
Clinical Advisor

Oct 3rd, 2022 - Presidents from 5 advanced practice provider (APP) associations shined a light on strategies to increase the health care workforce, key bills that may change the practice landscape, how to create greater diversity among practitioners, and what keeps them up at night at an online panel discussion held in honor of the second annual National APP Week. The presidents all noted access to care issues...

Tocilizumab Normalizes Serum Amyloid Levels in Familial Mediterranean Fever
Rheumatology Advisor

Oct 3rd, 2022 - Tocilizumab vs placebo was found to normalize serum amyloid A (SAA) levels and decrease disease activity in patients with Familial Mediterranean Fever (FMF), according to findings published in the Journal of Clinical Medicine. FMF is an autoinflammatory disease that causes chronic inflammation without the presence of autoantibodies or antigen-specific T-lymphocytes. Symptoms include recurrent f...

Bupivacaine Now Available for Analgesia After Shoulder Surgery
Rheumatology Advisor

Oct 3rd, 2022 - Posimir® (bupivacaine solution) is now available for postsurgical analgesia for up to 72 hours following arthroscopic subacromial decompression. Posimir is a novel formulation of bupivacaine, an amide local anesthetic, designed to be administered into the subacromial space under direct arthroscopic visualization. The depot product uses a sucrose-based biodegradable matrix (sucrose acetate isobu...

Monkeypox Outbreak Can Still Be Contained, Says Columbia Epidemiologist
Rheumatology Advisor

Oct 3rd, 2022 - Health officials worldwide can still take steps to contain the monkeypox outbreak, says Dr Alissa Davis, Associate Professor at the Columbia School of Social Work, but it will require addressing the challenges of stigma, misinformation, and health inequity. “Overall case numbers of monkeypox are growing, although the number of new infections has recently been trending downward,” says Davis, an ...

Monkeypox features include mucocutaneous involvement in almost all cases
Ted Bosworth

Oct 3rd, 2022 - MILAN – In the current spread of monkeypox among countries outside of Africa, this zoonotic orthopox DNA virus is sexually transmitted in more than 90% of cases, mostly among men having sex with men (MSM), and can produce severe skin and systemic symptoms but is rarely fatal, according to a breaking news presentation at the annual congress of the European Academy of Dermatology and Venereology.

ACR Updates Guidelines for Glucocorticoid-Induced Osteoporosis
Clinical Advisor

Oct 3rd, 2022 - The American College of Rheumatology (ACR) updated their 2017 ACR guidelines for preventing and treating glucocorticoid-induced osteoporosis (GIOP). The full manuscript will be published in Arthritis & Rheumatology and Arthritis Care and Research in early 2023. Since the publication of the 2017 ACR guidelines for GIOP, treatments, including abaloparatide (PTHrP) and romosozumab, have been avail...

High Procedural Success With Novel LAA Occluder for Preventing Stroke in AF
Cardiology Advisor

Oct 3rd, 2022 - Left atrial appendage (LAA) closure with use of a novel, disc-like occluder (the Leftear device [Pulse Scientific]) has demonstrated a high rate of procedural success, and satisfactory safety and efficacy for stroke prevention among patients with nonvalvular atrial fibrillation (NVAF). These findings were published in the journal JACC: Asia. Researchers sought to explore the effectiveness and s...

Study Confirms Benefits of Lecanemab in Early Alzheimer Disease
Clinical Advisor

Oct 3rd, 2022 - Topline results were announced from a large global phase 3 confirmatory study of lecanemab for the treatment of early Alzheimer disease. Lecanemab is a humanized monoclonal antibody that works by selectively binding to, neutralizing, and eliminating soluble toxic amyloid beta aggregates. The investigational agent was by the Food and Drug Administration (FDA) in July 2022 for the treatment of mi...

Six-Lead ECG Device Highly Accurate for Atrial Fibrillation Detection
Cardiology Advisor

Oct 3rd, 2022 - The Kardia Mobile 6-lead electrocardiogram (ECG) device is superior for detecting atrial fibrillation (AF) when compared with a pair of single-lead smartwatches according to cardiologists’ interpretation. These findings were published in the American Heart Journal. A prospective, nonrandomized study compared ECG-based devices for AF detection at a nonacademic, regional hospital in Blaricum, the...

Air pollution linked to increased IBS incidence
Tara Haelle

Oct 3rd, 2022 - Increased levels of air pollution were linked to a slight uptick in new diagnoses of irritable bowel syndrome (IBS) in California residents, according to an ecologic study published in Clinical Gastroenterology and Hepatology. “These data provide support for the role of environmental pollutants, especially air pollutants, in the development of IBS,” Philip N.

In Patients With Alopecia Areata, Shared Decision Making Increases Satisfaction
Dermatology Advisor

Oct 3rd, 2022 - Patients with alopecia areata (AA) prefer to make treatment decisions with their dermatologist with use of shared decision making (SDM), researchers reported in a study published in JAMA Dermatology. The findings are based on a cross-sectional study that used an online survey to assess patient preferences in SDM during AA treatment decision making and to determine which aspects of their involve...

Atopic Dermatitis Not Linked to VTE or JAK Inhibitors
Dermatology Advisor

Oct 3rd, 2022 - Atopic dermatitis (AD) is not associated with an increased risk for venous thromboembolism events, and neither are JAK inhibitors when used to treat AD, according to data from a systematic review and meta-analysis published in JAMA Dermatology. Investigators conducted a comprehensive literature search on electronic databases for cohort studies analyzing the association of AD with incident venou...

Children and Adolescents Present Differently With Eosinophilic Esophagitis
Dermatology Advisor

Oct 3rd, 2022 - Young children and adolescent patients present differently with eosinophilic esophagitis (EoE), according to study results published in the Journal of Pediatric Gastroenterology and Nutrition. For the study, researchers sourced data from the European Pediatric Eosinophilic Esophagitis Registry (pEEr) registry, which was initiated in 2015 by the Eosinophilic Gastrointestinal Disorders Working Gr...

Worldwide trial seeks to revolutionize pediatric leukemia care
Randy Dotinga

Oct 3rd, 2022 - While great strides have been made in children’s leukemia care during the past 50 years, statistics have remained grim. For acute myeloid leukemia (AML), the most common type, 5-year survival rates were just 69% for children younger than 15 between 2009 and 2015.

CAR T-cell therapy neurotoxicity linked to NfL elevations
Nancy A. Melville

Oct 3rd, 2022 - Patients undergoing chimeric antigen receptor (CAR) T-cell therapy who develop potentially serious neurotoxicity from the therapy show elevated plasma levels of neurofilament light chain (NfL) prior to the treatment, suggesting a possibly important predictor of risk for the side effect. “This is the first study to show NfL levels are elevated even before CAR T treatment is given,” first author.

Novel Haploidentical Bone Marrow Transplantation Approach Effective in Relapsed/Refractory Severe Aplastic Anemia
Cardiology Advisor

Oct 3rd, 2022 - According to research published in Lancet Haematology, a novel approach to haploidentical bone marrow transplantation results in excellent overall survival (OS) with minimal graft vs host disease (GVHD) in patients with relapsed or refractory severe aplastic anemia and may now be considered a standard salvage treatment for the disorder. The researchers reported the outcomes of BMT CTN 1502, a s...

Hepatitis C in Patients With HIV Increases Age-Related Cardiovascular Disease Risk
Cardiology Advisor

Oct 3rd, 2022 - The association between increasing age and risk for type 1 myocardial infarction (MI) in patients with HIV is more significant among those with vs without hepatitis C virus (HCV) coinfection, suggesting that HCV status should be considered when evaluating cardiovascular disease (CVD) risk in this patient population. These study findings were published in The Journal of the American Heart Associ...

Positive psychiatry: An introduction
Erick Messias, MD, PhD, MPH, Dilip V. Jeste, MD

Oct 3rd, 2022 - Historically, psychology and psychiatry have mostly focused on negative emotions and pathological states. However, during the last few decades, new developments in both disciplines have created novel vistas for a more comprehensive understanding of human behavior.

Using the tools of positive psychiatry to improve clinical practice
Samantha Boardman, MD, Rosemary Odem et. al.

Oct 3rd, 2022 - FIRST OF 4 PARTS What does wellness mean to you? A 2018 survey posed this question to more than 6,000 people living with depression and bipolar disorder. In addition to better treatment and greater understanding of their illnesses, other priorities emerged: a longing for better days, a sense of purpose, and a longing to function well and be happy.

The accelerating societal entropy undermines mental health
Henry A. Nasrallah, MD

Oct 3rd, 2022 - According to the second law of thermodynamics, it is inevitable that entropy will continue to increase over time. 1 Entropy is a measure of disorder, which can eventuate in chaos and lead to profound uncertainty, with serious psychological consequences.

More on varenicline
Ian R. Tofler, MBBS

Oct 3rd, 2022 - Murray et al have written a timely, thoughtful, and useful article (“Smoking cessation: Varenicline and the risk of neuropsychiatric adverse events,” Current Psychiatry, July 2022, p. 41-45) about the role of the nicotinic acetylcholine receptor partial agonist varenicline for helping patients stop smoking, which is still the main preventable cause of morbidity and premature death.

Faulty fences: Blood-brain barrier dysfunction in schizophrenia
Delaney A. Schrenk, BS, Henry A. Nasrallah, MD

Oct 3rd, 2022 - The blood-brain barrier (BBB) is an essential barrier of closely spaced cells that regulates entry into the CNS. What passes should be highly regulated to protect the brain from potentially harmful peripheral cells or molecules from the rest of the body.

Generalized anxiety disorder: 8 studies of psychosocial interventions
Sy Atezaz Saeed, MD, MS, Daniel John Majarwitz, MD

Oct 3rd, 2022 - SECOND OF 2 PARTS For patients with generalized anxiety disorder (GAD), the intensity, duration, and frequency of an individual’s anxiety and worry are out of proportion to the actual likelihood or impact of an anticipated event, and they often find it difficult to prevent worrisome thoughts from interfering with daily life. 1 Successful treatment for GAD is patient-specific and requires clinici.

Using SNRIs to prevent migraines in patients with depression
Huda H. Ismail, PharmD, Kelly Powell, PharmD et. al.

Oct 3rd, 2022 - Ms. D, age 45, has major depressive disorder (MDD), generalized anxiety disorder (GAD), migraines, and hypertension.

Medical record documentation: What to do, and what to avoid
Kaustubh G. Joshi, MD

Oct 3rd, 2022 - Medical record documentation serves as a reminder of previous discussions with patients and what happened during their visits, a reimbursement justification for services, a communication tool to coordinate care with current and future clinicians, and a basis for defense in legal or regulatory matters. 1,2 Documentation should be thorough, accurate, timely, and objective, with the ultimate goal o.

Lithium, valproate, and suicide risk: Analysis of 98,831 cases
Dan Giurca, MD

Oct 3rd, 2022 - The current academic psychiatry paradigm reinforces that lithium reduces suicide risk, more so than other medications, including valproate. However, data from multiple sources contradict this “evidence-based” belief.

Postop analgesia in Saudi Arabia and the United States: A resident’s perspective
Hashem N. Akbar, MD

Oct 3rd, 2022 - I had the opportunity to experience first-hand acute postoperative pain management in both the United States and Saudi Arabia. In this article, I discuss some of the differences in how postop pain is managed in each location, potential reasons for these differences, how they may impact patients over time, and the psychiatrist’s role in raising awareness about the hazards of overprescribing anal.

The State of the Art in NAFLD/NASH Identification and Management

Oct 3rd, 2022 - This transcript has been edited for clarity. Seth J. Baum, MD, FACC, FAHA, FNLA, FASPC: Hi. My name is Seth Baum. I'm a preventive cardiologist and clinical lipidologist, the chief scientific officer for Flourish Research, and a past president of the American Society for Preventive Cardiology. I'm joined today by Dr Jay Shubrook, who is an expert in diabetes, nonalcoholic steatohepatitis (NASH)...

Fast Five Quiz: Monkeypox

Oct 3rd, 2022 - Caused by the same family of viruses (Poxviridae) as the variola virus, monkeypox was discovered in 1958 after outbreaks occurred among research monkeys. It was first identified in humans in 1970. Before the 2022 outbreak, nearly all cases seen outside Africa were linked to the continent via travel or animal export. However, data suggest that men who have sex with men (MSM) account for a sizeab...

Standing Up for Our Patients' Rights and Our Right to Care For Them

Oct 3rd, 2022 - As a family medicine physician specializing in HIV for over two decades, standing up for my patients' rights and speaking out against discrimination in healthcare have become an unavoidable and integral part of caring for my patients. When the Trump Administration in 2019 launched an initiative to end the HIV epidemic in the United States by 2030 featuring HIV preexposure prophylaxis (PrEP) as ...

Intracranial Atherosclerotic Disease Clinical Practice Guidelines (ESO, 2022)

Oct 3rd, 2022 - Guidelines for the management of patients with intracranial atherosclerotic disease (ICAD) were published in September 2022 by the European Stroke Organisation (ESO) in European Stroke Journal.[1] Oral anticoagulation is not recommended over aspirin in patients with an ischemic stroke or transient ischemic attack due to high-grade stenosis related to intracranial atherosclerotic disease (ICAD)....

FDA Approves Futibatinib (Lytgobi) for Certain Biliary Tract Cancers

Oct 3rd, 2022 - The US Food and Drug Administration (FDA) has granted an accelerated approval for a new drug, futibatinib (Lytgobi), to be used for patients with a certain type of biliary tract cancer. Futibatinib was granted priority review and breakthrough designation, the agency said in its announcement. Futibatinib is indicated for use in adult patients with previously treated, unresectable, locally advanc...

Gardasil 9 HPV Vaccine Advised for MSM Living With HIV

Oct 3rd, 2022 - Men who have sex with men (MSM) living with HIV, especially those who are young or who've had gonorrhea should get the human papillomavirus (HPV) 9-valent vaccine (Gardasil 9), findings of a newly published study in JAIDS suggests. According to the World Health Organization, only 30% of the target population worldwide has received the HPV vaccine. Despite increased risk for HPV anal infection (...

Ruxolitinib Repigments Many Vitiligo Affected Body Areas

Oct 3rd, 2022 - Ruxolitinib (Opzelura) cream can help repigment the skin in many body areas affected with vitiligo, researchers reported at the European Academy of Dermatology and Venereology (EADV) 2022 Annual Meeting. Those difficult areas include the hands and feet, said Thierry Passeron, MD, PhD, of Université Côte d'Azur and Centre Hospitalier Universitaire de Nice in France. Indeed, a 50% or greater impr...

Will AI Affect the Burden of Patient Surveillance After Polyp Removal?

Oct 3rd, 2022 - While the use of artificial intelligence (AI) during colonoscopy may contribute to improved cancer prevention, it may also add to patient burden in terms of increased colonoscopy frequency and, in turn, healthcare costs, a new study suggests. The study found that colonoscopy plus AI (vs colonoscopy alone) increased the proportion of patients requiring intensive postpolypectomy colonoscopy surve...

High-Dose Folic Acid During Pregnancy Tied to Cancer Risk in Kids

Oct 3rd, 2022 - Prenatal exposure to high-dose folic acid is associated with a greater than twofold increased risk for cancer in children of mothers with epilepsy, new data from a Scandinavian registry of more than 3 million pregnancies suggests. The increased risk for cancer did not change after considering other factors that could explain the risk, such as use of antiseizure medication (ASM). There was no in...

Schools Are Significant Sites of COVID Transmission

Oct 3rd, 2022 - The school setting is an important site of SARS-CoV-2 transmission, new data suggest. An analysis of surveillance data for almost 1000 exposures to SARS-CoV-2 found that students accounted for a higher proportion of infected individuals who caused onward transmission than did the public overall (46.2% vs 25%). “Our analysis suggests that younger age groups were deeply involved in the spread of ...