About 298,200 results

Clinical features and multidisciplinary treatment outcome of COVID-19 pneumonia: A report of three cases

The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic threatening global public health. In the current paper, we describe our successful treatment of three COVID-19 pneumonia patients cases including severe cases and cases with mortality risk factors. One 32-year-old male COVID-19 patient was diagnosed with sev...

Compassionate remdesivir treatment of severe Covid-19 pneumonia in intensive care unit (ICU) and Non-ICU patients: Clinical outcome and differences in post-treatment hospitalisation status

SARS-CoV-2 is causing an increasing number of deaths worldwide because no effective treatment is currently available. Remdesivir has shown in vitro activity against coronaviruses and is a possible antiviral treatment for SARS-CoV-2 infection.

Risk factors of levodopa-induced dyskinesia in Parkinson’s disease: results from the PPMI cohort
NPJ Parkinson's Disease;

Levodopa-induced dyskinesias (LID) negatively impact on the quality of life of patients with Parkinson’s disease (PD). We assessed the risk factors for LID in a cohort of de-novo PD patients enrolled in the Parkinson’s Progression Markers Initiative (PPMI). This retrospective cohort study included all PD patients enrolled in the PPMI cohort. Main outcome was the incidence rate of dyskinesia, de...

WFH Guidelines for the Management of Hemophilia, 3rd edition

Aug 2nd, 2020 - This new edition of the World Federation of Hemophilia (WFH) guidelines for the management of hemophilia comes at an exciting time in the evolution of the diagnosis and treatment of this condition. Since the publication of the second edition in 2012, tremendous advances have been made in several aspects of the management of hemophilia. These include genetic assessment as well as therapy with ma...

Covid-19 infection in therapy-naive patients with B-cell chronic lymphocytic leukemia
Leukemia Research; Paneesha S

Apr 29th, 2020 - The global pandemic of the novel coronavirus SARS-CoV-2 represents one of the greatest infectious challenges to human health in recent history. At the current time over 3.2 million people have been infected and this has proved fatal in over 230,000 cases. Patients who are immune suppressed, from underlying disease or iatrogenic intervention, are believed to be at increased risk of severe clinic...

The ABO Blood Group is an Independent Prognostic Factor in Patients with Ovarian Cancer
Journal of Cancer; Song Q

Oct 21st, 2019 - Previous studies have suggested a relationship between ABO blood group and clinical outcome of various cancers.

Outcome of Children With Hypodiploid Acute Lymphoblastic Leukemia: A Retrospective Multinational Study
Pui,C.,et al

Jan 17th, 2019 - We determined the prognostic factors and utility of allogeneic hematopoietic cell transplantation among children with newly diagnosed hypodiploid acute lymphoblastic leukemia (ALL) treated in contemporary clinical trials. This retrospective study collected data on 306 patients with hypodiploid ALL who were enrolled in the protocols of 16 cooperative study groups or institutions between 1997 and...

Use of Antibiotics and Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies
Cancers Petrelli,F.,et al

Jul 30th, 2019 - The association between antibiotic use and risk of cancer development is unclear, and clinical trials are lacking. We performed a systematic review and meta-analysis of observational studies to assess the association between antibiotic use and risk of cancer. PubMed, the Cochrane Library and EMBASE were searched from inception to 24 February 2019 for studies reporting antibiotic use and subsequ...

Daiichi Sankyo Announces Outcome of FDA Oncologic Drugs Advisory Committee Meeting to Review FLT3 Inhibitor Quizartinib for the Treatment of Patients with Relapsed/Refractory FLT3-ITD AML

May 13th, 2019 - Daiichi Sankyo Company, Limited (hereafter, Daiichi Sankyo) today announced the outcome of the U.S. Food and Drug Administration (FDA) Oncologic Drugs Advisory Committee (ODAC) to discuss the company’s New Drug Application (NDA) for quizartinib for the treatment of adults with relapsed/refractory FLT3-ITD acute myeloid leukemia (AML). Three committee members voted yes and 8 committee membe...

Rocky Mountain Spotted Fever (RMSF) - CDC

Feb 18th, 2019 - Doxycycline is the treatment of choice for RMSF, and all other tickborne rickettsial diseases. Use of antibiotics other than doxycycline is associated with a higher risk of fatal outcome from RMSF.

Significance of chimerism in hematopoietic stem cell transplantation: new variations on an old theme
Bone Marrow Transplantation;

May 23rd, 2004 - The main goal of post-transplantation monitoring in hematopoietic stem cell transplantation (HSCT) is to predict negative events, such as disease relapse, graft rejection and graft-versus-host disease, in order to intervene with appropriate therapy. In this context, chimerism analysis is an important method in monitoring post HSCT outcome. Mixed chimerism (MC) is mainly evaluated to define engr...

Practice Guideline for the Treatment of Patients With Bipolar Disorder

Mar 31st, 2002 - The American Psychiatric Association (APA) Practice Guidelines are not intended to be construed or to serve as a standard of medical care. Standards of medical care are determined on the basis of all clinical data available for an individual patient and are subject to change as scientific knowledge and technology advance and practice patterns evolve. These parameters of practice should be consi...

Coffee and caffeine intake and risk of ovarian cancer: a systematic review and meta-analysis
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society; Shafiei F,et al

Mar 4th, 2019 - Results from earlier publications on the association of coffee and caffeine and risk of ovarian cancer are inconsistent.To evaluate the link between coffee, caffeine, caffeinated coffee, and decaffeinated coffee consumption and risk of ovarian cancer.We searched PubMed/Medline, ISI Web of Science, Scopus, and Google Scholar to identify relevant publications up to April 2018. All case–control st...

Machine learning approaches to predict lupus disease activity from gene expression data
Scientific Reports; Kegerreis,B.,et al

Jul 2nd, 2019 - The integration of gene expression data to predict systemic lupus erythematosus (SLE) disease activity is a significant challenge because of the high degree of heterogeneity among patients and study cohorts, especially those collected on different microarray platforms. Here we deployed machine learning approaches to integrate gene expression data from three SLE data sets and used it to classify...

Treating Bipolar Disorder: A Quick Reference Guide

Oct 31st, 2005 - The Practice Guidelines and the Quick Reference Guides are not intended to be construed or to serve as a standard of medical care. Standards of medical care are determined on the basis of all clinical data available for an individual patient and are subject to change as scientific knowledge and technology advance and practice patterns evolve. These parameters of practice should be considered gu...

Differential Diagnosis of Meningococcal Meningitis Based on Common Clinical and Laboratory Findings: Are There Criterion Standards?
Infectious Diseases in Clinical Practice; Fretzayas,A.,et al

Jul 1st, 2010 - Background: The prompt diagnosis of meningitis is essential for a good outcome. Aim: This study was designed to differentiate children with meningococcal meningitis, aseptic meningitis, and no meningitis. Patients and Methods: A total of 150 children aged 1 month to 12 years and adolescents aged 12 to 14 years, who had had a lumbar puncture, were recruited. In all patients, demographic charac...

Primary angiitis of the central nervous system: description of the first fifty-two adul...
Arthritis & Rheumatology (Hoboken, N.J.); de Boysson H, Zuber M et. al.

May 1st, 2014 - To describe characteristics and outcomes of a multicenter cohort of patients diagnosed as having primary angiitis of the central nervous system (PACNS). In 2010, we initiated a cohort study of adults diagnosed as having PACNS ≤15 years ago and with followup of >6 months (unless they died earlier of biopsy-proven PACNS). Its first analysis was planned at 2 years. Multidisciplinary investigators ...

Effect of acetazolamide on visual function in patients with idiopathic intracranial hyp...
JAMA , Wall M et. al.

Apr 23rd, 2014 - Acetazolamide is commonly used to treat idiopathic intracranial hypertension (IIH), but there is insufficient information to establish an evidence base for its use. To determine whether acetazolamide is beneficial in improving vision when added to a low-sodium weight reduction diet in patients with IIH and mild visual loss. Multicenter, randomized, double-masked, placebo-controlled study of ace...

Event-free survival at 24 months is a robust end point for disease-related outcome in d...
Journal of Clinical Oncology : Official Journal of the Am... Maurer MJ, Ghesquières H et. al.

Feb 19th, 2014 - Studies of diffuse large B-cell lymphoma (DLBCL) are typically evaluated by using a time-to-event approach with relapse, re-treatment, and death commonly used as the events. We evaluated the timing and type of events in newly diagnosed DLBCL and compared patient outcome with reference population data. Patients with newly diagnosed DLBCL treated with immunochemotherapy were prospectively enrolle...

Rosuvastatin for sepsis-associated acute respiratory distress syndrome.
The New England Journal of Medicine; , Truwit JD et. al.

May 19th, 2014 - In the acute respiratory distress syndrome (ARDS), inflammation in the lungs and other organs can cause life-threatening organ failure. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins) can modulate inflammatory responses. Previous observational studies suggested that statins improved clinical outcomes in patients with sepsis. We hypothesized that rosuvastatin therapy woul...