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About 45,283 results

FT-GPI, a highly sensitive and accurate predictor of GPI-anchored proteins, reveals the...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876418
Malaria Journal; Sauer LM, Canovas R et. al.

Jan 27th, 2023 - Protozoan parasites are known to attach specific and diverse group of proteins to their plasma membrane via a GPI anchor. In malaria parasites, GPI-anchored proteins (GPI-APs) have been shown to play an important role in host-pathogen interactions and a key function in host cell invasion and immune evasion. Because of their immunogenic properties, some of these proteins have been considered as ...

Glasgow Prognostic Score Predicts Survival and Recurrence Pattern in Patients With Hepa...
https://doi.org/10.21873/anticanres.16230
Anticancer Research; Kumamoto T, Takeda K et. al.

Jan 26th, 2023 - The prognostic significance of the Glasgow Prognostic Score (GPS) on outcomes of liver resection for hepatocellular carcinoma (HCC) remains unclear; the aim of the study was to assess its significance. A total of 480 patients with HCC who underwent liver resection with curative intent at the Yokohama City University Hospital and Medical Center were enrolled in the study. Patients were classifie...

QuPath Analysis for CD30+ Cutaneous T-Cell Lymphoma.
https://doi.org/10.1097/DAD.0000000000002330
The American Journal of Dermatopathology; Cieslak C, Mitteldorf C et. al.

Jan 21st, 2023 - Mycosis fungoides is the most common subtype of cutaneous T-cell lymphoma, in which the expression of cluster of differentiation 30 (CD30)+ subtype can now be treated with the CD30 antibody conjugate brentuximab vedotin. Diagnostic methods are based on immunohistochemical (IHC) staining followed by manual assessment by pathologists, which is always a subjective calculation. QuPath, an open-sour...

Primary Cutaneous Ewing Sarcoma of the Scalp With Metastasis to the Lung: An Unusual Ma...
https://doi.org/10.1097/DAD.0000000000002348
The American Journal of Dermatopathology; Regmi A, Raouf M et. al.

Jan 21st, 2023 - A 32-year-old G2P1L1 (5 months pregnant) woman presented with a 3-month history of a slow-growing cystic lesion on her scalp vertex. Similar lesions in the exact location were excised twice in the past with a diagnosis of trichilemmal carcinoma (TC). A biopsy of the scalp lesion showed morphology and immunoprofile consistent with previously diagnosed TC. Staging PET/CT demonstrated a 4.7 cm rig...

SARS-CoV-2 genotyping and sequencing following a simple and economical RNA extraction a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851494
PloS One; Hernandez S, Nguyen PV et. al.

Jan 20th, 2023 - Since the beginning of the SARS-CoV-2 pandemic, supply chain shortages have caused major disruptions in sourcing the materials needed for laboratory-based molecular assays. With increasing demand for molecular testing, these disruptions have limited testing capacity and hindered efforts to mitigate spread of the virus and new variants. Here we evaluate an economical and reliable protocol for th...

HIV and SARS-CoV-2 infection in postpartum Kenyan women and their infants.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844875
PloS One; Begnel ER, Chohan BH et. al.

Jan 18th, 2023 - HIV may increase SARS-CoV-2 infection risk and COVID-19 severity generally, but data are limited about its impact on postpartum women and their infants. As such, we characterized SARS-CoV-2 infection among mother-infant pairs in Nairobi, Kenya. We conducted a nested study of 62 HIV-uninfected and 64 healthy women living with HIV, as well as their HIV-exposed uninfected (N = 61) and HIV-unexpose...

A comparative study of three models to analyze the impact of air pollutants on the numb...
https://doi.org/10.1371/journal.pone.0277314
PloS One; Wang Y, Gao C et. al.

Jan 18th, 2023 - In this paper, we separately constructed ARIMA, ARIMAX, and RNN models to determine whether there exists an impact of the air pollutants (such as PM2.5, PM10, CO, O3, NO2, and SO2) on the number of pulmonary tuberculosis cases from January 2014 to December 2018 in Urumqi, Xinjiang. In addition, by using a new comprehensive evaluation index DISO to compare the performance of three models, it was...

Association of Sialic Acid-Binding Immunoglobulin-Like Lectin 15 With Phenotypes in Eso...
https://doi.org/10.1001/jamanetworkopen.2022.50965
JAMA Network Open; Zhou S, Wang Y et. al.

Jan 18th, 2023 - Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is a novel immune checkpoint molecule that is highly homologous to programmed cell death ligand 1 (PD-L1), but information remains limited about its role in esophageal squamous cell carcinoma (ESCC). To explore the expression pattern and association of Siglec-15 with outcomes among patients with ESCC who received neoadjuvant chemorad...

Joint effects of meteorological factors and PM2.5 on age-related macular degeneration: ...
https://doi.org/10.1265/ehpm.22-00237
Environmental Health and Preventive Medicine; He J, Liu Y et. al.

Jan 12th, 2023 - Weather conditions are a possible contributing factor to age-related macular degeneration (AMD), a leading cause of irreversible loss of vision. The present study evaluated the joint effects of meteorological factors and fine particulate matter (PM2.5) on AMD. Data was extracted from a national cross-sectional survey conducted across 10 provinces in rural China. A total of 36,081 participants a...

Investigation and monitoring of heavy metal poisoning.
https://doi.org/10.1136/jcp-2021-207793
Journal of Clinical Pathology; Barlow NL, Bradberry SM

Jan 6th, 2023 - Historically, heavy metal measurement and interpretation has been a highly specialised area performed only in a handful of centres within the UK. However, recent years have seen a move to more local testing due to the repatriation of referred work into pathology networks and the increased availability of inductively coupled plasma mass spectrometry technology. While management of significant po...

Evaluation and clinical validation of monkeypox (mpox) virus real-time PCR assays.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783225
Journal of Clinical Virology : the Official Publication O... Mills MG, Juergens KB et. al.

Jan 6th, 2023 - In spring of 2022, an outbreak of monkeypox (mpox) spread worldwide. Here, we describe performance characteristics of monkeypox virus (MPXV)-specific and pan-orthopoxvirus qPCR assays for clinical use. We validated probe-based qPCR assays targeting MPXV-specific loci F3L and G2R (genes MPXVgp052/OPG065 and MPXVgp002 and gp190/OPG002, respectively) and a pan-orthopoxvirus assay targeting the E9L...

The profiles of durian (Durio zibethinus Murr.) shell phenolics and their antioxidant e...
https://doi.org/10.1016/j.foodres.2022.112122
Food Research International (Ottawa, Ont.); He Y, Peng L et. al.

Jan 4th, 2023 - Durian is a nutritious tropical fruit with potent antioxidant, anti-inflammatory, antibacterial and anti-cancer effects. However, the durian shell was mainly discarded as waste, while there were few studies on the characterization of its phenolic profiles, antioxidant activities, and in vivo metabolites. In the present study, a total of 17 compounds were identified in durian shell extract (DSE)...

Development of diagnostic algorithm using machine learning for distinguishing between a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798640
BMC Infectious Diseases; Luo Y, Xue Y et. al.

Dec 30th, 2022 - The discrimination between active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remains challenging. The present study aims to investigate the value of diagnostic models established by machine learning based on multiple laboratory data for distinguishing Mycobacterium tuberculosis (Mtb) infection status. T-SPOT, lymphocyte characteristic detection, and routine laboratory tests wer...

PM2.5 and constituent component impacts on global DNA methylation in patients with idio...
https://doi.org/10.1016/j.envpol.2022.120942
Environmental Pollution (Barking, Essex : 1987); Goobie GC, Li X et. al.

Dec 28th, 2022 - Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD) whose outcomes are worsened with air pollution exposures. DNA methylation (DNAm) patterns are altered in lungs and blood from patients with IPF, but the relationship between air pollution exposures and DNAm patterns in IPF remains unexplored. This study aimed to evaluate the association of PM2.5 and co...

Event-Specific Transmission Forecasting of SARS-CoV-2 in a Mixed-Mode Ventilated Office...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779012
International Journal of Environmental Research and Publi... Kapoor NR, Kumar A et. al.

Dec 24th, 2022 - The emerging novel variants and re-merging old variants of SARS-CoV-2 make it critical to study the transmission probability in mixed-mode ventilated office environments. Artificial neural network (ANN) and curve fitting (CF) models were created to forecast the R-Event. The R-Event is defined as the anticipated number of new infections that develop in particular events occurring over the course...

Spatiotemporal Analysis of Black Carbon Sources: Case of Santiago, Chile, under SARS-Co...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779851
International Journal of Environmental Research and Publi... Adasme C, Villalobos AM et. al.

Dec 24th, 2022 - The SARS-CoV-2 pandemic has temporarily decreased black carbon emissions worldwide. The use of multi-wavelength aethalometers provides a quantitative apportionment of black carbon (BC) from fossil fuels (BCff) and wood-burning sources (BCwb). However, this apportionment is aggregated: local and non-local BC sources are lumped together in the aethalometer results. We propose a spatiotemporal ana...

Comprehensive Analysis of the Association between Human Diseases and Water Pollutants.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779172
International Journal of Environmental Research and Publi... Jiang X, Zhang H et. al.

Dec 24th, 2022 - Drinking water is an important natural resource. For many people worldwide, especially in developing countries, access to safe drinking water is still a dream. An increasing number of human activities and industrialization have caused various physical, chemical, and biological pollutants to enter water bodies, affecting human health. Water pollutants contain a vast number of additives, such as ...

Utility of the neutrophil-to-lymphocyte ratio in the prediction of anti-neutrophil cyto...
https://doi.org/10.1007/s10067-022-06483-7
Clinical Rheumatology; Liu R, Li M et. al.

Dec 24th, 2022 - This study aimed to evaluate the predictive value of the neutrophil-to-lymphocyte ratio (NLR) for infection in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Newly onset patients with AAV in China were included, and their laboratory tests and disease activity were analyzed. Based on infection, patients were divided into the infection group (A-I) and the n...

Nationwide survey of refractory asthma with bronchiectasis by inflammatory subtypes.
https://doi.org/10.1186/s12931-022-02289-y
Respiratory Research; Nomura N, Matsumoto H et. al.

Dec 21st, 2022 - Bronchiectasis and bronchiolitis are differential diagnoses of asthma; moreover, they are factors associated with worse asthma control. We determined clinical courses of bronchiectasis/bronchiolitis-complicated asthma by inflammatory subtypes as well as factors affecting them. We conducted a survey of refractory asthma with non-cystic fibrosis bronchiectasis/bronchiolitis in Japan. Cases were c...

Von Willebrand Disease in Older Patients: A Retrospective Electronic Health Record Review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772937
Clinical and Applied Thrombosis/hemostasis : Official Jou... Seaman CD

Dec 21st, 2022 - Von Willebrand disease (VWD) is often diagnosed as a consequence of symptoms experienced with hemostatic stressors, such as menstruation and childbirth. Thus, patients seeking medical care for VWD are generally younger. As a result, the natural course of VWD in older adults has not been well described. A retrospective electronic health record review was performed to provide a descriptive analys...