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About 59,183 results

Delta reinfection risk low among unvaccinated children
https://www.nature.com/articles/d41586-022-01763-3
Nature Ledford H.

Jun 29th, 2022 - Children and adolescents who had not been vaccinated against COVID-19 mounted a long-lasting immune response to infection with the Delta variant of the coronavirus SARS-CoV-2, according to a large study of Israeli health records1. The study, which has been published as a preprint on medRxiv, has not yet been peer reviewed.

COVID and smell loss: answers begin to emerge
https://www.nature.com/articles/d41586-022-01589-z
Nature Marshall M.

Jun 9th, 2022 - Researchers are finally making headway in understanding how the SARS-CoV-2 coronavirus causes loss of smell. And a multitude of potential treatments to tackle the condition are undergoing clinical trials, including steroids and blood plasma.

Ambient air pollution and COVID-19 risk: Evidence from 35 observational studies
https://www.sciencedirect.com/science/article/pii/S0013935121013608?via=ihub
Environmental Research; Zang ST, .

Mar 30th, 2022 - Coronavirus disease 2019 (COVID-19) is induced by a previously undiscovered coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Lu et al., 2020). Since SARS-CoV-2 was first discovered in December 2019, as of April 25, 2021, more than four million fatalities have been attributed to COVID-19, accounting for approximately 2% of the infected cases (>214 million)...

Coronavirus (COVID-19) Update: FDA Recommends Inclusion of Omicron BA.4/5 Component for COVID-19 Vaccine Booster Doses | FDA
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-recommends-inclusion-omicron-ba45-component-covid-19-vaccine-booster

Jun 30th, 2022 - For Immediate Release: June 30, 2022 Statement From: Peter Marks, M.D., PhD. Director - Center for Biologics Evaluation and Research (CBER) On Tuesday, the U.S. Food and Drug Administration’s independent experts on the Vaccines and Related Biological Products Advisory Committee met to publicly discuss whether a change to the current vaccine strain composition of COVID-19 vaccines for booster do...

Dementia prevalence, a contextual factor associated with SARS-CoV-2 in veterans affairs...
https://doi.org/10.1111/jgs.17945
Journal of the American Geriatrics Society; Bayer TA, DeVone F et. al.

Jun 30th, 2022 - Alzheimer's disease and related dementias (ADRD) impact the diagnosis and infection control of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in nursing homes (NH) by influencing the behavior of residents and their caregivers. Health system data show an association between ADRD and SARS-CoV-2. Whether this association is present in NH populations remains unknown. How increased SAR...

Early spontaneous breathing for acute respiratory distress syndrome in individuals with...
https://doi.org/10.1002/14651858.CD015077
The Cochrane Database of Systematic Reviews; Hohmann F, Wedekind L et. al.

Jun 30th, 2022 - Acute respiratory distress syndrome (ARDS) represents the most severe course of COVID-19 (caused by the SARS-CoV-2 virus), usually resulting in a prolonged stay in an intensive care unit (ICU) and high mortality rates. Despite the fact that most affected individuals need invasive mechanical ventilation (IMV), evidence on specific ventilation strategies for ARDS caused by COVID-19 is scarce. Spo...

BNT162b2 Vaccine Effectiveness against Omicron in Children 5 to 11 Years of Age.
https://doi.org/10.1056/NEJMoa2205011
The New England Journal of Medicine; Cohen-Stavi CJ, Magen O et. al.

Jun 30th, 2022 - Limited evidence is available on the real-world effectiveness of the BNT162b2 vaccine against coronavirus disease 2019 (Covid-19) and specifically against infection with the omicron variant among children 5 to 11 years of age. Using data from the largest health care organization in Israel, we identified a cohort of children 5 to 11 years of age who were vaccinated on or after November 23, 2021,...

Data-Driven Commentary on SARS-CoV-2 Infection, Vaccination, and Fertility.
https://doi.org/10.1093/aje/kwac073
American Journal of Epidemiology; Klipstein S, Dionne JA et. al.

Jun 30th, 2022 - A recent study by Wesselink et al. (Am J Epidemiol. 2022;191(XX):XXXX-XXXX) adds to the growing body of research finding that vaccination for coronavirus disease 2019 (COVID-19) is safe for individuals either seeking pregnancy or who are pregnant. The study's authors found no effect of COVID-19 vaccination on fecundity in a population of individuals with no known infertility who were attempting...

SARS-CoV-2 and Guillain-Barré Syndrome: Lessons from Viral Infections.
https://doi.org/10.1089/vim.2021.0187
Viral Immunology; Meidaninikjeh S, Sabouni N et. al.

Jun 30th, 2022 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. COVID-19 has a broad clinical spectrum from asymptomatic patients to multiorgan dysfunction and septic shock. Most of the common symptoms of COVID-19 are classified as respiratory disorders, but some reports show neurological involvements. During the COVID-19 pandemic, a case series of neurolo...

Trends in Telehealth Antibiotic Prescribing for Children Through the COVID-19 Pandemic.
https://doi.org/10.1542/peds.2022-056209
Pediatrics Payvandi L, Correa ET et. al.

Jun 30th, 2022 - Telehealth visits increased significantly during the coronavirus disease 2019 (COVID-19) pandemic without consensus on the appropriate scope of telehealth antibiotic prescribing within pediatric primary care. We describe telehealth antibiotic prescribing patterns within our statewide pediatric primary care network during the COVID-19 pandemic. In a retrospective observational study of a large s...

South Korea Approves First Domestically Developed COVID Vaccine
https://www.medscape.com/viewarticle/976355

Jun 30th, 2022 - SEOUL (Reuters) - South Korea approved its first domestically developed COVID-19 vaccine, manufactured by SK bioscience Co Ltd, for general public use following positive clinical data, authorities said on Wednesday. The SKYCovione vaccine was authorised for a two-dose regimen on people aged 18 or older, with shots given four weeks apart, according to the Ministry of Food and Drug Safety. In a p...

Vaccines for New COVID Variants Might Come Too Late
https://www.medscape.com/viewarticle/976441

Jun 30th, 2022 - Not surprisingly for an RNA virus, SARS-CoV-2 is proving its propensity for mutation. In swabs from infected patients, the proportion of the Omicron subvariant BA.4 is 2.1% (calendar week 21) compared with 1.2% in the previous week. In the same period of time, the frequency of subvariant BA.5 jumped up to 10.0%compared with 5.0% in the previous week. This dynamic leads to a crucial question: Wh...

Severe COVID-19 in Chronic Liver Disease Linked With Cholestasis and Secondary Sclerosing Cholangitis
https://www.medscape.com/viewarticle/976382

Jun 30th, 2022 - NEW YORK (Reuters Health) - Severe COVID-19 increases the risk for cholestasis and secondary sclerosing cholangitis (SSC) in patients with chronic liver disease (CLD), researchers say. Among 65 patients with preexisting CLD who were hospitalized for COVID-19, 23% developed cholestatic liver failure (cholestasis plus bilirubin at least 6mg/dL) and 15.4% developed SSC on the basis of cross-sectio...

Pfizer Plans a Vaccine to Target All Coronaviruses
https://www.medscape.com/viewarticle/976462

Jun 30th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Ask the sibling of any celebrity and they'll tell you they don't get anywhere near the same attention. The same is true for coronaviruses – the one that causes COVID-19 has been in the spotlight for more than 2 years now, while the others at the moment circulate in relative obscurity. With the k...

Mechanisms of host type I interferon response modulation by the nucleocapsid proteins o...
https://doi.org/10.1007/s00705-022-05513-8 10.1038/s41579-020-00468-6 10.1007/BF01317606 10.1016/j.vetmic.2016.11.029 10.1016/j.tvjl.2015.02.017 10.3389/fpubh.2020.00383 10.3390/molecules26010039 10.1007/s12250-021-00364-0 10.1128/JVI.00697-06 10.3389/fmicb.2019.01900 10.1038/s41467-021-26809-4 10.1016/j.cell.2021.06.008 10.7554/eLife.57309 10.3389/fvets.2021.744276 10.1038/s41586-020-2286-9 10.1038/s41590-021-01091-0 10.1128/mSystems.00336-21:e0033621 10.3390/pathogens9050367 10.1038/s41577-019-0165-0 10.3389/fimmu.2022.832394 10.1038/s41467-021-25015-6 10.1038/s41392-021-00575-7 10.1126/science.aat8657 10.1099/vir.0.051169-0 10.1038/s41586-022-04421-w 10.1038/nri3581 10.1016/j.bcp.2020.114316 10.1016/j.bcp.2022.115026 10.1016/j.it.2020.10.005 10.1016/j.it.2021.10.009 10.1016/j.cell.2021.02.029 10.1016/j.coviro.2021.08.004 10.1016/j.virusres.2016.05.015 10.3390/v13061115 10.1016/j.antiviral.2013.12.009 10.3390/v6082991 10.1016/j.csbj.2021.01.032 10.1371/journal.pone.0212632 10.1128/JVI.00687-21 10.2217/fvl-2018-0008 10.1016/j.molcel.2020.11.025 10.1038/s41467-020-20768-y 10.1016/j.jprot.2022.104501 10.1016/j.febslet.2005.03.039 10.1016/j.virol.2017.11.020 10.1128/JVI.00700-14 10.3389/fimmu.2021.688758 10.1007/s00705-020-04747-8 10.1080/15548627.2019.1707487 10.1128/JVI.00645-21 10.1007/s00705-021-05080-4 10.3390/v13010047 10.3390/v13081439 10.1038/s41467-020-17665-9 10.3390/cells10030530 10.1038/s41556-021-00710-0 10.1016/j.celrep.2020.108234 10.1038/s41392-022-00878-3 10.3390/v12090984 10.1038/s41421-021-00275-0 10.1016/j.jmb.2022.167516 10.1038/s41421-020-00208-3 10.1038/s41392-021-00742-w 10.1007/s40121-022-00633-9 10.1128/Spectrum.00908-21 10.15252/embj.2020105938 10.1042/BSR20211491 10.1128/mBio.01316-21
Archives of Virology; Yelemali P, Hao L et. al.

Jun 29th, 2022 - Coronaviruses can have a devastating impact on the health of humans and animals. Porcine epidemic diarrhea virus (PEDV) causes extremely high fatality rates in neonatal piglets, whereas severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic in humans. As a critical component of the host antiviral innate immune response, type I interferon pr...

Limb ischemia due to spontaneous heparin-induced thrombocytopenia as the primary presen...
https://doi.org/10.1007/s11239-022-02676-8 10.1056/NEJMcp1411910 10.1111/jth.13813 10.1111/jth.14411 10.1136/bcr-2019-232769 10.1080/09537104.2017.1366973 10.1016/J.ARTD.2021.03.005 10.1016/j.amjmed.2008.03.012 10.1016/j.thromres.2020.08.017 10.1111/jth.15283 10.1056/nejmoa2104882 10.1182/blood-2014-01-549741 10.1136/BCR-2021-243315 10.1111/trf.16226 10.1182/bloodadvances.2021005314 10.1111/trf.15105 10.1182/blood-2017-04-778993
Journal of Thrombosis and Thrombolysis; Shiuan E, Sharma D et. al.

Jun 29th, 2022 - Heparin-induced thrombocytopenia (HIT) occurs with the development of IgG antibodies that bind complexes of heparin and platelet factor 4 (PF4), which activate platelets and result in a profoundly prothrombotic condition. In rare instances, this syndrome develops in the absence of proximate heparin administration, referred to as spontaneous HIT, for which less than three dozen cases have been r...

Effect of Chemokine Gene Variants on Covid-19 Disease Severity.
https://doi.org/10.1080/08820139.2022.2088383
Immunological Investigations; Dogan S, Mart Komurcu SZ et. al.

Jun 29th, 2022 - Patients immune phenotype/genotype data may be useful to understand the molecular mechanisms involved in SARS-CoV-2 infection and can contribute to the identify the different levels of disease severity. The roles of chemokines have been reported in the coronavirus-related diseases SARS and MERS and they may likewise play a critical role in the development of the symptoms of COVID-19 disease. We...

Characterization of a thermostable Cas13 enzyme for one-pot detection of SARS-CoV-2.
https://doi.org/10.1073/pnas.2118260119
Proceedings of the National Academy of Sciences of the Un... Mahas A, Marsic T et. al.

Jun 29th, 2022 - Type VI CRISPR-Cas systems have been repurposed for various applications such as gene knockdown, viral interference, and diagnostics. However, the identification and characterization of thermophilic orthologs will expand and unlock the potential of diverse biotechnological applications. Herein, we identified and characterized a thermostable ortholog of the Cas13a family from the thermophilic or...

Rapid self-test of unprocessed viruses of SARS-CoV-2 and its variants in saliva by port...
https://doi.org/10.1073/pnas.2206521119
Proceedings of the National Academy of Sciences of the Un... Ban DK, Bodily T et. al.

Jun 29th, 2022 - We have developed a DNA aptamer-conjugated graphene field-effect transistor (GFET) biosensor platform to detect receptor-binding domain (RBD), nucleocapsid (N), and spike (S) proteins, as well as viral particles of original Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus and its variants in saliva samples. The GFET biosensor is a label-free, rapid (≤20 min), ultrasensit...

The dynamics of SARS-CoV-2 infectivity with changes in aerosol microenvironment.
https://doi.org/10.1073/pnas.2200109119
Proceedings of the National Academy of Sciences of the Un... Oswin HP, Haddrell AE et. al.

Jun 29th, 2022 - Understanding the factors that influence the airborne survival of viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in aerosols is important for identifying routes of transmission and the value of various mitigation strategies for preventing transmission. We present measurements of the stability of SARS-CoV-2 in aerosol droplets (∼5 to 10 µm equilibrated radius) over ...