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About 115,130 results

Ultrasonography of the colon in pediatric ulcerative colitis: a prospective, blind, com...
https://doi.org/10.1016/j.jpeds.2014.02.055
The Journal of Pediatrics; Civitelli F, Di Nardo G et. al.

Apr 14th, 2014 - To evaluate the usefulness of colonic ultrasonography (US) in assessing the extent and activity of disease in pediatric ulcerative colitis (UC) and to compare US findings with clinical and endoscopic features. Consecutive pediatric patients (n = 60) with a diagnosis of UC and suspected disease flare-up were prospectively enrolled; of these, 50 patients were eligible for the study. All underwent...

Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy.
https://doi.org/10.1056/NEJMoa1307362
The New England Journal of Medicine; Navon Elkan P, Pierce SB et. al.

Feb 20th, 2014 - Polyarteritis nodosa is a systemic necrotizing vasculitis with a pathogenesis that is poorly understood. We identified six families with multiple cases of systemic and cutaneous polyarteritis nodosa, consistent with autosomal recessive inheritance. In most cases, onset of the disease occurred during childhood. We carried out exome sequencing in persons from multiply affected families of Georgia...

Pediatric mycosis fungoides in Singapore: a series of 46 children.
https://doi.org/10.1111/pde.12352
Pediatric Dermatology; Heng YK, Koh MJ et. al.

Jun 3rd, 2014 - Few studies have evaluated Asian children with mycosis fungoides (MF). We report a series of patients from a tertiary dermatologic institution in Singapore. A retrospective review was performed of patients younger than 16 years old diagnosed with MF between 2000 and 2008 at the National Skin Centre, Singapore. Forty-six patients were identified. At initial presentation, a provisional diagnosis ...

Clinical picture and treatment of 2212 patients with common variable immunodeficiency.
https://doi.org/10.1016/j.jaci.2013.12.1077
The Journal of Allergy and Clinical Immunology; Gathmann B, Mahlaoui N et. al.

Mar 3rd, 2014 - Common variable immunodeficiency (CVID) is an antibody deficiency with an equal sex distribution and a high variability in clinical presentation. The main features include respiratory tract infections and their associated complications, enteropathy, autoimmunity, and lymphoproliferative disorders. This study analyzes the clinical presentation, association between clinical features, and differen...

Sleep environment risks for younger and older infants.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187235
Pediatrics Colvin JD, Collie-Akers V et. al.

Jul 15th, 2014 - Sudden infant death syndrome and other sleep-related causes of infant mortality have several known risk factors. Less is known about the association of those risk factors at different times during infancy. Our objective was to determine any associations between risk factors for sleep-related deaths at different ages. A cross-sectional study of sleep-related infant deaths from 24 states during 2...

Spread of artemisinin resistance in Plasmodium falciparum malaria.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143591
The New England Journal of Medicine; Ashley EA, Dhorda M et. al.

Jul 30th, 2014 - Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria. Mapping the geographic extent of resistance is essential for planning containment and elimination strategies. Between May 2011 and April 2013, we enrolled 1241 adults and children with acute, uncomplicated falciparum malaria in an open-label trial at 15...

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191900
The New England Journal of Medicine; Roberts KG, Li Y et. al.

Sep 10th, 2014 - Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and ad...

Prenatal antidepressant exposure is associated with risk for attention-deficit hyperact...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427538
Molecular Psychiatry; Clements CC, Castro VM et. al.

Aug 26th, 2014 - Previous studies suggested that risk for Autism Spectrum Disorder (ASD) may be increased in children exposed to antidepressants during the prenatal period. The disease specificity of this risk has not been addressed and the possibility of confounding has not been excluded. Children with ASD or attention-deficit hyperactivity disorder (ADHD) delivered in a large New England health-care system we...

Chimeric antigen receptor T cells for sustained remissions in leukemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267531
The New England Journal of Medicine; Maude SL, Frey N et. al.

Oct 15th, 2014 - Relapsed acute lymphoblastic leukemia (ALL) is difficult to treat despite the availability of aggressive therapies. Chimeric antigen receptor-modified T cells targeting CD19 may overcome many limitations of conventional therapies and induce remission in patients with refractory disease. We infused autologous T cells transduced with a CD19-directed chimeric antigen receptor (CTL019) lentiviral v...

Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines in the United States: Re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919600
MMWR. Recommendations and Reports : Morbidity and Mortali... Liang JL, Tiwari T et. al.

Apr 27th, 2018 - This report compiles and summarizes all recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) regarding prevention and control of tetanus, diphtheria, and pertussis in the United States. As a comprehensive summary of previously published recommendations, this report does not contain any new recommendations and replaces all previously published reports and policy notes; ...

Antidepressants during pregnancy and autism in offspring: population based cohort study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516223
BMJ (Clinical Research Ed.); Rai D, Lee BK et. al.

Jul 20th, 2017 - Objectives To study the association between maternal use of antidepressants during pregnancy and autism spectrum disorder (ASD) in offspring.Design Observational prospective cohort study with regression methods, propensity score matching, sibling controls, and negative control comparison.Setting Stockholm County, Sweden.Participants 254 610 individuals aged 4-17, including 5378 with autism, liv...

Beneficial effects of growth hormone treatment on cognition in children with Prader-Wil...
https://doi.org/10.1210/jc.2012-1182
The Journal of Clinical Endocrinology and Metabolism; Siemensma EP, Tummers-de Lind van Wijngaarden RF et. al.

Apr 17th, 2012 - Knowledge about the effects of GH treatment on cognitive functioning in children with Prader-Willi syndrome (PWS) is limited. Fifty prepubertal children aged 3.5 to 14 yr were studied in a randomized controlled GH trial during 2 yr, followed by a longitudinal study during 4 yr of GH treatment. Cognitive functioning was measured biennially by short forms of the WPPSI-R or WISC-R, depending on ag...

Prospective open-label trial of etanercept as adjunctive therapy for kawasaki disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970727
The Journal of Pediatrics; Choueiter NF, Olson AK et. al.

Jul 29th, 2010 - To determine the safety and pharmacokinetics of etanercept (Amgen, Thousand Oaks, California) a tumor necrosis factor-α receptor blocker, in children with acute Kawasaki disease (KD). Standard therapy of acute KD includes intravenous immunoglobulin (IVIG) and high-dose aspirin, but a substantial number of patients are refractory and require additional treatment. Tumor necrosis factor-α levels a...

Long-term outcome of children with steroid-resistant nephrotic syndrome treated with ta...
https://doi.org/10.1007/s00467-010-1471-8
Pediatric Nephrology (Berlin, Germany); Roberti I, Vyas S

Mar 10th, 2010 - We report the outcome of our single-center, long-term follow-up study of tacrolimus therapy in children with steroid-resistant nephrotic syndrome (SRNS). All cases of nephrotic syndrome (NS) with kidney biopsies treated at our center between January 2000 and July 2008 were reviewed. Children with systemic lupus erythematosus and steroid-dependent NS were excluded. Nineteen children with SRNS re...

Long-term outcomes of pediatric living donor liver transplantation at a single institut...
https://doi.org/10.1111/j.1399-3046.2010.01357.x
Pediatric Transplantation; Oh SH, Kim KM et. al.

Jul 8th, 2010 - There have only been a few studies on the long-term outcomes and prognostic factors after pediatric LDLT. We conducted a retrospective, single-center assessment of the outcomes as well as the demographic and clinical factors that influenced the poor outcomes in 113 children aged <16 (median age 21 months; 6 months-15.5 yr) who underwent 115 LDLTs, predominantly for biliary atresia (60.9%) and F...

Tailored approach to the treatment of vernal keratoconjunctivitis.
https://doi.org/10.1016/j.ophtha.2009.11.043
Ophthalmology Sacchetti M, Lambiase A et. al.

Apr 12th, 2010 - To develop a standardized clinical grading system for the management of patients with vernal keratoconjunctivitis (VKC) and to identify the risk factors associated with a worsened outcome of the disease, including decrease of visual acuity and ocular complications development. Retrospective cohort study. A total of 207 consecutive patients with VKC, referred to our Cornea and External Diseases ...

Re-evaluating cost effectiveness of universal meningitis vaccination (Bexsero) in Engla...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192138
BMJ (Clinical Research Ed.); Christensen H, Trotter CL et. al.

Oct 10th, 2014 - To use mathematical and economic models to predict the epidemiological and economic impact of vaccination with Bexsero, designed to protect against group B meningococcal disease, to help inform vaccine policy in the United Kingdom. Modelling study. England. People aged 0-99. Incremental impact of introductory vaccine strategies simulated with a transmission dynamic model of meningococcal infect...

Clinicopathologic Features of Hydroa Vacciniforme-Like Lymphoma: A Series of 9 Patients.
https://doi.org/10.1097/DAD.0000000000000385
The American Journal of Dermatopathology; Magaña M, Massone C et. al.

Sep 14th, 2015 - Hydroa vacciniforme-like lymphoma is a recently recognized cutaneous T-cell lymphoma associated with Epstein-Barr virus. The disease is observed in children of Latin American or Asian ethnicity. The authors report the clinical, histopathological, and immunophenotypical features of 9 new Mexican patients (M:F = 2:1; mean age, 14.5 years; median age, 13.3 years; age range, 4-27 years), expanding ...

Preschool neurodevelopmental outcome of children following fetal myelomeningocele closure.
https://doi.org/10.1016/j.ajog.2010.02.014
American Journal of Obstetrics and Gynecology; Danzer E, Gerdes M et. al.

Mar 29th, 2010 - We sought to investigate the preschool neurodevelopmental outcomes of children following fetal myelomeningocele (fMMC) surgery. Prior to the Management of Myelomeningocele Study trial, 54 children underwent fMMC closure at our institution. Thirty (56%) returned at 5 years of age for standardized neurocognitive examination. Scores were grouped as high-average, average, mildly delayed, and severe...

Outcomes of a modified approach to transcatheter closure of perimembranous ventricular ...
https://doi.org/10.1002/ccd.24774
Catheterization and Cardiovascular Interventions : Offici... Landman G, Kipps A et. al.

Dec 11th, 2012 - To describe the immediate and midterm results of a modified method for transcatheter closure of perimembranous ventricular septal defects (pmVSDs). Transcatheter closure of pmVSDs has been associated with development of heart block due to impingement on the ventricular conduction system. Ventricular septal aneurysms (VSAs) are common; the VSA tissue can serve as a target for the device without ...