The clinical presentation of Parkinson’s disease (PD) is heterogeneous and overlaps with other conditions, including the parkinsonian variant of multiple system atrophy (MSA-P), progressive supranuclear palsy (PSP) and essential tremor. Imaging of the brain in patients with parkinsonism has the ability to increase the accuracy of differential diagnosis. Magnetic resonance imaging (MRI), single ...
Immunoglobulin G (IgG) mediates pro- and anti-inflammatory activities through the engagement of its Fc fragment (Fc) with distinct Fcg receptors (FcgRs). One class of Fc-FcgR interactions generates pro-inflammatory effects of immune complexes and cytotoxic antibodies. In contrast, therapeutic intravenous gamma globulin and its Fc fragments are anti-inflammatory. We show here that these distinct...
DHMOSH - Public Health Unit
As COVID-19 has a variety of clinical manifestations, including fever, cough, headache, myalgia, fatigue. etc., it may be challenging to distinguish the infection from other diseases with similar presentations such as malaria, especially in endemic areas. Furthermore, there is always a potential of co-infections in the same patient.
American Family Physician; Saguil,A.,et al
Sep 30th, 2019 - Hand-foot-and-mouth disease is caused by human enteroviruses and coxsackieviruses. Outbreaks can occur in the spring to fall and are common in North America, and most cases occur in patients younger than 10 years. Hand-foot-and-mouth disease is transmitted by fecal-oral, oral-oral, and respiratory droplet contact. Patients present with a low-grade fever, a maculopapular or papulovesicular rash ...
Orphanet Journal of Rare Diseasesvolume;
Nov 2nd, 2011 - Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease characterized by degeneration of alpha motor neurons in the spinal cord, resulting in progressive proximal muscle weakness and paralysis. Estimated incidence is 1 in 6,000 to 1 in 10,000 live births and carrier frequency of 1/40-1/60. This disease is characterized by generalized muscle weakness and atrophy predominati...
Mar 28th, 2019 - Question Is criminal and socially inappropriate behavior more common among patients with frontotemporal dementia than in those with Alzheimer disease, and is a certain type of protein pathology associated with criminal behavior in patients with frontotemporal dementia? Findings This cohort study of 220 Swedish patients with neuropathologically verified frontotemporal dementia or Alzheimer di...
Jun 28th, 2011 - Doctors should consider patient history (exposure); symptoms; duration and progression of illness; and laboratory tests to help determine if rabies should be on the differential diagnosis list for a patient.
Sep 23rd, 2019 - Although androgen excess can manifest in many ways, the most common and recognizable symptoms are hirsutism and acne. Reports of hirsutism and acne should be taken seriously because of their possible association with medical disorders, their substantial effect on self-esteem and quality of life, and the potential for psychosocial morbidity. In patients with symptoms of androgen excess, the diff...
Italian Journal of Pediatrics; La Rosa,M.,et al
Mar 13th, 2013 - Ocular allergy represents one of the most common conditions encountered by allergists and ophthalmologists. Allergic conjunctivitis is often underdiagnosed and consequently undertreated. Basic and clinical research has provided a better understanding of the cells, mediators, and immunologic events, which occur in ocular allergy. New pharmacological agents have improved the efficacy and safety o...
Infectious Diseases in Clinical Practice; Fretzayas,A.,et al
Jul 1st, 2010 - Background: The prompt diagnosis of meningitis is essential for a good outcome. Aim: This study was designed to differentiate children with meningococcal meningitis, aseptic meningitis, and no meningitis. Patients and Methods: A total of 150 children aged 1 month to 12 years and adolescents aged 12 to 14 years, who had had a lumbar puncture, were recruited. In all patients, demographic charac...
Journal of the American Academy of Dermatology; Brown TT, Choi EY et. al.
Mar 24th, 2014 - Distinction of rosacea and cutaneous lupus erythematosus (LE) can be challenging because of significant clinical and histologic overlap. A controlled study comparing these conditions is lacking. We compared the histologic features, T-cell subsets, and plasmacytoid dendritic cells in rosacea and LE. Biopsy specimens of rosacea (n = 27) and facial LE (n = 30) were retrospectively reviewed and rea...
The New England Journal of Medicine; Spivak JL, Considine M et. al.
Aug 27th, 2014 - Polycythemia vera is the ultimate phenotypic consequence of the V617F mutation in Janus kinase 2 (encoded by JAK2), but the extent to which this mutation influences the behavior of the involved CD34+ hematopoietic stem cells is unknown. We analyzed gene expression in CD34+ peripheral-blood cells from 19 patients with polycythemia vera, using oligonucleotide microarray technology after correctin...
Gut Haanstra JF, Al-Toma A et. al.
Sep 11th, 2014 - The aim was to determine the prevalence of small-bowel neoplasia in asymptomatic patients with Lynch syndrome (LS) by video capsule endoscopy (VCE). After obtaining informed consent, asymptomatic proven gene mutation carriers aged 35-70 years were included in this prospective multicentre study in the Netherlands. Patients with previous small-bowel surgery were excluded. After bowel preparation,...
Movement Disorders : Official Journal of the Movement Dis... Schwingenschuh P, Katschnig P et. al.
Sep 30th, 2011 - A confident clinical diagnosis of psychogenic tremor is often possible, but, in some cases, a "laboratory-supported" level of certainty would aid in early positive diagnosis. Various electrophysiological tests have been suggested to identify patients with psychogenic tremor, but their diagnostic reliability has never been assessed "head to head" nor compared to forms of organic tremor other tha...
Kidney International; Schreuder MF
Jun 30th, 2011 - Abnormal renal development results in congenital anomalies of the kidney and urinary tract. As many studies suggest that renal malformations are more often found on the left side, a meta-analysis was performed on the distribution of five different unilateral anomalies: multicystic dysplastic kidney, renal agenesis/aplasia, renal ectopia, pelviureteral junction obstruction, and non-obstructive n...
Current Rheumatology Reports; Callen JP
Apr 28th, 2010 - Dermatomyositis is a condition with pathognomonic and characteristic cutaneous lesions. This article describes the skin manifestations observed in patients with dermatomyositis, their differential diagnosis, their relationship to internal disease (particularly malignancy), and their management.
International Journal of Dermatology; Sehgal VN, Verma P et. al.
Sep 28th, 2011 - Ever since its inception, acrodermatitis continua of Hallopeau, has been recognized as an uncommon clinical entity which has been sparingly reported from across the globe. The attempt to have cumulative information on prevalent nomenclature, definition, reminiscences, and clinical overtures has brought differential diagnosis and diagnosis in sharp focus, the highlights of which are outlined. He...
American Journal of Epidemiology; Houot J, Marquant F et. al.
Sep 17th, 2015 - Childhood leukemia may be associated with traffic-related environmental exposure to benzene, and additional data are needed. The Géolocalisation des Cancers Pédiatriques (GEOCAP) Study, a nationwide French case-control study, was designed to avoid selection bias due to differential participation and misclassification. The study compared the 2,760 childhood leukemia cases diagnosed in France bet...
Neurology Morelli M, Arabia G et. al.
Aug 12th, 2011 - Magnetic resonance parkinsonism index (MRPI) has been proposed as a powerful tool to discriminate patients with progressive supranuclear palsy (PSP) from those with Parkinson disease (PD) or other parkinsonisms, on an individual basis. We investigated the usefulness of MRPI in predicting the clinical evolution in PSP of patients with clinically unclassifiable parkinsonism (CUP), i.e., parkinson...
Pediatric Diabetes; Shaw-Smith C, Flanagan SE et. al.
Feb 29th, 2012 - Permanent neonatal diabetes mellitus (PNDM) is diagnosed within the first 6 months of life, and is usually monogenic in origin. Heterozygous mutations in ABCC8, KCNJ11, and INS genes account for around half of cases of PNDM; mutations in 10 further genes account for a further 10%, and the remaining 40% of cases are currently without a molecular genetic diagnosis. Thiamine-responsive megaloblast...