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About 71,240 results

Systemic Lupus Erythematosus: Primary Care Approach to Diagnosis and Management
https://www.aafp.org/afp/2016/0815/p284.html
American Family Physician;

Aug 14th, 2016 - Systemic lupus erythematosus is an autoimmune disease that affects many systems, including the skin, musculoskeletal, renal, neuropsychiatric, hematologic, cardiovascular, pulmonary, and reproductive systems. Family physicians should be familiar with the manifestations of lupus to aid in early diagnosis, monitoring patients with mild disease, recognizing warning signs that require referral to a...

Aseptic and Bacterial Meningitis: Evaluation, Treatment, and Prevention
https://www.aafp.org/afp/2017/0901/p314.html
American Family Physician;

Aug 31st, 2017 - The etiologies of meningitis range in severity from benign and self-limited to life-threatening with potentially severe morbidity. Bacterial meningitis is a medical emergency that requires prompt recognition and treatment. Mortality remains high despite the introduction of vaccinations for common pathogens that have reduced the incidence of meningitis worldwide. Aseptic meningitis is the most c...

Breast Cancer Screening in High-Risk Men: A 12-Year Longitudinal Observational Study of Male Breast Imaging Utilization and Outcomes
https://pubs.rsna.org/doi/10.1148/radiol.2019190971
Radiology

Sep 16th, 2019 - Background Male breast cancer incidence is rising. There may be a potential role in selective screening in men at elevated risk for breast cancer, but the effectiveness of such screening remains unexplored. Purpose To evaluate patterns of male breast imaging utilization, to determine high-risk screening outcomes, and to delineate risk factors associated with cancer diagnosis. Materials and Me...

Spinal muscular atrophy
https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-6-71/
Orphanet Journal of Rare Diseasesvolume;

Nov 2nd, 2011 - Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease characterized by degeneration of alpha motor neurons in the spinal cord, resulting in progressive proximal muscle weakness and paralysis. Estimated incidence is 1 in 6,000 to 1 in 10,000 live births and carrier frequency of 1/40-1/60. This disease is characterized by generalized muscle weakness and atrophy predominati...

Fasting Triglycerides & Glucose Index: A Useful Screening Test for Assessing Insulin Resistance in Patients Diagnosed with Rheumatoid Arthritis & Systemic Lupus Erythematosus
https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-019-0495-x
Diabetology & Metabolic Syndrome; Contreras-Haro B,et al

Nov 26th, 2019 - Insulin resistance (IR) is frequently observed in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). In clinical practice, IR assessment is limited to a low proportion of patients due to cost and equipment and technical expertise requirements. The surrogate index of triglycerides and glucose (TyG index) has been validated in non-rheumatic populations, showing adequat...

Performance of human papillomavirus testing on self-collected versus clinician-collected samples for the detection of cervical intraepithelial neoplasia of grade 2 or worse: a randomised, paired sc...
https://www.thelancet.com/action/showPdf?pii=S1470-2045%2818%2930763-0
Polman,N.,et al

Jan 14th, 2019 - Human papillomavirus (HPV) testing on self-collected samples is a potential alternative to HPV testing on clinician-collected samples, but non-inferiority of its clinical accuracy remains to be assessed in the regular screening population. The IMPROVE study was done to evaluate the clinical accuracy of primary HPV testing on self-collected samples within an organised screening setting. In this ...

Inclusion Body Myositis - StatPearls
https://www.ncbi.nlm.nih.gov/books/NBK538200/

Jun 3rd, 2019 - Inclusion body myositis (IBM) is the most common subtype of autoimmune myopathy in patients older than the age of 50 years. Several diagnostic criteria have been proposed for IBM based on expert opinion and consensus groups. Their use in clinical practice is however limited due to low sensitivity. The European Neuromuscular Centre (ENMC) 2011 clinically defined diagnostic criteria have a high s...

Distinguishing rheumatoid arthritis from psoriatic arthritis
https://rmdopen.bmj.com/content/4/2/e000656
RMD Open; Merola,J.,et al

Aug 12th, 2018 - Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) have key differences in clinical presentation, radiographic findings, comorbidities and pathogenesis to distinguish between these common forms of chronic inflammatory arthritis. Joint involvement is typically, but not always, asymmetric in PsA, while it is predominantly symmetric in RA. Bone erosions, without new bone growth, and cervical ...

Early lung ultrasonography predicts the occurrence of acute respiratory distress syndro...
https://doi.org/10.1007/s00134-014-3382-9
Intensive Care Medicine; Leblanc D, Bouvet C et. al.

Jul 15th, 2014 - Extent of lung contusion on initial computed tomography (CT) scan predicts the occurrence of acute respiratory distress syndrome (ARDS) in blunt chest trauma patients. We hypothesized that lung ultrasonography (LUS) on admission could also predict subsequent ARDS. Forty-five blunt trauma patients were prospectively studied. Clinical examination, chest radiography, and LUS were performed on arri...

A test for Creutzfeldt-Jakob disease using nasal brushings.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186748
The New England Journal of Medicine; Orrú CD, Bongianni M et. al.

Aug 7th, 2014 - Definite diagnosis of sporadic Creutzfeldt-Jakob disease in living patients remains a challenge. A test that detects the specific marker for Creutzfeldt-Jakob disease, the prion protein (PrP(CJD)), by means of real-time quaking-induced conversion (RT-QuIC) testing of cerebrospinal fluid has a sensitivity of 80 to 90% for the diagnosis of sporadic Creutzfeldt-Jakob disease. We have assessed the ...

Prenatal antidepressant exposure is associated with risk for attention-deficit hyperact...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427538
Molecular Psychiatry; Clements CC, Castro VM et. al.

Aug 26th, 2014 - Previous studies suggested that risk for Autism Spectrum Disorder (ASD) may be increased in children exposed to antidepressants during the prenatal period. The disease specificity of this risk has not been addressed and the possibility of confounding has not been excluded. Children with ASD or attention-deficit hyperactivity disorder (ADHD) delivered in a large New England health-care system we...

Moving toward "laboratory-supported" criteria for psychogenic tremor.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664413
Movement Disorders : Official Journal of the Movement Dis... Schwingenschuh P, Katschnig P et. al.

Sep 30th, 2011 - A confident clinical diagnosis of psychogenic tremor is often possible, but, in some cases, a "laboratory-supported" level of certainty would aid in early positive diagnosis. Various electrophysiological tests have been suggested to identify patients with psychogenic tremor, but their diagnostic reliability has never been assessed "head to head" nor compared to forms of organic tremor other tha...

Three-dimensional echocardiographic assessment of right ventricular volume and function...
https://doi.org/10.1016/j.echo.2009.11.002
Journal of the American Society of Echocardiography : Off... Grewal J, Majdalany D et. al.

Dec 7th, 2009 - The aim of this study was to evaluate the accuracy of three-dimensional (3D) ultrasound compared with the standard magnetic resonance imaging method in determining right ventricular (RV) volumes and function in adult patients with congenital heart disease and chronic, severe pulmonary regurgitation (PR). Twenty-five patients with severe PR secondary to either pulmonary valvotomy or tetralogy of...

Systematic review with meta-analysis: magnetic resonance enterography vs. computed tomo...
https://doi.org/10.1111/apt.12815
Alimentary Pharmacology & Therapeutics; Qiu Y, Mao R et. al.

Jun 10th, 2014 - Magnetic resonance enterography (MRE) has been proposed as a non-ionising alternative method to computed tomography enterography (CTE). Some studies have directly compared CTE and MRE in patients with small bowel Crohn's disease (CD) with variable results. To compare the overall diagnostic accuracy in assessing the activity of small bowel and complications. MEDLINE, EMBASE and Cochrane database...

A comparison of tau and 14-3-3 protein in the diagnosis of Creutzfeldt-Jakob disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098812
Neurology Hamlin C, Puoti G et. al.

Jul 30th, 2012 - To compare the respective efficiency of CSF tau (quantitative) and CSF 14-3-3 protein (qualitative) in the diagnosis of prion disease. We made measurements on 420 live subjects, who subsequently underwent a postmortem neuropathology examination, including protein chemistry, immunohistochemistry, and histology. We performed tau by ELISA. We detected 14-3-3 protein by Western blot. Both assays we...

Identification of cell-type-specific mutations in nodal T-cell lymphomas.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301031
Blood Cancer Journal; Nguyen TB, Sakata-Yanagimoto M et. al.

Feb 5th, 2017 - Recent genetic analysis has identified frequent mutations in ten-eleven translocation 2 (TET2), DNA methyltransferase 3A (DNMT3A), isocitrate dehydrogenase 2 (IDH2) and ras homolog family member A (RHOA) in nodal T-cell lymphomas, including angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified. We examined the distribution of mutations in these subtypes of m...

Update on rapid diagnostic testing for malaria.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223842
Clinical Microbiology Reviews; Murray CK, Gasser RA et. al.

Jan 18th, 2008 - To help mitigate the expanding global impact of malaria, with its associated increasing drug resistance, implementation of prompt and accurate diagnosis is needed. Malaria is diagnosed predominantly by using clinical criteria, with microscopy as the current gold standard for detecting parasitemia, even though it is clearly inadequate in many health care settings. Rapid diagnostic tests (RDTs) h...

Overweight/Obese adults with pituitary disorders require lower peak growth hormone cuto...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255132
The Journal of Clinical Endocrinology and Metabolism; Dichtel LE, Yuen KC et. al.

Sep 11th, 2014 - Obesity is associated with diminished GH secretion, which may result in the overdiagnosis of adult GH deficiency (GHD) in overweight/obese pituitary patients. However, there are no body mass index (BMI)-specific peak GH cutoffs for the glucagon stimulation test (GST), the favored dynamic test for assessing adult GHD in the United States. The objective of the study was to determine a peak GH cut...

Dermatologic and dental aspects of the 2012 International Tuberous Sclerosis Complex Co...
https://doi.org/10.1001/jamadermatol.2014.938
JAMA Dermatology; Teng JM, Cowen EW et. al.

Jul 16th, 2014 - The 2012 International Tuberous Sclerosis Complex Clinical Consensus Conference was convened to update the last consensus statement in 1998. Skin and dental lesions are common in tuberous sclerosis complex (TSC) and are a frequent concern for patients. Recognition of these lesions is imperative for early diagnosis, given the treatment advances that may improve patient outcomes. To detail recomm...

MR enteroclysis in refractory celiac disease: proposal and validation of a severity sco...
https://doi.org/10.1148/radiol.11101808
Radiology Van Weyenberg SJ, Meijerink MR et. al.

Feb 18th, 2011 - To determine magnetic resonance (MR) enteroclysis findings in patients with uncomplicated celiac disease (CD), refractory CD (RCD) type I, and RCD type II, to develop and validate a scoring system to identify patients with RCD II and to determine the diagnostic accuracy of MR enteroclysis to detect CD-related malignancies. This study was performed with approval of the institutional review board...