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How should PRAME be used to evaluate melanocytic lesions?
https://www.mdedge.com/dermatology/article/260874/melanoma/how-should-prame-be-used-evaluate-melanocytic-lesions
Doug Brunk

Jan 27th, 2023 - SAN DIEGO – As with many markers for the evaluation of challenging melanocytic lesions, preferentially expressed antigen in melanoma (PRAME) has its benefits and drawbacks, according to Cora Humberson, MD. “I’m a fan, but there are issues with it,” Dr.

Analysis of ctDNA Pinpoints Responders to Second-Line GIST Therapy
https://www.medpagetoday.com/hematologyoncology/othercancers/102862

Jan 27th, 2023 - Circulating tumor DNA (ctDNA) analysis of KIT mutational status may be able to guide second-line treatment in patients with imatinib-resistant gastrointestinal stromal tumors (GIST), according to an exploratory analysis from the INTRIGUE trial. Specifically, patients with KIT exon 11 plus 17/18 (activation loop) mutations had superior responses and better survival outcomes with ripretinib (Qinl...

Are Boiled Peanuts the Answer to Peanut Allergy?
https://www.clinicaladvisor.com/home/topics/allergy-and-immunology-information-center/boiled-peanuts-immunotherapy-peanut-allergy/
Clinical Advisor

Jan 27th, 2023 - Children with peanut allergies may benefit from an unusual oral immunotherapy regimen: boiled peanuts. Use of a boiled peanut regimen led to desensitization in 80% of children with peanut allergies enrolled in an open-label, phase 2 trial, which was published in Clinical & Experimental Allergy. Few children withdrew from the trial because of adverse events. “Small and increasing doses of boiled...

How Racial and Ethnic Disparities in Alzheimer Disease Affect Diagnosis, Quality of Care
https://www.clinicaladvisor.com/home/topics/neurology-information-center/racial-ethnic-disparities-adrd-impact-diagnosis-quality-of-care/
Clinical Advisor

Jan 27th, 2023 - As researchers continue to seek insights to improve the understanding, prevention, and treatment of Alzheimer disease and related dementias (ADRD), a growing body of research highlights significant racial and ethnic disparities in various aspects of these diseases.1 “In Blacks and Hispanics, the prevalence of ADRD is 1.5 to 2 times higher compared to non-Hispanic Whites,” said Timothy S. Chang,...

Factors That Affect Your Risk of Getting Very Sick from COVID-19
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/731463

Factors That Affect Your Risk of Getting Very Sick from COVID-19

ODAC to Review Lymphoma Drug; Tobacco Control; Artificial Skin Aids Cancer Studies
https://www.medpagetoday.com/hematologyoncology/lymphoma/102854

Jan 27th, 2023 - The FDA announced that the Oncologic Drugs Advisory Committee (ODAC) will meet March 9 to review the accelerated approval of polatuzumab vedotin (Polivy) plus rituximab (Rituxan) and chemotherapy for untreated diffuse large B-cell lymphoma. Janssen and Legend Biotech announced early termination of a phase III trial after an interim analysis showed that ciltacabtagene autoleucel (cilta-cel, Carv...

FDA Panel Backs Plan to Only Use Omicron-Containing COVID Vaccines
https://www.medpagetoday.com/infectiousdisease/covid19vaccine/102852

Jan 27th, 2023 - The FDA's vaccine advisors unanimously backed the agency's proposal to harmonize COVID-19 primary and booster vaccines to contain a single bivalent composition with components targeting BA.4/5 and the original SARS-CoV-2 strain. With a 21-0 vote on Thursday, members of the Vaccines and Related Biological Products Advisory Committee (VRBPAC) supported FDA's plan, which aims to offer better prote...

Joy Joy's Bakery Issues Allergy Alert on Undeclared Wheat in Ube Spanish Bread, Ube Ensaymada, and Ube Roll
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/733637

January 26, 2023, Joy Joy's Bakery Lakewood, Washington is recalling Ube Spanish Bread, Ube Ensaymada, and Ube Roll because it may contain undeclared wheat. People who have an allergy or severe sensitivity to wheat run the risk of serious or life-threatening allergic reaction if they consume this p

Joy Joy's Bakery Issues Allergy Alert on Undeclared Wheat in Ube Spanish Bread, Ube Ensaymada, and Ube Roll
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/733636

January 26, 2023, Joy Joy's Bakery Lakewood, Washington is recalling Ube Spanish Bread, Ube Ensaymada, and Ube Roll because it may contain undeclared wheat. People who have an allergy or severe sensitivity to wheat run the risk of serious or life-threatening allergic reaction if they consume this p

FDA OKs Adjuvant Pembrolizumab for NSCLC
https://www.medpagetoday.com/hematologyoncology/lungcancer/102849

Jan 27th, 2023 - The FDA has approved pembrolizumab (Keytruda) as an adjuvant therapy following surgical resection and platinum-based chemotherapy for patients with stage IB, II, or IIIA non-small cell lung cancer (NSCLC), Merck announced. The approval makes pembrolizumab the only immunotherapy to be approved for NSCLC regardless of PD-L1 expression in both the adjuvant and metastatic settings, the company note...

Small, convenient mosquito repellent device passes test to protect military personnel
https://www.eurekalert.org/news-releases/978005

Jan 27th, 2023 - A device developed at the University of Florida for the U.S. military provides protection from mosquitos for an extended period and requires no heat, electricity or skin contact. Funded by the Department of Defense Deployed Warfighter Protection program, the controlled-release passive device was designed by Nagarajan Rajagopal, a PhD candidate and Dr. Christopher Batich in UF’s Department of Ma...

Measles virus 'cooperates' with itself to cause fatal encephalitis
https://www.eurekalert.org/news-releases/977624

Jan 27th, 2023 - Fukuoka, Japan—Researchers in Japan have uncovered the mechanism for how the measles virus can cause subacute sclerosing panencephalitis, or SSPE, a rare but fatal neurological disorder that can occur several years after a measles infection. Although the normal form of the measles virus cannot infect the nervous system, the team found that viruses that persist in the body can develop mutations ...

Dr. Katerina Mastovska named AOAC INTERNATIONAL Deputy Executive Director and Chief Science Officer
https://www.eurekalert.org/news-releases/977974

Jan 27th, 2023 - AOAC INTERNATIONAL Executive Director David B. Schmidt is pleased to announce that Dr. Katerina (Kate) Mastovska has been named Deputy Executive Director and Chief Science Officer. Two current staff members, each with almost 20 years of experience at AOAC, Dawn L. Frazier and Deborah McKenzie, have been promoted to new roles at the nonprofit organization which ensures the safety and integrity o...

Testing a immunological drug as a new treatment for early type 1 diabetes
https://www.eurekalert.org/news-releases/977926

Jan 27th, 2023 - A large clinical study is now beginning on an approved drug for treating psoriasis. The drug will be tested on patients who were recently diagnosed with type 1 diabetes. The theory is that the drug could preserve the patient’s remaining insulin production. A large number of hospitals throughout Sweden are participating in this large project, which is funded by the Swedish Research Council withi...

Study shows FDA-approved TB regimen may not work against the deadliest form of TB due to multidrug-resistant strains
https://www.eurekalert.org/news-releases/977942

Jan 27th, 2023 - FOR IMMEDIATE RELEASE Findings from a Johns Hopkins Children’s Center study in animal models show that a U.S. Food and Drug Administration (FDA)-approved antibiotic regimen for multidrug-resistant (MDR) tuberculosis (TB) may not work for TB meningitis. Studies in a small number of people also provide evidence that a new combination of drugs is needed to develop effective treatments for TB menin...

Development, validation of a deep learning algorithm to differentiate colon carcinoma from diverticulitis in CT images
https://www.eurekalert.org/news-releases/977766

Jan 27th, 2023 - About The Study: The results of this study suggest that a deep learning model able to distinguish colon carcinoma and acute diverticulitis in computed tomography (CT) images as a support system may significantly improve the diagnostic performance of radiologists, which may improve patient care. As an artificial intelligence support system, the model significantly improved the sensitivity and sp...

Non-invasive neurotechnology reduces symptoms of insomnia and improves autonomic nervous system function
https://www.eurekalert.org/news-releases/977947

Jan 27th, 2023 - WINSTON-SALEM, N.C. – Jan. 27, 2023 – A good night’s sleep is crucial to health and well-being. Numerous research studies have shown that insomnia can increase the risk of cardiovascular events, obesity, diabetes and other illnesses. Now, a new study from researchers at Wake Forest University School of Medicine shows significant improvements in not only sleep quality, but also in improved auton...

New study debunks the assumption that menstrual cycles disqualify women from exercise research
https://www.eurekalert.org/news-releases/977913

Jan 27th, 2023 - Peruse any women’s magazine, and you’ll likely find advice on how to boost workouts. But what many don’t realize is that the research behind most exercise advice is based almost entirely on men. Female subjects are excluded from over 90% of studies on exercise performance and fatigability because hormonal changes during the menstrual cycle were thought to affect exercise capability — which, if ...

COVID by the numbers at UCLA Health: A million tests; 300,000 vaccines; 55,000 patients
https://www.eurekalert.org/news-releases/977968

Jan 27th, 2023 - Three years ago this month, the first case of COVID was diagnosed in the United States. Here are the latest figures on the pandemic, collected by UCLA Health hospitals and clinics. Clinical care Testing and vaccination Telehealth Also see: A bird’s-eye view of the COVID-19 pandemic from 2020 to now.

From AI software to surgical robots
https://www.eurekalert.org/news-releases/977933

Jan 27th, 2023 - A doctor needs a great deal of experience, knowledge and years of training to be able to expertly analyze an ECG. Automated procedures based on AI can offer effective support here. And an AI system in this field also has to be trained. This is namely undertaken (in this case) with very large amounts of high-quality ECG data. Such training means that, for instance, even the smallest abnormalitie...