About 1,642,538 results

Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in Rhesus macaques

The outbreak of Corona Virus Disease 2019 caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) is highly transmitted. The potential extra-respiratory transmission routes remain uncertain. Five rhesus macaques were inoculated with 1×106 TCID50 of SARS-CoV-2 via conjunctival (CJ), intratracheal (IT), and intragastric (IG) routes, respectively. Remarkably, the CJ inoculated-mac...

Transoral Resection Followed by Low-Dose Radiation for Some Oropharyngeal Cancers

May 29th, 2020 - The final results of the randomized phase II ECOG-ACRIN E3311 trial were presented by Robert L. Ferris, MD, PhD, and colleagues during the ASCO20 Virtual Scientific Program (Abstract 6500) and in today's Head and Neck Cancer Oral Abstract Session. The trial, conducted in patients undergoing transoral robotic surgery, tested reduced postoperative radiation therapy in patients with human papillom...

COVID‐19: Lessons from SARS and MERS
European Journal of Immunology;

In December 2019, a new pneumonic disease began to appear in Wuhan, Hubei Province, China. It seemed highly infectious and resistant to therapy, causing considerable concern amongst physicians. Within a month, 41 patients had been admitted to a single hospital and one had died. The initial cases were strongly associated with the Huanan seafood market, in which exotic animals were sold for food....

Testing and Management Considerations for Nursing Home Residents with Acute Respiratory Illness Symptoms when SARS-CoV-2 and Influenza Viruses are Co-circulating
Centers for Disease Control and Prevention (CDC)

The following practices should be considered when SARS-CoV-2 and Influenza viruses are found to be co-circulating based upon local public health surveillance data and testing at local healthcare facilities. While these considerations are specific to care of residents residing in nursing homes, some practices could be adapted for use in other long-term care settings (e.g. assisted living facilit...

Options to Reduce Quarantine for Contacts of Persons with SARS-CoV-2 Infection Using Symptom Monitoring and Diagnostic Testing
Centers for Disease Control and Prevention (CDC)

Local public health authorities determine and establish the quarantine options for their jurisdictions. CDC currently recommends a quarantine period of 14 days. However, based on local circumstances and resources, the following options to shorten quarantine are acceptable alternatives.

History’s deadliest pandemics, from ancient Rome to modern America
The Washington Post; Rosenwald MS.

Feb 21st, 2021 - Centuries before coronavirus, plague, smallpox, yellow fever and other contagions killed hundreds of millions around the world

Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2
New England Journal of Medicine; Blumenthal KG, .

Mar 2nd, 2021 - Baden et al.1 report on a phase 3 clinical trial of the mRNA-1273 vaccine against SARS-CoV-2, and they provide information on immediate injection-site reactions, which were observed in 84.2% of the participants after the first dose.

Tuberculosis — United States, 2020
MMWR Morb Mortal Wkly; Deutsch-Feldman M, Pratt RH et. al.

Mar 25th, 2021 - Tuberculosis (TB) disease incidence has decreased steadily since 1993 (1), a result of decades of work by local TB programs to detect, treat, and prevent TB disease and transmission. During 2020, a total of 7,163 TB cases were provisionally reported to CDC’s National Tuberculosis Surveillance System (NTSS) by the 50 U.S. states and the District of Columbia (DC), a relative reduction of 20%, com...

Supplement to: Delayed large local reactions to mRNA-1273 vaccine against SARS-CoV-2
New England Journal of Medicine; Blumenthal KG, Freeman EE et. al.

Mar 31st, 2021 - A 27-year old Caucasian male developed an erythematous plaque at the site of Moderna vaccine inoculation, 7 days after injection of Dose 1. A skin punch biopsy was taken.

Direct-Acting Antiviral Therapy not Associated with Recurrence of Hepatocellular Carcinoma in a Multicenter North American Cohort Study
Singal,A.,et al

Jan 16th, 2019 - Background & Aims There is controversy over the effects of direct-acting antiviral (DAA) therapies for hepatitis C (HCV) infection on hepatocellular carcinoma (HCC) recurrence and tumor aggressiveness. We compared HCC recurrence patterns between DAA-treated and untreated HCV-infected patients who had achieved a complete response to HCC treatment in a North American cohort.

Ewing Sarcoma Treatment (PDQ®)–Health Professional Version

Aug 15th, 2019 - Ewing sarcoma treatment options include multidrug chemotherapy, surgery, and radiation therapy. Treatment approaches titrate therapeutic aggressiveness to maximizing local control while minimizing morbidity. Get detailed treatment information for Ewing sarcoma in this summary for clinicians.

Definitive Pelvic Radiotherapy and Survival of Patients With Newly Diagnosed Metastatic Anal Cancer
Wang,Y.,et al

Jan 16th, 2019 - Background: Chemotherapy with or without pelvic radiotherapy (RT) is included in the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for metastatic anal cancer (MAC), despite limited clinical evidence for RT in this setting. In addition, increasing evidence shows that local therapies, including RT, may increase patient survival for some types of metastatic cancers. The purpose o...

2019 NCCN Consensus Guidelines on the Diagnosis and Treatment of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL)
Clemens,M.,et al

Jan 30th, 2019 - National Comprehensive Cancer Network (NCCN) guidelines represent the consensus standard of care for diagnosis and management of the majority of known cancers. NCCN guidelines on breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) have been recognized by the US Food and Drug Administration and widely advocated by national specialty societies. Consensus guidelines have helped cre...

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma
Cloughesy,T.,et al

Feb 10th, 2019 - Glioblastoma is the most common primary malignant brain tumor in adults and is associated with poor survival. The Ivy Foundation Early Phase Clinical Trials Consortium conducted a randomized, multi-institution clinical trial to evaluate immune responses and survival following neoadjuvant and/or adjuvant therapy with pembrolizumab in 35 patients with recurrent, surgically resectable glioblastoma...

U.S. measles cases in first five months of 2019 surpass total cases per year for past 25 years

May 29th, 2019 - Today, CDC is reporting 971 cases of measles in the United States thus far in 2019. This is the greatest number of cases reported in the U.S. since 1994, when 963 cases were reported for the entire year. CDC continues to work with affected state and local health departments to get ongoing outbreaks under control.

Risk factors and outcomes for acute respiratory failure in coronavirus disease 2019: An...
Advances in Clinical and Experimental Medicine : Official... Piwowarczyk P, Szczukocka M et. al.

Dec 31st, 2020 - The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread throughout Europe. However, there is a lack of data on the full clinical course of patients infected with SARS-CoV-2 in Europe, especially in the population that developed acute respiratory failure (ARF). To identify risk factors associated with developing ARF during SARS-CoV-2 infection. This was an observationa...

Variation in SARS-CoV-2 outbreaks across sub-Saharan Africa.
Nature Medicine; Rice BL, Annapragada A et. al.

Feb 3rd, 2021 - A surprising feature of the SARS-CoV-2 pandemic to date is the low burdens reported in sub-Saharan Africa (SSA) countries relative to other global regions. Potential explanations (for example, warmer environments1, younger populations2-4) have yet to be framed within a comprehensive analysis. We synthesized factors hypothesized to drive the pace and burden of this pandemic in SSA during the per...

Primary angiitis of the central nervous system: description of the first fifty-two adul...
Arthritis & Rheumatology (Hoboken, N.J.); de Boysson H, Zuber M et. al.

May 1st, 2014 - To describe characteristics and outcomes of a multicenter cohort of patients diagnosed as having primary angiitis of the central nervous system (PACNS). In 2010, we initiated a cohort study of adults diagnosed as having PACNS ≤15 years ago and with followup of >6 months (unless they died earlier of biopsy-proven PACNS). Its first analysis was planned at 2 years. Multidisciplinary investigators ...

Risk of cerebral arteriovenous malformation rupture during pregnancy and puerperium.
Neurology Liu XJ, Wang S et. al.

Apr 24th, 2014 - To determine whether the risk of arteriovenous malformation (AVM) rupture is increased during pregnancy and puerperium. Participants included 979 female patients with intracranial AVM admitted to Beijing Tiantan Hospital between 1960 and 2010. Two neurosurgery residents reviewed medical records for each case. Of them, 393 patients with ruptured AVM between 18 and 40 years of age were used for c...

Use of Vibrio cholerae vaccine in an outbreak in Guinea.
The New England Journal of Medicine; Luquero FJ, Grout L et. al.

May 29th, 2014 - The use of vaccines to prevent and control cholera is currently under debate. Shanchol is one of the two oral cholera vaccines prequalified by the World Health Organization; however, its effectiveness under field conditions and the protection it confers in the first months after administration remain unknown. The main objective of this study was to estimate the short-term effectiveness of two d...