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About 40,150 results

Preoperative ALBI grade predicts the outcomes in non-B non-C HCC patients undergoing pr...
https://doi.org/10.1186/s12876-021-01944-w 10.1038/nrdp.2016.18 10.3322/caac.21262 10.1038/s41575-019-0186-y 10.1016/0016-5085(86)90919-4 10.1126/science.8211155 10.1002/ijc.22045 10.1002/hep4.1182 10.1111/liv.13099 10.1007/s00535-018-1532-5 10.1186/s13027-020-0273-2 10.35772/ghm.019.01018 10.1056/NEJMra1001683 10.1016/j.jhep.2004.11.015 10.1016/S0140-6736(85)91447-3 10.1080/00365518109092047 10.1200/JCO.2014.57.9151 10.1097/MD.0000000000010226 10.1155/2018/9289421 10.1038/s41598-020-64354-0 10.1007/s00268-019-05197-3 10.1002/hep.20933 10.1016/j.jhep.2011.12.001 10.1002/bjs.1800600817 10.1016/j.surge.2019.09.002 10.3390/jcm8101676 10.1016/j.jhep.2009.07.009 10.1097/SLA.0000000000000710 10.1016/j.jhep.2019.03.034 10.3748/wjg.v22.i39.8720 10.1016/S1473-3099(02)00345-6 10.1111/j.1365-3148.2010.01036.x 10.1016/j.jhep.2008.09.017 10.1111/j.1478-3231.2011.02481.x 10.1097/MD.0000000000024476 10.21037/atm.2019.06.01 10.1016/j.jamcollsurg.2019.12.007
BMC Gastroenterology; Tsai YC, Sou FM et. al.

Oct 21st, 2021 - The albumin-bilirubin (ALBI) grade has been validated as a significant prognostic predictor for hepatocellular carcinoma (HCC). However, there is little information about the ALBI grade in patients with non-B non-C HCC (NBNC-HCC) receiving surgery. This study aimed to evaluate the prognostic significance of the ALBI grade in patients with NBNC-HCC after primary curative resection. From January ...

Evaluation of Respiratory Emissions During Labor and Delivery: Potential Implications f...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462302
Obstetrics and Gynecology; Mok T, Harris E et. al.

Oct 9th, 2021 - To characterize respiratory emissions produced during labor and vaginal delivery vis-à-vis the potential for transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Observational study of three women who tested negative for SARS-CoV-2 and had uncomplicated vaginal deliveries. Using background-oriented schlieren imaging, we evaluated the propagation of respiratory emissions...

Humoral response after SARS-CoV-2 mRNA vaccines in dialysis patients: Integrating anti-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491898
PloS One; Bachelet T, Bourdenx JP et. al.

Oct 6th, 2021 - Dialysis patients are both the most likely to benefit from vaccine protection against SARS-CoV-2 and at the highest risk of not developing an immune response. Data from the medical field are thus mandatory. We report our experience with a BNT162b2-mRNA vaccine in a retrospective analysis of 241 dialysis patients including 193 who underwent anti-Spike-Protein-Receptor-Binding-Domain (RBD) IgG an...

Standardized preservation, extraction and quantification techniques for detection of fe...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486790
Nature Communications; Natarajan A, Han A et. al.

Oct 3rd, 2021 - Patients with COVID-19 shed SARS-CoV-2 RNA in stool, sometimes well after their respiratory infection has cleared. This may be significant for patient health, epidemiology, and diagnosis. However, methods to preserve stool, and to extract and quantify viral RNA are not standardized. We test the performance of three preservative approaches at yielding detectable SARS-CoV-2 RNA: the OMNIgene-GUT ...

Polymorphisms of matrix metalloproteinases affect the susceptibility of esophageal canc...
https://doi.org/10.1097/MD.0000000000027229 10.3390/ijms20163847
Medicine Chen H, Xu X et. al.

Sep 25th, 2021 - The results of how matrix metalloproteinases (MMPs) polymorphisms affect esophageal cancer (EC) risk are not consistent, especially for MMP1,2,7 and 9. A meta-analysis focused on the impact of MMPs to digestive cancers, but not a precise analysis to EC, therefore, we designed the current study to make a clear understanding of the association between MMPs polymorphisms and EC. Up to March 2020, ...

SARS-CoV-2 mucosal antibody development and persistence and their relation to viral loa...
https://doi.org/10.1038/s41467-021-25949-x 10.1016/j.cmi.2020.04.040 10.1056/NEJMe2009758 10.1056/NEJMoa2008457 10.3201/eid2702.203517 10.1038/s41467-020-19545-8 10.1056/NEJMoa2034577 10.1038/s41586-020-2639-4 10.1128/JVI.00647-20 10.1172/jci.insight.142386 10.4049/jimmunol.180.2.948 10.1128/JVI.80.8.4079-4087.2006 10.1038/s41591-020-0868-6 10.1016/j.cell.2020.05.042 10.1038/s41564-020-00813-8 10.1371/journal.pone.0240205 10.1093/infdis/jis033 10.1016/j.jcv.2014.04.017 10.1038/s41467-020-16256-y 10.1093/infdis/jiaa479 10.18637/jss.v082.i13
Nature Communications; Fröberg J, Gillard J et. al.

Sep 25th, 2021 - Although serological studies have shown that antibodies against SARS-CoV-2 play an important role in protection against (re)infection, the dynamics of mucosal antibodies during primary infection and their potential impact on viral load and the resolution of disease symptoms remain unclear. During the first pandemic wave, we assessed the longitudinal nasal antibody response in index cases with m...

IFITM1, CD10, SMA, and h-caldesmon as a helpful combination in differential diagnosis b...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461929
BMC Cancer; Zhao W, Cui M et. al.

Sep 25th, 2021 - The differential diagnosis of endometrial stromal tumor (EST) and uterine cellular leiomyoma (CL) remains a challenge in clinical practice, especially low grade endometrial stromal sarcoma (ESS) and CL, suggesting the need for novel immunomarkers panels for differential diagnosis. Interferon-induced transmembrane protein 1 (IFITM1) is a novel immunomarker for endometrial stromal cells, h-caldes...

Control of SARS-CoV-2 infection after Spike DNA or Spike DNA+Protein co-immunization in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489704
PLoS Pathogens; Rosati M, Agarwal M et. al.

Sep 23rd, 2021 - The speed of development, versatility and efficacy of mRNA-based vaccines have been amply demonstrated in the case of SARS-CoV-2. DNA vaccines represent an important alternative since they induce both humoral and cellular immune responses in animal models and in human trials. We tested the immunogenicity and protective efficacy of DNA-based vaccine regimens expressing different prefusion-stabil...

Bedside estimates of dead space using end-tidal CO2 are independently associated with m...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442447
Critical Care (London, England); Lecompte-Osorio P, Pearson SD et. al.

Sep 17th, 2021 - In acute respiratory distress syndrome (ARDS), dead space fraction has been independently associated with mortality. We hypothesized that early measurement of the difference between arterial and end-tidal CO2 (arterial-ET difference), a surrogate for dead space fraction, would predict mortality in mechanically ventilated patients with ARDS. We performed two separate exploratory analyses. We fir...

Hereditary Hemochromatosis: Rapid Evidence Review.
https://www.ncbi.nlm.nih.gov/pubmed/34523883
American Family Physician; Kane SF, Roberts C et. al.

Sep 16th, 2021 - Hereditary hemochromatosis is an autosomal recessive disorder that disrupts iron homeostasis, resulting in systemic iron overload. It is the most common inherited disorder among people of northern European ancestry. Despite the high prevalence of the gene mutation, there is a low and variable clinical penetrance. The deposition of excess iron into parenchymal cells leads to cellular dysfunction...

Application of CD54 in diagnosing bone marrow involvement by using flow cytometry in pa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431857
BMC Cancer; Wang W, Li Y et. al.

Sep 11th, 2021 - Flow cytometry plays a key role in detecting bone marrow (BM) involvement in patients with diffuse large B-cell lymphoma (DLBCL). To improve its detection sensitivity, we need to explore novel markers. In this study, we detected the expression CD54 on lymphoma cells in BM specimens from DLBCL patients and clarified its diagnostic significance in BM involvement by DLBCL. We collected BM specimen...

Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Sy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428573
PloS One; Kulkarni R, Chen WC et. al.

Sep 10th, 2021 - COVID-19 in humans is caused by Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that belongs to the beta family of coronaviruses. SARS-CoV-2 causes severe respiratory illness in 10-15% of infected individuals and mortality in 2-3%. Vaccines are urgently needed to prevent infection and to contain viral spread. Although several mRNA- and adenovirus-based vaccines are highly effective...

Application of the amplification-free SERS-based CRISPR/Cas12a platform in the identifi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424404
Journal of Nanobiotechnology; Liang J, Teng P et. al.

Sep 10th, 2021 - The control of contagious or refractory diseases requires early, rapid diagnostic assays that are simple, fast, and easy-to-use. Here, easy-to-implement CRISPR/Cas12a-based diagnostic platform through Raman transducer generated by Raman enhancement effect, term as SERS-CRISPR (S-CRISPR), are described. The S-CRISPR uses high-activity noble metallic nanoscopic materials to increase the sensitivi...

Prognostic significance of long non coding maternally expressed gene 3 in pediatric acu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415930
Medicine Xue H, Gao H et. al.

Sep 4th, 2021 - The purpose of this study was to evaluate the correlation of long non-coding RNA maternally expressed gene 3 (Lnc-MEG3) with disease features, treatment response, and survival in pediatric acute myeloid leukemia (AML) patients.Among 92 de novo pediatric AML patients (before treatment and after 1 course of induction) and 40 controls, bone marrow mononuclear cells were obtained. Then, Lnc-MEG3 ex...

Prognostic significance of volume-based 18F-FDG PET/CT parameters and correlation with ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415941
Medicine Wang D, Li Y et. al.

Sep 4th, 2021 - The aim of this study was to retrospectively analyze 18F-FDG positron emission tomography/computed tomography (18F-FDG PET/CT) metabolic variables, programmed death-ligand 1 (PD-L1) and phosphorylated signal transducer and activator of transcription 3 (p-STAT3) tumor expression, and other factors as predictors of disease-free survival (DFS) in patients with lung adenocarcinoma (LUAD) (stage IA-...

PD-L1 Expression and Clinicopathological Factors in Renal Cell Carcinoma: A Comparison ...
https://doi.org/10.21873/anticanres.15271
Anticancer Research; Ikeda J, Ohe C et. al.

Sep 4th, 2021 - Expression of programmed death ligand-1 (PD-L1) is associated with poor prognosis in renal cell carcinoma (RCC). Although a new antibody clone for immunohistochemical assay, 73-10, has shown greater sensitivity than other assays (28-8, 22C3, SP142, and SP263) in non-small cell lung cancer, PD-L1 expression using 73-10 has never been assessed in RCC. Therefore, this study aimed to evaluate the a...

Paediatric post-COVID-19 hyperinflammatory syndrome mimicking appendicitis: a case series.
https://doi.org/10.1308/rcsann.2021.0132
Annals of the Royal College of Surgeons of England; Coles V, Yardley I et. al.

Sep 1st, 2021 - A novel hyperinflammatory syndrome has emerged in the paediatric population: paediatric inflammatory multisystem syndrome - temporally associated with SARS-CoV-2 (PIMS-TS). Up to 50% of patients develop shock with cardiac dysfunction but presentation with acute abdominal pain is common and difficult to distinguish from appendicitis. Prospective case series of PIMS-TS patients presenting to a si...

Diagnostic performance and clinical implications of rapid SARS-CoV-2 antigen testing in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407542
PloS One; Bello-Chavolla OY, Antonio-Villa NE et. al.

Sep 1st, 2021 - SARS-CoV-2 testing capacity is important to monitor epidemic dynamics and as a mitigation strategy. Given difficulties of large-scale quantitative reverse transcription polymerase chain reaction (qRT-PCR) implementation, rapid antigen tests (Rapid Ag-T) have been proposed as alternatives in settings like Mexico. Here, we evaluated diagnostic performance of Rapid Ag-T for SARS-CoV-2 infection an...

Long-term personal air pollution exposure and risk for acute exacerbation of idiopathic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406600
Environmental Health : a Global Access Science Source; Tomos I, Dimakopoulou K et. al.

Sep 1st, 2021 - Urban air pollution is involved in the progress of idiopathic pulmonary fibrosis (IPF). Its potential role on the devastating event of Acute Exacerbation of IPF (AE-IPF) needs to be clarified. This study examined the association between long-term personal air pollution exposure and AE- IPF risk taking into consideration inflammatory mediators and telomere length (TL). All consecutive IPF-patien...

Infiltration of CD1a-positive dendritic cells in advanced laryngeal cancer correlates w...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406956
BMC Cancer; Minesaki A, Kai K et. al.

Sep 1st, 2021 - The prognosis of advanced laryngeal cancer is unfavorable despite advances in multidisciplinary therapy. Dendritic cells (DCs) play a central role in antitumor immunity. Tumor-infiltrating CD1a+ DCs have been reported to be associated with clinical outcomes in carcinomas of various organs, but the clinical impact of CD1a+ DCs in laryngeal cancer remains to be unequivocally established. We retro...