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About 38,570 results

Eosinophilic esophagitis in adults is associated with IgG4 and not mediated by IgE.
https://doi.org/10.1053/j.gastro.2014.05.036
Gastroenterology Clayton F, Fang JC et. al.

Jun 7th, 2014 - Eosinophilic esophagitis is usually triggered by foods, by unclear mechanisms. We evaluated the roles of IgE and IgG4 in the development of eosinophilic esophagitis. We performed a prospective, randomized, double-blind, placebo-controlled trial of adults with eosinophilic esophagitis given an antibody against IgE (omalizumab, n = 16) or placebo (n = 14) every 2-4 weeks for 16 weeks, based on we...

A comparison of tau and 14-3-3 protein in the diagnosis of Creutzfeldt-Jakob disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098812
Neurology Hamlin C, Puoti G et. al.

Jul 30th, 2012 - To compare the respective efficiency of CSF tau (quantitative) and CSF 14-3-3 protein (qualitative) in the diagnosis of prion disease. We made measurements on 420 live subjects, who subsequently underwent a postmortem neuropathology examination, including protein chemistry, immunohistochemistry, and histology. We performed tau by ELISA. We detected 14-3-3 protein by Western blot. Both assays we...

High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Fe...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848229
Clinical Infectious Diseases : an Official Publication Of... Olupot-Olupot P, Engoru C et. al.

Mar 31st, 2017 - In the Fluid Expansion as a Supportive Treatment (FEAST) trial, an unexpectedly high proportion of participants from eastern Uganda presented with blackwater fever (BWF). We describe the prevalence and outcome of BWF among trial participants and compare the prevalence of 3 malaria-protective red blood cell polymorphisms in BWF cases vs both trial (non-BWF) and population controls. Of 3170 trial...

Podocyte effacement closely links to suPAR levels at time of posttransplantation focal ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026282
Transplantation Alachkar N, Wei C et. al.

Jul 11th, 2013 - Focal segmental glomerulosclerosis (FSGS) recurs after kidney transplantation in more than 30% of cases and can lead to allograft loss. Serum soluble urokinase-type plasminogen activator receptor (suPAR) is implicated in the pathogenesis of native and recurrent FSGS. We conducted a retrospective study of 25 adults with posttransplantation FSGS. We investigated the relationship between suPAR lev...

Endothelial-to-mesenchymal transition in pulmonary hypertension.
https://doi.org/10.1161/CIRCULATIONAHA.114.008750
Circulation Ranchoux B, Antigny F et. al.

Jan 16th, 2015 - The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-smooth muscle actin-expressing cells. In situ evidence of EndoMT in human PAH was obtained by using con...

Fibroblast Growth Factor 23 and Kidney Disease Progression in Autosomal Dominant Polycy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586583
Clinical Journal of the American Society of Nephrology : ... Chonchol M, Gitomer B et. al.

Jul 14th, 2017 - Increases in fibroblast growth factor 23 precede kidney function decline in autosomal dominant polycystic kidney disease; however, the role of fibroblast growth factor 23 in autosomal dominant polycystic kidney disease has not been well characterized. We measured intact fibroblast growth factor 23 levels in baseline serum samples from 1002 participants in the HALT-PKD Study A (n=540; mean eGFR ...

Reactivity to the p305 Epitope of the α1G T-Type Calcium Channel and Autoimmune-Associa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599413
Journal of the American Heart Association; Markham AJ, Rasmussen SE et. al.

May 22nd, 2015 - Only 2% of mothers positive for anti-SSA/Ro (Ro) antibodies have children with congenital heart block (CHB). This study aimed to determine whether reactivity with p305, an epitope within the α1G T-type calcium channel, confers added risk over anti-Ro antibodies. Using sera from anti-Ro-exposed pregnancies resulting in offspring with CHB, no disease but CHB-sibling, and no disease and no CHB-sib...

Blood glucose and prognosis in children with presumed severe malaria: is there a thresh...
https://doi.org/10.1111/j.1365-3156.2009.02444.x
Tropical Medicine & International Health : TM & IH; Willcox ML, Forster M et. al.

Dec 7th, 2009 - Hypoglycaemia (glucose <2.2 mmol/l) is a defining feature of severe malaria, but the significance of other levels of blood glucose has not previously been studied in children with severe malaria. A prospective study of 437 consecutive children with presumed severe malaria was conducted in Mali. We defined hypoglycaemia as <2.2 mmol/l, low glycaemia as 2.2-4.4 mmol/l and hyperglycaemia as >8.3 m...

Determinants of survival in progressive multifocal leukoencephalopathy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777072
Neurology Marzocchetti A, Tompkins T et. al.

Nov 10th, 2009 - We sought to characterize the role of immunologic, virologic, and radiologic determinants of survival in patients with progressive multifocal leukoencephalopathy (PML). We recorded the clinical outcome of 60 patients with PML (73% HIV+) who were prospectively evaluated between 2000 and 2007 for the presence of JC virus (JCV)-specific CD8+ cytotoxic T-lymphocytes (CTL) in blood. Estimated probab...

Effect of azithromycin maintenance treatment on infectious exacerbations among patients...
https://doi.org/10.1001/jama.2013.1937
JAMA Altenburg J, de Graaff CS et. al.

Mar 27th, 2013 - Macrolide antibiotics have been shown beneficial in cystic fibrosis (CF) and diffuse panbronchiolitis, and earlier findings also suggest a benefit in non-CF bronchiectasis. To determine the efficacy of macrolide maintenance treatment for adults with non-CF bronchiectasis. The BAT (Bronchiectasis and Long-term Azithromycin Treatment) study, a randomized, double-blind, placebo-controlled trial co...

The utility of biomarkers in the diagnosis and therapy of inflammatory bowel disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749298
Gastroenterology Lewis JD

May 2nd, 2011 - Fecal and serologic biomarkers can be used in the diagnosis and management of inflammatory bowel disease (IBD). Fecal markers such as calprotectin and lactoferrin have been studied for their ability to identify patients with IBD, assess disease activity, and predict relapse. Antibodies against Saccharomyces cerevisiae and perinuclear antineutrophil cytoplasmic proteins have been used in diagnos...

Good outcome of interstitial lung disease in patients with scleroderma associated to an...
https://doi.org/10.1016/j.semarthrit.2014.07.002
Seminars in Arthritis and Rheumatism; Guillen-Del Castillo A, Pilar Simeón-Aznar C et. al.

Aug 11th, 2014 - The objective of this article was to establish the clinical course of interstitial lung disease (ILD) in scleroderma related to the presence of anti-PM/Scl antibody compared with anti-Scl-70 in a Spanish cohort. Furthermore, no study has thoroughly investigated the outcome of pulmonary function test in the first group of patients. A total of 63 Spanish patients with scleroderma and ILD were sel...

Characterisation and utility of thiopurine methyltransferase and thiopurine metabolite ...
https://doi.org/10.1016/j.jhep.2009.10.004
Journal of Hepatology; Hindorf U, Jahed K et. al.

Nov 12th, 2009 - Corticosteroids alone or in conjunction with azathioprine (AZA) is the standard treatment in autoimmune hepatitis (AiH). Individual variations in thiopurine (TP) metabolism may affect both drug efficacy and toxicity. Our aim was to investigate the utility of thiopurine methyltransferase (TPMT) as well as thioguanine nucleotide (TGN) and methylthioinosine monophosphate (meTIMP) metabolite measur...

PTH(1-84) administration reverses abnormal bone-remodeling dynamics and structure in hy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019384
Journal of Bone and Mineral Research : the Official Journ... Rubin MR, Dempster DW et. al.

Jul 7th, 2011 - Hypoparathyroidism is associated with abnormal structural and dynamic skeletal properties. We hypothesized that parathyroid hormone(1-84) [PTH(1-84)] treatment would restore skeletal properties toward normal in hypoparathyroidism. Sixty-four subjects with hypoparathyroidism were treated with PTH(1-84) for 2 years. All subjects underwent histomorphometric assessment with percutaneous iliac crest...

Time-dependent analysis of predisposing factors for the recurrence of hepatocellular ca...
https://doi.org/10.1111/j.1478-3231.2010.02252.x
Liver International : Official Journal of the Internation... Iwadou S, Nouso K et. al.

May 24th, 2010 - There are many reports dealing with the risk factors for hepatocellular carcinoma (HCC) recurrence. However, in most of these reported studies, factors were analysed only at the initial treatment stage, and the predisposing factors for the recurrence during follow-up have not been well studied. The aim of this study is to evaluate the predisposing factors after treatments. Two hundred and seven...

Is it safe to ligate the left renal vein during open abdominal aortic aneurysm repair?
https://doi.org/10.1016/j.avsg.2010.02.008
Annals of Vascular Surgery; Mehta T, Wade RG et. al.

Apr 23rd, 2010 - Open repair of juxta-renal abdominal aortic aneurysms (AAA) sometimes involves the ligation and division of the left renal vein (LRV). Some surgeons advocate repair, but this is not common practice. The aim was to study the effect of LRV ligation on renal function. A retrospective audit of all open AAA repairs between February 2004 and September 2007 in our unit was completed. Pre- and postoper...

Clinical and laboratory features that distinguish dengue from other febrile illnesses i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756447
Tropical Medicine & International Health : TM & IH; Potts JA, Rothman AL

Sep 22nd, 2008 - Clinicians in resource-poor countries need to identify patients with dengue using readily-available data. The objective of this systematic review was to identify clinical and laboratory features that differentiate dengue fever (DF) and/or dengue haemorrhagic fever (DHF) from other febrile illnesses (OFI) in dengue-endemic populations. Systematic review of the literature from 1990 to 30 October ...

Hyperferritinemia as a Diagnostic Marker for Severe Fever with Thrombocytopenia Syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350410
Disease Markers; Kim UJ, Oh TH et. al.

Mar 29th, 2017 - Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral disease in East Asia with high mortality. Few studies have examined markers that suggest SFTS in febrile patients. To determine useful biochemical markers for SFTS, patients aged 18 years or older with SFTS or microbiologically confirmed community-onset bacteremia with thrombocytopenia (BT) at presentation between June 2013...

Acquired and genetic complement abnormalities play a critical role in dense deposit dis...
https://doi.org/10.1038/ki.2012.63
Kidney International; Servais A, Noël LH et. al.

Mar 29th, 2012 - Dense deposit disease and glomerulonephritis with isolated C3 deposits are glomerulopathies characterized by deposits of C3 within or along the glomerular basement membrane. Previous studies found a link between dysregulation of the complement alternative pathway and the pathogenesis of these diseases. We analyzed the role of acquired and genetic complement abnormalities in a cohort of 134 pati...

A new leukocyte hyperadhesion syndrome of delayed cord separation, skin infection, and ...
https://doi.org/10.1542/peds.2013-0884
Pediatrics Simpson BN, Hogg N et. al.

Dec 17th, 2013 - Leukocyte adhesion deficiency (LAD) I is a well-described genetic disorder in which leukocytes are unable to migrate to sites of inflammation due to mutations in the ITGB2 gene coding for the β subunit of β2 (CD18) leukocyte integrins. The classic symptoms of the disease present in the newborn period as failure of separation of the umbilical cord and recurrent bacterial infections, which contin...