https://doi.org/10.1111/epi.17530
Epilepsia Nissenkorn A, Kluger G et. al.
Feb 4th, 2023 - Perampanel, an antiseizure drug with AMPA-receptor antagonist properties, may have a targeted effect in genetic epilepsies with overwhelming glutamate receptor activation. Special interest holds epilepsies with loss of GABA inhibition (e.g. SCN1A), overactive excitatory neurons (e.g. SCN2A, SCN8A ), and variants in glutamate receptors (e.g. GRIN2A). We aimed to collect data from a large rare ge...
https://clinicaltrials.gov/ct2/show/NCT04019444
Feb 3rd, 2023 - This is a single-center, observer-blinded, Phase 1, dosage-escalation trial to evaluate the safety, tolerability, reactogenicity, and immunogenicity of ChAd155-RG compared with RABAVERT in rabies virus-naïve healthy male and non-pregnant female adult subjects ages 18-49. Subjects who have never received a licensed or investigational rabies virus vaccine, or an Ad-based investigational vaccine, ...
https://clinicaltrials.gov/ct2/show/NCT05376124
Feb 3rd, 2023 - Refractory sex hepatitis B is to point to although standard application nucleoside (acid) analogue treatment undertakes first treat and 2 strengthen treat cure, but existence is persistent viraemia. These patients have active liver inflammation and are at high risk for progression to cirrhosis or primary liver cancer due to persistent virus-positive symptoms. Therefore, it is of great significa...
https://clinicaltrials.gov/ct2/show/NCT05453578
Feb 3rd, 2023 - This is a phase 1b/2, multicenter, randomized placebo-controlled double-blind study of a single dose of intravenous (IV) bacteriophage in males and non-pregnant females, at least 18 years old, diagnosed with Cystic Fibrosis (CF). This clinical trial is designed to assess the safety and microbiological activity of bacteriophage product WRAIR_PAM-CF1, directed at P. aeruginosa in clinically stabl...
https://clinicaltrials.gov/ct2/show/NCT04386239
Feb 3rd, 2023 - In February 2020, the emergence of the COVID-19 epidemic in Italy and, especially, in Lombardy, with a potential fatal outcome in a significant proportion of cases, determined the need for adopting new therapeutic approached based on the few data available in literature. Although there are no clinical data available in COVID-19 patients concomitantly treated with Sarilumab subcutaneously (SC) n...
https://doi.org/10.1177/09612033231155837
Lupus Patil A, Shobha V et. al.
Feb 3rd, 2023 - Patients with SLE (systemic lupus erythematosus) have a higher risk of infection due to dysregulated immune system as well as long-term use of immunosuppressants (IS). This could influence the risk of COVID-19 and its outcome. We conducted a longitudinal prospective study across 15 rheumatology centres during the first wave of the pandemic to understand the risk factors contributing to COVID-19...
https://doi.org/10.1016/j.intimp.2023.109788
International Immunopharmacology; Liang J, Abulikemu K et. al.
Feb 3rd, 2023 - Bullous pemphigoid is an autoimmune blistering disease that affects the elderly mostly. First-line treatment of systemic corticosteroids may cause significant adverse effects, especially in patients with multiple co-morbidities. Dupilumab shows certain effectiveness in treating BP. We aim to profile our experience with dupilumab in a series of patients with BP and review the articles published ...
https://doi.org/10.1016/j.seizure.2023.01.008
Seizure Knight R, Craig J et. al.
Feb 3rd, 2023 - Many women with epilepsy need to continue anti-seizure medications (ASMs) throughout pregnancy. The current study investigated adaptive behaviour outcomes in children exposed to topiramate in the womb. An observational, cross-sectional study was designed, recruiting mother-child-pairs from the UK Epilepsy and Pregnancy Register (UKEPR). Health, developmental histories and Vineland Adaptive Beha...
https://doi.org/10.1016/j.ejmg.2023.104716
European Journal of Medical Genetics; Santos-Rebouças CB, Boy R et. al.
Feb 3rd, 2023 - Sequence variants and duplications in the HECT, UBA and WWE domain -containing 1 (HUWE1) E3 ubiquitin ligase gene have been associated with X-linked mild to severe intellectual disability (ID), but a solid phenotype pattern among the affected males is still remaining to be established. Here, we report a male patient with sporadic, severe and syndromic ID, carrying a novel and unique 842 kb dupl...
https://doi.org/10.1097/ICU.0000000000000933
Current Opinion in Ophthalmology; Chen X, Shen T
Feb 3rd, 2023 - Currently, glaucoma treatment drugs are facing problems such as low bioavailability, poor patient compliance, discontinuous administration affecting the efficacy of intraocular pressure (IOP) lowering and chronic damage to the eye caused by side effects of drugs. In order to solve these problems and to better meet clinical needs, various new dosage forms have been developed and applied in the c...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0b1332a1-0581-4707-9bf6-1eccfa39bef4
Feb 2nd, 2023 - LYTGOBI is indicated for the treatment of adult patients with previously treated, unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma harboring fibroblast growth factor receptor 2 (FGFR2) gene fusions or other rearrangements [see Dosage and Administration (2.1)]. This indication is approved under accelerated approval based on overall response rate and duration of respon...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=14f64ceb-ea5c-4d7c-a0c1-3f6a64847290
Feb 2nd, 2023 - Cyclobenzaprine hydrochloride extended-release capsules are indicated as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions. Improvement is manifested by relief of muscle spasm and its associated signs and symptoms, namely, pain, tenderness, and limitation of motion. Limitations of Use: Cyclobenzaprine hydrochloride exten...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=14124e56-77ba-426d-8f5a-dbe42eda1a20
Feb 2nd, 2023 - Amlodipine and atorvastatin tablets are indicated in patients for whom treatment with both amlodipine and atorvastatin is appropriate. Amlodipine Amlodipine and atorvastatin tablets are a combination of amlodipine besylate, a calcium channel blocker, and atorvastatin calcium, a HMG CoA-reductase inhibitor, indicated in patients for whom treatment with both amlodipine and atorvastatin is appropr...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=19ec8066-f0e7-4f80-b596-abe7b1ad92cb
Feb 2nd, 2023 - Baclofen is useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. Patients should have reversible spasticity so that baclofen treatment will aid in restoring residual function. Baclofen may also be of some value in patients with spinal cord injuries and o...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4eb83e73-9dba-07ae-e054-00144ff8d46c
Feb 2nd, 2023 - 1.1 Infections of the Ear, Nose, and Throat Amoxicillin capsules are indicated in the treatment of infections due to susceptible (ONLY β-lactamase–negative) isolates of Streptococcus species. (α- and β-hemolytic isolates only), Streptococcus pneumoniae, Staphylococcus spp., or Haemophilus influenzae. 1.2 Infections of the Genitourinary Tract Amoxicillin capsules are indicated in the treatment o...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=59de488c-c3f8-415d-9e9f-9102c090aac8
Feb 2nd, 2023 - Attention Deficit Disorders (previously known as Minimal Brain Dysfunction in Children). Other terms being used to describe the behavioral syndrome below include: Hyperkinetic Child Syndrome, Minimal Brain Damage, Minimal Cerebral Dysfunction, Minor Cerebral Dysfunction. Methylphenidate HCl Oral Solution is indicated as an integral part of a total treatment program which typically includes othe...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a2a5bb34-671b-499c-b8b4-c40fb51af09a
Feb 2nd, 2023 - Recent Major Changes Section Warnings and Precautions (5) 11/2022 Indications & Usage Section Adults and Pediatric Patients Upper Respiratory Tract Infections of the Ear, Nose, and Throat: Amoxicillin for oral suspension is indicated in the treatment of infections due to susceptible (ONLY β-lactamase–negative) isolates of Streptococcus species. (α- and β-hemolytic isolates only), Streptococcu...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7d5cb52e-37dd-4dfa-a6f4-09f9548846c6
Feb 2nd, 2023 - Valproic acid is indicated for: Monotherapy and adjunctive therapy of complex partial seizures; sole and adjunctive therapy of simple and complex absence seizures; adjunctive therapy in patients with multiple seizure types that include absence seizures (1) Valproic acid is indicated as monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures that occur eithe...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d0644a68-d1bf-4fe0-92e6-b79037cf4d12
Feb 2nd, 2023 - Baclofen tablets USP are useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. Patients should have reversible spasticity so that baclofen tablet treatment will aid in restoring residual function. Baclofen tablets USP may also be of some value in patients...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d3ce21de-849a-47ab-8405-968d8de6f1e9
Feb 2nd, 2023 - Perennial and seasonal allergic rhinitis Vasomotor rhinitis Allergic conjunctivitis due to inhalant allergens and foods Mild, uncomplicated allergic skin manifestations of urticaria and angioedema Amelioration of allergic reactions to blood or plasma Cold urticaria Dermatographism As therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifes...
