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About 155,352 results

Levodopa‐induced dyskinesia in Parkinson's disease: clinical features, pathogenesis, prevention and treatment
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600052/
Postgraduate Medical Journal;

Jun 4th, 2007 - Levodopa is the most effective drug for treating Parkinson's disease. However, long‐term use of levodopa is often complicated by significantly disabling fluctuations and dyskinesias negating its beneficial effects. Younger age of Parkinson's disease onset, disease severity, and high levodopa dose increase the risk of development of levodopa‐induced dyskinesias (LID). The underlying mechanisms f...

Use of Vibrio cholerae vaccine in an outbreak in Guinea.
https://doi.org/10.1056/NEJMoa1312680
The New England Journal of Medicine; Luquero FJ, Grout L et. al.

May 29th, 2014 - The use of vaccines to prevent and control cholera is currently under debate. Shanchol is one of the two oral cholera vaccines prequalified by the World Health Organization; however, its effectiveness under field conditions and the protection it confers in the first months after administration remain unknown. The main objective of this study was to estimate the short-term effectiveness of two d...

Effect of acetazolamide on visual function in patients with idiopathic intracranial hyp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362615
JAMA , Wall M et. al.

Apr 23rd, 2014 - Acetazolamide is commonly used to treat idiopathic intracranial hypertension (IIH), but there is insufficient information to establish an evidence base for its use. To determine whether acetazolamide is beneficial in improving vision when added to a low-sodium weight reduction diet in patients with IIH and mild visual loss. Multicenter, randomized, double-masked, placebo-controlled study of ace...

Event-free survival at 24 months is a robust end point for disease-related outcome in d...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965261
Journal of Clinical Oncology : Official Journal of the Am... Maurer MJ, Ghesquières H et. al.

Feb 19th, 2014 - Studies of diffuse large B-cell lymphoma (DLBCL) are typically evaluated by using a time-to-event approach with relapse, re-treatment, and death commonly used as the events. We evaluated the timing and type of events in newly diagnosed DLBCL and compared patient outcome with reference population data. Patients with newly diagnosed DLBCL treated with immunochemotherapy were prospectively enrolle...

Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698790
JAMA Hsieh MM, Fitzhugh CD et. al.

Jul 24th, 2014 - Myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) is curative for children with severe sickle cell disease, but toxicity may be prohibitive for adults. Nonmyeloablative transplantation has been attempted with degrees of preparative regimen intensity, but graft rejection and graft-vs-host disease remain significant. To determine the efficacy, safety, and outcome on end-orga...

Effect of postoperative antibiotic administration on postoperative infection following ...
https://doi.org/10.1001/jama.2014.7586
JAMA Regimbeau JM, Fuks D et. al.

Jul 9th, 2014 - Ninety percent of cases of acute calculous cholecystitis are of mild (grade I) or moderate (grade II) severity. Although the preoperative and intraoperative antibiotic management of acute calculous cholecystitis has been standardized, few data exist on the utility of postoperative antibiotic treatment. To determine the effect of postoperative amoxicillin plus clavulanic acid on infection rates ...

Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a...
https://doi.org/10.1016/S0140-6736(14)61185-5
Lancet (London, England); Chang LJ, Dowd KA et. al.

Aug 18th, 2014 - Chikungunya virus--a mosquito-borne alphavirus--is endemic in Africa and south and southeast Asia and has recently emerged in the Caribbean. No drugs or vaccines are available for treatment or prevention. We aimed to assess the safety, tolerability, and immunogenicity of a new candidate vaccine. VRC 311 was a phase 1, dose-escalation, open-label clinical trial of a virus-like particle (VLP) chi...

Subcutaneous veltuzumab, a humanized anti-CD20 antibody, in the treatment of refractory...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897695
JAMA Dermatology; Ellebrecht CT, Choi EJ et. al.

Aug 18th, 2014 - IMPORTANCE B-cell depletion with the anti-CD20 antibody rituximab is highly effective for pemphigus vulgaris (PV) treatment. However,most patients experience relapse, and intravenous rituximab infusions are expensive. Therefore, cost-effective anti-CD20 therapies are desirable.OBSERVATIONS A compassionate-use investigational new drug protocol was approved to administer veltuzumab, a second-gene...

Starting lithium prophylaxis early v. late in bipolar disorder.
https://doi.org/10.1192/bjp.bp.113.142802
The British Journal of Psychiatry : the Journal of Mental... Kessing LV, Vradi E et. al.

Jul 11th, 2014 - No study has investigated when preventive treatment with lithium should be initiated in bipolar disorder. To compare response rates among patients with bipolar disorder starting treatment with lithium early v. late. Nationwide registers were used to identify all patients with a diagnosis of bipolar disorder in psychiatric hospital settings who were prescribed lithium during the period 1995-2012...

Recombinant long-acting glycoPEGylated factor IX in hemophilia B: a multinational rando...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271178
Blood Collins PW, Young G et. al.

Sep 27th, 2014 - This multinational, randomized, single-blind trial investigated the safety and efficacy of nonacog beta pegol, a recombinant glycoPEGylated factor IX (FIX) with extended half-life, in 74 previously treated patients with hemophilia B (FIX activity ≤2 IU/dL). Patients received prophylaxis for 52 weeks, randomized to either 10 IU/kg or 40 IU/kg once weekly or to on-demand treatment of 28 weeks. No...

Prospective evaluation of ursodeoxycholic acid withdrawal in patients with primary scle...
https://doi.org/10.1002/hep.27074
Hepatology (Baltimore, Md.); Wunsch E, Trottier J et. al.

Feb 12th, 2014 - Ursodeoxycholic acid (UDCA) is no longer recommended for management of adult patients with primary sclerosing cholangitis (PSC). We undertook a prospective evaluation of UDCA withdrawal in a group of consecutive patients with PSC. Twenty six patients, all treated with UDCA (dose range: 10-15 mg/kg/day) were included. Paired blood samples for liver biochemistry, bile acids, and fibroblast growth...

Retrospective review of Stevens-Johnson syndrome/toxic epidermal necrolysis treatment c...
https://doi.org/10.1016/j.jaad.2014.07.016
Journal of the American Academy of Dermatology; Kirchhof MG, Miliszewski MA et. al.

Aug 4th, 2014 - Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are mucocutaneous reactions, typically to medications, that are associated with a high patient mortality. Controversy exists over which systemic treatments decrease mortality associated with SJS/TEN. In this study we sought to determine whether intravenous immunoglobulin (IVIg) or cyclosporine use for SJS/TEN results in better ...

Autologous transplantation and maintenance therapy in multiple myeloma.
https://doi.org/10.1056/NEJMoa1402888
The New England Journal of Medicine; Palumbo A, Cavallo F et. al.

Sep 3rd, 2014 - This open-label, randomized, phase 3 study compared melphalan at a dose of 200 mg per square meter of body-surface area plus autologous stem-cell transplantation with melphalan-prednisone-lenalidomide (MPR) and compared lenalidomide maintenance therapy with no maintenance therapy in patients with newly diagnosed multiple myeloma. We randomly assigned 273 patients 65 years of age or younger to h...

Dalfampridine may activate latent trigeminal neuralgia in patients with multiple sclero...
https://doi.org/10.1212/WNL.0000000000000931
Neurology Birnbaum G, Iverson J

Sep 27th, 2014 - To determine the effect of dalfampridine (4-aminopyridine), a broad-spectrum, voltage-dependent potassium channel blocker, on patients with trigeminal nerve dysfunction due to multiple sclerosis (MS). We reviewed histories of 71 patients in our clinic with clinically definite MS who were treated with dalfampridine for at least 2 to 3 months. Of the 71 patients, 5 had a history of either trigemi...

Randomized comparison of gemcitabine, dexamethasone, and cisplatin versus dexamethasone...
https://doi.org/10.1200/JCO.2013.53.9593
Journal of Clinical Oncology : Official Journal of the Am... Crump M, Kuruvilla J et. al.

Sep 30th, 2014 - For patients with relapsed or refractory aggressive lymphoma, we hypothesized that gemcitabine-based therapy before autologous stem-cell transplantation (ASCT) is as effective as and less toxic than standard treatment. We randomly assigned 619 patients with relapsed/refractory aggressive lymphoma to treatment with gemcitabine, dexamethasone, and cisplatin (GDP) or to dexamethasone, cytarabine, ...

National, Regional, State, and Selected Local Area Vaccination Coverage Among Adolescen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687818
MMWR. Morbidity and Mortality Weekly Report; Walker TY, Elam-Evans LD et. al.

Aug 24th, 2017 - The Advisory Committee on Immunization Practices (ACIP) recommends that adolescents routinely receive tetanus, diphtheria, and acellular pertussis vaccine (Tdap), meningococcal conjugate vaccine (MenACWY), and human papillomavirus (HPV) vaccine (1) at age 11-12 years. ACIP also recommends catch-up vaccination with hepatitis B vaccine, measles, mumps, and rubella (MMR) vaccine, and varicella vac...

Lymphoma Remissions Caused by Anti-CD19 Chimeric Antigen Receptor T Cells Are Associate...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455597
Journal of Clinical Oncology : Official Journal of the Am... Kochenderfer JN, Somerville RPT et. al.

Mar 15th, 2017 - Purpose T cells genetically modified to express chimeric antigen receptors (CARs) targeting CD19 (CAR-19) have potent activity against acute lymphoblastic leukemia, but fewer results supporting treatment of lymphoma with CAR-19 T cells have been published. Patients with lymphoma that is chemotherapy refractory or relapsed after autologous stem-cell transplantation have a grim prognosis, and new...

Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines in the United States: Re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919600
MMWR. Recommendations and Reports : Morbidity and Mortali... Liang JL, Tiwari T et. al.

Apr 27th, 2018 - This report compiles and summarizes all recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) regarding prevention and control of tetanus, diphtheria, and pertussis in the United States. As a comprehensive summary of previously published recommendations, this report does not contain any new recommendations and replaces all previously published reports and policy notes; ...

Antidepressants during pregnancy and autism in offspring: population based cohort study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516223
BMJ (Clinical Research Ed.); Rai D, Lee BK et. al.

Jul 20th, 2017 - Objectives To study the association between maternal use of antidepressants during pregnancy and autism spectrum disorder (ASD) in offspring.Design Observational prospective cohort study with regression methods, propensity score matching, sibling controls, and negative control comparison.Setting Stockholm County, Sweden.Participants 254 610 individuals aged 4-17, including 5378 with autism, liv...

Ataluren in patients with nonsense mutation Duchenne muscular dystrophy (ACT DMD): a mu...
https://doi.org/10.1016/S0140-6736(17)31611-2
Lancet (London, England); McDonald CM, Campbell C et. al.

Jul 21st, 2017 - Duchenne muscular dystrophy (DMD) is a severe, progressive, and rare neuromuscular, X-linked recessive disease. Dystrophin deficiency is the underlying cause of disease; therefore, mutation-specific therapies aimed at restoring dystrophin protein production are being explored. We aimed to assess the efficacy and safety of ataluren in ambulatory boys with nonsense mutation DMD. We did this multi...