×
About 43,688 results

Association between long-term exposure to ambient air pollution and COVID-19 severity: ...
https://doi.org/10.1503/cmaj.220068
CMAJ : Canadian Medical Association Journal = Journal De ... Chen C, Wang J et. al.

May 25th, 2022 - The tremendous global health burden related to COVID-19 means that identifying determinants of COVID-19 severity is important for prevention and intervention. We aimed to explore long-term exposure to ambient air pollution as a potential contributor to COVID-19 severity, given its known impact on the respiratory system. We used a cohort of all people with confirmed SARS-CoV-2 infection, aged 20...

Analysis of risk factors for pulmonary tuberculosis with persistent severe inflammation...
https://doi.org/10.1097/MD.0000000000029297
Medicine Shimoda M, Yoshiyama T et. al.

May 19th, 2022 - Patients with pulmonary tuberculosis (TB) sometimes show persistent severe inflammation for more than 1 month, even if TB treatment is effective. Although this inflammation can be improved through continuous antituberculous therapy, the risk factors for persistent inflammation remain unclear. Therefore, we sought to study the characteristics of patients with persistent severe inflammation. We r...

Lagged Effects of Exposure to Air Pollutants on the Risk of Pulmonary Tuberculosis in a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106023
International Journal of Environmental Research and Publi... Feng Y, Wei J et. al.

May 15th, 2022 - Although significant correlations have been observed between air pollutants and the development of pulmonary tuberculosis (PTB) in many developed countries, data are scarce for developing and highly polluted regions. A combined Poisson generalized linear regression-distributed lag nonlinear model was used to determine the associations between long-term exposure (2005-2017) to air pollutants and...

Long-term exposure to wildfires and cancer incidence in Canada: a population-based obse...
https://doi.org/10.1016/S2542-5196(22)00067-5
The Lancet. Planetary Health; Korsiak J, Pinault L et. al.

May 14th, 2022 - Wildfires emit many carcinogenic pollutants that contaminate air, water, terrestrial, and indoor environments. However, little is known about the relationship between exposure to wildfires and cancer risk. We aimed to assess the associations between residential exposure to wildfires and the incidence of several cancer outcomes (lung cancer, brain cancer, non-Hodgkin lymphoma, multiple myeloma, ...

Etiology of meningitis among adults in three quaternary hospitals in Mozambique, 2016-2...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094547
PloS One; Nhantumbo AA, Comé CE et. al.

May 12th, 2022 - Meningitis remains an important cause of morbi-mortality in adults in sub-Saharan Africa. Data on the etiological investigation of meningitis in adults in Mozambique is limited and most studies were conducted in southern Mozambique. Identification of the etiology of meningitis in adults are crucial to guide prevention and treatments strategies. In this study, we determine the burden of fungal a...

Multicenter international assessment of a SARS-CoV-2 RT-LAMP test for point of care cli...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094544
PloS One; Lu S, Duplat D et. al.

May 12th, 2022 - Continued waves, new variants, and limited vaccine deployment mean that SARS-CoV-2 tests remain vital to constrain the coronavirus disease 2019 (COVID-19) pandemic. Affordable, point-of-care (PoC) tests allow rapid screening in non-medical settings. Reverse-transcription loop-mediated isothermal amplification (RT-LAMP) is an appealing approach. A crucial step is to optimize testing in low/mediu...

Field evaluation of the performance of seven Antigen Rapid diagnostic tests for the dia...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089886
PloS One; Bwogi J, Lutalo T et. al.

May 11th, 2022 - The objective of this study was to evaluate the performance of seven antigen rapid diagnostic tests (Ag RDTs) in a clinical setting to identify those that could be recommended for use in the diagnosis of SARS-CoV-2 infection in Uganda. This was a cross-sectional prospective study. Nasopharyngeal swabs were collected consecutively from COVID-19 PCR positive and COVID-19 PCR negative participants...

High-throughput Confocal Imaging of Quantum Dot-Conjugated SARS-CoV-2 Spike Trimers to ...
https://doi.org/10.3791/63202
Journal of Visualized Experiments : JoVE; Tran BN, Oh E et. al.

May 10th, 2022 - The development of new technologies for cellular fluorescence microscopy has facilitated high-throughput screening methods for drug discovery. Quantum dots are fluorescent nanoparticles with excellent photophysical properties imbued with bright and stable photoluminescence as well as narrow emission bands. Quantum dots are spherical in shape, and with the proper modification of the surface chem...

The effect of TGF-β1 polymorphisms on pulmonary disease progression in patients with cy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080196
BMC Pulmonary Medicine; Trojan T, Alejandre Alcazar MA et. al.

May 8th, 2022 - Transforming Growth Factor-β1 (TGF-β1) is a genetic modifier in patients with cystic fibrosis (CF). Several single nucleotide polymorphisms (SNPs) of TGF-β1 are associated with neutrophilic inflammation, lung fibrosis and loss of pulmonary function. The aim of this study was to assess the relationship between genetic TGF-β1 polymorphisms and pulmonary disease progression in CF patients. Further...

Early Identification, Accurate Diagnosis, and Treatment of Silicosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9061058
Canadian Respiratory Journal; Li T, Yang X et. al.

May 6th, 2022 - Silicosis is a global problem, and it has brought about great burdens to society and patients' families. The etiology of silicosis is clear, preventable, and controllable, but the onset is hidden and the duration is long. Thus, it is difficult to diagnose it early and treat it effectively, leaving workers unaware of the consequences of dust exposure. As such, a lack of details in the work histo...

Laboratory testing for VITT antibodies.
https://doi.org/10.1053/j.seminhematol.2022.03.003
Seminars in Hematology; Warkentin TE, Greinacher A

May 6th, 2022 - Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a highly prothrombotic disorder that like heparin-induced thrombocytopenia (HIT) is caused by platelet-activating antibodies that recognize platelet factor 4 (PF4). However, unlike HIT-where heparin at low concentrations (0.1-0.5 U/mL) typically enhances antibody-induced platelet activation, platelet activation by VITT sera is usually...

A low cost, easy-to-assemble, open-source modular mobile sampler design for thermal des...
https://doi.org/10.1088/1752-7163/ac6c9f
Journal of Breath Research; Chew BS, Pimentel Contreras R et. al.

May 5th, 2022 - Exhaled breath vapor contains hundreds of volatile organic compounds (VOCs), which are the byproducts of health and disease metabolism, and they have clinical and diagnostic potential. Simultaneous collection of breath VOCs and background environmental VOCs is important to ensure analyses eliminate exogenous compounds from clinical studies. We present a mobile sampling system to extract gaseous...

Risk stratification of pancreatic cancer by a blood test for apolipoprotein A2-isoforms.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108558
Cancer Biomarkers : Section A of Disease Markers; Honda K

May 3rd, 2022 - Though pancreatic cancer is uncommon, with an age-adjusted annual incidence of 12.9 cases per 100,000 person-years, it is considered a refractory cancer due to the mortality of 11.0 per 100,000 person-years. To efficiently identify patients with potentially surgically-curable pancreatic cancer, high-risk individuals (HRIs) for pancreatic cancer should be identified by easily and minimally invas...

Clinical performance of DNA and RNA based HPV tests for test of cure (TOC) post treatme...
https://doi.org/10.1016/j.jcv.2022.105165
Journal of Clinical Virology : the Official Publication O... Bhatia R, Graham C et. al.

Apr 30th, 2022 - HPV testing as a "test of cure" (TOC) of women treated for cervical high-grade lesions can support and inform appropriate clinical management pathways. However, there is a lack of studies that report the discrete performance of different HPV assays in this context, including HPV mRNA based assays. To address this, we performed an analysis of the clinical performance of two hrHPV assays in the (...

Cooking outdoors or with cleaner fuels does not increase malarial risk in children unde...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044678
Malaria Journal; Woolley KE, Bartington SE et. al.

Apr 29th, 2022 - Smoke from solid biomass cooking is often stated to reduce household mosquito levels and, therefore, malarial transmission. However, household air pollution (HAP) from solid biomass cooking is estimated to be responsible for 1.67 times more deaths in children aged under 5 years compared to malaria globally. This cross-sectional study investigates the association between malaria and (i) cleaner ...

Ambient Air Pollution and Kawasaki Disease in Korean Children: A Study of the National ...
https://doi.org/10.1161/JAHA.121.024092
Journal of the American Heart Association; Kwon D, Choe YJ et. al.

Apr 28th, 2022 - Background Kawasaki disease (KD) is a systemic vasculitis of unknown etiology that primarily affects children under 5 years of age. Some researchers suggested a potential triggering effect of air pollution on KD, but the findings are inconsistent and limited by small sample size. We investigated the association between ambient air pollution and KD among the population of South Korea younger tha...

Effect of Ramadan intermittent fasting on inflammatory markers, disease severity, depre...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036734
BMC Gastroenterology; Negm M, Bahaa A et. al.

Apr 26th, 2022 - Intermittent fasting (IF) during the month of Ramadan is part of the religious rituals of Muslims. The effect of intermittent fasting on disease activity in inflammatory bowel diseases (IBD) is still unknown. This is the first study to assess the effect of IF during Ramadan on inflammatory markers in patients diagnosed with IBD. The effects on clinical disease activity, quality of life, and lev...

Polymorphisms of potential drug resistant molecular markers in Plasmodium vivax from Ch...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036727
Infectious Diseases of Poverty; Wang Z, Wei C et. al.

Apr 26th, 2022 - Plasmodium vivax remains the predominant species at the China-Myanmar border, imposing a major challenge to the recent gains in regional malaria elimination. To closely supervise the emerging of drug resistance in this area, we surveyed the variations in genes potentially correlated with drug resistance in P. vivax parasite and the possible drug selection with time. A total of 235 P. vivax samp...

Acute glomerulonephritis.
https://doi.org/10.1016/S0140-6736(22)00461-5
Lancet (London, England); Sethi S, De Vriese AS et. al.

Apr 25th, 2022 - Glomerulonephritis is a heterogeneous group of disorders that present with a combination of haematuria, proteinuria, hypertension, and reduction in kidney function to a variable degree. Acute presentation with full blown nephritic syndrome or rapidly progressive glomerulonephritis is uncommon and is mainly restricted to patients with post-infectious glomerulonephritis, anti-neutrophil cytoplasm...

An Epidemiological Study to Investigate Links between Atmospheric Pollution from Farmin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029287
International Journal of Environmental Research and Publi... Contiero P, Borgini A et. al.

Apr 24th, 2022 - Exposure to atmospheric particulate matter and nitrogen dioxide has been linked to SARS-CoV-2 infection and death. We hypothesized that long-term exposure to farming-related air pollutants might predispose to an increased risk of COVID-19-related death. To test this hypothesis, we performed an ecological study of five Italian Regions (Piedmont, Lombardy, Veneto, Emilia-Romagna and Sicily), link...