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About 171,232 results

Ultrasonography of the colon in pediatric ulcerative colitis: a prospective, blind, com...
https://doi.org/10.1016/j.jpeds.2014.02.055
The Journal of Pediatrics; Civitelli F, Di Nardo G et. al.

Apr 14th, 2014 - To evaluate the usefulness of colonic ultrasonography (US) in assessing the extent and activity of disease in pediatric ulcerative colitis (UC) and to compare US findings with clinical and endoscopic features. Consecutive pediatric patients (n = 60) with a diagnosis of UC and suspected disease flare-up were prospectively enrolled; of these, 50 patients were eligible for the study. All underwent...

Efficacy of dietary interventions for inducing histologic remission in patients with eo...
https://doi.org/10.1053/j.gastro.2014.02.006
Gastroenterology Arias A, González-Cervera J et. al.

Feb 18th, 2014 - Various dietary interventions have been used to treat patients with eosinophilic esophagitis (EoE), yielding varied results. This systematic review assesses the efficacy of different dietary therapies in inducing disease remission. We performed a systematic search of the MEDLINE, EMBASE, and SCOPUS databases for studies investigating the efficacy of dietary interventions (reducing infiltration ...

Contributions of the social environment to first-onset and recurrent mania.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206672
Molecular Psychiatry; Gilman SE, Ni MY et. al.

Apr 22nd, 2014 - In treated cohorts, individuals with bipolar disorder are more likely to report childhood adversities and recent stressors than individuals without bipolar disorder; similarly, in registry-based studies, childhood adversities are more common among individuals who later become hospitalized for bipolar disorder. Because these types of studies rely on treatment-seeking samples or hospital diagnose...

Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy.
https://doi.org/10.1056/NEJMoa1307362
The New England Journal of Medicine; Navon Elkan P, Pierce SB et. al.

Feb 20th, 2014 - Polyarteritis nodosa is a systemic necrotizing vasculitis with a pathogenesis that is poorly understood. We identified six families with multiple cases of systemic and cutaneous polyarteritis nodosa, consistent with autosomal recessive inheritance. In most cases, onset of the disease occurred during childhood. We carried out exome sequencing in persons from multiply affected families of Georgia...

Pediatric mycosis fungoides in Singapore: a series of 46 children.
https://doi.org/10.1111/pde.12352
Pediatric Dermatology; Heng YK, Koh MJ et. al.

Jun 3rd, 2014 - Few studies have evaluated Asian children with mycosis fungoides (MF). We report a series of patients from a tertiary dermatologic institution in Singapore. A retrospective review was performed of patients younger than 16 years old diagnosed with MF between 2000 and 2008 at the National Skin Centre, Singapore. Forty-six patients were identified. At initial presentation, a provisional diagnosis ...

Clinical picture and treatment of 2212 patients with common variable immunodeficiency.
https://doi.org/10.1016/j.jaci.2013.12.1077
The Journal of Allergy and Clinical Immunology; Gathmann B, Mahlaoui N et. al.

Mar 3rd, 2014 - Common variable immunodeficiency (CVID) is an antibody deficiency with an equal sex distribution and a high variability in clinical presentation. The main features include respiratory tract infections and their associated complications, enteropathy, autoimmunity, and lymphoproliferative disorders. This study analyzes the clinical presentation, association between clinical features, and differen...

Spread of artemisinin resistance in Plasmodium falciparum malaria.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143591
The New England Journal of Medicine; Ashley EA, Dhorda M et. al.

Jul 30th, 2014 - Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria. Mapping the geographic extent of resistance is essential for planning containment and elimination strategies. Between May 2011 and April 2013, we enrolled 1241 adults and children with acute, uncomplicated falciparum malaria in an open-label trial at 15...

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191900
The New England Journal of Medicine; Roberts KG, Li Y et. al.

Sep 10th, 2014 - Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and ad...

Prenatal antidepressant exposure is associated with risk for attention-deficit hyperact...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427538
Molecular Psychiatry; Clements CC, Castro VM et. al.

Aug 26th, 2014 - Previous studies suggested that risk for Autism Spectrum Disorder (ASD) may be increased in children exposed to antidepressants during the prenatal period. The disease specificity of this risk has not been addressed and the possibility of confounding has not been excluded. Children with ASD or attention-deficit hyperactivity disorder (ADHD) delivered in a large New England health-care system we...

Ten-year follow-up after initiation of statin therapy in children with familial hyperch...
https://doi.org/10.1001/jama.2014.8892
JAMA Kusters DM, Avis HJ et. al.

Sep 9th, 2014 - Ten-year follow-up after initiation of statin therapy in children with familial hypercholesterolemia.|2014|Kusters DM,Avis HJ,de Groot E,Wijburg FA,Kastelein JJ,|therapeutic use,blood,drug therapy,blood,therapeutic use,

Chimeric antigen receptor T cells for sustained remissions in leukemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267531
The New England Journal of Medicine; Maude SL, Frey N et. al.

Oct 15th, 2014 - Relapsed acute lymphoblastic leukemia (ALL) is difficult to treat despite the availability of aggressive therapies. Chimeric antigen receptor-modified T cells targeting CD19 may overcome many limitations of conventional therapies and induce remission in patients with refractory disease. We infused autologous T cells transduced with a CD19-directed chimeric antigen receptor (CTL019) lentiviral v...

Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines in the United States: Re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919600
MMWR. Recommendations and Reports : Morbidity and Mortali... Liang JL, Tiwari T et. al.

Apr 27th, 2018 - This report compiles and summarizes all recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) regarding prevention and control of tetanus, diphtheria, and pertussis in the United States. As a comprehensive summary of previously published recommendations, this report does not contain any new recommendations and replaces all previously published reports and policy notes; ...

Antidepressants during pregnancy and autism in offspring: population based cohort study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516223
BMJ (Clinical Research Ed.); Rai D, Lee BK et. al.

Jul 20th, 2017 - Objectives To study the association between maternal use of antidepressants during pregnancy and autism spectrum disorder (ASD) in offspring.Design Observational prospective cohort study with regression methods, propensity score matching, sibling controls, and negative control comparison.Setting Stockholm County, Sweden.Participants 254 610 individuals aged 4-17, including 5378 with autism, liv...

Ataluren in patients with nonsense mutation Duchenne muscular dystrophy (ACT DMD): a mu...
https://doi.org/10.1016/S0140-6736(17)31611-2
Lancet (London, England); McDonald CM, Campbell C et. al.

Jul 21st, 2017 - Duchenne muscular dystrophy (DMD) is a severe, progressive, and rare neuromuscular, X-linked recessive disease. Dystrophin deficiency is the underlying cause of disease; therefore, mutation-specific therapies aimed at restoring dystrophin protein production are being explored. We aimed to assess the efficacy and safety of ataluren in ambulatory boys with nonsense mutation DMD. We did this multi...

Liver and combined lung and liver transplantation for cystic fibrosis: analysis of the ...
https://doi.org/10.1111/j.1399-3046.2010.01460.x
Pediatric Transplantation; Arnon R, Annunziato RA et. al.

Jan 11th, 2011 - A proportion of patients with CF develop cirrhosis and portal hypertension. LT and combined LLT are rarely performed in patients with CF. To determine the outcome of LT and LLT in patients with CF. Patients with CF who had LT or LLT between 10/1987 and 5/2008 were identified from UNOS database. A total of 182 children (<18 yr) and 48 adults underwent isolated LT for CF. Seven more children and ...

Beneficial effects of growth hormone treatment on cognition in children with Prader-Wil...
https://doi.org/10.1210/jc.2012-1182
The Journal of Clinical Endocrinology and Metabolism; Siemensma EP, Tummers-de Lind van Wijngaarden RF et. al.

Apr 17th, 2012 - Knowledge about the effects of GH treatment on cognitive functioning in children with Prader-Willi syndrome (PWS) is limited. Fifty prepubertal children aged 3.5 to 14 yr were studied in a randomized controlled GH trial during 2 yr, followed by a longitudinal study during 4 yr of GH treatment. Cognitive functioning was measured biennially by short forms of the WPPSI-R or WISC-R, depending on ag...

Long-term outcome of children with steroid-resistant nephrotic syndrome treated with ta...
https://doi.org/10.1007/s00467-010-1471-8
Pediatric Nephrology (Berlin, Germany); Roberti I, Vyas S

Mar 10th, 2010 - We report the outcome of our single-center, long-term follow-up study of tacrolimus therapy in children with steroid-resistant nephrotic syndrome (SRNS). All cases of nephrotic syndrome (NS) with kidney biopsies treated at our center between January 2000 and July 2008 were reviewed. Children with systemic lupus erythematosus and steroid-dependent NS were excluded. Nineteen children with SRNS re...

Long-term outcomes of pediatric living donor liver transplantation at a single institut...
https://doi.org/10.1111/j.1399-3046.2010.01357.x
Pediatric Transplantation; Oh SH, Kim KM et. al.

Jul 8th, 2010 - There have only been a few studies on the long-term outcomes and prognostic factors after pediatric LDLT. We conducted a retrospective, single-center assessment of the outcomes as well as the demographic and clinical factors that influenced the poor outcomes in 113 children aged <16 (median age 21 months; 6 months-15.5 yr) who underwent 115 LDLTs, predominantly for biliary atresia (60.9%) and F...

Tailored approach to the treatment of vernal keratoconjunctivitis.
https://doi.org/10.1016/j.ophtha.2009.11.043
Ophthalmology Sacchetti M, Lambiase A et. al.

Apr 12th, 2010 - To develop a standardized clinical grading system for the management of patients with vernal keratoconjunctivitis (VKC) and to identify the risk factors associated with a worsened outcome of the disease, including decrease of visual acuity and ocular complications development. Retrospective cohort study. A total of 207 consecutive patients with VKC, referred to our Cornea and External Diseases ...

Re-evaluating cost effectiveness of universal meningitis vaccination (Bexsero) in Engla...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192138
BMJ (Clinical Research Ed.); Christensen H, Trotter CL et. al.

Oct 10th, 2014 - To use mathematical and economic models to predict the epidemiological and economic impact of vaccination with Bexsero, designed to protect against group B meningococcal disease, to help inform vaccine policy in the United Kingdom. Modelling study. England. People aged 0-99. Incremental impact of introductory vaccine strategies simulated with a transmission dynamic model of meningococcal infect...