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About 42,950 results

Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lym...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973325
Nature Compagno M, Lim WK et. al.

May 4th, 2009 - Diffuse large B-cell lymphoma (DLBCL), the most common form of lymphoma in adulthood, comprises multiple biologically and clinically distinct subtypes including germinal centre B-cell-like (GCB) and activated B-cell-like (ABC) DLBCL. Gene expression profile studies have shown that its most aggressive subtype, ABC-DLBCL, is associated with constitutive activation of the NF-kappaB transcription c...

Reactivity to the p305 Epitope of the α1G T-Type Calcium Channel and Autoimmune-Associa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599413
Journal of the American Heart Association; Markham AJ, Rasmussen SE et. al.

May 22nd, 2015 - Only 2% of mothers positive for anti-SSA/Ro (Ro) antibodies have children with congenital heart block (CHB). This study aimed to determine whether reactivity with p305, an epitope within the α1G T-type calcium channel, confers added risk over anti-Ro antibodies. Using sera from anti-Ro-exposed pregnancies resulting in offspring with CHB, no disease but CHB-sibling, and no disease and no CHB-sib...

Neutral antibodies to the TSH receptor are present in Graves' disease and regulate sele...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954721
Endocrinology Morshed SA, Ando T et. al.

Sep 16th, 2010 - TSH receptor (TSHR) antibodies (Abs) may be stimulating, blocking, or neutral in their functional influences and are found in patients with autoimmune thyroid disease, especially Graves' disease (GD). Stimulators are known to activate the thyroid epithelial cells via both Gs- and Gq-coupled signaling pathways, whereas blockers inhibit the action of TSH and may act as weak agonists. However, TSH...

Synergistic growth inhibition of squamous cell carcinoma of the head and neck by erloti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744235
Cancer Prevention Research (Philadelphia, Pa.); Amin AR, Khuri FR et. al.

May 27th, 2009 - We have previously reported that the green tea polyphenol epigallocatechin-3-gallate (EGCG) and the epidermal growth factor receptor-tyrosine kinase inhibitor erlotinib had synergistic growth-inhibitory effects in cell culture and a nude mouse xenograft model of squamous cell carcinoma of the head and neck. However, the mechanism of their antitumor synergism is not fully understood. In the curr...

Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904512
Cancer Cell; Gregory MA, Phang TL et. al.

Jul 8th, 2010 - Although Bcr-Abl kinase inhibitors have proven effective in the treatment of chronic myeloid leukemia (CML), they generally fail to eradicate Bcr-Abl(+) leukemia cells. To identify genes whose inhibition sensitizes Bcr-Abl(+) leukemias to killing by Bcr-Abl inhibitors, we performed an RNAi-based synthetic lethal screen with imatinib mesylate in CML cells. This screen identified numerous compone...

Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulisin...
https://doi.org/10.1136/gut.2010.214841
Gut Ciccocioppo R, Bernardo ME et. al.

Jan 24th, 2011 - External fistulas represent a disabling manifestation of Crohn's disease with a difficult curability and a high relapse rate despite a large therapeutic armamentarium. Stem cell therapy is a novel and promising approach for treatment of chronic inflammatory conditions. We therefore investigated the feasibility, safety and efficacy of serial intrafistular injections of autologous bone marrow-der...

Monoclonal antibodies in the treatment of multiple myeloma: current status and future p...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777772
Leukemia Lonial S, Durie B et. al.

Aug 12th, 2015 - The treatment landscape for patients with multiple myeloma (MM) is constantly evolving. Over the past decade, the introduction of novel agents such as proteasome inhibitors and immunomodulatory drugs has led to notable changes in therapeutic strategy, and improvements in survival, yet MM remains incurable in the vast majority of cases. More recently, a targeted approach to MM treatment has emer...

Apoptosis is essential for neutrophil functional shutdown and determines tissue damage ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682662
PLoS Pathogens; Koedel U, Frankenberg T et. al.

May 29th, 2009 - During acute bacterial infections such as meningitis, neutrophils enter the tissue where they combat the infection before they undergo apoptosis and are taken up by macrophages. Neutrophils show pro-inflammatory activity and may contribute to tissue damage. In pneumococcal meningitis, neuronal damage despite adequate chemotherapy is a frequent clinical finding. This damage may be due to excessi...

Identification of apoptotic proteins in thyroid gland from patients with Graves' diseas...
https://doi.org/10.1080/08916930701727749
Autoimmunity Bossowski A, Czarnocka B et. al.

Mar 7th, 2008 - Apoptosis, i.e. natural programmed cell death, is a physiological phenomenon indispensable for normal functioning of the organism. The signal to apoptosis can be started practically in any cell. Disturbances in the apoptosis regulation determine the essential link of the pathogenesis of many diseases, including autoimmune thyroid disorders. The aim of the study was to assess the expression of F...

Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid ox...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867752
Proceedings of the National Academy of Sciences of the Un... Mitchell J, Paul P et. al.

Apr 6th, 2010 - We report a unique mutation in the D-amino acid oxidase gene (R199W DAO) associated with classical adult onset familial amyotrophic lateral sclerosis (FALS) in a three generational FALS kindred, after candidate gene screening in a 14.52 cM region on chromosome 12q22-23 linked to disease. Neuronal cell lines expressing R199W DAO showed decreased viability and increased ubiquitinated aggregates c...

Localized low-dose radiotherapy for follicular lymphoma: history, clinical results, mec...
https://doi.org/10.1016/j.ijrobp.2010.06.056
International Journal of Radiation Oncology, Biology, Phy... Ganem G, Cartron G et. al.

Oct 25th, 2010 - The extreme radiosensitivity of indolent lymphomas was reported in the early years of radiotherapy (RT). The efficacy of low-dose total body irradiation (1.5-2 Gy) was particularly demonstrative. Higher doses were considered appropriate for localized disease. The optimal (or conventional) dose of curative RT derived from the early studies was determined to be 30-35 Gy. Nevertheless, in older se...

Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacte...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136176
Immunity Clay H, Volkman HE et. al.

Aug 11th, 2008 - Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized aggregates of macrophages and other immune cells. Loss of TNF signaling causes progression of tuberculosis in humans, and the increased mortality of Mycobacterium tuberculosis-infected mice is associated with disorganized necrotic granulomas, al...

Sustained alpha-sarcoglycan gene expression after gene transfer in limb-girdle muscular...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970162
Annals of Neurology; Mendell JR, Rodino-Klapac LR et. al.

Oct 29th, 2010 - The aim of this study was to attain long-lasting alpha-sarcoglycan gene expression in limb-girdle muscular dystrophy, type 2D (LGMD2D) subjects mediated by adeno-associated virus (AAV) gene transfer under control of a muscle specific promoter (tMCK). rAAV1.tMCK.hSGCA (3.25 × 10¹¹ vector genomes) was delivered to the extensor digitorum brevis muscle of 3 subjects with documented SGCA mutations v...

Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257862
Nature Medicine; Hashizume R, Andor N et. al.

Nov 17th, 2014 - Pediatric brainstem gliomas often harbor oncogenic K27M mutation of histone H3.3. Here we show that GSKJ4 pharmacologic inhibition of K27 demethylase JMJD3 increases cellular H3K27 methylation in K27M tumor cells and demonstrate potent antitumor activity both in vitro against K27M cells and in vivo against K27M xenografts. Our results demonstrate that increasing H3K27 methylation by inhibiting ...

Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768793
Clinical Cancer Research : an Official Journal of the Ame... Kephart JJ, Tiller RG et. al.

Jun 13th, 2015 - Rhabdomyosarcoma (RMS) is a soft tissue sarcoma associated with the skeletal muscle lineage. Of the two predominant subtypes, known as embryonal (eRMS) and alveolar (aRMS), aRMS has the poorer prognosis, with a five-year survival rate of <50%. The majority of aRMS tumors express the fusion protein PAX3-FOXO1. As PAX3-FOXO1 has proven chemically intractable, this study aims to identify targetabl...

Immune deficiency disorders with autoimmunity and abnormalities in immune regulation-mo...
https://doi.org/10.1007/s12016-007-8038-x
Clinical Reviews in Allergy & Immunology; Lehman HK, Ballow M

Mar 11th, 2008 - Autoimmunity is frequently observed in patients with primary immune deficiency disorders. Monogenic autoimmune diseases include a group of disorders with characteristic autoimmunity and immune deficiency for which single gene defects have been identified. Currently recognized monogenic autoimmune diseases include autoimmune polyendocrinopathy candidiasis and ectodermal dystrophy, immunodysregul...

The role of defective clearance of apoptotic cells in systemic autoimmunity.
https://doi.org/10.1038/nrrheum.2010.46
Nature Reviews. Rheumatology; Muñoz LE, Lauber K et. al.

Apr 30th, 2010 - The inefficient clearance of dying cells can result in the accumulation of apoptotic cell remnants. This occurrence is considered an intrinsic defect that can cause the permanent presence of cellular debris responsible for the initiation of systemic autoimmunity in diseases such as systemic lupus erythematosus (SLE). If postapoptotic debris accumulates in germinal centers, activates complement ...

Lane-Hamilton syndrome: ferritin protects lung macrophages against iron and oxidation.
https://doi.org/10.1378/chest.10-0818
Chest Persson HL, Vainikka LK et. al.

Aug 13th, 2010 - Lysosomal disruption and consequent apoptosis have been implicated in lung diseases characterized by iron overload. Free reactive iron in lysosomes sensitizes cells to oxidative stress. Apoptosis is prevented by heavy-chain (H)-ferritin, which can incorporate lysosomal iron into ferritin molecules. Tumor necrosis factor (TNF)-α stimulates the synthesis of H-ferritin. Idiopathic pulmonary hemosi...

Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas.
https://doi.org/10.1016/S1470-2045(08)70125-6
The Lancet. Oncology; Brandsma D, Stalpers L et. al.

May 2nd, 2008 - Since the introduction of chemoradiotherapy with temozolomide as the new standard of care for patients with glioblastoma, there has been an increasing awareness of progressive and enhancing lesions on MRI, noted immediately after the end of treatment, which are not related to tumour progression, but which are a treatment effect. This so-called pseudoprogression can occur in up to 20% of patient...

Distinct mechanisms of inadequate erythropoiesis induced by tumor necrosis factor alpha...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363658
PloS One; Lamikanra AA, Merryweather-Clarke AT et. al.

Mar 17th, 2015 - The role of infection in erythropoietic dysfunction is poorly understood. In children with P. falciparum malaria, the by-product of hemoglobin digestion in infected red cells (hemozoin) is associated with the severity of anemia which is independent of circulating levels of the inflammatory cytokine tumor necrosis alpha (TNF-α). To gain insight into the common and specific effects of TNF-α and h...