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About 196,952 results

Primary angiitis of the central nervous system: description of the first fifty-two adul...
https://doi.org/10.1002/art.38340
Arthritis & Rheumatology (Hoboken, N.J.); de Boysson H, Zuber M et. al.

May 1st, 2014 - To describe characteristics and outcomes of a multicenter cohort of patients diagnosed as having primary angiitis of the central nervous system (PACNS). In 2010, we initiated a cohort study of adults diagnosed as having PACNS ≤15 years ago and with followup of >6 months (unless they died earlier of biopsy-proven PACNS). Its first analysis was planned at 2 years. Multidisciplinary investigators ...

Use of Vibrio cholerae vaccine in an outbreak in Guinea.
https://doi.org/10.1056/NEJMoa1312680
The New England Journal of Medicine; Luquero FJ, Grout L et. al.

May 29th, 2014 - The use of vaccines to prevent and control cholera is currently under debate. Shanchol is one of the two oral cholera vaccines prequalified by the World Health Organization; however, its effectiveness under field conditions and the protection it confers in the first months after administration remain unknown. The main objective of this study was to estimate the short-term effectiveness of two d...

Ultrasonography of the colon in pediatric ulcerative colitis: a prospective, blind, com...
https://doi.org/10.1016/j.jpeds.2014.02.055
The Journal of Pediatrics; Civitelli F, Di Nardo G et. al.

Apr 14th, 2014 - To evaluate the usefulness of colonic ultrasonography (US) in assessing the extent and activity of disease in pediatric ulcerative colitis (UC) and to compare US findings with clinical and endoscopic features. Consecutive pediatric patients (n = 60) with a diagnosis of UC and suspected disease flare-up were prospectively enrolled; of these, 50 patients were eligible for the study. All underwent...

Event-free survival at 24 months is a robust end point for disease-related outcome in d...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965261
Journal of Clinical Oncology : Official Journal of the Am... Maurer MJ, Ghesquières H et. al.

Feb 19th, 2014 - Studies of diffuse large B-cell lymphoma (DLBCL) are typically evaluated by using a time-to-event approach with relapse, re-treatment, and death commonly used as the events. We evaluated the timing and type of events in newly diagnosed DLBCL and compared patient outcome with reference population data. Patients with newly diagnosed DLBCL treated with immunochemotherapy were prospectively enrolle...

A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depres...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200497
Neuropsychopharmacology : Official Publication of the Ame... Brown ES, Park J et. al.

Jun 11th, 2014 - Depression in bipolar disorder (BPD) is challenging to treat. Therefore, additional medication options are needed. In the current report, the effect of the neurosteroid pregnenolone on depressive symptoms in BPD was examined. Adults (n=80) with BPD, depressed mood state, were randomized to pregnenolone (titrated to 500 mg/day) or placebo, as add-on therapy, for 12 weeks. Outcome measures includ...

Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698790
JAMA Hsieh MM, Fitzhugh CD et. al.

Jul 24th, 2014 - Myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) is curative for children with severe sickle cell disease, but toxicity may be prohibitive for adults. Nonmyeloablative transplantation has been attempted with degrees of preparative regimen intensity, but graft rejection and graft-vs-host disease remain significant. To determine the efficacy, safety, and outcome on end-orga...

Contributions of the social environment to first-onset and recurrent mania.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206672
Molecular Psychiatry; Gilman SE, Ni MY et. al.

Apr 22nd, 2014 - In treated cohorts, individuals with bipolar disorder are more likely to report childhood adversities and recent stressors than individuals without bipolar disorder; similarly, in registry-based studies, childhood adversities are more common among individuals who later become hospitalized for bipolar disorder. Because these types of studies rely on treatment-seeking samples or hospital diagnose...

Actionable diagnosis of neuroleptospirosis by next-generation sequencing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134948
The New England Journal of Medicine; Wilson MR, Naccache SN et. al.

Jun 4th, 2014 - A 14-year-old boy with severe combined immunodeficiency presented three times to a medical facility over a period of 4 months with fever and headache that progressed to hydrocephalus and status epilepticus necessitating a medically induced coma. Diagnostic workup including brain biopsy was unrevealing. Unbiased next-generation sequencing of the cerebrospinal fluid identified 475 of 3,063,784 se...

Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy.
https://doi.org/10.1056/NEJMoa1307362
The New England Journal of Medicine; Navon Elkan P, Pierce SB et. al.

Feb 20th, 2014 - Polyarteritis nodosa is a systemic necrotizing vasculitis with a pathogenesis that is poorly understood. We identified six families with multiple cases of systemic and cutaneous polyarteritis nodosa, consistent with autosomal recessive inheritance. In most cases, onset of the disease occurred during childhood. We carried out exome sequencing in persons from multiply affected families of Georgia...

Antidepressant use in pregnancy and the risk of cardiac defects.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062924
The New England Journal of Medicine; Huybrechts KF, Palmsten K et. al.

Jun 18th, 2014 - Whether the use of selective serotonin-reuptake inhibitors (SSRIs) and other antidepressants during pregnancy is associated with an increased risk of congenital cardiac defects is uncertain. In particular, there are concerns about a possible association between paroxetine use and right ventricular outflow tract obstruction and between sertraline use and ventricular septal defects. We performed ...

Pediatric mycosis fungoides in Singapore: a series of 46 children.
https://doi.org/10.1111/pde.12352
Pediatric Dermatology; Heng YK, Koh MJ et. al.

Jun 3rd, 2014 - Few studies have evaluated Asian children with mycosis fungoides (MF). We report a series of patients from a tertiary dermatologic institution in Singapore. A retrospective review was performed of patients younger than 16 years old diagnosed with MF between 2000 and 2008 at the National Skin Centre, Singapore. Forty-six patients were identified. At initial presentation, a provisional diagnosis ...

Clinical picture and treatment of 2212 patients with common variable immunodeficiency.
https://doi.org/10.1016/j.jaci.2013.12.1077
The Journal of Allergy and Clinical Immunology; Gathmann B, Mahlaoui N et. al.

Mar 3rd, 2014 - Common variable immunodeficiency (CVID) is an antibody deficiency with an equal sex distribution and a high variability in clinical presentation. The main features include respiratory tract infections and their associated complications, enteropathy, autoimmunity, and lymphoproliferative disorders. This study analyzes the clinical presentation, association between clinical features, and differen...

Spread of artemisinin resistance in Plasmodium falciparum malaria.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143591
The New England Journal of Medicine; Ashley EA, Dhorda M et. al.

Jul 30th, 2014 - Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria. Mapping the geographic extent of resistance is essential for planning containment and elimination strategies. Between May 2011 and April 2013, we enrolled 1241 adults and children with acute, uncomplicated falciparum malaria in an open-label trial at 15...

Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a...
https://doi.org/10.1016/S0140-6736(14)61185-5
Lancet (London, England); Chang LJ, Dowd KA et. al.

Aug 18th, 2014 - Chikungunya virus--a mosquito-borne alphavirus--is endemic in Africa and south and southeast Asia and has recently emerged in the Caribbean. No drugs or vaccines are available for treatment or prevention. We aimed to assess the safety, tolerability, and immunogenicity of a new candidate vaccine. VRC 311 was a phase 1, dose-escalation, open-label clinical trial of a virus-like particle (VLP) chi...

Multidrug-resistant tuberculosis and culture conversion with bedaquiline.
https://doi.org/10.1056/NEJMoa1313865
The New England Journal of Medicine; Diacon AH, Pym A et. al.

Aug 20th, 2014 - Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial ATP synthase, has been associated with accelerated sputum-culture conversion in patients with multidrug-resistant tuberculosis, when added to a preferred background regimen for 8 weeks. In this phase 2b trial, we randomly assigned 160 patients with newly diagnosed, smear-positive, multidrug-resistant tuberculosis to re...

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191900
The New England Journal of Medicine; Roberts KG, Li Y et. al.

Sep 10th, 2014 - Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and ad...

Effect of a quadrivalent meningococcal ACWY glycoconjugate or a serogroup B meningococc...
https://doi.org/10.1016/S0140-6736(14)60842-4
Lancet (London, England); Read RC, Baxter D et. al.

Aug 25th, 2014 - Meningococcal conjugate vaccines protect individuals directly, but can also confer herd protection by interrupting carriage transmission. We assessed the effects of meningococcal quadrivalent glycoconjugate (MenACWY-CRM) or serogroup B (4CMenB) vaccination on meningococcal carriage rates in 18-24-year-olds. In this phase 3, observer-blind, randomised controlled trial, university students aged 1...

Surveillance for stage I nonseminoma testicular cancer: outcomes and long-term follow-u...
https://doi.org/10.1200/JCO.2013.53.5831
Journal of Clinical Oncology : Official Journal of the Am... Daugaard G, Gundgaard MG et. al.

Sep 30th, 2014 - To describe treatment results in a large cohort with stage I nonseminoma germ cell cancer (NSGCC) treated in a surveillance program. From January 1, 1984, to December 31, 2007, 1,226 patients with stage I NSGCC, including high-risk patients with vascular invasion, were observed in a surveillance program. The relapse rate after orchiectomy alone was 30.6% at 5 years. Presence of vascular invasio...

Ten-year follow-up after initiation of statin therapy in children with familial hyperch...
https://doi.org/10.1001/jama.2014.8892
JAMA Kusters DM, Avis HJ et. al.

Sep 9th, 2014 - Ten-year follow-up after initiation of statin therapy in children with familial hypercholesterolemia.|2014|Kusters DM,Avis HJ,de Groot E,Wijburg FA,Kastelein JJ,|therapeutic use,blood,drug therapy,blood,therapeutic use,

Dietary elimination therapy is an effective option for adults with eosinophilic esophag...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102669
Clinical Gastroenterology and Hepatology : the Official C... Wolf WA, Jerath MR et. al.

Jan 20th, 2014 - Eosinophilic esophagitis (EoE) is an immune-mediated disorder. Food elimination is an established treatment for children, but data in adults are limited. We aimed to determine the response of adults with EoE to dietary therapy. This was a retrospective cohort study using the University of North Carolina EoE database from 2006 to 2012. Subjects were age 18 and older, had EoE by consensus guideli...