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About 343,183 results

Fish Oil Supplementation and Pro-inflammatory and Pro-Resolving Lipid Mediators in Patients with and Without Systemic Lupus Erythematosus
https://acrabstracts.org/abstract/fish-oil-supplementation-and-pro-inflammatory-and-pro-resolving-lipid-mediators-in-patients-with-and-without-systemic-lupus-erythematosus/
May Choi, Nancy Cook, Emma Stevens et. al.

Nov 8th, 2021 - Background/Purpose: Omega-3 fatty acid-derived “specialized pro-resolving mediators” (SPM) are low-abundance lipid mediators (LM) central to inflammation resolution. In this cross-sectional study, we investigated whether fish oil (FO) supplementation was associated with pro-inflammatory and pro-resolving LM in SLE patients compared to matched non-SLE controls. Methods: Within the Mass General B...

In vitro metabolic profile of mexedrone, a mephedrone analog, studied by high- and low-...
https://doi.org/10.1002/dta.3179
Drug Testing and Analysis; Camuto C, Guglielmelli A et. al.

Oct 16th, 2021 - Mexedrone is a synthetic cathinone structurally related to mephedrone, which belongs to the class of N-alkyl cathinone derivatives, whose metabolic profile has not been fully clarified yet. This study considers the in vitro phase I metabolism of mexedrone, to pre-select the most appropriate marker(s) of intake. Mexedrone was incubated in the presence of either human liver microsomes or single r...

Cytotoxic and antitumoral activity of N-(9H-purin-6-yl) benzamide derivatives and relat...
https://doi.org/10.2174/1874467214666211014164406
Current Molecular Pharmacology; Cros-Perrial E, Saulnier S et. al.

Oct 16th, 2021 - The development of small molecules as cancer treatments is still of both interest and importance. Having synthesized and identified the initial cytotoxic activity of a series of chemically related N-(9H-purin-6-yl) benzamide derivatives, we continued their evaluation on cancer cell models. We also synthesized water-soluble prodrugs of the main compound and performed in vivo experiments. We used...

Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)
https://clinicaltrials.gov/ct2/show/NCT02543996

Oct 15th, 2021 - The diversity of human research programs at the National Institutes of Health (NIH) provides a unique opportunity to study different patient populations with monogenetic and undiagnosed diseases with vascular implications. Patient populations with mutations in almost every major signaling pathway related to cardiovascular diseases are actively investigated at the NIH Clinical Center. The purpos...

Palladium-Catalyzed Asymmetric Intramolecular Dearomative Heck Annulation of Aryl Halid...
https://doi.org/10.1021/acs.joc.1c01478
The Journal of Organic Chemistry; Li Y, Zhang HY et. al.

Oct 15th, 2021 - An unprecedented Pd-catalyzed asymmetric intramolecular cascade cyclization of aryl halides with readily available arylboronic acids proceeds through a Heck-type dearomative cyclization terminated with arylation in the presence of Pd2(dba)3 (10 mol %), Cu2O (5 mol %), and Cs2CO3 (2.0 equiv) in 1,2-dichloroethane (1.0 mL) at 100 °C for 15 h in air using BINOL-based phosphoramidite as the chiral ...

One-Pot Transformation of Hypervalent Iodines into Diversified Phenoxazine Analogues as...
https://doi.org/10.1021/acs.joc.1c01883
The Journal of Organic Chemistry; Cheng J, Huang L et. al.

Oct 15th, 2021 - A facile and efficient quinoline-fused 4H-benzo[b][1,4]oxazine has been successfully fabricated through an oxidative O-arylation, Pd-catalyzed double N-arylation of 4-hydroxyquinoline derivatives and trivalent aryl iodides. Diversified fused heterocycles could be easily constructed in overall high isolated yields with great substrate scope. The afforded heteroatom-"doped" phenoxazine 3 demonstr...

CF3CO2H-Catalyzed Synthesis of 3-Alkynylpyrrole Derivatives and Their Controlled Reduct...
https://doi.org/10.1021/acs.joc.1c02078
The Journal of Organic Chemistry; Zhao Y, Guo X et. al.

Oct 15th, 2021 - A transition-metal-free methodology employing nitroenynes and enaminones has been developed to access 3-alkynylpyrrole derivatives. This mild cyclization reaction might proceed through the nucleophilic addition, intramolecular cyclization, and the subsequent elimination processes. The protocol features a broad substrate scope, good selectivity, and functional group tolerance. Notably, the advan...

Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like c...
https://doi.org/10.1007/s00204-021-03159-0
Archives of Toxicology; Wrobel SA, Bury D et. al.

Oct 14th, 2021 - Few human data on exposure and toxicity are available on neonicotinoids and neonicotinoid-like compounds (NNIs), an important group of insecticides worldwide. Specifically, exposure assessment of humans by biomonitoring remains a challenge due to the lack of appropriate biomarkers. We investigated the human metabolism and metabolite excretion in urine of acetamiprid (ACE), clothianidin (CLO), f...

Double π-Extended Helicene Derivatives Containing Pentagonal Rings: Synthesis, Crystal ...
https://doi.org/10.1021/acs.joc.1c00989
The Journal of Organic Chemistry; Wei L, Deng X et. al.

Oct 14th, 2021 - Two novel double π-extended [n]helicene (n = 5, 6) derivatives (7b and 9) including pentagonal rings have been synthesized and characterized. Both of them have three isomers containing two enantiomers (P6), (M6), and a diastereoisomer in a meso form (P,M). X-ray single crystal analyses suggest that molecules 7b and 9 exhibit offset packing models of (P6,P5)- and (M6,M5)-isomers. Optical resolut...

Traditional Chinese medicine reverses cancer multidrug resistance and its mechanism.
https://doi.org/10.1007/s12094-021-02716-4 10.3322/caac.21492 10.3390/ijms21093233 10.1023/A:1007521430236 10.1016/j.drup.2019.100645 10.3892/or.2017.5410 10.1016/j.ijpharm.2016.09.001 10.1186/s12951-019-0448-4 10.3390/ijms20174305 10.3177/jnsv.60.122 10.1038/s41388-019-0949-5 10.1007/s13577-021-00598-w 10.1371/journal.pone.0180023 10.1016/j.semcancer.2019.07.022 10.1038/s41388-019-0986-0 10.1158/1541-7786.MCR-18-1369 10.1016/j.neo.2018.01.001 10.1016/j.biopha.2018.05.063 10.1016/j.cbi.2019.108865 10.1038/s41388-019-0904-5 10.1016/j.jep.2020.113302 10.1016/j.trecan.2019.02.010 10.1074/jbc.RA118.006983 10.1038/nature22393 10.1007/s10495-016-1284-8 10.3389/fonc.2019.00487 10.1016/j.phymed.2014.12.009 10.1016/j.biopha.2019.108812 10.1111/1759-7714.12093 10.1002/jcb.25451 10.3892/ijo.2017.4005 10.3390/molecules24152751 10.1089/cbr.2020.4147 10.3892/mmr.2016.6049 10.1177/0960327115627686 10.1111/jcmm.16928 10.1038/s41388-019-0999-8 10.1016/j.yexcr.2019.111671 10.1002/jcp.28361 10.1016/j.canlet.2015.10.010 10.1002/jcb.27063 10.1016/j.ejphar.2020.173486 10.3389/fphar.2019.00565 10.1007/s12094-007-0138-9 10.3390/molecules24183274 10.5483/BMBRep.2017.50.3.222 10.3892/mmr.2013.1760 10.1093/carcin/bgy039 10.1038/s41401-019-0234-8 10.1038/nature01972 10.3892/mmr.2016.5471 10.1038/s41416-019-0573-8 10.3390/molecules21101267 10.1016/j.phrs.2019.03.011 10.3892/ol.2016.5099 10.1111/cbdd.13737 10.1186/s12906-015-0710-8 10.1007/s00418-020-01849-x 10.3390/molecules21030374 10.1200/JCO.19.01488 10.1016/j.biopha.2019.109169 10.3892/mmr.2017.7503 10.1016/j.bcp.2017.10.012 10.1038/s41419-019-1660-8 10.1016/j.carbpol.2020.115981 10.1016/j.biomaterials.2017.07.002 10.1002/jcb.27588 10.1016/j.bbrc.2018.09.094 10.3389/fcell.2020.609285 10.3892/or.2014.3083 10.1080/13880209.2016.1200634 10.1186/s12935-020-01270-3 10.3892/or.2017.5917 10.1186/s12964-018-0218-1 10.1093/cvr/cvp244 10.1080/15384101.2016.1160986 10.3892/or.2014.3190 10.1186/s12906-018-2204-y 10.1038/oncsis.2013.4 10.1038/s41419-018-0314-6 10.18632/oncotarget.8880 10.1038/s41419-018-0574-1 10.1016/j.biopha.2019.109611 10.1016/j.jep.2016.08.041 10.7150/jca.25163 10.2147/OTT.S208924 10.1016/j.phymed.2018.09.181 10.3390/molecules21121677 10.1111/cas.14345 10.1016/j.phymed.2020.153414 10.1016/j.jep.2017.03.051 10.1016/j.jep.2020.113295 10.3389/fphar.2019.01039 10.1186/s12906-017-1872-3 10.1038/s41419-018-0277-7 10.3892/ol.2017.6148 10.3892/etm.2017.4951 10.3892/mmr.2017.7500 10.1016/j.phymed.2018.05.012 10.1002/ptr.7096
Clinical & Translational Oncology : Official Publication ... Wei J, Liu Z et. al.

Oct 14th, 2021 - Chemotherapy is one of the most commonly used clinical treatments among the currently available cancer therapies. However, the phenomenon of Multidrug resistance (MDR) has become a challenge in the treatment process, weakening the impact of chemotherapy. Extensive research on elucidating the development of cancer MDR has identified the following mechanisms that play a critical role in the devel...

Study of Safety of CSJ117 in Participants With Moderate to Severe Uncontrolled Asthma
https://clinicaltrials.gov/ct2/show/NCT04946318

Oct 14th, 2021 - This is a 12/24-week Phase llb, multicenter, multi-national, double-blind, randomized, parallel-arm, placebo-controlled extension study to evaluate the safety and tolerability, pharmacokinetics and immunogenicity of 5 dose levels of CSJ117 in adult asthma participants treated with medium or high dose ICS plus LABA alone or with additional asthma controllers (allowed: LTRA, LAMA, theophylline or...

Furosemide - furosemide injection-Covetrus North America
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fa1dd6d0-e15d-4ce6-9edd-cb134c170a64

Oct 14th, 2021 - VETERINARY INDICATIONS SECTION Dogs and cats: Acepromazine maleate injection can be used as an aid in controlling intractable animals during examination, treatment, grooming, x-ray and minor surgical procedures; to alleviate itching as a result of skin irritation; as an antiemetic to control vomiting associated with motion sickness. Acepromazine maleate injection is particularly useful as a pre...

Multi-Targeted Metallo-Ciprofloxacin Derivatives Rationally Designed and Developed to O...
https://doi.org/10.1016/j.ijantimicag.2021.106449
International Journal of Antimicrobial Agents; Ude Z, Flothkötter N et. al.

Oct 14th, 2021 - Antimicrobial resistance is a major global threat to human health due to the rise, spread and persistence of multidrug-resistant bacteria or 'superbugs'. There is an urgent need to develop novel chemotherapeutics to overcome this overarching challenge. We have derivatised a clinically used fluoroquinolone antibiotic ciprofloxacin and complexed it to a copper phenanthrene framework. This has res...

Nazarov Cyclizations Catalyzed by BINOL Phosphoric Acid Derivatives: Quantum Chemistry ...
https://doi.org/10.1021/acs.joc.1c01823
The Journal of Organic Chemistry; Chin YP, Krenske EH

Oct 13th, 2021 - Quantum chemical calculations have successfully predicted the stereoselectivities of many BINOL phosphoric acid catalyzed reactions over the past 10-15 years. Herein we report a contrasting example: a reaction for which standard quantum chemistry techniques have proven unexpectedly ineffective at explaining the stereoselectivity. The Nazarov cyclizations of a divinyl ketone catalyzed by a BINOL...

Innovative antimicrobial substances based on uracil S-derivatives.
https://doi.org/10.1002/ddr.21886
Drug Development Research; Meshcheryakova S, Shumadalova A et. al.

Oct 13th, 2021 - The problem of antimicrobial resistance is an important global public health challenge. We propose that a development of new antibiotic compounds around known natural substances is a solution to this problem. We investigate reengineer natural products into potent antibiotics. Uracil fragment is abundant in nature and significant to treat infectious diseases due to its affection to the replicati...

Chemoenzymatic Synthesis of Sialosides Containing 7-N- or 7,9-Di-N-acetyl Sialic Acid a...
https://doi.org/10.1021/acs.joc.1c01091
The Journal of Organic Chemistry; Kooner AS, Diaz S et. al.

Oct 13th, 2021 - A novel chemoenzymatic synthon strategy has been developed to construct a comprehensive library of α2-3- and α2-6-linked sialosides containing 7-N- or 7,9-di-N-acetyl sialic acid, the stable analogue of naturally occurring 7-O-acetyl- or 7,9-di-O-acetyl-sialic acid. Diazido and triazido-mannose derivatives that were readily synthesized chemically from inexpensive galactose were shown to be effe...

Assessment of Safety and Efficacy of Nerivio for the Migraine Prevention
https://clinicaltrials.gov/ct2/show/NCT04828707

Oct 13th, 2021 - Nerivio is a neuromodulation device approved for the acute treatment of migraine with or without aura in patients 12 years of age or older. The device utilizes electro stimulation to achieve conditioned pain modulation (CPM). CPM stimulate endogenous analgesic mechanism. Treatments are self-administered by the user at the onset of a migraine attack. this study intends to demonstrate the safety ...

Irbesartan and hydrochlorothiazide - irbesartan and hydrochlorothiazide tablet, film coated-Macleods Pharmaceuticals Limited
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1898f438-4571-4aab-ae06-9bf1aabf0486

Oct 13th, 2021 - Recent Major Changes Section Warnings and Precautions (5.8) 5/2021 Boxed Warning Section WARNING: FETAL TOXICITY • When pregnancy is detected, discontinue irbesartan and hydrochlorothiazide tablets as soon as possible [see Warnings and Precautions (5.1) and Use in Specific Populations (8.1)]. • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developin...

MEFAS, a hybrid of artesunate-mefloquine active against asexual stages of Plasmodium vi...
https://doi.org/10.1016/j.ijpddr.2021.09.003
International Journal for Parasitology. Drugs and Drug Re... Penna-Coutinho J, da Silva Araújo M et. al.

Oct 13th, 2021 - Human malaria continues to be a public health problem and an important cause of morbidity and mortality in the world. Malaria control is achieved through both individual protection against mosquito bites and drug treatment, which is hampered by the spread of Plasmodium falciparum resistance to most antimalarials, including artemisinin derivatives. One of the key pharmacological strategies for c...

Rufomycins or Ilamycins: Naming Clarifications and Definitive Structural Assignments.
https://doi.org/10.1021/acs.jnatprod.1c00198
Journal of Natural Products; Zhou B, Achanta PS et. al.

Oct 12th, 2021 - Rufomycin and ilamycin are synonymous for the same class of cyclopeptides, currently encompassing 33 structurally characterized isolates and 9 semisynthetic derivatives. Elucidation of new structures prioritized the consolidation of the names and established the structures of four diastereoisomeric rufomycins with a 2-piperidinone, named rufomycins 4-7, including full 1H/13C NMR assignments. Th...