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Clinical Edge Journal Scan Commentary: Multiple Sclerosis June 2022
https://www.mdedge.com/neurology/msresourcecenter/article/255056/multiple-sclerosis/clinical-edge-journal-scan-commentary
Mark Gudesblatt, MD

May 27th, 2022 - Mark Gudesblatt, MD Multiple sclerosis (MS) remains a complex disease with varied effects, some visible and clinically symptomatic and others invisible (eg, effects on cognition). However much we focus on the visible and uncovering the currently invisible effects, we must be aware of the effects of prior infection with SARS-CoV-2 (ie, post-acute COVID-19 syndrome, aka long COVID) in people with.

Psychological intervention looks promising in Crohn’s disease
https://www.mdedge.com/internalmedicine/article/255054/gastroenterology/psychological-intervention-looks-promising-crohns
Laird Harrison

May 27th, 2022 - SAN DIEGO – A combination of cognitive-behavioral therapy and mindfulness meditation could reduce pain and fatigue from Crohn’s disease, researchers say. Patients who followed the program not only felt better but were also more often able to show up for work and leisure activities, compared with a control group assigned to a wait list, said Shmuel Odes, MD, a professor of internal medicine at B.

Medical trauma an under-recognized trigger for PTSD
https://www.mdedge.com/psychiatry/article/255051/ptsd/medical-trauma-under-recognized-trigger-ptsd
Randy Dotinga

May 27th, 2022 - NEW ORLEANS – Recent studies have confirmed that posttraumatic stress disorder can be triggered by health-related stress such as stints in the ICU and life-threatening medical emergencies, but most psychiatrists may not be aware of the latest research, according to an expert in mental trauma. “This is true among children as well as adults, but it is not generally appreciated by psychiatrists an.

Race-, ethnicity-based clinical guidelines miss the mark: Study
https://www.mdedge.com/internalmedicine/article/255047/diversity-medicine/race-ethnicity-based-clinical-guidelines-miss
Jim Kling

May 27th, 2022 - SAN DIEGO – Race-based recommendations and clinical algorithms may be doing more harm than good, according to a systematic review of databases and guidelines. The study found examples of screening recommendations based on race or ethnicity that were likely misleading since these are social constructs that don’t reflect a patient’s individual risk, said Shazia Siddique, MD, who presented the stu.

Does taking isotretinoin worsen a patient’s baseline IBD symptoms?
https://www.mdedge.com/dermatology/article/255034/acne/does-taking-isotretinoin-worsen-patients-baseline-ibd-symptoms
Doug Brunk

May 27th, 2022 - A limited association exists between the use of isotretinoin for severe acne and worsening of a patient’s baseline inflammatory bowel disease, results from a small retrospective study suggests. “Early studies of isotretinoin for use in severe acne suggested the drug may serve as a trigger for new-onset inflammatory bowel disease (IBD),” researchers led by Christina G.

Urinating multiple times per night
https://www.mdedge.com/prostate-cancer-challenge-center/article/255032/prostate-cancer/urinating-multiple-times-night

May 27th, 2022 - On the basis of the patient's history and presentation, this is likely a case of adenocarcinoma of the prostate. Although most patients with prostate cancer are diagnosed on screening, when localized symptoms do occur, they may include urinary frequency, decreased urine stream, urinary urgency, and hematuria.

Sugar-sweetened beverage and sugar consumption tied with incidence of and mortality from proximal colon cancer
https://www.mdedge.com/hematology-oncology/article/255022/gastrointestinal-cancer/sugar-sweetened-beverage-and-sugar

May 27th, 2022 - Key clinical point: High sugar-sweetened beverage (SSB) and total fructose intake was associated with increased incidence of and mortality from proximal colon cancer, especially during the later stages of colorectal tumorigenesis. Major finding: SSB and total fructose consumption was associated with a significant increase in the incidence of (hazard ratio [HR] per 1-serving/d increment 1.

ctDNA: Strong prognostic biomarker but lacks true clinical utility in mCRC
https://www.mdedge.com/hematology-oncology/article/255021/gastrointestinal-cancer/ctdna-strong-prognostic-biomarker-lacks

May 27th, 2022 - Key clinical point: Circulating tumor DNA (ctDNA) has substantiated its role as a strong prognostic biomarker in patients with metastatic colorectal cancer (mCRC). However, uncovering its true clinical value for these patients calls for prospective clinical trials with standardized methodologies.

KRAS p.G12C mutations may have prognostic implications in mCRC
https://www.mdedge.com/hematology-oncology/article/255019/gastrointestinal-cancer/kras-pg12c-mutations-may-have-prognostic

May 27th, 2022 - Key clinical point: Patients with KRAS p. G12C-mutant metastatic colorectal cancer (mCRC) show poor treatment outcomes, which are numerically worse than those in patients without this mutation or with KRAS non-p.

COVID-19 Vaccines Work Better and for Longer Than Expected Across Populations, Including Immunocompromised Individuals
https://www.medscape.com/viewarticle/974363

May 27th, 2022 - The mRNA vaccines are powerful in terms of preventing severe disease with COVID-19 across populations because of the multifaceted immune response they generate, a redundancy that can help among patients on agents which cause immunocompromise. Although antibodies from the vaccines will wane over time, or these antibodies can be less effective against new variants like Omicron, the vaccines do no...

The Next US Abortion Battle Is Over Pills, and It's Already Begun
https://www.medscape.com/viewarticle/974646

May 27th, 2022 - WASHINGTON (Reuters) - The U.S. Supreme Court has not yet released its decision that looks set to dramatically scale back abortion rights, but one of the next legal battles has already begun in a Mississippi court. That is where the manufacturer of a pill used to carry out medication abortions, Las Vegas-based GenBioPro Inc, has filed a federal lawsuit challenging the conservative state's restr...

Acupoint Hot Compress May Be Helpful After Vaginal Delivery
https://www.medscape.com/viewarticle/974680

May 27th, 2022 - NEW YORK (Reuters Health) - Following vaginal birth, acupoint hot compress involving the abdominal, lumbosacral and plantar regions appears to lessen postpartum urinary retention, uterine contraction pain and depressive symptoms, while promoting lactation, a randomized controlled trial has found. "Findings of this trial suggest that acupoint hot compress could be considered as an adjunctive int...

Patent Foramen Ovale Clinical Practice Guidelines (SCAI, 2022)
https://www.medscape.com/viewarticle/974545

May 27th, 2022 - Clinical practice guidelines on the management of patent foramen ovale (PFO) from the Society for Cardiovascular Angiography and Interventions (SCAI) were published in May 2022 in  JSCAI.[1] In patients aged 18-60 years who have had a PFO-related stroke, PFO closure is strongly recommended instead of antiplatelet therapy alone. For patients aged 60 years and older with a history of PFO-related ...

WHO Asks Countries to Increase Surveillance for Monkeypox
https://www.medscape.com/viewarticle/974685

May 27th, 2022 - (Reuters) - About 200 confirmed and more than 100 suspected cases of Monkeypox have been detected so far outside of the countries where it usually spreads, a World Health Organization official said on Thursday, urging countries to increase surveillance for the infectious disease. Monkeypox, a mild viral infection, is endemic in the African countries of Cameroon, Central African Republic, Democr...

Senegal Health Minister Sacked After Babies Die in Hospital Fire
https://www.medscape.com/viewarticle/974697

May 27th, 2022 - DAKAR (Reuters) - Senegal President Macky Sall on Thursday sacked his health minister, Abdoulaye Diouf Sarr, a government decree showed, after 11 babies were killed by a fire in a hospital neonatal ward. Sarr will be replaced by Marie Khemesse Ngom Ndiaye, the ministry's director general, according to the decree.

Breakthrough Infections May Be Less Contagious
https://www.medscape.com/viewarticle/974700

May 27th, 2022 - (Reuters) - Fully vaccinated individuals who get infected with the coronavirus spread the infection to fewer people and are contagious for less time compared to people who are partially vaccinated or unvaccinated, a small study from South Korea suggests. In 173 hospital workers with COVID-19, including 50 who had breakthrough infections, researchers found that the virus had been transmitted to ...

MRI Technique May Yield Clues to Long COVID Breathlessness
https://www.medscape.com/viewarticle/974705

May 27th, 2022 - (Reuters) - In people with lasting breathlessness after COVID-19, a special type of magnetic resonance imaging (MRI) reveals lung abnormalities that traditional imaging techniques do not detect, a small study shows. In 23 patients with shortness of breath lasting for months after COVID-19, including 11 who had not required hospitalization, the researchers performed hyperpolarized xenon 129MRI, ...

Early Liver Transplant Outcomes Not Impacted by New US Allocation System
https://www.medscape.com/viewarticle/974702

May 27th, 2022 - NEW YORK (Reuters Health) - A new system for allocating liver allografts in the United States, implemented in 2020, has been associated with procurement-related delays but has had no adverse impact on early transplant outcomes, a new study shows. To assess the effect of Liver Acuity Circle Allocation (AC), researchers compared data from the Organ Procurement and Transplantation Network (OPTN) o...

UCLA Reinstates Mask Mandate as California COVID Cases Surge
https://www.medscape.com/viewarticle/974729

May 27th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. LOS ANGELES (AP) — The University of California, Los Angeles said Thursday it will reinstate an indoor mask policy as coronavirus cases surge in the nation's most populous state, which now forecasts hospitalizations will nearly triple in the next month. UCLA's 45,000 students and all faculty, st...

Baby Formula Shortage Highlights Racial Disparities
https://www.medscape.com/viewarticle/974731

May 27th, 2022 - COLUMBIA, Md. (AP) — Capri Isidoro broke down in tears in the office of a lactation consultant. The mother of two had been struggling to breastfeed her 1-month-old daughter ever since she was born, when the hospital gave the baby formula first without consulting her on her desire to breastfeed. Now, with massive safety recall and supply disruptions causing formula shortages across the United St...