About 1,128,270 results

Clinical Edge Journal Scan Commentary: Multiple Sclerosis June 2022
Mark Gudesblatt, MD

May 27th, 2022 - Mark Gudesblatt, MD Multiple sclerosis (MS) remains a complex disease with varied effects, some visible and clinically symptomatic and others invisible (eg, effects on cognition). However much we focus on the visible and uncovering the currently invisible effects, we must be aware of the effects of prior infection with SARS-CoV-2 (ie, post-acute COVID-19 syndrome, aka long COVID) in people with.

Psychological intervention looks promising in Crohn’s disease
Laird Harrison

May 27th, 2022 - SAN DIEGO – A combination of cognitive-behavioral therapy and mindfulness meditation could reduce pain and fatigue from Crohn’s disease, researchers say. Patients who followed the program not only felt better but were also more often able to show up for work and leisure activities, compared with a control group assigned to a wait list, said Shmuel Odes, MD, a professor of internal medicine at B.

Medical trauma an under-recognized trigger for PTSD
Randy Dotinga

May 27th, 2022 - NEW ORLEANS – Recent studies have confirmed that posttraumatic stress disorder can be triggered by health-related stress such as stints in the ICU and life-threatening medical emergencies, but most psychiatrists may not be aware of the latest research, according to an expert in mental trauma. “This is true among children as well as adults, but it is not generally appreciated by psychiatrists an.

Race-, ethnicity-based clinical guidelines miss the mark: Study
Jim Kling

May 27th, 2022 - SAN DIEGO – Race-based recommendations and clinical algorithms may be doing more harm than good, according to a systematic review of databases and guidelines. The study found examples of screening recommendations based on race or ethnicity that were likely misleading since these are social constructs that don’t reflect a patient’s individual risk, said Shazia Siddique, MD, who presented the stu.

Does taking isotretinoin worsen a patient’s baseline IBD symptoms?
Doug Brunk

May 27th, 2022 - A limited association exists between the use of isotretinoin for severe acne and worsening of a patient’s baseline inflammatory bowel disease, results from a small retrospective study suggests. “Early studies of isotretinoin for use in severe acne suggested the drug may serve as a trigger for new-onset inflammatory bowel disease (IBD),” researchers led by Christina G.

Urinating multiple times per night

May 27th, 2022 - On the basis of the patient's history and presentation, this is likely a case of adenocarcinoma of the prostate. Although most patients with prostate cancer are diagnosed on screening, when localized symptoms do occur, they may include urinary frequency, decreased urine stream, urinary urgency, and hematuria.

Sugar-sweetened beverage and sugar consumption tied with incidence of and mortality from proximal colon cancer

May 27th, 2022 - Key clinical point: High sugar-sweetened beverage (SSB) and total fructose intake was associated with increased incidence of and mortality from proximal colon cancer, especially during the later stages of colorectal tumorigenesis. Major finding: SSB and total fructose consumption was associated with a significant increase in the incidence of (hazard ratio [HR] per 1-serving/d increment 1.

ctDNA: Strong prognostic biomarker but lacks true clinical utility in mCRC

May 27th, 2022 - Key clinical point: Circulating tumor DNA (ctDNA) has substantiated its role as a strong prognostic biomarker in patients with metastatic colorectal cancer (mCRC). However, uncovering its true clinical value for these patients calls for prospective clinical trials with standardized methodologies.

KRAS p.G12C mutations may have prognostic implications in mCRC

May 27th, 2022 - Key clinical point: Patients with KRAS p. G12C-mutant metastatic colorectal cancer (mCRC) show poor treatment outcomes, which are numerically worse than those in patients without this mutation or with KRAS non-p.

Senegal Health Minister Sacked After Babies Die in Hospital Fire

May 27th, 2022 - DAKAR (Reuters) - Senegal President Macky Sall on Thursday sacked his health minister, Abdoulaye Diouf Sarr, a government decree showed, after 11 babies were killed by a fire in a hospital neonatal ward. Sarr will be replaced by Marie Khemesse Ngom Ndiaye, the ministry's director general, according to the decree.

Breakthrough Infections May Be Less Contagious

May 27th, 2022 - (Reuters) - Fully vaccinated individuals who get infected with the coronavirus spread the infection to fewer people and are contagious for less time compared to people who are partially vaccinated or unvaccinated, a small study from South Korea suggests. In 173 hospital workers with COVID-19, including 50 who had breakthrough infections, researchers found that the virus had been transmitted to ...

MRI Technique May Yield Clues to Long COVID Breathlessness

May 27th, 2022 - (Reuters) - In people with lasting breathlessness after COVID-19, a special type of magnetic resonance imaging (MRI) reveals lung abnormalities that traditional imaging techniques do not detect, a small study shows. In 23 patients with shortness of breath lasting for months after COVID-19, including 11 who had not required hospitalization, the researchers performed hyperpolarized xenon 129MRI, ...

Elderly Still Make Up Most of the COVID-19 Deaths

May 27th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. The number of daily COVID-19 deaths is dropping in the United States, but one fact has not changed in two-plus years of the pandemic: The elderly are still most at risk of dying from the virus. The seven-day moving average of COVID-related deaths is now 288, a number far lower than the peaks of ...

Telemedicine in Cancer Care: Not All Patients Can Access

May 27th, 2022 - The COVID pandemic pushed telemedicine forward as a safe, accessible, and more widely reimbursed approach to care delivery for patients with cancer, but uptake of telemedicine was plagued by inequities, a retrospective study suggests. Before March 2020, only a very small percentage of patients with cancer used telemedicine services. By November 2021, nearly 16% of patients initiating cancer tre...

Don't Equate Mass Shootings With Mental Illness

May 27th, 2022 - Here we go, again, and again, and again. There just aren't enough tears, and before the bodies of 19 small children are identified, the political noise starts up. Mass shootings are a part of the American landscape, but when they happen at schools, we all feel a distinct sense of violation and gaping grief. Those children are so innocent, so deserving of a right to live their lives, hold their ...

UCLA Reinstates Mask Mandate as California COVID Cases Surge

May 27th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. LOS ANGELES (AP) — The University of California, Los Angeles said Thursday it will reinstate an indoor mask policy as coronavirus cases surge in the nation's most populous state, which now forecasts hospitalizations will nearly triple in the next month. UCLA's 45,000 students and all faculty, st...

Is Subfertility Linked With Postpartum Mental Illness?

May 27th, 2022 - Mothers with previous subfertility have increased risk for postpartum mental illness, compared with mothers who conceived spontaneously, according to a new study. In a population-based cohort study that examined almost 800,000 births, the adjusted relative risk (RR) for postpartum mental illness was 1.14 in women with subfertility, compared with women without reproductive assistance. The magnit...

FDA Okays IN.PACT 018 Drug-Coated Balloon for PAD

May 27th, 2022 - The US Food and Drug Administration has approved the IN.PACT 018 drug-coated balloon (DCB) for the treatment of peripheral arterial disease, Medtronic announced today. The paclitaxel-coated balloon is indicated for percutaneous transluminal angioplasty of de novo, restenotic, or in-stent restenotic lesions up to 360 mm in length with vessel diameters of 4 to 7 mm, located in the superficial fem...

'It's an Amazing Time to Be a Hemophilia Provider'

May 27th, 2022 - New medications such as emicizumab (Hemlibra) are transforming the lives of patients with hemophilia A, and more treatments are in the pipeline. "It's an amazing time to be a hemophilia provider," Alice D. Ma, MD, University of North Carolina at Chapel Hill hematologist and bleeding disorder specialist, said in an interview. "There are real options, and it's very exciting." But the drugs come w...

After Texas School Shooting, Parents Search for New Answers

May 27th, 2022 - Amy Chambers is planning a visit soon with the principal of her son's elementary school in Joplin, MO. The grade level of the 19 children killed in the Tuesday school shooting in Uvalde, TX, was not unnoticed by her. Her son, the youngest of her three, is also a fourth grader. Chambers, a church secretary in Joplin, thinks the security to get into her son's school is good, but she has questions...

Nutrients and Exercise Affect Tumor Development

May 27th, 2022 - MADRID, Spain — Researchers discussed an update on the latest evidence regarding the cancer-lifestyle link as part of the Precision Health session: Oncology, held during the 7th International Congress of the Spanish Society of Precision Health (SESAP). The role that certain nutrients can have on tumor development was analyzed, along with the most recent data justifying the idea that the prescri...

Artificial Insemination Births Ebb in Women With Underweight

May 27th, 2022 - Researchers published the study covered in this summary on researchsquare.com as a preprint that has not yet been peer reviewed. Key Takeaways In a large cohort of women with a body mass index (BMI) below 30 kg/m2 receiving up to four intrauterine insemination (IUI) infertility treatments in China, those with underweight were significantly less likely to become pregnant or have a live birth, wh...

Increased Social Services Spending Ups Cancer Survival of Blacks

May 27th, 2022 - Increasing social services spending by 10% led to improved survival for non-Hispanic Black adults with cancer, according to new research. Five-year overall survival increased among non-Hispanic Black patients by 2.02% in conjunction with a 10% increase in spending. In addition, there was a decrease in racial disparities in survival between non-Hispanic Black patients and White patients for many...

ESG's Cardiometabolic Benefits Last 5 Years

May 27th, 2022 - SAN DIEGO – Endoscopic sleeve gastroplasty (ESG) led to sustained weight loss and a reduction of cardiometabolic syndrome comorbidities at 5 years, according to a new retrospective analysis of prospectively collected data. Dr Donevan Westerveld Improved cardiometabolic outcomes following bariatric surgery have been well documented, but ESG is relatively new, so its outcomes haven't been as well...

'Unlimited' Cancer Costs: The Medicare Part D Dilemma

May 27th, 2022 - Learning that a family member has cancer can be devastating enough. Waiting to find out whether a loved one can afford their treatment takes the concern to another level. That was the case for health policy expert Stacie B. Dusetzina, PhD, when her mother was diagnosed with metastatic breast cancer. "There is this period where you are waiting to learn more about the cancer type and treatment op...

Number of US Monkeypox Cases Grows to 10, CDC Says

May 27th, 2022 - Ten monkeypox cases have been identified in eight states, according to the CDC. The CDC website said that as of 5 p.m. Thursday, health officials had identified two cases in Florida, two cases in Utah, and one case each in California, Colorado, Massachusetts, New York, Virginia, and Washington state. CDC Director Rochelle Walensky, MD, said Thursday that most of the cases "are within gay [and] ...

Double the Pleasure: Stim Patch Delays Early Ejaculation: Study

May 27th, 2022 - A wearable patch that delivers electrical stimulation to the perineum may postpone premature ejaculation, according to research presented at the 2022 annual meeting of the American Urological Association. The disposable device appears to work by helping men contract the muscles in the pelvic floor, allowing them to postpone climax. Among 34 men with a lifelong history of premature ejaculation, ...

Interatrial Shunt in HF Hints at Heart Structural, Functional Benefits

May 27th, 2022 - Transcatheter implants designed to alleviate high left atrial (LA) pressures — which, as a possible way to treat heart failure (HF) once seemed like a long shot — are emerging as new stars of heart failure research. Clinical trial results have been mixed but also seem to have dispelled most doubts about whether interatrial shunt devices may eventually prove an effective treatment for HF. That w...

H pylori Antibiotics Briefly Disrupt Gut Microbiome

May 27th, 2022 - SAN DIEGO – Treatments to eradicate Helicobacter pylori (H. pylori) infections do increase the antibiotic resistance of the gut microbiota, but for only a few months, researchers reported at Digestive Disease Week® (DDW). The finding applies similarly to levofloxacin quadruple therapy and bismuth quadruple therapy, both of which are equally efficacious as second-line treatments, said Jyh-Ming L...

When Does an Elite Athlete Need Mental Health Treatment?

May 27th, 2022 - MAR DEL PLATA, Argentina — Many athletes get the "jitters" — a feeling of anxiety — just prior to competing. For elite athletes, whether they're participating in an individual event or as part of a team, whether on a track, court, rink, or field, this feeling can affect performance. It is a well-known, and not unexpected, phenomenon that comes with the territory. Nevertheless, specialists shoul...

Distal Radial Access Does Not Impair Hand Function: RATATOUILLE

May 27th, 2022 - A systematic battery of tests revealed no worsening of hand function out to 1 year following distal radial access (DRA) for percutaneous coronary procedures in the multicenter RATATOUILLE study. Further, patients experienced only modest access-site pain and very few complications. "This is reassuring, totally reassuring, because patients start at one level and they end exactly at the same level...

Eosinophilic Diseases Often Overlap, Raising Costs

May 27th, 2022 - Eosinophilic GI diseases (EGIDs) often overlap with other eosinophil-associated diseases (EADs), which leads to greater health care costs, according to an analysis of the U.S. Optum Clinformatics claims database. EADs have gained increased attention in recent years. They include eosinophilic esophagitis (EoE), eosinophilic asthma, bullous pemphigoid, eosinophilic granulomatosis with polyangiiti...

New Test Might Transform Male Infertility

May 27th, 2022 - A new study suggests that, at least for certain male patients, the answer to infertility might lie with epigenetics. According to the study, a commercially-available test of epigenetic anomalies — factors that affect how genes express themselves — can grade the likelihood that sperm are viable for conception. "The uniqueness of epigenetics is that some of the abnormalities detected have the pot...

Race-, Ethnicity-Based Clinical Guidelines Miss the Mark: Study

May 27th, 2022 - SAN DIEGO, California — Race-based recommendations and clinical algorithms may be doing more harm than good, according to a systematic review of databases and guidelines. The study found examples of screening recommendations based on race or ethnicity that were likely misleading since these are social constructs that don't reflect a patient's individual risk, said Shazia Siddique, MD, who prese...

Psychological Intervention Looks Promising in Crohn's Disease

May 27th, 2022 - SAN DIEGO — A combination of cognitive-behavioral therapy and mindfulness meditation could reduce pain and fatigue from Crohn's disease, researchers say. Patients who followed the program not only felt better but were also more often able to show up for work and leisure activities, compared with a control group assigned to a wait list, said Shmuel Odes, MD, a professor of internal medicine at B...

Steroid Use May Increase Relapse Risk in Some Patients With Ulcerative Colitis

May 27th, 2022 - Patients who have histologically active ulcerative colitis (UC) with a Mayo endoscopic subscore (MES) of 1 and a history of steroid use may be at increased risk for clinical relapse, according to a new single-center, retrospective analysis. In recent years, treat-to-target approaches in UC have incorporated clinician and patient-reported outcomes, along with endoscopic remission, defined as MES...

Rapid Review Quiz: Nonalcoholic Fatty Liver Disease (NAFLD)

May 27th, 2022 - Approximately 25% of the global population has nonalcoholic fatty liver disease (NAFLD), a broad term that covers a range of conditions. NAFLD is defined by the presence of macrovesicular steatosis without secondary causes, such as chronic use of medications, significant alcohol consumption, or hereditary disorders. Several phases of progression are noted, including simple steatosis, fibrosis, ...

Update on Rabies, TBE, and Cholera Vaccines Before Travel

May 27th, 2022 - Healthcare providers should be aware of important updates to vaccine recommendations that could affect patients preparing to travel internationally this summer. This includes information about: New rabies pre-exposure prophylaxis guidelines (PrEP); The new tick-borne encephalitis (TBE) vaccine; and Updated cholera vaccine recommendations and a restart of Vaxchora manufacturing and distribution....

The Next US Abortion Battle Is Over Pills, and It's Already Begun

May 27th, 2022 - WASHINGTON (Reuters) - The U.S. Supreme Court has not yet released its decision that looks set to dramatically scale back abortion rights, but one of the next legal battles has already begun in a Mississippi court. That is where the manufacturer of a pill used to carry out medication abortions, Las Vegas-based GenBioPro Inc, has filed a federal lawsuit challenging the conservative state's restr...

Acupoint Hot Compress May Be Helpful After Vaginal Delivery

May 27th, 2022 - NEW YORK (Reuters Health) - Following vaginal birth, acupoint hot compress involving the abdominal, lumbosacral and plantar regions appears to lessen postpartum urinary retention, uterine contraction pain and depressive symptoms, while promoting lactation, a randomized controlled trial has found. "Findings of this trial suggest that acupoint hot compress could be considered as an adjunctive int...

WHO Asks Countries to Increase Surveillance for Monkeypox

May 27th, 2022 - (Reuters) - About 200 confirmed and more than 100 suspected cases of Monkeypox have been detected so far outside of the countries where it usually spreads, a World Health Organization official said on Thursday, urging countries to increase surveillance for the infectious disease. Monkeypox, a mild viral infection, is endemic in the African countries of Cameroon, Central African Republic, Democr...

Early Liver Transplant Outcomes Not Impacted by New US Allocation System

May 27th, 2022 - NEW YORK (Reuters Health) - A new system for allocating liver allografts in the United States, implemented in 2020, has been associated with procurement-related delays but has had no adverse impact on early transplant outcomes, a new study shows. To assess the effect of Liver Acuity Circle Allocation (AC), researchers compared data from the Organ Procurement and Transplantation Network (OPTN) o...

Disparities Exist in Diabetes-Related ED Visits

May 27th, 2022 - Wide disparities exist in diabetes-related emergency department (ED) use between racial and ethnic groups, rural and urban patients, and Medicare and Medicaid-insured adults versus those who were privately insured between 2008 and 2017, a serial cross-sectional study indicates. All-cause ED visits increased by over 50% during the same period even though substantial health reforms were made duri...

Baby Formula Shortage Highlights Racial Disparities

May 27th, 2022 - COLUMBIA, Md. (AP) — Capri Isidoro broke down in tears in the office of a lactation consultant. The mother of two had been struggling to breastfeed her 1-month-old daughter ever since she was born, when the hospital gave the baby formula first without consulting her on her desire to breastfeed. Now, with massive safety recall and supply disruptions causing formula shortages across the United St...

Gout App Improves Treat to Target, Reduces Flares

May 27th, 2022 - Self-management of gout using a smartphone app to record self-test urate levels and flares, and communicate those results to clinicians, could see more patients reaching target urate levels and even reducing flare frequency, a study has found. Writing in The Lancet Rheumatology, Philip Riches, PhD, of the rheumatic disease unit at Western General Hospital in Edinburgh, and coauthors presented t...

Study Addresses Whether Isotretinoin Precipitates IBD Flares

May 27th, 2022 - A limited association exists between the use of isotretinoin for severe acne and worsening of a patient's baseline inflammatory bowel disease, results from a small retrospective study suggests. "Early studies of isotretinoin for use in severe acne suggested the drug may serve as a trigger for new-onset inflammatory bowel disease (IBD)," researchers led by Christina G. Lopez, MD, of the Lewis Ka...

Overlooked: Black Woman Doctor's Key Role in Oncology History 

May 27th, 2022 - When Jane Cooke Wright, MD, entered the medical profession in 1945, the notion that toxic drugs could target tumors struck many physicians and patients as outlandish. How could one poison be weaponized against another poison — a cancerous tumor — without creating more havoc? Let alone a combination of two or more chemicals? Yet by the time Wright retired in 1987, chemotherapy treatments that sh...

Screening Finds Albuminuria in 3% of Community Adults

May 27th, 2022 - Roughly 3% of adults in the general population of The Netherlands have microalbuminuria or macroalbuminuria, and in nearly two thirds of this subgroup — roughly 2% of the general population — kidney disease had previously gone unidentified, based on screening results in a study of about 15,000 adults. "This is the first study to prospectively investigate population screening for albuminuria," s...

Betting on 'Golden Age' of Colonoscopies, Private Equity Invests in Gastro Docs

May 27th, 2022 - Mariel needed a new gastroenterologist. Having just moved back to San Antonio, the 30-something searched for a doctor to manage her Crohn's disease, an inflammatory bowel condition that is successfully managed with medications and lifelong monitoring — including regular colonoscopies. Mariel booked an appointment and learned she would be on the hook for a $1,100 colonoscopy — about three times ...

Index Cholecystectomy Cuts Readmissions After Acute Cholangitis

May 27th, 2022 - Patients with acute cholangitis are twice as likely to be readmitted within 30 days if they don't get a cholecystectomy in the same hospital admission for which they get biliary decompression, researchers say. The readmissions result mostly from sepsis and recurrence of the acute cholangitis, said Ahmad Khan, MD, MS, a gastroenterology fellow at Case Western Reserve University in Cleveland, at ...