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About 39,563 results

Glutathione combined with mecobalamin in the treatment of chemotherapy-induced peripher...
https://doi.org/10.21037/apm-21-3313
Annals of Palliative Medicine; Huang H, Zhao M et. al.

Jan 13th, 2022 - This study sought to examine the use of glutathione combined with mecobalamin in the prevention and treatment peripheral neuropathy (PN) in multiple myeloma (MM) patients, observe its effectiveness and safety, and explore the risk factors and prognostic factors of chemotherapy-induced peripheral neuropathy (CIPN). Patients in the study group were administered 2.4 g of glutathione intravenously ...

A pyridinium‑type fullerene derivative suppresses primary effusion lymphoma cell viabil...
https://doi.org/10.3892/or.2022.8257
Oncology Reports; Kadota A, Moriguchi M et. al.

Jan 12th, 2022 - Primary effusion lymphoma (PEL) is defined as a rare subtype of non‑Hodgkin's B cell lymphoma, which is caused by Kaposi's sarcoma‑associated herpesvirus (KSHV) in immunosuppressed patients. PEL is an aggressive type of lymphoma and is frequently resistant to conventional chemotherapeutics. Therefore, the discovery of novel drug candidates for the treatment of PEL is of utmost importance. In or...

Arteritic Anterior Ischemic Optic Neuropathy in the Course of Giant Cell Arteritis Afte...
https://doi.org/10.12659/AJCR.933471
The American Journal of Case Reports; Szydełko-Paśko U, Przeździecka-Dołyk J et. al.

Jan 12th, 2022 - BACKGROUND Giant cell arteritis (GCA) is an inflammation of large vessels that affects the lining of the arteries and leads to vessel swelling and the eventual reduction of blood flow. This can result in ischemia of the optic nerve, which is known as arteritic anterior ischemic optic neuropathy (AAION). The present case seems noteworthy because the patient developed GCA with the ocular manifest...

Guanidinoacetate-creatine in secondary progressive multiple sclerosis: a case report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753084
The Journal of International Medical Research; Ostojic SM, Ostojic J et. al.

Jan 11th, 2022 - Acute secondary progressive multiple sclerosis (SPMS) is characterized by escalating neurological disability, with limited disease-modifying therapeutic options. A 48-year-old woman with acute SPMS being treated with interferon beta-1a and oral corticosteroids presented as a clinical outpatient with no disease-modifying effects after treatment. A decision was made to treat her with a combinatio...

Histopathological Features of Parathyroid Adenoma and 18F-Choline Uptake in PET/MR of P...
https://doi.org/10.1097/RLU.0000000000003987
Clinical Nuclear Medicine; Liberini V, Morand GB et. al.

Jan 11th, 2022 - The aim of this study was to assess the relationship between the histopathological properties of hyperfunctioning parathyroids and parathyroid 18F-choline uptake. A total of 31 parathyroid adenomas were retrospectively analyzed in patients with primary hyperparathyroidism and preoperative 18F-choline PET/MR. PET/MR parameters of parathyroid glands (SUVmax and target-to-background ratio in early...

Phytonadione - phytonadione injection, emulsion-Henry Schein, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1cf90be3-a744-4db5-999d-a84c67372304

Jan 10th, 2022 - Phytonadione injectable emulsion, USP is indicated in the following coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by Vitamin K deficiency or interference with Vitamin K activity. Phytonadione injectable emulsion is indicated in­­  anticoagulant-induced prothrombin deficiency caused by coumarin or indanedione derivatives; prophylaxis and therapy...

Leishmanicidal activity of Morita-Baylis-Hillman adducts.
https://doi.org/10.1007/s00436-021-07421-3 10.1016/j.fitote.2011.12.025 10.1016/j.fitote.2020.104632 10.1371/journal.pone.0035671 10.1016/j.tetlet.2010.02.169 10.1590/S0074-02762007005000020 10.1016/j.bmc.2011.05.055 10.1021/jo981761b 10.1039/b613741p 10.1039/C8NJ02483A 10.1016/j.parint.2019.101928 10.1021/np500809a 10.1016/j.bmcl.2016.07.022 10.1248/cpb.54.1725 10.1016/j.pt.2016.08.005 10.1007/s00436-020-06787-0 10.1016/0022-1759(93)90012-V 10.1016/j.drudis.2013.08.005 10.1016/j.bioorg.2010.08.002 10.1016/j.bmc.2012.04.061 10.1016/j.tet.2013.10.050 10.1055/s-0030-1261161 10.1016/J.LFS.2019.01.015 10.1093/cid/civ416 10.1016/0022-1759(83)90303-4 10.1007/s00436-020-06706-3 10.1016/j.micinf.2004.08.022 10.1007/S00436-020-06736-X 10.4269/ajtmh.2007.77.266 10.1371/journal.pone.0093936 10.1039/b418069k 10.1016/j.ejmech.2011.06.036 10.1016/j.bmcl.2016.07.022 10.3390/molecules22122071 10.1021/ja00494a045 10.3390/molecules26061756 10.1080/14728222.2018.1472241 10.3390/molecules21111483
Parasitology Research; Vieira ACS, da Silva Santos M et. al.

Jan 7th, 2022 - Leishmaniasis is a neglected disease that affects millions of people, mostly in developing countries. Although this disease has a high impact on public health, there are few drug options to treat the different leishmaniasis forms. Additionally, these current therapies have various adverse effects, including gastrointestinal disturbances, headache, pancreatitis, and hepatotoxicity. Thus, it is e...

Optimization of physicochemical properties is a strategy to improve drug-likeness assoc...
https://doi.org/10.1016/j.ejps.2021.106114
European Journal of Pharmaceutical Sciences : Official Jo... Varela MT, Amaral M et. al.

Jan 6th, 2022 - Trypanosoma cruzi is the causing agent of Chagas disease, a parasitic infection without efficient treatment for chronic patients. Despite the efforts, no new drugs have been approved for this disease in the last 60 years. Molecular modifications based on a natural product led to the development of a series of compounds (LINS03 series) with promising antitrypanosomal activity, however previous c...

The Type 2 Asthma Mediator IL-13 Inhibits SARS-CoV-2 Infection of Bronchial Epithelium.
https://doi.org/10.1165/rcmb.2021-0364OC
American Journal of Respiratory Cell and Molecular Biology; Bonser LR, Eckalbar WL et. al.

Jan 5th, 2022 - Asthma is associated with chronic changes in the airway epithelium, a key target of SARS-CoV-2. Many epithelial changes, including goblet cell metaplasia, are driven by the type 2 cytokine IL-13, but the effects of IL-13 on SARS-CoV-2 infection are unknown. We found that IL-13 stimulation of differentiated human bronchial epithelial cells (HBECs) cultured at air-liquid interface reduced viral R...

Quetiapine fumarate - quetiapine fumarate tablet-A-S Medication Solutions
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ccacb909-8ee5-4223-bfee-9cfeae470ecf

Jan 3rd, 2022 - Recent Major Changes Section Warnings and Precautions (5.20) 09/2020 BOXED WARNING SECTION Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death [ see Warnings and Precautions (5.1) ]. Quetiapine is not approved for the treatment of patients with dementia-relat...

A 5% Glucose Solution for the Liquid Formulation Gemcitabine Solvent Decreases Gemcitab...
https://doi.org/10.21873/anticanres.15491
Anticancer Research; Uchiyama K, Saito Y et. al.

Jan 1st, 2022 - Gemcitabine (GEM)-induced vascular pain often occurs in patients. A 5% glucose solution for the lyophilized formulation of GEM solvent is known to decrease the frequency of GEM-induced vascular pain compared with saline. In this study, we aimed to examine the availability of glucose for a liquid formulation GEM solvent for the prevention of GEM-induced vascular pain. In total, 214 patients with...

Synthesis and Antiviral Activities of Neoechinulin B and Its Derivatives.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751641
Journal of Natural Products; Nishiuchi K, Ohashi H et. al.

Dec 31st, 2021 - We have previously reported that neoechinulin B (1a), a prenylated indole diketopiperazine alkaloid, shows antiviral activities against hepatitis C virus (HCV) via the inactivation of the liver X receptors (LXRs) and the resultant disruption of double-membrane vesicles. In this study, a two-step synthesis of the diketopiperazine scaffold of 1a was achieved by the base-induced coupling of 1,4-di...

Furosemide - furosemide injection-MWI/VetOne
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b51f3e7f-8944-4d40-8ce6-e609ea9107d1

Dec 30th, 2021 - SPL UNCLASSIFIED SECTION Approved by FDA under NADA # 131-538 SPL UNCLASSIFIED SECTION Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION SECTION Furosemide is a potent loop diuretic which is a derivative of anthranilic acid. The structure is: Chemical Name: 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid. Furosemide is pharmacodynamically char...

Donepezil hydrochloride - donepezil hydrochloride tablet-ACI Healthcare USA, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=297e86e8-d248-4cc9-9d9c-2ef9efb4414d

Dec 30th, 2021 - Indications & Usage Section Donepezil Hydrochloride tablets are indicated for the treatment of dementia of the Alzheimer’s type. Efficacy has been demonstrated in patients with mild, moderate, and severe Alzheimer’s disease. Donepezil is an acetylcholinesterase inhibitor indicated for the treatment of dementia of the Alzheimer’s type. Efficacy has been demonstrated in patients with mild, modera...

Furosemide - furosemide injection-Covetrus North America
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fa1dd6d0-e15d-4ce6-9edd-cb134c170a64

Dec 30th, 2021 - SPL UNCLASSIFIED SECTION Approved by FDA under NADA # 131-538 SPL UNCLASSIFIED SECTION Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION SECTION Furosemide is a potent loop diuretic which is a derivative of anthranilic acid. The structure is: Chemical Name: 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid. Furosemide is pharmacodynamically char...

Familial Hypercholesterolemia Medication
http://emedicine.medscape.com/article/121298-medication

Dec 29th, 2021 - Medication Summary HMG-CoA reductase inhibitors (statins) are the medications of choice for the treatment of LDLc elevations in patients with heterozygous FH because they have the greatest efficacy and are easily tolerated and because multiple randomized, placebo-controlled trials have shown that lowering LDLc levels with statins reduces coronary morbidity and mortality and, in some cases, tota...

New acetylphenol-based acyl thioureas broaden the scope of drug candidates for urease i...
https://doi.org/10.1016/j.ijbiomac.2021.12.064
International Journal of Biological Macromolecules; Zahra U, Zaib S et. al.

Dec 27th, 2021 - Helicobacter pylori urease remains a validated drug target for the eradication of pervasive chronic stomach infection that leads to severe human health diseases such as gastritis and stomach cancer. The increased failure of current treatment protocols because of resistance to broadband antibiotics, severe side effects and low compliance underscore the need for a targeted eradication therapy. Th...

Severe COVID-19 Complicated by Cerebral Venous Thrombosis in a Newborn Successfully Tre...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701660
International Journal of Environmental Research and Publi... Cursi L, Calo Carducci FI et. al.

Dec 25th, 2021 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic, affecting all age groups with a wide spectrum of clinical presentation ranging from asymptomatic to severe interstitial pneumonia, hyperinflammation, and death. Children and infants generally show a mild course of the disease, although infants have been observed to h...

Atorvastatin calcium - atorvastatin calcium tablet, film coated-A-S Medication Solutions
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=103cc381-3266-409d-bdc2-1de620bae355

Dec 23rd, 2021 - Recent Major Changes Section Dosage and Administration, Dosage in Patients Taking Cyclosporine, Clarithromycin, Itraconazole, Letermovir, or Certain Protease Inhibitors (2.6) 11/2019 Warnings and Precautions, Myopathy and Rhabdomyolysis (5.1) 11/2020 Warnings and Precautions, Immune-Mediated Necrotizing Myopathy (5.2)                          9/2020 Indications & Usage Section Therapy with li...

Omeprazole - omeprazole capsule, delayed release-Rising Health, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a1b1c61b-d4fe-433d-ad31-0b11758976fa

Dec 23rd, 2021 - Indications & Usage Section Omeprazole is a proton pump inhibitor (PPI) indicated for the: Treatment of active duodenal ulcer in adults (1.1) Eradication of Helicobacter pylori to reduce the risk of duodenal ulcer recurrence in adults (1.2) Treatment of active benign gastric ulcer in adults (1.3) Treatment of symptomatic gastroesophageal reflux disease (GERD) in patients 2 years of age and olde...