We assessed the prevalence and impact of COVID-19 among multiple sclerosis (MS) patients across Europe by leveraging participant data collected as part of the ongoing EU IMI2 RADAR-CNS major programme aimed at finding new ways of monitoring neurological disorders using wearable devices and smartphone technology. In the present study, 399 patients of RADAR-MS have been included (mean age 43.9 ye...
Since the start of the outbreak in December 2019, COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), has led to an increasing number of infections worldwide, with an estimated overall mortality of 5·7%.1 Meanwhile, many patients who were hospitalised have recovered and were discharged to self-quarantine. However, some patients have tested positive for COVID-19 aga...
In December 2019 and January 2020, novel coronavirus (2019-nCoV) - infected pneumonia (NCIP) occurred in Wuhan, and has already posed a serious threat to public health. ACE2 (Angiotensin Converting Enzyme 2) has been shown to be one of the major receptors that mediate the entry of 2019-nCoV into human cells, which also happens in severe acute respiratory syndrome coronavirus (SARS). Several res...
Journal of Parkinson's Disease;
Jul 29th, 2019 - Evaluate prevalence of troublesome dyskinesia and OFF through the day, assessed by 30-minute intervals, as well as the mean number and duration of troublesome dyskinesia and OFF episodes, transitions between PD states, and effects of Gocovri® (amantadine) extended release capsules on these episodes.
The unprecedented pandemic of SARS-CoV-2 has created worldwide shortages of personal protective equipment, in particular respiratory protection such as N95 respirators. SARS-CoV-2 transmission is frequently occurring in hospital settings, with numerous reported cases of nosocomial transmission highlighting the vulnerability of healthcare workers. In general, N95 respirators are designed for sin...
Journal of NeuroEngineering and Rehabilitation;
Despite the effectiveness of levodopa for treatment of Parkinson’s disease (PD), prolonged usage leads to development of motor complications, most notably levodopa-induced dyskinesia (LID). Persons with PD and their physicians must regularly modify treatment regimens and timing for optimal relief of symptoms. While standardized clinical rating scales exist for assessing the severity of PD sympt...
Aug 2nd, 2020 - This new edition of the World Federation of Hemophilia (WFH) guidelines for the management of hemophilia comes at an exciting time in the evolution of the diagnosis and treatment of this condition. Since the publication of the second edition in 2012, tremendous advances have been made in several aspects of the management of hemophilia. These include genetic assessment as well as therapy with ma...
COVID-19 represents a global crisis, yet major knowledge gaps remain about human immunity to SARS-CoV-2. We analyzed immune responses in 76 COVID-19 patients and 69 healthy individuals from Hong Kong and Atlanta. In PBMCs of COVID-19 patients, there was reduced expression of HLA-DR and pro-inflammatory cytokines by myeloid cells, and impaired mTOR-signaling and IFN-α production by plasmacytoid ...
Parkinson's disease (PD) is a common neurodegenerative condition that usually presents with symptoms related to asymmetric bradykinesia, resting tremor, rigidity and postural instability. Making the correct diagnosis can be challenging as many conditions—including tremor, gait and atypical parkinsonian disorders—can mimic PD. PD can present with unanticipated motor and non-motor symptoms, and s...
Journal of Clinical Medicine; Chimenti MS
Mar 5th, 2020 - Ocular involvement in Psoriatic Arthritis (PsA) patients is mainly associated with uveitis but there remains a paucity of data on dry eye and retinal abnormalities. We aimed to analyze dry eye and subclinical retinal abnormalities in a cohort of PsA patients sine-psoriasis (PsO).
NEJM Journal Watch; Gluck, T.
Now, three major organizations — the WHO, the Infectious Diseases Society of America (IDSA), and the NIH — have coincidently, but independently, published updated guidelines on the management of patients with SARS-CoV-2-infection (COVID-19), reflecting the rapidly increasing knowledge and emerging evidence from completed studies. All three guidelines were developed by panels of experts using ev...
Journal of the National Comprehensive Cancer Network;
Evolving standard first-line approaches to the treatment for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) are once again focusing on the integration of minimal residual disease (MRD) status as a response assessment tool. MRD status correlates with clinical outcomes, therefore making it a good early indicator of response and expected outcomes, noted William G. Wierda, MD, Ph...
Scientific Reports; Romano, M. et. al.
Oct 26th, 2020 - Chronic inflammation and proteinuria is a risk factor for cardiovascular disease (CVD) in patients with chronic kidney diseases and rheumatologic disorders. Our aim was to investigate the CVD events (CVDEs) and survival between the patients with FMF-related AA amyloidosis and glomerulonephropathies (GN) to define possible predictors for CVDEs.
Food Standards Agency
Jun 8th, 2020 - Risk question: What is the risk of food, food contact materials, or food packaging being a source or transmission route of SARS-CoV-2 for UK consumers?
The Lancet; Hansen CH, Michlmayr D et. al.
Mar 16th, 2021 - The degree to which infection with SARS-CoV-2 confers protection towards subsequent reinfection is not well described. In 2020, as part of Denmark's extensive, free-of-charge PCR-testing strategy, approximately 4 million individuals (69% of the population) underwent 10·6 million tests.
BMJ Open; Dennis A, Wamil M et. al.
Mar 29th, 2021 - Early in the COVID-19 pandemic, research and clinical practice focused on pulmonary manifestations.1 There is increasing evidence for direct multiorgan effects,2–7 as well as indirect effects on other organ systems and disease processes, such as cardiovascular diseases and cancers, through changes in healthcare delivery and patient behaviours.8–10 The clear long-term impact on individuals and h...
NAM Perspectives.; DeSalvo, K. et. al.
Apr 6th, 2021 - Gains in life expectancy and quality of life over the course of American history can be attributed to forward-looking investments in public health infrastructure . For example, the creation of municipal public health authorities in the 19th century supported improvements in sanitation and reduced the mortality burden from infectious diseases such as typhoid and cholera.
Jan 17th, 2019 - We determined the prognostic factors and utility of allogeneic hematopoietic cell transplantation among children with newly diagnosed hypodiploid acute lymphoblastic leukemia (ALL) treated in contemporary clinical trials. This retrospective study collected data on 306 patients with hypodiploid ALL who were enrolled in the protocols of 16 cooperative study groups or institutions between 1997 and...
Jan 9th, 2019 - All patients diagnosed with pancreatic adenocarcinoma should undergo assessment of risk for hereditary syndromes known to be associated with an increased risk for pancreatic adenocarcinoma. Assessment of risk should include a comprehensive review of family history of cancer. Individuals with a family history of pancreatic cancer affecting two first-degree relatives meet criteria for familial pa...