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About 150,845 results

Fluconazole - fluconazole tablet-REMEDYREPACK INC.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d11e0926-cd15-49ba-b0ee-2b6d4e009dd8

Dec 30th, 2022 - Fluconazole tablets are indicated for the treatment of: Vaginal candidiasis (vaginal yeast infections due to Candida). Oropharyngeal and esophageal candidiasis. In open noncomparative studies of relatively small numbers of patients, fluconazole tablets were also effective for the treatment of Candida urinary tract infections, peritonitis, and systemic Candida infections including candidemia, di...

Cortrosyn - cosyntropin injection, powder, lyophilized, for solution-Amphastar Pharmaceuticals, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=746856e9-3930-4f6a-b8e6-a03845d6dd0b

Dec 1st, 2022 - CORTROSYN® (cosyntropin) for Injection is intended for use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency. Because of its rapid effect on the adrenal cortex it may be utilized to perform a 30-minute test of adrenal function (plasma cortisol response) as an office or outpatient procedure, using only 2 venipunctures (see DOSAGE AND ADMINISTRATION ...

FASlpr Gene Dosage Differentiates Lymphoproliferative from Non-lymphoproliferative Autoimmunity – a Novel Mouse Model of Lupus
https://acrabstracts.org/abstract/faslpr-gene-dosage-differentiates-lymphoproliferative-from-non-lymphoproliferative-autoimmunity-a-novel-mouse-model-of-lupus/
Ritu Bohat, Chunyu Xu, Xiaofang Liang et. al.

Nov 14th, 2022 - Background/Purpose: Sle1 and FASlpr are two lupus susceptibility loci that lead to manifestations of systemic lupus erythematosus (SLE) by altering the FAS/FASL pathway and adaptive immunity. Although C57BL/6 (B6) mice bearing either of these genes display mild phenotypes, the epistatic interaction of Sle1 and FASlpr results in severe lupus, confirming that these two genes impact non-redundant,...

Impaired Dynamic X-Chromosome Inactivation Maintenance in T Lymphocytes Is a Feature of Spontaneous Lupus in Female Mice and Is Exacerbated in Female-Biased Disease Models
https://acrabstracts.org/abstract/impaired-dynamic-x-chromosome-inactivation-maintenance-in-t-lymphocytes-is-a-feature-of-spontaneous-lupus-in-female-mice-and-is-exacerbated-in-female-biased-disease-models/
Nikhil Jiwrajka, Natalie Toothacre, Zachary Beethem et. al.

Nov 14th, 2022 - Background/Purpose: SLE is highly female-biased, yet the molecular origins of this bias remain unclear. The X chromosome contains many immune-related genes, suggesting that X-linked epigenetic dysregulation may contribute to female-biased immune responses. X-Chromosome Inactivation (XCI) is an X-chromosome-specific epigenetic regulatory mechanism that equalizes X-linked gene dosage between XX f...

Factors Associated with Disease Flare Following SARS-CoV-2 Vaccination in People with Inflammatory Rheumatic and Musculoskeletal Diseases – Results from the Physician-Reported EULAR Coronavirus Vac...
https://acrabstracts.org/abstract/factors-associated-with-disease-flare-following-sars-cov-2-vaccination-in-people-with-inflammatory-rheumatic-and-musculoskeletal-diseases-results-from-the-physician-reported-eular-coronaviru/
Bayram Farisoğulları, Saskia Lawson-Tovey, Kimme Hyrich et. al.

Nov 14th, 2022 - Background/Purpose: To investigate the frequency and factors associated with disease flare following vaccination against SARS-CoV-2 in people with inflammatory/autoimmune rheumatic and musculoskeletal diseases (I-RMD). Methods: The European Alliance of Associations for Rheumatology (EULAR) Coronavirus Vaccine (COVAX) physician-reported registry is an observational registry of patients with a pr...

Association of Glucocorticoid Use with Healthcare Utilization Among Persons with Systemic Lupus Erythematosus
https://acrabstracts.org/abstract/association-of-glucocorticoid-use-with-healthcare-utilization-among-persons-with-systemic-lupus-erythematosus/
Patricia Katz, Sofia Pedro, Jiyoon Choi3 and Kaleb Michaud et. al.

Nov 13th, 2022 - Background/Purpose: Glucocorticoids (GCs) have long been a mainstay of treatment for systemic lupus erythematosus (SLE). While GCs do provide benefit, there are potential side effects which increase with dose and duration. GC-associated adverse events have been linked to significant increased health care costs7, although excess healthcare utilization due to GC events has not been examined in SL...

Clinical and Economic Characterization of Systemic Lupus Erythematosus Patients by Cumulative Corticosteroid Dose over 1 Year: Real-World Observation of Commercially Insured Adults in the United St...
https://acrabstracts.org/abstract/clinical-and-economic-characterization-of-systemic-lupus-erythematosus-patients-by-cumulative-corticosteroid-dose-over-1-year-real-world-observation-of-commercially-insured-adults-in-the-united-state/
Sandra Sze-jung Wu, Allison Perry, Helen Varker et. al.

Nov 12th, 2022 - Background/Purpose: Systemic lupus erythematosus (SLE) is a complex, heterogeneous disease associated with periods of flares. Identifying patients at risk of severe disease and associated resource burden is challenging. While corticosteroids are a mainstay of SLE treatment, dosing regimens are based on limited data and associated with clinical challenges. Identifying the relationship between co...

Sirolimus - sirolimus tablet-Dr. Reddy's Laboratories Limited
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2e6130e5-fa94-dcf8-605c-817bf396e93d

Nov 5th, 2022 - Sirolimus is an mTOR inhibitor immunosuppressant indicated for the prophylaxis of organ rejection in patients aged ≥13 years receiving renal transplants: Patients at low-to moderate-immunologic risk: Use initially with cyclosporine (CsA) and corticosteroids. CsA withdrawal is recommended 2 to 4 months after transplantation (1.1). Patients at high-immunologic risk: Use in combination with CsA an...

FDA Approves New Treatment Option for Patients with ALS | FDA
https://www.fda.gov/news-events/press-announcements/fda-approves-new-treatment-option-patients-als

Oct 4th, 2022 - For Immediate Release: September 29, 2022 Español The U.S. Food and Drug Administration today approved Relyvrio (sodium phenylbutyrate/taurursodiol) to treat patients with amyotrophic lateral sclerosis (ALS), commonly referred to as Lou Gehrig’s disease. “This approval provides another important treatment option for ALS, a life-threatening disease that currently has no cure,” said Billy Dunn, M...

Sotatercept May Have Long Term Benefit in Pulmonary Arterial Hypertension
https://www.pulmonologyadvisor.com/home/topics/pulmonary-hypertension/sotatercept-may-have-long-term-benefit-in-pulmonary-arterial-hypertension/
Pulmonology Advisor

Oct 3rd, 2022 - Long-term use of sotatercept may allow patients with pulmonary arterial hypertension (PAH) to maintain significantly reduced pulmonary vascular resistance, according to results of an 18- to 24- month open-label extension trial published in The European Respiratory Journal. The previously conducted 24-week, placebo-controlled, phase 2 PULSAR clinical trial (ClinicalTrials.gov Identifier: NCT0349...

Prostin vr pediatric - alprostadil injection, solution-Pharmacia & Upjohn Company LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=930f8c02-46a8-4cff-a484-660468ab23c3

Oct 3rd, 2022 - PROSTIN VR PEDIATRIC Sterile Solution is indicated for palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Such congenital heart defects include pulmonary atresia, pulmonary stenosis, tricuspid atre...

Lorazepam - lorazepam injection-International Medication Systems, Limited
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7dda070d-7809-46c4-8592-eb4e4c509707

Oct 1st, 2022 - Lorazepam Injection, is indicated for the treatment of the status epilepticus. Lorazepam Injection, is indicated in adult patients for preanesthetic medication, producing sedation (sleepiness or drowsiness), relief of anxiety, and a decreased ability to recall events related to the day of surgery. It is most useful in those patients who are anxious about their surgical procedure and who would p...

Intermittent preventive treatment with Sulphadoxine-Pyrimethamine (IPTp-SP) is associat...
https://doi.org/10.1371/journal.pone.0275370
PloS One; Apinjoh TO, Ntui VN et. al.

Oct 1st, 2022 - The current guidelines for malaria prevention and control during pregnancy in Africa is predicated on the prevention of infection and/or disease through intermittent preventive treatment in pregnancy (IPTp), insecticide-treated nets (ITNs) and effective malaria case diagnosis and management. Concerns that increasing SP resistance in some areas of SSA may have compromised IPTp-SP efficacy prompt...

A systematic review on the use of clozapine in treatment of tardive dyskinesia and tard...
https://doi.org/10.1007/s00213-022-06241-2
Psychopharmacology Wong J, Pang T et. al.

Oct 1st, 2022 - Though clozapine is recommended for treatment of tardive dyskinesia (TD) relating to the use of antipsychotic medications, studies comprehensively investigating the treatment effect of clozapine on TD are still limited. This review examines the effectiveness of clozapine as an intervention for tardive dyskinesia and dystonia in patients with all psychiatric conditions. Effectiveness of clozapin...

Daptomycin - daptomycin injection, powder, lyophilized, for suspension-Slate Run Pharmaceuticals, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3890474a-4425-43b3-97d4-5370cc35c2f7

Oct 1st, 2022 - Daptomycin for injection is a lipopeptide antibacterial indicated for the treatment of: Complicated skin and skin structure infections (cSSSI) in adult and pediatric patients (1 to 17 years of age) ( 1.1) and, Staphylococcus aureus bloodstream infections (bacteremia), in adult patients including those with right-sided infective endocarditis. ( 1.2) Staphylococcus aureus bloodstream infections (...

Metoclopramide - metoclopramide injection, solution-HF Acquisition Co LLC, DBA HealthFirst
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7678bcd5-1071-0a9b-e053-2a91aa0a3853

Oct 1st, 2022 - Diabetic Gastroparesis (Diabetic Gastric Stasis) Metoclopramide is indicated for the relief of symptoms associated with acute and recurrent diabetic gastric stasis. The Prevention of Nausea and Vomiting Associated with Emetogenic Cancer Chemotherapy Metoclopramide Injection, USP is indicated for the prophylaxis of vomiting associated with emetogenic cancer chemotherapy. The Prevention of Postop...

Gentamicin sulfate - gentamicin sulfate injection, solution-HF Acquisition Co LLC, DBA HealthFirst
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e9fbe619-2afe-f1d7-e053-2a95a90aab29

Oct 1st, 2022 - To reduce the development of drug-resistant bacteria and maintain the effectiveness of gentamicin and other antibacterial drugs, gentamicin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial thera...

Famotidine - famotidine injection, solution-HF Acquisition Co LLC, DBA HealthFirst
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9948991d-9405-c7c8-e053-2995a90a60ca

Oct 1st, 2022 - Famotidine injection, supplied as a concentrated solution for intravenous injection, is intended for intravenous use only. Famotidine injection is indicated in some hospitalized patients with pathological hypersecretory conditions or intractable ulcers, or as an alternative to the oral dosage forms for short term use in patients who are unable to take oral medication for the following condition...

Optimizing Protein Patterns for Skeletal Muscle Preservation and Sleep in the Medical Management of Parkinson Disease
https://clinicaltrials.gov/ct2/show/NCT05437640

Sep 30th, 2022 - Parkinson's disease (PD) is a complex neurological disease that affects ~6.1 million people worldwide - mostly older adults >60 years. The most effective treatment for PD is dopaminergic therapy, particularly levodopa (Ldopa). People with PD have variable responses to Ldopa, including degrees of motor fluctuations (MF) throughout the day. The half-life of Ldopa is ~1.5 h and therefore, dosage a...

Intrathecal Pemetrexed for Leptomeningeal Metastasis
https://clinicaltrials.gov/ct2/show/NCT05289908

Sep 30th, 2022 - This is a phase I/II clinical trial. The objective of the study is patients with leptomeningeal metastases from solid tumors. Pemetrexed (Alimta, Eli Lilly and Company) is administrated by intrathecal injection, plus dexamethasone 5 mg, twice per week for 2 weeks, followed by once per week for 4 weeks. In phase I study, the initial dose of intrathecal pemetrexed is 15 mg, escalated to 20 mg, an...