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About 90,468 results

Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy.
https://doi.org/10.1056/NEJMoa1307362
The New England Journal of Medicine; Navon Elkan P, Pierce SB et. al.

Feb 20th, 2014 - Polyarteritis nodosa is a systemic necrotizing vasculitis with a pathogenesis that is poorly understood. We identified six families with multiple cases of systemic and cutaneous polyarteritis nodosa, consistent with autosomal recessive inheritance. In most cases, onset of the disease occurred during childhood. We carried out exome sequencing in persons from multiply affected families of Georgia...

Sleep environment risks for younger and older infants.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187235
Pediatrics Colvin JD, Collie-Akers V et. al.

Jul 15th, 2014 - Sudden infant death syndrome and other sleep-related causes of infant mortality have several known risk factors. Less is known about the association of those risk factors at different times during infancy. Our objective was to determine any associations between risk factors for sleep-related deaths at different ages. A cross-sectional study of sleep-related infant deaths from 24 states during 2...

Transplantation outcomes for severe combined immunodeficiency, 2000-2009.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183064
The New England Journal of Medicine; Pai SY, Logan BR et. al.

Jul 30th, 2014 - The Primary Immune Deficiency Treatment Consortium was formed to analyze the results of hematopoietic-cell transplantation in children with severe combined immunodeficiency (SCID) and other primary immunodeficiencies. Factors associated with a good transplantation outcome need to be identified in order to design safer and more effective curative therapy, particularly for children with SCID diag...

Spread of artemisinin resistance in Plasmodium falciparum malaria.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143591
The New England Journal of Medicine; Ashley EA, Dhorda M et. al.

Jul 30th, 2014 - Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria. Mapping the geographic extent of resistance is essential for planning containment and elimination strategies. Between May 2011 and April 2013, we enrolled 1241 adults and children with acute, uncomplicated falciparum malaria in an open-label trial at 15...

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191900
The New England Journal of Medicine; Roberts KG, Li Y et. al.

Sep 10th, 2014 - Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and ad...

Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines in the United States: Re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919600
MMWR. Recommendations and Reports : Morbidity and Mortali... Liang JL, Tiwari T et. al.

Apr 27th, 2018 - This report compiles and summarizes all recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) regarding prevention and control of tetanus, diphtheria, and pertussis in the United States. As a comprehensive summary of previously published recommendations, this report does not contain any new recommendations and replaces all previously published reports and policy notes; ...

Antidepressants during pregnancy and autism in offspring: population based cohort study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516223
BMJ (Clinical Research Ed.); Rai D, Lee BK et. al.

Jul 20th, 2017 - Objectives To study the association between maternal use of antidepressants during pregnancy and autism spectrum disorder (ASD) in offspring.Design Observational prospective cohort study with regression methods, propensity score matching, sibling controls, and negative control comparison.Setting Stockholm County, Sweden.Participants 254 610 individuals aged 4-17, including 5378 with autism, liv...

Population-Based Surveillance of Birth Defects Potentially Related to Zika Virus Infect...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812309
MMWR. Morbidity and Mortality Weekly Report; Delaney A, Mai C et. al.

Jan 25th, 2018 - Zika virus infection during pregnancy can cause serious birth defects, including microcephaly and brain abnormalities (1). Population-based birth defects surveillance systems are critical to monitor all infants and fetuses with birth defects potentially related to Zika virus infection, regardless of known exposure or laboratory evidence of Zika virus infection during pregnancy. CDC analyzed dat...

The incidence of visual impairment due to retinopathy of prematurity (ROP) and concomit...
https://doi.org/10.1136/bjo.2010.192542
The British Journal of Ophthalmology; van Sorge AJ, Termote JU et. al.

Feb 11th, 2011 - To determine the incidence of visual impairment (VI) caused by retinopathy of prematurity (ROP) and concomitant disabilities in preterm neonates born between 2000 and 2009 in the Netherlands. Data were retrieved from the Dutch institutes for the visually impaired. They were compared with similar Dutch studies conducted in 1975-1987, 1986-1994 and 1994-2000. Records of 42 infants with VI due to ...

Prospective open-label trial of etanercept as adjunctive therapy for kawasaki disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970727
The Journal of Pediatrics; Choueiter NF, Olson AK et. al.

Jul 29th, 2010 - To determine the safety and pharmacokinetics of etanercept (Amgen, Thousand Oaks, California) a tumor necrosis factor-α receptor blocker, in children with acute Kawasaki disease (KD). Standard therapy of acute KD includes intravenous immunoglobulin (IVIG) and high-dose aspirin, but a substantial number of patients are refractory and require additional treatment. Tumor necrosis factor-α levels a...

Long-term outcome of children with steroid-resistant nephrotic syndrome treated with ta...
https://doi.org/10.1007/s00467-010-1471-8
Pediatric Nephrology (Berlin, Germany); Roberti I, Vyas S

Mar 10th, 2010 - We report the outcome of our single-center, long-term follow-up study of tacrolimus therapy in children with steroid-resistant nephrotic syndrome (SRNS). All cases of nephrotic syndrome (NS) with kidney biopsies treated at our center between January 2000 and July 2008 were reviewed. Children with systemic lupus erythematosus and steroid-dependent NS were excluded. Nineteen children with SRNS re...

Long-term outcomes of pediatric living donor liver transplantation at a single institut...
https://doi.org/10.1111/j.1399-3046.2010.01357.x
Pediatric Transplantation; Oh SH, Kim KM et. al.

Jul 8th, 2010 - There have only been a few studies on the long-term outcomes and prognostic factors after pediatric LDLT. We conducted a retrospective, single-center assessment of the outcomes as well as the demographic and clinical factors that influenced the poor outcomes in 113 children aged <16 (median age 21 months; 6 months-15.5 yr) who underwent 115 LDLTs, predominantly for biliary atresia (60.9%) and F...

Re-evaluating cost effectiveness of universal meningitis vaccination (Bexsero) in Engla...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192138
BMJ (Clinical Research Ed.); Christensen H, Trotter CL et. al.

Oct 10th, 2014 - To use mathematical and economic models to predict the epidemiological and economic impact of vaccination with Bexsero, designed to protect against group B meningococcal disease, to help inform vaccine policy in the United Kingdom. Modelling study. England. People aged 0-99. Incremental impact of introductory vaccine strategies simulated with a transmission dynamic model of meningococcal infect...

Haploinsufficiency of TNFAIP3 (A20) by germline mutation is involved in autoimmune lymp...
https://doi.org/10.1016/j.jaci.2016.09.038
The Journal of Allergy and Clinical Immunology; Takagi M, Ogata S et. al.

Nov 15th, 2016 - Autoimmune diseases in children are rare and can be difficult to diagnose. Autoimmune lymphoproliferative syndrome (ALPS) is a well-characterized pediatric autoimmune disease caused by mutations in genes associated with the FAS-dependent apoptosis pathway. In addition, various genetic alterations are associated with the ALPS-like phenotype. The aim of the present study was to elucidate the gene...

Genomic alterations in biliary atresia suggest region of potential disease susceptibili...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914625
American Journal of Medical Genetics. Part A; Leyva-Vega M, Gerfen J et. al.

Apr 1st, 2010 - Biliary atresia (BA) is a progressive, idiopathic obliteration of the extrahepatic biliary system occurring exclusively in the neonatal period. It is the most common disease leading to liver transplantation in children. The etiology of BA is unknown, although infectious, immune and genetic causes have been suggested. Although the recurrence of BA in families is not common, there are more than 3...

CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia.
https://doi.org/10.1002/ana.21628
Annals of Neurology; Berrih-Aknin S, Ruhlmann N et. al.

Oct 22nd, 2009 - Myasthenia gravis (MG), a neuromuscular disease mediated by anti-acetylcholine receptor (AChR) autoantibodies, is associated with thymic hyperplasia characterized by ectopic germinal centers that contain pathogenic antibody-producing B cells. Our thymic transcriptome study demonstrated increased expression of CCL21, a recruiter of immune cells. Accordingly, we are investigating its implication ...

High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Fe...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848229
Clinical Infectious Diseases : an Official Publication Of... Olupot-Olupot P, Engoru C et. al.

Mar 31st, 2017 - In the Fluid Expansion as a Supportive Treatment (FEAST) trial, an unexpectedly high proportion of participants from eastern Uganda presented with blackwater fever (BWF). We describe the prevalence and outcome of BWF among trial participants and compare the prevalence of 3 malaria-protective red blood cell polymorphisms in BWF cases vs both trial (non-BWF) and population controls. Of 3170 trial...

Cholestasis and meconium ileus in infants with cystic fibrosis and their clinical outco...
https://doi.org/10.1136/archdischild-2013-304159
Archives of Disease in Childhood; Leeuwen L, Magoffin AK et. al.

Jan 17th, 2014 - To identify the incidence and outcomes of cholestasis and meconium ileus (MI) in infants with cystic fibrosis (CF). Retrospective cohort study. Single-centre study. From January 1986 to December 2011, 401 infants with CF (69 with MI) presented to our centre. (1) incidence of cholestasis, (2) identification of risk factors for cholestasis, (3) association between the presence of cholestasis and ...

Characteristics of Clinically Diagnosed Pediatric Myocarditis in a Contemporary Multi-C...
https://doi.org/10.1007/s00246-017-1638-1
Pediatric Cardiology; Butts RJ, Boyle GJ et. al.

May 25th, 2017 - The objective of this study was to describe a contemporary cohort of pediatric patients hospitalized for clinically suspected myocarditis. A retrospective chart review was performed at seven tertiary pediatric hospitals. Electronic medical records were searched between 2008 and 2012 for patients ≤18 years admitted with an ICD-9 code consistent with myocarditis. Patients were excluded if the adm...

Hematopoietic stem cell transplantation for advanced myelodysplastic syndrome in childr...
https://doi.org/10.1038/leu.2010.297
Leukemia Strahm B, Nöllke P et. al.

Jan 7th, 2011 - We report on the outcome of children with advanced primary myelodysplastic syndrome (MDS) transplanted from an HLA-matched sibling (MSD) or an unrelated donor (UD) following a preparative regimen with busulfan, cyclophosphamide and melphalan. Ninety-seven patients with refractory anemia with excess blasts (RAEB, n=53), RAEB in transformation (RAEB-T, n=29) and myelodysplasia-related acute myelo...