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Evolving Patterns of Metastasis in Renal Cell Carcinoma: Do We Need to Perform Routine Bone Imaging?
Journal of Kidney Cancer and VHL; Lin J

Oct 13th, 2021 - Advance diagnostic and treatment modalities have improved outcomes for renal cell carcinoma (RCC) patients, but the prognosis for those with metastatic disease (mRCC) remains poor. As given metastatic distribution is critical in guiding treatment decisions for mRCC patients, we evaluated evolving metastatic patterns to assess if our current practice standards effectively address patient needs.

Germline Variants Identified in Patients with Early-onset Renal Cell Carcinoma Referred for Germline Genetic Testing
European Urology Oncology; Truong H

Oct 12th, 2021 - Despite guidelines recommending genetic counseling for patients with early-onset renal cell carcinoma (RCC), studies interrogating the spectrum of germline mutations and clinical associations in patients with early-onset RCC are lacking.

The epidemiological relevance of the COVID-19-vaccinated population is increasing
The Lancet; Kampf G.

Dec 1st, 2021 - High COVID-19 vaccination rates were expected to reduce transmission of SARS-CoV-2 in populations by reducing the number of possible sources for transmission and thereby to reduce the burden of COVID-19 disease. Recent data, however, indicate that the epidemiological relevance of COVID-19 vaccinated individuals is increasing. In the UK it was described that secondary attack rates among househol...

Call to apply a consistent scale in public COVID-19 reporting
The Lancet; Kampf G.

Dec 1st, 2021 - The Robert Koch-Institute in Germany regularly reports about the national COVID-19 situation and population-based vaccination level. But a consistent scale is not used. A person is classified as “COVID-19 case” whenever tested positive for SARS-CoV-2 irrespective of any symptoms. But symptomatic fully vaccinated COVID-19 patients are described as “probable breakthrough infection”

Where did ‘weird’ Omicron come from?
Science Kupferschmidt K.

Dec 1st, 2021 - Since South African scientists announced last week they had identified an unsettling new variant of SARS-CoV-2, the world has anxiously awaited clues about how it might change the trajectory of the pandemic. But as big a mystery—if less urgent—is where and how Omicron evolved, and what lessons its emergence holds for avoiding future dangerous variants.

First Alternative to Eye Injections for Age-related Macular Degeneration Shown Effective
American Academy of Ophthalmology

Nov 15th, 2021 - NEW ORLEANS, La. – An implant that delivers medication to the back of the eye was found to effectively treat age-related macular degeneration (AMD) for at least six months. This represents a vast improvement over the typical regimen of nearly monthly eye injections. The implant offers more than convenience for patients and physicians, it provides an opportunity for more consistent treatment so ...

EU lists rare spinal condition as side effect of J&J COVID-19 shot
MDedge Reuters Staff

Nov 12th, 2021 - (Reuters) - Europe’s drug regulator has recommended adding a rare type of spinal inflammation called transverse myelitis as a side-effect of Johnson & Johnson’s single-dose COVID-19 vaccine. Reports of this serious neurological illness were also at the heart of trial halts in the early stages of development for both AstraZeneca and J&J’s shots, which are based on similar technology.

Global Progress Against Measles Threatened Amidst COVID-19 Pandemic
Centers for Disease Control and Prevention (CDC)

Nov 10th, 2021 - The largest increase in unvaccinated children in 20 years and critical gaps in disease surveillance increase risk of measles outbreaks, putting lives at risk: WHO, CDC

Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants
BioRxiv Tada T, Zhou H et. al.

Jul 19th, 2021 - The increasing prevalence of SARS-CoV-2 variants has raised concerns regarding possible decreases in vaccine efficacy. Here, neutralizing antibody titers elicited by mRNA-based and an adenoviral vector-based vaccine against variant pseudotyped viruses were compared.

DSHS Statement on Monkeypox Investigation
Texas Health and Human Services

Jul 16th, 2021 - The Texas Department of State Health Services is working with Dallas County Health and Human Services and the CDC to investigate a single case of monkeypox virus infection in a Dallas County resident who recently returned from Nigeria. The patient is isolated in the hospital, and the public health investigation has identified a few people who may have been exposed in Dallas and are monitoring t...

CDC and Texas Confirm Monkeypox In U.S. Traveler
Centers for Disease Control and Prevention (CDC)

Jul 16th, 2021 - The Centers for Disease Control and Prevention (CDC) and the Texas Department of State Health Services confirmed on July 15 a case of human monkeypox in a U.S. resident who recently traveled from Nigeria to the United States. The person is currently hospitalized in Dallas. CDC is working with the airline and state and local health officials to contact airline passengers and others who may have ...

SARS-CoV-2 vaccine protection and deaths among US veterans during 2021
Science Cohn BA, .

Nov 4th, 2021 - The messenger RNA vaccines BNT162b2 (Pfizer–BioNTech) and mRNA-1273 (Moderna) and the viral vector vaccine JNJ-78436735 (Janssen) have effectively prevented clinically significant disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since their rollout in the U.S. in late 2020 (1, 2).

In Covid-19 vaccinated people, those with prior infection likely to have more antibodies

Nov 1st, 2021 - In what is believed to be one of the largest studies of its kind, Johns Hopkins Medicine researchers have shown that antibody levels against SARS-CoV-2 (the COVID-19 virus) stay more durable — that is, remain higher over an extended period of time — in people who were infected by the virus and then received protection from two doses of messenger RNA (mRNA) vaccine compared with those who only g...

Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study
The Lancet Infectious Diseases; Singanayagam A, .

Oct 29th, 2021 - The SARS-CoV-2 delta (B.1.617.2) variant is highly transmissible and spreading globally, including in populations with high vaccination rates. We aimed to investigate transmission and viral load kinetics in vaccinated and unvaccinated individuals with mild delta variant infection in the community.

Is It Ethical to Turn Away New Patients Who Refuse COVID-19 Vaccinations?
Medscape Wilner AN, Pies RW.

Oct 20th, 2021 - The ongoing pandemic has raised complex, often troubling ethical issues for medical professionals. In addition to the enormous emotional and logistical burdens imposed by caring for those with COVID-19, there is now the stress and ambivalence in dealing with patients who have refused vaccination against SARS-CoV-2 infection. In this dialogue, neurologist Dr Andrew N. Wilner and psychiatrist/...

Heterologous SARS-CoV-2 Booster Vaccinations – Preliminary Report
Medrxiv Atmar RL, .

Oct 13th, 2021 - Background: While Coronavirus disease 2019 (Covid-19) vaccines are highly effective, breakthrough infections are occurring. Booster vaccinations have recently received emergency use authorization (EUA) for certain populations but are restricted to homologous mRNA vaccines. We evaluated homologous and heterologous booster vaccination in persons who had received an EUA Covid-19 vaccine regimen.

Levetiracetam - levetiracetam tablet, film coated-Solco Healthcare US, LLC

Jan 8th, 2022 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older (1.1) Levetiracetam is indicated for adjunctive therapy for the treatment of: •Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy (1.2) •Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilep...

Dimethyl fumarate - dimethyl fumarate kit-Lupin Pharmaceuticals, Inc.

Dec 10th, 2021 - Dimethyl fumarate is indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults. Dimethyl fumarate is indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active s...

Physicians may be overprescribing immunotherapy for unfit cancer patients
Katie Robinson

Dec 7th, 2021 - The use of immune checkpoint inhibitors for cancer patients with advanced disease may be contradictory and cause more harm than good, according to a new study in JAMA Oncology. The study, by Ravi B.

FDA Picks Apart Drug for Alport Syndrome CKD Ahead of Advisory Meeting

Dec 7th, 2021 - FDA staff raised doubts over bardoxolone methyl as a treatment for chronic kidney disease (CKD) caused by Alport syndrome, citing trial-design issues and questioning the drug's efficacy in briefing documents released ahead of a Cardiovascular and Renal Drugs Advisory Committee meeting on Wednesday. Agency reviewers weren't sold on the design of developer Reata Pharmaceuticals' phase III CARDINA...