Journal of the American Academy of Dermatology; Regauer S, Reich O et. al.
Jul 7th, 2014 - Vulvar squamous cell carcinomas (SCCs) arising in association with vulvar lichen planus (LP) are poorly documented. We sought to present clinicopathological features of 38 patients (median age 61 years, range 39-90 years) with LP-associated vulvar SCCs. Evaluated were location of vulvar SCC and metastases at presentation, recurrences, survival, precursor lesions, presence of human papillomaviru...
Journal of the American Academy of Dermatology; Brown TT, Choi EY et. al.
Mar 24th, 2014 - Distinction of rosacea and cutaneous lupus erythematosus (LE) can be challenging because of significant clinical and histologic overlap. A controlled study comparing these conditions is lacking. We compared the histologic features, T-cell subsets, and plasmacytoid dendritic cells in rosacea and LE. Biopsy specimens of rosacea (n = 27) and facial LE (n = 30) were retrospectively reviewed and rea...
Journal of the European Academy of Dermatology and Venere... Cinotti E, Merlo V et. al.
Aug 4th, 2014 - Reticular erythematous mucinosis (REM) and lupus erythematosus tumidus (LET) share similarities. However, to our knowledge no study extensively compared the histological features of these two conditions. The aim of this study is to compare the histological and immunohistochemical features of REM and LET. We evaluated epidermal thickness, hyperkeratosis, dermo-epidermal junction changes, interst...
The American Journal of Dermatopathology; Magaña M, Massone C et. al.
Sep 14th, 2015 - Hydroa vacciniforme-like lymphoma is a recently recognized cutaneous T-cell lymphoma associated with Epstein-Barr virus. The disease is observed in children of Latin American or Asian ethnicity. The authors report the clinical, histopathological, and immunophenotypical features of 9 new Mexican patients (M:F = 2:1; mean age, 14.5 years; median age, 13.3 years; age range, 4-27 years), expanding ...
Blood Cancer Journal; Nguyen TB, Sakata-Yanagimoto M et. al.
Feb 5th, 2017 - Recent genetic analysis has identified frequent mutations in ten-eleven translocation 2 (TET2), DNA methyltransferase 3A (DNMT3A), isocitrate dehydrogenase 2 (IDH2) and ras homolog family member A (RHOA) in nodal T-cell lymphomas, including angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified. We examined the distribution of mutations in these subtypes of m...
Hepatology (Baltimore, Md.); Komuta M, Govaere O et. al.
Jan 24th, 2012 - Cholangiocellular carcinoma (CC) originates from topographically heterogeneous cholangiocytes. The cylindrical mucin-producing cholangiocytes are located in large bile ducts and the cuboidal non-mucin-producing cholangiocytes are located in ductules containing bipotential hepatic progenitor cells (HPCs). We investigated the clinicopathological and molecular features of 85 resected CCs (14 hilar...
Nature Genetics; Wu G, Diaz AK et. al.
Apr 7th, 2014 - Pediatric high-grade glioma (HGG) is a devastating disease with a less than 20% survival rate 2 years after diagnosis. We analyzed 127 pediatric HGGs, including diffuse intrinsic pontine gliomas (DIPGs) and non-brainstem HGGs (NBS-HGGs), by whole-genome, whole-exome and/or transcriptome sequencing. We identified recurrent somatic mutations in ACVR1 exclusively in DIPGs (32%), in addition to pre...
Digestive Diseases and Sciences; Koch DG, Bogatkevich G et. al.
Oct 3rd, 2011 - Hepatopulmonary syndrome is a pulmonary vascular complication of cirrhosis in which intrapulmonary vasodilatation (IPV) results in hypoxemia. Endothelin-1 (ET-1), produced by proliferating cholangiocytes, has been identified as a mediator of IPV in an animal model of HPS, but the pathophysiology of IPV in humans has not been defined. The purpose of this study was to assess whether cirrhosis wit...
Clinics in Dermatology; Semkova K, Gergovska M et. al.
Jun 8th, 2015 - Human sweat glands disorders are common and can have a significant impact on the quality of life and on professional, social, and emotional burdens. It is of paramount importance to diagnose and treat them properly to ensure optimal patient care. Hyperhidrosis is characterized by increased sweat secretion, which can be idiopathic or secondary to other systemic conditions. Numerous therapeutic o...
Gastroenterology Senter L, Clendenning M et. al.
Jul 7th, 2008 - Although the clinical phenotype of Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer) has been well described, little is known about disease in PMS2 mutation carriers. Now that mutation detection methods can discern mutations in PMS2 from mutations in its pseudogenes, more mutation carriers have been identified. Information about the clinical significance of PMS2 mutations...
The American Journal of Surgical Pathology; Skálová A, Vanecek T et. al.
Apr 22nd, 2010 - We present a series of 16 salivary gland tumors with histomorphologic and immunohistochemical features reminiscent of secretory carcinoma of the breast. This is a hitherto undescribed and distinctive salivary gland neoplasm, with features resembling both salivary acinic cell carcinoma (AciCC) and low-grade cystadenocarcinoma, and displaying strong similarities to breast secretory carcinoma. Mic...
Best Practice & Research. Clinical Obstetrics & Gynaecology; Xue WC, Cheung AN
Aug 8th, 2011 - Endometrial stromal sarcomas are the second most common uterine sarcomas. Currently, they are classified into low-grade endometrial stromal sarcomas and undifferentiated endometrial sarcoma. Low-grade endometrial stromal sarcomas are biologically low-grade uterine sarcomas, and typically composed of uniform cells intimately associated with prominent arterioles, resembling the endometrial stroma...
Hypertension (Dallas, Tex. : 1979); Persu A, Van der Niepen P et. al.
Aug 9th, 2016 - Revisiting Fibromuscular Dysplasia: Rationale of the European Fibromuscular Dysplasia Initiative.|2016|Persu A,Van der Niepen P,Touzé E,Gevaert S,Berra E,|methods,etiology,physiopathology,complications,pathology,physiopathology,etiology,physiopathology,
Gastroenterology Miehlke S, Madisch A et. al.
Mar 23rd, 2009 - Budesonide is effective in treating collagenous colitis, but no treatment is established for lymphocytic colitis. We performed a randomized, double-blind, placebo-controlled study to evaluate the effects of budesonide in patients with lymphocytic colitis. Forty-two patients (median age, 61 years) with lymphocytic colitis and chronic diarrhea were randomly assigned to groups that were given oral...
Journal of Cancer Research and Clinical Oncology; Yamamoto H, Tobo T et. al.
Nov 20th, 2008 - Multiple gastrointestinal stromal tumors (GISTs) rarely occur in patients with neurofibromatosis type 1 (NF-1). In contrast to sporadic GISTs characterized by frequent allelic losses of 1p, 14q and 22q and mutations of KIT or PDGFRA gene with the activation of the downstream RAS-MAPK pathway, the molecular pathogenetic mechanisms of NF-1-related GISTs (NF-1 GISTs) remain unclear. Thirty-one GIS...
Seminars in Liver Disease; Sempoux C, Fan C et. al.
Feb 23rd, 2011 - The authors present an interesting case of a 60-year-old man who underwent right hepatectomy for a diagnosis of hepatocellular carcinoma (HCC) on a background of noncirrhotic chronic hepatitis C. Pathologic examination confirmed the presence of HCC near the porta hepatis, which invaded the right portal vein branch. In addition, a well-demarcated 13.5 × 7.8 × 4.0 cm yellow and firm area upstream...
Pediatric Dermatology; Karimian-Teherani D, Parissa M et. al.
Feb 28th, 2008 - We report juvenile circumscribed pityriasis rubra pilaris (type IV) in a 12-year-old Afghani girl in whom local therapy with tazarotene led to rapid, sustained remission. Tazarotene might be considered a useful treatment for circumscribed pityriasis rubra pilaris.
The American Journal of Surgical Pathology; Harder A, Wesemann M et. al.
Mar 26th, 2012 - We analyzed the histologic features of peripheral nerve sheath tumors occurring in 14 patients with schwannomatosis. Among a total of 31 tumors, 19 tumors (61%) showed schwannoma-like nodules within a neurofibroma-like tumor, corresponding to hybrid neurofibroma/schwannoma. At least 1 hybrid tumor occurred in 10 of 14 (71%) schwannomatosis patients. We then retrieved cases of hybrid tumors with...
Cancer Di Napoli A, Signoretti S
Apr 29th, 2009 - Renal cell carcinoma (RCC) is an aggressive malignancy that is associated with a high rate of metastasis. Although several promising therapeutic strategies are now available for the treatment of patients with metastatic kidney cancer, the prognosis of these patients remains poor. Research is ongoing to identify RCC-specific biomarkers that can improve early diagnosis, surveillance of tumor prog...
Clinical Cancer Research : an Official Journal of the Ame... Goldinger SM, Stieger P et. al.
Mar 9th, 2016 - Immunotherapy has experienced impressive progress in cancer treatment. Antibodies against PD-1 improved survival in different types of cancer including melanoma. They are generally well tolerated. However, skin toxicities including pruritus, rashes, and vitiligo are reported. Although frequent, they have not been characterized further yet. In this analysis, we aimed to systematically assess and...