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About 42,215 results

Novel insights on 1,2oxazolo[5,4-e]isoindoles on multidrug resistant acute myeloid leuk...
https://doi.org/10.1002/ddr.21962
Drug Development Research; Labbozzetta M, Barreca M et. al.

Jun 25th, 2022 - A series of [1,2]oxazolo[5,4-e]isoindole derivatives was evaluated against HL-60 cell line and its multidrug resistance (MDR) variant, HL-60R, resistant to doxorubicin and to other P-gp substrates by overexpressing the efflux pump. They displayed antiproliferative activities, with IC50 values ranging from 0.02 to 5.5 µM. In particular, the newly synthesized compound 4k produced synergistic effe...

Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria.
https://doi.org/10.1002/14651858.CD006404.pub4
The Cochrane Database of Systematic Reviews; Pryce J, Taylor M et. al.

Jun 22nd, 2022 - The World Health Organization (WHO) recommends artemisinin-based combination therapies (ACTs) to treat uncomplicated Plasmodium falciparum malaria. Concerns about artemisinin resistance have led to global initiatives to develop new partner drugs to protect artemisinin derivatives in ACT. Pyronaridine-artesunate is a novel ACT. To evaluate the efficacy of pyronaridine-artesunate compared to alte...

An Insight into the Structural Requirements and Pharmacophore Identification of Carboni...
https://doi.org/10.3390/cimb44030068
Current Issues in Molecular Biology; Ali A, Ali A et. al.

Jun 21st, 2022 - Carbonic anhydrases (CA) inhibitory action could be linked to the treatment of a number of ailments, including cancer, osteoporosis, glaucoma, and several neurological problems. For the development of effective CA inhibitors, a variety of heterocyclic rings have been investigated. Furthermore, at high altitudes, oxygen pressure drops, resulting in the formation of reactive oxygen and nitrogen s...

Animal venoms as a source of antiviral peptides active against arboviruses: a systemati...
https://doi.org/10.1007/s00705-022-05494-8 10.1016/j.onehlt.2017.06.001 10.1007/s10096-018-3375-7 10.1016/j.tmaid.2016.07.002 10.1038/nature12060 10.1002/rmv.2056 10.21577/0103-5053.20160242 10.1007/s00705-017-3641-5 10.1021/acs.jcim.9b00933 10.1021/acs.jcim.9b00809 10.3390/toxins12070451 10.1016/j.bcp.2017.03.005 10.2174/1568026616666160930151242 10.4331/wjbc.v6.i2.28 10.1007/s41048-018-0067-x 10.1590/S1678-91992009000300021 10.1016/j.toxicon.2018.07.008 10.1016/j.ejps.2020.105592 10.1038/s41429-021-00421-6 10.1002/ptr.6872 10.1007/s12275-016-6376-1 10.1007/s00726-009-0385-x 10.1177/1535370220966963 10.2174/1389203721666200116091911 10.3390/toxins11040203 10.1586/14787210.2014.976613 10.1371/journal.pmed.1000100 10.1016/j.tmaid.2019.07.015 10.2307/2529310 10.1007/s00018-008-8250-8 10.1007/s10989-019-09888-2 10.3390/toxins11100584 10.1007/s12250-018-0068-4 10.1074/jbc.RA118.005015 10.1016/j.virol.2017.11.009 10.1186/1471-2180-14-140 10.1016/j.antiviral.2014.05.019 10.1016/j.peptides.2013.07.014 10.3389/fmicb.2020.01871 10.1021/jm300655h 10.3390/biom10050790 10.1016/j.pop.2018.05.001 10.1136/bmjgh-2017-000530 10.3390/toxins2122851 10.3389/fmicb.2013.00321 10.3390/v7102883 10.5433/2316-52002014v3p2p16 10.1128/jvi.78.24.13708-13716.2004 10.1128/jvi.06225-11 10.1016/j.peptides.2013.10.021
Archives of Virology; Lima WG, Maia CQ et. al.

Jun 21st, 2022 - Arthropod-borne viruses (arboviruses), such as Zika virus (ZIKV), chikungunya virus (CHIKV), dengue virus (DENV), yellow fever virus (YFV), and West Nile virus (WNV), are pathogens of global importance. Therefore, there has been an increasing need for new drugs for the treatment of these viral infections. In this context, antimicrobial peptides (AMPs) obtained from animal venoms stand out as pr...

E2F2 enhances the chemoresistance of pancreatic cancer to gemcitabine by regulating the...
https://doi.org/10.1007/s12032-022-01715-x 10.3322/caac.21551 10.1002/jso.23213 10.1016/S0140-6736(10)62307-0 10.1056/NEJMra0901557 10.1016/j.gtc.2011.12.004 10.1097/00001622-199807000-00014 10.1016/j.ejphar.2014.07.041 10.1634/theoncologist.2007-0215 10.1016/S1368-7646(02)00002-X 10.1200/JCO.1997.15.6.2403 10.1016/j.drup.2006.02.002 10.1101/gad.864201 10.1016/j.febslet.2012.08.023 10.18632/aging.101441 10.4103/1319-3767.166206 10.1371/journal.pone.0010147 10.1007/s10529-014-1715-y 10.1158/0008-5472.CAN-14-2173 10.1038/s41568-018-0008-5 10.1038/sj.onc.1207272 10.1371/journal.pone.0053436 10.1038/bjc.2013.817 10.1111/cpr.12456 10.1002/jcb.24652 10.18632/oncotarget.5128 10.1038/nrgastro.2010.188 10.1097/MPA.0b013e31826c6aee 10.1200/JCO.2012.43.3680 10.1016/j.canlet.2012.03.007 10.1200/JCO.2006.07.9525 10.1200/JCO.2010.28.1386 10.1016/S1470-2045(11)70004-3 10.1200/JCO.2009.25.7550 10.1093/annonc/mds135 10.3390/cells9071643 10.1038/nature09515
Medical Oncology (Northwood, London, England); Liu Q, Song C et. al.

Jun 19th, 2022 - Both pro-oncogenic and anti-oncogenic effects of E2F2 have been revealed in different malignancies. However, the precise role of E2F2 in pancreatic cancer, in particular in relation to therapeutic intervention with gemcitabine, remains unclear. In this study, the effect of E2F2 on the proliferation and cell cycle modulation of pancreatic cancer cells, and whether E2F2 plays a role in the treatm...

Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hype...
https://doi.org/10.1164/rccm.202110-2274OC
American Journal of Respiratory and Critical Care Medicine; Al-Qazazi R, Lima PDA et. al.

Jun 15th, 2022 - Pulmonary arterial hypertension (PAH) often results in death from right ventricular failure (RVF). NLRP3-macrophage activation may promote RVF in PAH. Evaluating the contribution of the NLRP3 inflammasome in RV-macrophages to PAH-RVF. Rats with decompensated RV hypertrophy (RVH) [monocrotaline (MCT) and Sugen-5416 hypoxia (SuHx)] were compared with compensated RVH rats [pulmonary artery banding...

Genetic assessment in primary hyperoxaluria: why it matters.
https://doi.org/10.1007/s00467-022-05613-2 10.1038/ki.2014.222 10.1681/ASN.2014070698 10.1016/j.bone.2015.07.010 10.1253/circj.CJ-10-0107 10.1002/mus.24495 10.1056/NEJMoa2021712 10.1007/s00240-016-0860-2 10.1056/NEJMra1301564 10.1016/0014-5793(86)80563-4 10.1016/0888-7543(91)90481-S 10.1016/j.bbadis.2012.03.004 10.1016/S0272-6386(12)80624-X 10.1016/j.ajo.2019.04.036 10.1023/A:1005326510239 10.1016/S0009-8981(97)00165-4 10.1017/S1462399404007203 10.1002/humu.21021 10.1111/j.1523-1755.2004.00842.x 10.1038/ki.2009.435 10.1007/s40620-016-0287-4 10.1073/pnas.88.23.10900 10.1089/gtmb.2015.0136 10.1073/pnas.1131968100 10.1007/s00240-020-01201-x 10.1007/s00240-017-0996-8 10.1007/s11596-018-1941-y 10.1093/ndt/gfs078 10.2215/CJN.06820613 10.1016/j.bbadis.2013.04.010 10.1074/jbc.M808965200 10.1016/j.clinbiochem.2013.11.021 10.1371/journal.pone.0071963 10.1016/j.biochi.2016.10.001 10.1111/j.1523-1755.2005.00267.x 10.1111/j.1523-1755.2004.00796.x 10.1016/j.ekir.2021.11.006 10.1053/j.ajkd.2020.07.017 10.1681/ASN.2021060729 10.1016/j.bbapap.2015.07.002 10.1016/j.ymgme.2020.07.012 10.1016/j.bbadis.2013.09.002 10.1038/sj.ki.5001758 10.1016/j.bbapap.2010.12.005 10.1016/j.ekir.2020.04.004 10.1093/hmg/ddv276 10.1056/NEJM196802012780502 10.1016/j.kint.2019.08.018 10.1016/j.ajhg.2010.07.023 10.1007/s00109-012-0930-z 10.1016/j.kint.2021.03.031 10.1093/ndt/gfab027 10.1093/ndt/gfs039 10.1038/ejhg.2012.139 10.1007/s00467-019-04279-7 10.1159/000086357 10.1016/S0272-6386(97)90006-8 10.1038/ng1762 10.1152/ajpgi.00481.2005 10.1007/s00467-021-05393-1 10.1093/hropen/hoaa021 10.1007/s00467-002-0858-6 10.1016/j.kint.2021.08.015 10.1515/medgen-2021-2052
Pediatric Nephrology (Berlin, Germany); Mandrile G, Beck B et. al.

Jun 14th, 2022 - Accurate diagnosis of primary hyperoxaluria (PH) has important therapeutic consequences. Since biochemical assessment can be unreliable, genetic testing is a crucial diagnostic tool for patients with PH to define the disease type. Patients with PH type 1 (PH1) have a worse prognosis than those with other PH types, despite the same extent of oxalate excretion. The relation between genotype and c...

Ankylosing Spondylitis and Undifferentiated Spondyloarthropathy Medication
http://emedicine.medscape.com/article/332945-medication

Jun 14th, 2022 - Medication Summary The goal of pharmacotherapy is to reduce morbidity and to prevent complications—specifically, by reducing the pain and inflammation associated with ankylosing spondylitis (AS). Next: Nonsteroidal Anti-inflammatory Drugs Class Summary Nonsteroidal anti-inflammatory drugs (NSAIDs) are useful for reducing pain secondary to inflammation and systemic symptoms in AS patients. These...

Literature review and expert opinion on the impact of achondroplasia on medical complic...
https://doi.org/10.1186/s13023-022-02372-z 10.1186/s13023-018-0972-6 10.1016/j.bone.2021.115872 10.1080/09638288.2021.1963853 10.1038/s41436-021-01165-2 10.1186/s13023-021-01971-6 10.1038/s41574-021-00595-x 10.1056/NEJMoa1813446 10.1016/S0140-6736(20)31541-5 10.1038/s41436-021-01287-7 10.1016/S1096-7192(21)00236-5 10.1177/00368504211003782 10.1016/j.ajhg.2012.10.014 10.1124/jpet.114.218560 10.1186/s13023-021-01792-7 10.1111/cge.13542 10.1007/s00223-019-00518-z 10.1002/ajmg.a.62018 10.1111/cge.12045 10.1016/S1096-7192(21)00179-7 10.1186/s13023-020-01397-6 10.1016/S1096-7192(21)00280-8 10.1136/archdischild-2020-319625 10.1038/s41436-018-0070-0 10.1002/ajmg.a.61825 10.1097/BPB.0000000000000428 10.3109/17453674.2012.678802 10.1002/ajmg.a.38130
Orphanet Journal of Rare Diseases; Savarirayan R, Baratela W et. al.

Jun 14th, 2022 - Achondroplasia is associated with disproportionate short stature and significant and potentially severe medical complications. Vosoritide is the first medicine to treat the underlying cause of achondroplasia and data from phase 3 and phase 2 extension studies showed effects on growth and body proportions. However, there are currently no long-term data available on the direct impact on endpoints...

Artesunate and Dihydroartemisinin-Piperaquine treatment failure in a severe Plasmodium ...
https://doi.org/10.1016/j.ijid.2022.06.009
International Journal of Infectious Diseases : IJID : Off... Motta V, Verdenelli S et. al.

Jun 13th, 2022 - A 68-year-old man returning from Republic of Côte d'Ivoire (Ivory Coast) was diagnosed with severe Plasmodium falciparum malaria and treated with intravenous Artesunate followed by oral Dihydroartemisinin-Piperaquine (DDH-PQ). A month later the patient developed a new P. falciparum episode and analysis of Pfmsp1 and Pfpmsp2 revealed that the infection was caused by an identical genetic strain t...

Cinnamaldehyde decreases the invasion and u-PA expression of osteosarcoma by down-regul...
https://doi.org/10.1039/d2fo00634k
Food & Function; Chu SC, Hsieh YS et. al.

Jun 10th, 2022 - Cancer metastasis is the major cause of the high mortality risk of patients with osteosarcoma. Cinnamaldehyde has been shown to exhibit multiple tumour-suppressing activities, but its role in human osteosarcoma is not yet completely defined. In this study, the antimetastatic effect of cinnamaldehyde on highly metastatic human osteosarcoma cells was observed in vitro and in vivo using Saos-2 and...

The efficacy and safety of tacrolimus and entecavir combination therapy in the treatmen...
https://doi.org/10.21037/apm-22-328
Annals of Palliative Medicine; Xie XF, Xie BY et. al.

Jun 9th, 2022 - The proteinuria remission in hepatitis B virus-associated glomerulonephritis (HBV-GN) patients with massive proteinuria treated with antiviral therapy was low. Tacrolimus (TAC) is effective in primary nephropathy and can inhibit HBV infection by inhibiting HBV binding to sodium taurocholate cotransporting polypeptide on liver cells. This study evaluated the efficacy and safety of TAC combined w...

Insights from Transcriptomics: CD163+ Profibrotic Lung Macrophages in COVID-19.
https://doi.org/10.1165/rcmb.2022-0107TR
American Journal of Respiratory Cell and Molecular Biology; Bhattacharya M

Jun 9th, 2022 - COVID19 begins with upper airway symptoms but proceeds in a significant proportion of patients to life-threatening infection of the lower respiratory tract, where an exuberant inflammatory response, edema, and adverse parenchymal remodeling impair gas exchange. Respiratory failure is caused initially by flooding of the airspaces with plasma exudate, sloughed epithelium, and inflammatory cells. ...

KERATIN 17-related recessive atypical pachyonychia congenita with variable hair and too...
https://doi.org/10.1038/s41431-022-01128-4 10.1093/hmg/ddr379 10.1038/ng0395-273 10.1111/1523-1747.ep12335315 10.1046/j.0022-202x.2001.01565.x 10.1046/j.1523-1747.2001.01335.x 10.1046/j.0022-202x.2001.01701.x 10.1111/j.0022-202X.2004.22408.x 10.1038/jid.2011.20 10.1038/jid.2011.484 10.1111/ijd.14082 10.1111/bjd.18794 10.1111/ced.14030 10.1101/gad.979502
European Journal of Human Genetics : EJHG; Koprulu M, Naeem M et. al.

Jun 9th, 2022 - We present the first pachyonychia congenita (PC) to involve all ectodermal derivatives and the first recessive KRT17-related PC in total seven members of two consanguineous Pakistani families. This atypical PC is characterized by an unusual combination of pachyonychia, plantar keratoderma, folliculitis, alopecia, sparse eyebrows, dental anomalies and variable acanthosis nigricans of neck, dry s...

Metastasis From Clear Cell Renal Cell Carcinoma Mimicking Well-Differentiated Pancreati...
https://doi.org/10.1097/RLU.0000000000004151
Clinical Nuclear Medicine; Guglielmo P, Pesella F et. al.

Jun 9th, 2022 - Dual-tracer PET/CT with both 18F-FDG and 68Ga-DOTA-conjugated peptides is currently used in clinical routine for characterizing pNET (pancreatic masses suspicious for neuroendocrine tumor). We describe here the case of a 81-year-old man with a pancreatic lesion showing high 68Ga-DOTATOC uptake and mild 18F-FDG avidity, thus suggesting a well-differentiated pNET, which resulted at endoscopic ult...

Incremental Value of 18F-PSMA-1007 PET/CT in Detection of Metastatic Renal Cell Carcino...
https://doi.org/10.1097/RLU.0000000000004162
Clinical Nuclear Medicine; Sadeq A, Usmani S et. al.

Jun 9th, 2022 - 18F-PSMA PET/CT is an emerging standard of care in staging prostate cancer, evaluating biochemical recurrence and response to therapy. Despite the nomenclature, PSMA expression is also documented at the tumor-associated neovasculature of other malignant solid tumors including renal cell carcinoma. We report a case of 44-year-old man known to have renal cell carcinoma who underwent 18F-PSMA and ...

Photochemical Internalization of Gemcitabine Is Safe and Effective in Locally Advanced ...
https://doi.org/10.1093/oncolo/oyab074
The Oncologist; Trojan J, Hoffmeister A et. al.

Jun 9th, 2022 - Photochemical internalization (PCI) is a novel technology for light-induced enhancement of the local therapeutic effect of cancer drugs, utilizing a specially designed photosensitizing molecule (fimaporfin). The photosensitizing molecules are trapped in endosomes along with macromolecules or drugs. Photoactivation of fimaporfin disrupts the endosomal membranes so that drug molecules are release...

Autophagy is Impaired in Fetal Hypoplastic Lungs and Rescued by Administration of Amnio...
https://doi.org/10.1164/rccm.202109-2168OC
American Journal of Respiratory and Critical Care Medicine; Khalaj K, Antounians L et. al.

Jun 8th, 2022 - Pulmonary hypoplasia secondary to congenital diaphragmatic hernia (CDH) is characterized by reduced branching morphogenesis, which is responsible for poor clinical outcomes. Administration of amniotic fluid stem cell extracellular vesicles (AFSC-EVs) rescues branching morphogenesis in rodent fetal models of pulmonary hypoplasia. Herein, we hypothesized that AFSC-EVs exert their regenerative pot...

Outcomes from a mechanistic biomarker multi-arm and randomised study of liposomal MTP-P...
https://doi.org/10.1186/s12885-022-09697-9
BMC Cancer; Barnes DJ, Dutton P et. al.

Jun 8th, 2022 - The phase III clinical study of adjuvant liposomal muramyl tripeptide (MTP-PE) in resected high-grade osteosarcoma (OS) documented positive results that have been translated into regulatory approval, supporting initial promise for innate immune therapies in OS. There remains, however, no new approved treatment such as MTP-PE for either metastatic or recurrent OS. Whilst the addition of differen...

Going Beyond Hydroquinone: Alternative Skin Lightening Agents
https://www.mdedge.com/dermatology/article/255255/pigmentation-disorders/going-beyond-hydroquinone-alternative-skin
Nicole C. Syder, BA, Nada Elbuluk, MD, MSc

Jun 7th, 2022 - Disorders of hyperpigmentation—melasma, postinflammatory hyperpigmentation, lichen planus pigmentosus, erythema dyschromicum perstans, and pigmented contact dermatitis, among others—are common and challenging to treat. Although they can affect individuals of all skin types, they most commonly are seen in skin of color; in fact, dyspigmentation is one of the most common chief concerns for which.