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About 43,154 results

The increasing burden of HIV-associated malignancies in resource-limited regions.
https://doi.org/10.1146/annurev-med-050409-103711
Annual Review of Medicine; Casper C

Sep 27th, 2010 - Cancer is increasingly recognized as a complication of HIV infection in both resource-rich and resource-limited areas. The traditional AIDS-defining cancers, including Kaposi sarcoma, cervical cancer, and non-Hodgkin lymphoma, have become common comorbidities afflicting HIV-positive individuals and lack adequate prevention and management options. Additionally, several non-AIDS-defining cancers ...

Incidence of malignancy in patients treated for antineutrophil cytoplasm antibody-assoc...
https://doi.org/10.1136/ard.2010.145250
Annals of the Rheumatic Diseases; Heijl C, Harper L et. al.

May 27th, 2011 - Because standard immunosuppressive treatment for antineutrophil cytoplasm antibody-associated vasculitis (AAV) (granulomatosis with polyangiitis (Wegener's) (GPA) and microscopic polyangiitis (MPA)) has been associated with a significant risk of developing cancer, the cancer incidence of treated AAV patients was assessed. This analysis concerned 535 patients with newly diagnosed AAV from 15 cou...

Cytotoxic Cutaneous Adverse Drug Reactions during Anti-PD-1 Therapy.
https://doi.org/10.1158/1078-0432.CCR-15-2872
Clinical Cancer Research : an Official Journal of the Ame... Goldinger SM, Stieger P et. al.

Mar 9th, 2016 - Immunotherapy has experienced impressive progress in cancer treatment. Antibodies against PD-1 improved survival in different types of cancer including melanoma. They are generally well tolerated. However, skin toxicities including pruritus, rashes, and vitiligo are reported. Although frequent, they have not been characterized further yet. In this analysis, we aimed to systematically assess and...

Risks of Lynch syndrome cancers for MSH6 mutation carriers.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815724
Journal of the National Cancer Institute; Baglietto L, Lindor NM et. al.

Dec 23rd, 2009 - Germline mutations in MSH6 account for 10%-20% of Lynch syndrome colorectal cancers caused by hereditary DNA mismatch repair gene mutations. Because there have been only a few studies of mutation carriers, their cancer risks are uncertain. We identified 113 families of MSH6 mutation carriers from five countries that we ascertained through family cancer clinics and population-based cancer regist...

Bisphosphonate-induced osteonecrosis of the jaws: prospective study of 80 patients with...
https://doi.org/10.1016/j.oraloncology.2007.11.012
Oral Oncology; Boonyapakorn T, Schirmer I et. al.

Feb 19th, 2008 - A prospective study was performed in 80 patients receiving bisphosphonates in order to determine frequency of occurrence, risk factors, clinical presentation, radiology, pathology and proper treatment of osteonecrosis of the jaw (ONJ). Of 80 patients, 22 (28%) developed ONJ. There were 11 male and 11 female patients. Median age was 65 years. Ten patients (46%) had multiple myeloma (MM), 5 (23%)...

Pregnancies and live births after 20 transplantations of cryopreserved ovarian tissue i...
https://doi.org/10.1016/j.fertnstert.2014.10.045
Fertility and Sterility; Dittrich R, Hackl J et. al.

Dec 9th, 2014 - To report the results of 20 orthotopic retransplantations of cryopreserved ovarian tissue after cancer treatment. Retrospective analysis. Tertiary gynecology department. Twenty patients with malignant disease: 11 with hematological malignancies (55%), four with breast cancer (20%), three with anal cancer (15%), and two with ovarian cancer (10%); the mean age before oncological treatment was 30....

Detection of cases of progressive multifocal leukoencephalopathy associated with new bi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020696
Expert Opinion on Drug Safety; Raisch DW, Rafi JA et. al.

Jun 8th, 2016 - To identify and summarize FDA's Adverse Event Reporting System (FAERS) cases of progressive multifocal leukoencephalopathy (PML) associated with biological and targeted cancer therapies (BTCT) that were approved between 2009 and 2015. FAERS was searched using each BTCT name as primary or secondary suspect drug and the adverse reaction of PML. Among BTCTs with >2 case reports of PML, proportiona...

Risks of colorectal and other cancers after endometrial cancer for women with Lynch syn...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576323
Journal of the National Cancer Institute; Win AK, Lindor NM et. al.

Feb 6th, 2013 - Lynch syndrome is an autosomal dominantly inherited disorder caused by germline mutations in DNA mismatch repair (MMR) genes. Previous studies have shown that MMR gene mutation carriers are at increased risk of colorectal, endometrial, and several other cancers following an initial diagnosis of colorectal cancer. We estimated cancer risks following an endometrial cancer diagnosis for women carr...

Osteonecrosis in adult survivors of childhood cancer: a report from the childhood cance...
https://doi.org/10.1200/JCO.2007.14.9088
Journal of Clinical Oncology : Official Journal of the Am... Kadan-Lottick NS, Dinu I et. al.

Jun 20th, 2008 - Osteonecrosis (ON) is a potentially serious complication of therapy in survivors of childhood cancer. Our goals were to describe the incidence of ON and identify patient and treatment characteristics associated with elevated risk. The rate of self-reported ON was determined for 9,261 patients enrolled onto the Childhood Cancer Survivor Study, a cohort of 5-year survivors of childhood cancer dia...

Mortality and the risk of malignancy in autoimmune liver diseases: a population-based s...
https://doi.org/10.1002/hep.24743
Hepatology (Baltimore, Md.); Ngu JH, Gearry RB et. al.

Oct 13th, 2011 - Population-based quantitative data on the mortality and cancer incidence of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC) are scarce. Our aim was to systematically investigate the survival and risk of malignancy on population-based cohorts of AIH, PBC, and PSC in Canterbury, New Zealand. Multiple case-finding methods were employed, includi...

Prevalence and risk factors of radiation-induced growth hormone deficiency in childhood...
https://doi.org/10.1016/j.ctrv.2009.06.004
Cancer Treatment Reviews; Mulder RL, Kremer LC et. al.

Jul 30th, 2009 - Growth hormone deficiency (GHD) is usually the first and most frequent endocrine problem occurring after cranial radiotherapy (CRT). The aim of this systematic review was to evaluate the existing evidence of the prevalence and risk factors of radiation-induced GHD in childhood cancer survivors. MEDLINE, EMBASE and CENTRAL were searched for studies reporting on radiation-induced GHD in childhood...

Epigenotype, phenotype, and tumors in patients with isolated hemihyperplasia.
https://doi.org/10.1016/j.jpeds.2007.12.022
The Journal of Pediatrics; Bliek J, Maas S et. al.

Jun 23rd, 2008 - To investigate whether epigenotyping of patients with isolated hemihyperplasia (IH) can, analogous to genetic screening of patients with Beckwith-Wiedemann syndrome, be used for the prediction of tumor risk and tumor type of individual patients. Methylation analysis of H19 and KCNQ1OT1 of 73 patients. Questionnaires were sent to referring clinicians. In 75% of the clinically confirmed patients ...

Changes in causes of death and risk of cancer in Danish patients with autosomal dominan...
https://doi.org/10.1093/ndt/gfr467
Nephrology, Dialysis, Transplantation : Official Publicat... Orskov B, Sørensen VR et. al.

Aug 29th, 2011 - With the improved prognosis in patients with autosomal dominant polycystic kidney disease (ADPKD), causes of death and the risk of cancer might have changed. This was investigated in a Danish population with ADPKD and end-stage renal disease (ESRD) between 1 January 1993 and 31 December 2008. Data were retrieved from three Danish national registries and a total of 823 patients were identified o...

Children's Oncology Group's 2013 blueprint for research: rare tumors.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304764
Pediatric Blood & Cancer; Rodriguez-Galindo C, Krailo M et. al.

Dec 20th, 2012 - In the US, approximately 2,000 children are diagnosed with rare cancers each year, with 5-year survival ranging from <20% for children with advanced carcinomas to >95% for children with intraocular retinoblastoma or localized germ cell tumors. During the last years, 12 clinical studies have been successfully completed in children with retinoblastoma, liver tumors, germ cell tumors, and infreque...

Neurological sequelae of cancer immunotherapies and targeted therapies.
https://doi.org/10.1016/S1470-2045(16)30571-X
The Lancet. Oncology; Wick W, Hertenstein A et. al.

Dec 7th, 2016 - Neurological complications of cancer and of anticancer treatments can be substantially disabling to patients, especially with classic chemotherapies. As a rare but important complication, targeted therapies might also result in similar unwanted effects, partly because inhibition of VEGF is a common downstream effect. Therapeutic antibodies, such as the CD20-depleting antibody rituximab, and und...

Pathogenesis, diagnosis and management of paraneoplastic glomerulonephritis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058941
Nature Reviews. Nephrology; Lien YH, Lai LW

Dec 14th, 2010 - Paraneoplastic glomerulonephritis is a rare complication of malignancy that is frequently mistaken for idiopathic glomerulonephritis. Failure to recognize paraneoplastic glomerulonephritis can subject patients to ineffective and potentially harmful therapy. The pathology of paraneoplastic glomerulonephritis varies between different types of malignancies. This Review discusses the association of...

The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329941
Supportive Care in Cancer : Official Journal of the Multi... Kottschade LA, Sloan JA et. al.

Oct 11th, 2010 - Chemotherapy-induced peripheral neuropathy (CIPN) continues to be a substantial problem for many cancer patients. Pursuant to promising appearing pilot data, the current study evaluated the use of vitamin E for the prevention of CIPN. A phase III, randomized, double-blind, placebo-controlled study was conducted in patients undergoing therapy with neurotoxic chemotherapy, utilizing twice daily d...

Cardiotoxicity of anthracycline agents for the treatment of cancer: systematic review a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907344
BMC Cancer; Smith LA, Cornelius VR et. al.

Jun 30th, 2010 - We conducted a systematic review and meta-analysis to clarify the risk of early and late cardiotoxicity of anthracycline agents in patients treated for breast or ovarian cancer, lymphoma, myeloma or sarcoma. Randomized controlled trials were sought using comprehensive searches of electronic databases in June 2008. Reference lists of retrieved articles were also scanned for additional articles. ...

Disease course patterns after discontinuation of bevacizumab: pooled analysis of random...
https://doi.org/10.1200/JCO.2010.30.2794
Journal of Clinical Oncology : Official Journal of the Am... Miles D, Harbeck N et. al.

Nov 25th, 2010 - Preclinical studies have suggested accelerated tumor growth, local invasion, and distant metastasis after withdrawal of treatment with some antiangiogenic agents. To investigate whether discontinuation of bevacizumab treatment is associated with accelerated disease progression or increased mortality, we retrospectively analyzed five randomized, placebo-controlled phase III studies in 4,205 pati...

Autoimmune limbic encephalopathy and anti-Hu antibodies in children without cancer.
https://doi.org/10.1212/WNL.0b013e318296e9c3
Neurology Honnorat J, Didelot A et. al.

May 9th, 2013 - The aim of this study was to describe the clinical presentation of children and adolescents with anti-Hu antibodies (Hu-Abs). This was a retrospective study of children and adolescents with Hu-Abs collected by the French Paraneoplastic Neurological Syndrome (PNS) Reference Center between January 1, 2000 and December 31, 2011. The center identified 251 patients with Hu-Abs. Only 8 patients were ...