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About 33,410 results

Primary angiitis of the central nervous system: description of the first fifty-two adul...
https://doi.org/10.1002/art.38340
Arthritis & Rheumatology (Hoboken, N.J.); de Boysson H, Zuber M et. al.

May 1st, 2014 - To describe characteristics and outcomes of a multicenter cohort of patients diagnosed as having primary angiitis of the central nervous system (PACNS). In 2010, we initiated a cohort study of adults diagnosed as having PACNS ≤15 years ago and with followup of >6 months (unless they died earlier of biopsy-proven PACNS). Its first analysis was planned at 2 years. Multidisciplinary investigators ...

A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119497
The American Journal of Psychiatry; Phillips ML, Swartz HA

Mar 14th, 2014 - In this critical review, the authors appraise neuroimaging findings in bipolar disorder in emotion-processing, emotion-regulation, and reward-processing neural circuitry in order to synthesize the current knowledge of the neural underpinnings of bipolar disorder and provide a neuroimaging research road map for future studies. The authors examined findings from all major studies in bipolar disor...

The neuropsychiatry of tinnitus: a circuit-based approach to the causes and treatments ...
https://doi.org/10.1136/jnnp-2013-307339
Journal of Neurology, Neurosurgery, and Psychiatry; Minen MT, Camprodon J et. al.

Apr 19th, 2014 - Patients presenting with tinnitus commonly have neuropsychiatric symptoms with which physicians need to be familiar. We provide an overview of tinnitus, including its types and pathophysiology. We discuss how recent methods such as transcranial magnetic stimulation, positron emission tomography, MRI, magnetoencephalography and quantitative EEG improve our understanding of the pathophysiology of...

Actionable diagnosis of neuroleptospirosis by next-generation sequencing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134948
The New England Journal of Medicine; Wilson MR, Naccache SN et. al.

Jun 4th, 2014 - A 14-year-old boy with severe combined immunodeficiency presented three times to a medical facility over a period of 4 months with fever and headache that progressed to hydrocephalus and status epilepticus necessitating a medically induced coma. Diagnostic workup including brain biopsy was unrevealing. Unbiased next-generation sequencing of the cerebrospinal fluid identified 475 of 3,063,784 se...

A test for Creutzfeldt-Jakob disease using nasal brushings.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186748
The New England Journal of Medicine; Orrú CD, Bongianni M et. al.

Aug 7th, 2014 - Definite diagnosis of sporadic Creutzfeldt-Jakob disease in living patients remains a challenge. A test that detects the specific marker for Creutzfeldt-Jakob disease, the prion protein (PrP(CJD)), by means of real-time quaking-induced conversion (RT-QuIC) testing of cerebrospinal fluid has a sensitivity of 80 to 90% for the diagnosis of sporadic Creutzfeldt-Jakob disease. We have assessed the ...

Midlife migraine and late-life parkinsonism: AGES-Reykjavik study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180488
Neurology Scher AI, Ross GW et. al.

Sep 18th, 2014 - In the present study, we tested the hypothesis that having migraine in middle age is related to late-life parkinsonism and a related disorder, restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED). The AGES-Reykjavik cohort (born 1907-1935) has been followed since 1967. Headaches were classified based on symptoms assessed in middle age. From 2002 to 2006, 5,764 participants wer...

Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315021
The Lancet. Neurology; Byrne S, Elamin M et. al.

Feb 6th, 2012 - Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of upper and lower motor neurons, associated with frontotemporal dementia (FTD) in about 14% of incident cases. We assessed the frequency of the recently identified C9orf72 repeat expansion in familial and apparently sporadic cases of ALS and characterised the cognitive and clinical phenotype of patients with this ex...

A case of cerebrotendinous xanthomatosis presenting with epilepsy as an initial symptom...
https://doi.org/10.1016/j.clineuro.2012.01.032
Clinical Neurology and Neurosurgery; Koyama S, Kawanami T et. al.

Feb 17th, 2012 - A case of cerebrotendinous xanthomatosis presenting with epilepsy as an initial symptom with a novel V413D mutation in the CYP27A1 gene.|2012|Koyama S,Kawanami T,Tanji H,Arawaka S,Wada M,|pathology,therapeutic use,therapeutic use,genetics,blood,genetics,etiology,genetics,genetics,complications,drug therapy,genetics,

The Clinical Implications of Todd Paralysis in Children With Benign Rolandic Epilepsy.
https://doi.org/10.1177/0883073815589760
Journal of Child Neurology; Dai AI, Demiryürek S

Jun 10th, 2015 - The aim of this study was to describe the clinical and electroencephalographic (EEG) findings of postictal Todd paralysis in benign rolandic epilepsy of childhood and find out the possible correlation with migraine. Based on International Headache Society pediatric migraine criteria, patients were investigated for migraine, and 12 of the 108 patients with benign rolandic epilepsy (6 girls and 6...

Cerebral embolism of iodized oil (lipiodol) after transcatheter arterial chemoembolizat...
https://doi.org/10.1111/j.1552-6569.2009.00380.x
Journal of Neuroimaging : Official Journal of the America... Kim JT, Heo SH et. al.

Jun 5th, 2009 - Cerebral lipiodol embolism is a rare complication of transcatheter arterial chemoembolization (TACE). Its pathological mechanism remains ambiguous despite several investigations. In Case 1, a 67-year-old man with hepatocellular carcinoma (HCC) experienced neurological deficits soon after undergoing a fourth session of TACE. Computed tomography (CT) scan showed multiple hyperdense lesions along ...

Clinical, neuroradiological and genetic findings in pontocerebellar hypoplasia.
https://doi.org/10.1093/brain/awq287
Brain : a Journal of Neurology; Namavar Y, Barth PG et. al.

Oct 18th, 2010 - Pontocerebellar hypoplasia is a group of autosomal recessive neurodegenerative disorders with prenatal onset. The common characteristics are cerebellar hypoplasia with variable atrophy of the cerebellum and the ventral pons. Supratentorial involvement is reflected by variable neocortical atrophy, ventriculomegaly and microcephaly. Mutations in the transfer RNA splicing endonuclease subunit gene...

Biochemical correlates of neuropsychiatric illness in maple syrup urine disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613932
The Journal of Clinical Investigation; Muelly ER, Moore GJ et. al.

Mar 12th, 2013 - Maple syrup urine disease (MSUD) is an inherited disorder of branched chain amino acid metabolism presenting with neonatal encephalopathy, episodic metabolic decompensation, and chronic amino acid imbalances. Dietary management enables survival and reduces risk of acute crises. Liver transplantation has emerged as an effective way to eliminate acute decompensation risk. Psychiatric illness is a...

Physical treatments for bipolar disorder: a review of electroconvulsive therapy, stereo...
https://doi.org/10.1016/j.jad.2010.08.017
Journal of Affective Disorders; Loo C, Katalinic N et. al.

Sep 22nd, 2010 - Despite pharmacological advances, bipolar disorder continues to be difficult to treat. This article reviews the evidence base for the use of electroconvulsive therapy (ECT) and other brain stimulation therapies in bipolar disorder. The evidence base for the efficacy of ECT and transcranial magnetic stimulation in the treatment of mania, bipolar depression and mixed affective states was reviewed...

Alteration of dopamine D2/D3 receptor binding in patients with juvenile myoclonic epile...
https://doi.org/10.1111/j.1528-1167.2010.02569.x
Epilepsia Landvogt C, Buchholz HG et. al.

Apr 13th, 2010 - To quantify extrastriatal and striatal D2/D3 receptor binding in patients with juvenile myoclonic epilepsy (JME) using the high-affinity dopamine D2/D3 receptor positron emission tomography (PET) ligand (18) F-Fallypride ([(18) F]FP). Twelve patients with JME and 21 age-matched control subjects were studied. Dynamic images (180 min) were acquired after injection of [(18) F]FP. Patients had been...

Brain volume reductions within multiple cognitive systems in male preterm children at a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270939
The Journal of Pediatrics; Kesler SR, Reiss AL et. al.

Mar 18th, 2008 - To more precisely examine regional and subregional microstructural brain changes associated with preterm birth. We obtained brain volumes from 29 preterm children, age 12 years, with no ultrasound scanning evidence of intraventricular hemorrhage or cystic periventricular leukomalacia in the newborn period, and 22 age- and sex-matched term control subjects. Preterm male subjects demonstrated sig...

Severe hemorrhagic meningoencephalitis due to Angiostrongylus cantonensis among young c...
https://doi.org/10.1093/cid/cit444
Clinical Infectious Diseases : an Official Publication Of... Morton NJ, Britton P et. al.

Jul 11th, 2013 - Angiostrongylus cantonensis is the most common cause of eosinophilic meningitis worldwide. We describe 2 cases among young children from Sydney, Australia, where locally acquired infection of children has not been reported previously. Both cases manifested as severe hemorrhagic meningoencephalitis, one resulting in death. Angiostrongyliasis must be considered in acute neurological presentations...

Frequent occurrence of cerebral demyelination in adrenomyeloneuropathy.
https://doi.org/10.1212/WNL.0000000000001074
Neurology de Beer M, Engelen M et. al.

Nov 7th, 2014 - To study the frequency of additional cerebral demyelination in Dutch patients with adrenomyeloneuropathy (AMN). Consecutive patients with AMN from the Dutch X-linked adrenoleukodystrophy cohort without cerebral demyelination on MRI at inclusion, seen between January 1, 1992, and January 1, 1999, were included. Primary endpoints were brain involvement, death, or the end of follow-up on January 1...

Clinical features that distinguish PLS, upper motor neuron-dominant ALS, and typical ALS.
https://doi.org/10.1212/WNL.0b013e3181a8269b
Neurology Gordon PH, Cheng B et. al.

Jun 2nd, 2009 - To determine how clinical features at the first evaluation and in follow-up can be used to suggest a diagnostic outcome for patients with only upper motor neuron (UMN) signs at disease onset. We reviewed the records of 34 patients (9 primary lateral sclerosis [PLS], 15 UMN-dominant amyotrophic lateral sclerosis [ALS], and 10 randomly selected control patients with ALS) seen in 1984-2007. Analys...

Rheumatoid meningitis presenting with stroke-like episodes.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011466
Neurology Bourgeois P, Rivest J et. al.

Mar 21st, 2014 - Neurologic symptoms in patients with rheumatoid arthritis (RA) are most often caused by osseous compression, affecting the cervical spine or peripheral neurologic structures. CNS involvement in RA is infrequent, consisting of CNS vasculitis or meningitis with or without meningeal nodules.(1) When meningeal infiltration is seen, symptoms of presentation can include focal neurologic deficits, sei...

MRI parameters for prediction of multiple sclerosis diagnosis in children with acute CN...
https://doi.org/10.1016/S1474-4422(11)70250-2
The Lancet. Neurology; Verhey LH, Branson HM et. al.

Nov 9th, 2011 - Multiple sclerosis (MS) diagnostic criteria incorporate MRI features that can be used to predict later diagnosis of MS in adults with acute CNS demyelination. To identify MRI predictors of a subsequent MS diagnosis in a paediatric population, we created a standardised scoring method and applied it to MRI scans from a national prospective incidence cohort of children with CNS demyelination. Clin...