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About 93,556 results

Dietary and circulating vitamin D and risk of renal cell carcinoma: a meta-analysis of observational studies
https://pubmed.ncbi.nlm.nih.gov/33146974/
International Brazilian Journal of Urology; Wu J

May 31st, 2021 - This meta-analysis is the first to evaluate the associations of circulating and dietary intake of vitamin D with risk of risk of renal cell carcinoma (RCC). Our findings showed that higher circulating vitamin D level and dietary vitamin D intake were associated with a reduced risk of RCC. The possible explanation might be attributed to the anti-inflammatory effect, inhibiting cell proliferation...

Phosphodiesterase 5 inhibitors for pulmonary hypertension
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012621.pub2/full
Barnes,H.,et al

Jan 30th, 2019 - Pulmonary hypertension (PH) comprises a group of complex and heterogenous conditions, characterised by elevated pulmonary artery pressure, and which left untreated leads to right‐heart failure and death. PH includes World Health Organisation (WHO) Group 1 pulmonary arterial hypertension (PAH); Group 2 consists of PH due to left‐heart disease (PH‐LHD); Group 3 comprises PH as a result of lung di...

Inhibition of the mTORC pathway in the antiphospholipid syndrome.
https://doi.org/10.1056/NEJMoa1312890
The New England Journal of Medicine; Canaud G, Bienaimé F et. al.

Jul 23rd, 2014 - Although thrombosis is considered the cardinal feature of the antiphospholipid syndrome, chronic vascular lesions are common, particularly in patients with life-threatening complications. In patients who require transplantation, vascular lesions often recur. The molecular pathways involved in the vasculopathy of the antiphospholipid syndrome are unknown, and adequate therapies are lacking. We u...

Transplantation outcomes for severe combined immunodeficiency, 2000-2009.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183064
The New England Journal of Medicine; Pai SY, Logan BR et. al.

Jul 30th, 2014 - The Primary Immune Deficiency Treatment Consortium was formed to analyze the results of hematopoietic-cell transplantation in children with severe combined immunodeficiency (SCID) and other primary immunodeficiencies. Factors associated with a good transplantation outcome need to be identified in order to design safer and more effective curative therapy, particularly for children with SCID diag...

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191900
The New England Journal of Medicine; Roberts KG, Li Y et. al.

Sep 10th, 2014 - Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and ad...

Oral calcitriol for the treatment of persistent proteinuria in immunoglobulin A nephrop...
https://doi.org/10.1053/j.ajkd.2007.12.038
American Journal of Kidney Diseases : the Official Journa... Szeto CC, Chow KM et. al.

Apr 25th, 2008 - Laboratory research and previous retrospective study suggest that vitamin D and its analogues have profound effects on immune system function and glomerular mesangial cell proliferation. We conducted an open-label study to evaluate the antiproteinuric effect of calcitriol on proteinuria in patients with immunoglobulin A (IgA) nephropathy. Open-label prospective uncontrolled trial. 10 patients (...

Benefit of consolidative radiation therapy in patients with diffuse large B-cell lympho...
https://doi.org/10.1200/JCO.2009.27.3441
Journal of Clinical Oncology : Official Journal of the Am... Phan J, Mazloom A et. al.

Aug 17th, 2010 - The current standard therapy for patients with diffuse large B-cell lymphoma (DLBCL) is rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). The role of consolidative radiation therapy (RT) in the setting of R-CHOP chemotherapy is not well reported. This retrospective analysis is an attempt to clarify this role. Subjects were 469 patients with histologically confi...

Histological diversity in cholangiocellular carcinoma reflects the different cholangioc...
https://doi.org/10.1002/hep.25595
Hepatology (Baltimore, Md.); Komuta M, Govaere O et. al.

Jan 24th, 2012 - Cholangiocellular carcinoma (CC) originates from topographically heterogeneous cholangiocytes. The cylindrical mucin-producing cholangiocytes are located in large bile ducts and the cuboidal non-mucin-producing cholangiocytes are located in ductules containing bipotential hepatic progenitor cells (HPCs). We investigated the clinicopathological and molecular features of 85 resected CCs (14 hilar...

Elevated levels of endothelin-1 in hepatic venous blood are associated with intrapulmon...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547862
Digestive Diseases and Sciences; Koch DG, Bogatkevich G et. al.

Oct 3rd, 2011 - Hepatopulmonary syndrome is a pulmonary vascular complication of cirrhosis in which intrapulmonary vasodilatation (IPV) results in hypoxemia. Endothelin-1 (ET-1), produced by proliferating cholangiocytes, has been identified as a mediator of IPV in an animal model of HPS, but the pathophysiology of IPV in humans has not been defined. The purpose of this study was to assess whether cirrhosis wit...

Pheochromocytomas: the (pseudo)-hypoxia hypothesis.
https://doi.org/10.1016/j.beem.2010.10.004
Best Practice & Research. Clinical Endocrinology & Metabo... Favier J, Gimenez-Roqueplo AP

Nov 30th, 2010 - Hypoxia and pheochromocytoma/paraganglioma have a long common history. Since the description, almost 40 years ago, of an increased incidence of head and neck paragangliomas in chronic hypoxia, discoveries on oxygen-sensing and on hereditary paraganglioma in the beginning of years 2000 provided the proof of concept of a strong link between these neuroendocrine tumors and the hypoxic pathway. It ...

Integrative genomics identifies LMO1 as a neuroblastoma oncogene.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320515
Nature Wang K, Diskin SJ et. al.

Dec 2nd, 2010 - Neuroblastoma is a childhood cancer of the sympathetic nervous system that accounts for approximately 10% of all paediatric oncology deaths. To identify genetic risk factors for neuroblastoma, we performed a genome-wide association study (GWAS) on 2,251 patients and 6,097 control subjects of European ancestry from four case series. Here we report a significant association within LIM domain only...

Neurofibromatosis type 1-related gastrointestinal stromal tumors: a special reference t...
https://doi.org/10.1007/s00432-008-0514-z
Journal of Cancer Research and Clinical Oncology; Yamamoto H, Tobo T et. al.

Nov 20th, 2008 - Multiple gastrointestinal stromal tumors (GISTs) rarely occur in patients with neurofibromatosis type 1 (NF-1). In contrast to sporadic GISTs characterized by frequent allelic losses of 1p, 14q and 22q and mutations of KIT or PDGFRA gene with the activation of the downstream RAS-MAPK pathway, the molecular pathogenetic mechanisms of NF-1-related GISTs (NF-1 GISTs) remain unclear. Thirty-one GIS...

Cholangiolocellular carcinoma: an innocent-looking malignant liver tumor mimicking duct...
https://doi.org/10.1055/s-0031-1272838
Seminars in Liver Disease; Sempoux C, Fan C et. al.

Feb 23rd, 2011 - The authors present an interesting case of a 60-year-old man who underwent right hepatectomy for a diagnosis of hepatocellular carcinoma (HCC) on a background of noncirrhotic chronic hepatitis C. Pathologic examination confirmed the presence of HCC near the porta hepatis, which invaded the right portal vein branch. In addition, a well-demarcated 13.5 × 7.8 × 4.0 cm yellow and firm area upstream...

Advances in the pathogenesis and treatment of polycystic kidney disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820272
Current Opinion in Nephrology and Hypertension; Patel V, Chowdhury R et. al.

May 11th, 2009 - Polycystic kidney disease (PKD) is the most common genetic cause of chronic renal failure. Mouse models of PKD, especially those with mutations in genes that are orthologous to human disease genes, have provided insights into the pathogenesis of cyst formation and advanced the preclinical testing of new drugs. PKD is a ciliopathy that arises from abnormalities in the primary cilium, a sensory o...

Neutral antibodies to the TSH receptor are present in Graves' disease and regulate sele...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954721
Endocrinology Morshed SA, Ando T et. al.

Sep 16th, 2010 - TSH receptor (TSHR) antibodies (Abs) may be stimulating, blocking, or neutral in their functional influences and are found in patients with autoimmune thyroid disease, especially Graves' disease (GD). Stimulators are known to activate the thyroid epithelial cells via both Gs- and Gq-coupled signaling pathways, whereas blockers inhibit the action of TSH and may act as weak agonists. However, TSH...

Autoantigen-specific regulatory T cells, a potential tool for immune-tolerance reconsti...
https://doi.org/10.1002/hep.24039
Hepatology (Baltimore, Md.); Longhi MS, Hussain MJ et. al.

Jan 28th, 2011 - Effector CD4 and CD8 T cell immune responses to cytochrome P450IID6 (CYP2D6), the autoantigen of autoimmune hepatitis type 2 (AIH-2), are permitted by a numerical and functional impairment of CD4(pos) CD25(high) regulatory T cells (T-regs). We aimed to investigate whether T-regs specific for CYP2D6 immunodominant regions and restricted by the appropriate human leukocyte antigen (HLA)-DR molecul...

Epidemiology: clues to the pathogenesis of Burkitt lymphoma.
https://doi.org/10.1111/j.1365-2141.2011.09013.x
British Journal of Haematology; Magrath I

Jan 20th, 2012 - The two major epidemiological clues to the pathogenesis of Burkitt lymphoma (BL) are the geographical association with malaria--BL incidence relates to the malaria transmission rate--and early infection by Epstein-Barr virus (EBV). Both agents cause B cell hyperplasia, which is almost certainly an essential component of lymphomagenesis in BL. The critical event in lymphomagenesis is the creatio...

McCune-Albright syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2459161
Orphanet Journal of Rare Diseases; Dumitrescu CE, Collins MT

May 20th, 2008 - McCune-Albright syndrome (MAS) is classically defined by the clinical triad of fibrous dysplasia of bone (FD), café-au-lait skin spots, and precocious puberty (PP). It is a rare disease with estimated prevalence between 1/100,000 and 1/1,000,000. FD can involve a single or multiple skeletal sites and presents with a limp and/or pain, and, occasionally, a pathologic fracture. Scoliosis is common...

Down-regulation of core 1 beta1,3-galactosyltransferase and Cosmc by Th2 cytokine alter...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989791
Nephrology, Dialysis, Transplantation : Official Publicat... Yamada K, Kobayashi N et. al.

Jun 16th, 2010 - Patients with IgA nephropathy (IgAN) have an increased amount of abnormally O-glycosylated IgA1 in circulation, in glomerular deposits and produced by tissue cells in vitro. Although increased production of Th2 cytokines by peripheral blood lymphocytes and a functional abnormality of core 1 β1,3-galactosyltransferase (C1β3Gal-T) have been proposed as mechanisms underlying pathogenesis of IgAN, ...

Disseminated superficial actinic porokeratosis co-existing with linear and verrucous po...
https://doi.org/10.1016/j.jaad.2009.07.038
Journal of the American Academy of Dermatology; Murase J, Gilliam AC

May 10th, 2010 - Disseminated superficial actinic porokeratosis (DSAP) is the most common form of porokeratosis, occurring mainly in women on the extremities as atrophic patches rimmed by a ridge of keratin (the cornoid lamella that is diagnostic of porokeratosis histologically and is thought to be a clonal keratinocyte proliferation). DSAP can sometimes coexist with other forms of porokeratosis (Mibelli, linea...