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About 22,755 results

Applying Deep Learning to Quantify Empty Lacunae in Histologic Sections of Osteonecrosi...
https://doi.org/10.1002/jor.25201
Journal of Orthopaedic Research : Official Publication Of... Lui E, Maruyama M et. al.

Oct 23rd, 2021 - Osteonecrosis of the femoral head (ONFH) is a disease in which inadequate blood supply to the subchondral bone causes death of cells in the bone marrow. Decalcified histology and assessment of the percentage of empty lacunae are used to quantify the severity of ONFH. However, the current clinical practice of manually counting cells is a tedious and inefficient process. We utilized the power of ...

Thymoma-associated autoimmune enteropathy with colonic stricture: a diagnostic and hist...
https://doi.org/10.1007/s12328-021-01531-2 10.1038/cmi.2010.74 10.3109/08916930903555935 10.1080/08880010050211420 10.1007/s00428-017-2243-7 10.1016/j.cgh.2007.05.013 10.1056/NEJMcpc1406663 10.1093/ajcp/112.6.810 10.1007/s10620-005-2666-x 10.1007/s00428-018-2304-6 10.1007/s11894-012-0276-2 10.14309/crj.0000000000000520 10.1111/j.1572-0241.2004.40039.x 10.1136/gut.50.2.206
Clinical Journal of Gastroenterology; Pieplenbosch B, de Leijer JH et. al.

Oct 23rd, 2021 - Thymoma-associated autoimmune enteropathy is a rare paraneoplastic syndrome that is characterized by severe chronic diarrhea, malabsorption, and specific histological findings. Because of its rarity, it is difficult to diagnose. We describe an adult patient with protracted diarrhea and weight loss that developed recurrent sepsis and progressive colonic stenosis due to thymoma-associated autoimm...

Molecular landscape of vulvovaginal squamous cell carcinoma: new insights into molecula...
https://doi.org/10.1038/s41379-021-00942-3 10.3322/caac.21590 10.1038/emm.2017.265 10.1111/his.12034 10.1093/annonc/mdw242 10.1016/j.ygyno.2014.11.002 10.1016/j.pathol.2016.02.015 10.1111/j.1365-2354.2008.01011.x 10.1038/s41379-020-0573-5 10.1097/00000478-200405000-00012 10.1002/1097-0142(19920401)69:7<1750::AID-CNCR2820690717>3.0.CO;2-S 10.1007/s00428-021-03063-z 10.1038/modpathol.2017.46 10.1093/nar/gkw520 10.1038/nmeth.2883 10.5858/arpa.LGT200570 10.1097/PAS.0000000000000800 10.1200/PO.19.00406 10.1038/modpathol.2016.187 10.1097/pgp.0b0318134ea34 10.1158/1055-9965.EPI-09-0209 10.1097/01.pgp.0000177646.38266.6a 10.1097/PGP.0000000000000742 10.1038/s41379-020-00651-3 10.1016/j.ygyno.2018.06.026 10.1158/1078-0432.CCR-17-1302 10.1158/1078-0432.CCR-16-3230 10.3390/ijms21144880 10.1002/gcc.20230 10.1016/j.ygyno.2014.07.094 10.3390/ijms22137069 10.1016/j.ygyno.2003.11.052 10.1016/j.ygyno.2011.05.016 10.1111/his.13205 10.1097/PGP.0000000000000620 10.1016/j.ygyno.2020.09.024 10.1016/0092-8674(91)90529-8 10.4143/crt.2005.37.6.319 10.1097/01.MP.0000077518.78046.0C 10.1097/01.pas.0000213251.82940.bf 10.1002/ijc.31006 10.1097/00019606-199512000-00003 10.1111/j.1365-2133.2006.07604.x 10.1007/s40291-018-0336-x 10.1002/dc.20554 10.1371/journal.ppat.1003284 10.1038/modpathol.2009.179 10.1097/PGP.0b013e3182184c7a 10.1038/JID.2015.374 10.1001/jamaoncol.2016.1790 10.1158/1078-0432.CCR-17-3535 10.1002/hed.24372 10.1016/j.ygyno.2020.07.030 10.1007/s12253-018-0554-x 10.1371/journal.pone.0166311 10.1186/s12943-015-0361-x
Modern Pathology : an Official Journal of the United Stat... Salama AM, Momeni-Boroujeni A et. al.

Oct 16th, 2021 - Squamous cell carcinomas of the lower female genital tract may be human papillomavirus-associated or independent. We studied the HPV status, mutational repertoire, histology, and clinical data of 28 samples from 26 patients, 65% with a vulvar primary and 35% with a vaginal primary. These represented invasive vulvovaginal squamous cell carcinomas that underwent clinical tumor-normal targeted mas...

Older Age Is Associated With Worse Survival Outcomes in MCL
https://www.onclive.com/view/older-age-is-associated-with-worse-survival-outcomes-in-mcl

Oct 15th, 2021 - Patients with newly diagnosed mantle cell lymphoma (MCL) who were 65 years of age or older had worse progression-free survival (PFS) and overall survival (OS) at 1 and 2 years compared with patients under the age of 65 years, according to findings from a retrospective, multicenter analysis published in the American Journal of Hematology.1 With a median follow-up of 4.0 years in the younger coh...

A radiomics model can distinguish solitary pulmonary capillary haemangioma from lung ad...
https://doi.org/10.1093/icvts/ivab271
Interactive Cardiovascular and Thoracic Surgery; Wang HJ, Lin MW et. al.

Oct 15th, 2021 - Solitary pulmonary capillary haemangioma (SPCH) is a benign lung tumour that presents as ground-glass nodules on computed tomography (CT) images and mimics lepidic-predominant adenocarcinoma. This study aimed to establish a discriminant model using a radiomic feature analysis to distinguish SPCH from lepidic-predominant adenocarcinoma. In the adenocarcinoma group, all tumours were of the lepidi...

Neoadjuvant chemotherapy in high-risk soft tissue sarcomas: A Sarculator-based risk str...
https://doi.org/10.1002/cncr.33895
Cancer Pasquali S, Palmerini E et. al.

Oct 14th, 2021 - The value of neoadjuvant chemotherapy in soft tissue sarcoma (STS) is not completely understood. This study investigated the benefit of neoadjuvant chemotherapy according to prognostic stratification based on the Sarculator nomogram for STS. This study analyzed data from ISG-STS 1001, a randomized study that tested 3 cycles of neoadjuvant anthracycline plus ifosfamide (AI) or histology-tailored...

Diagnosis and Clinical Development of Sporadic Inclusion Body Myositis and Polymyositis...
https://doi.org/10.1093/jnen/nlab101
Journal of Neuropathology and Experimental Neurology; Winkler M, von Landenberg C et. al.

Oct 14th, 2021 - To review our diagnostic and treatment approaches concerning sporadic inclusion body myositis (sIBM) and polymyositis with mitochondrial pathology (PM-Mito), we conducted a retrospective analysis of clinical and histological data of 32 patients diagnosed as sIBM and 7 patients diagnosed as PM-Mito by muscle biopsy. Of 32 patients identified histologically as sIBM, 19 fulfilled the 2011 European...

Immune profile and radiological characteristics of progressive multifocal leukoencephal...
https://doi.org/10.1111/ene.15140
European Journal of Neurology; Zeiner PS, Mann L et. al.

Oct 14th, 2021 - Progressive multifocal leukoencephalopathy (PML) constitutes a severe disease with increasing incidence, mostly in the context of immunosuppressive therapies. The detailed understanding of immune response in PML appears critical for the treatment strategy. We aimed for a comprehensive immunoprofiling and radiological characterization of MRI-defined PML variants. We retrospectively analysed all ...

Comparison of renal remission and relapse-free rate in initial- and delayed-onset lupus...
https://doi.org/10.1111/1756-185X.14228
International Journal of Rheumatic Diseases; Suzuki E, Yashiro-Furuya M et. al.

Oct 13th, 2021 - Lupus nephritis (LN) is a major manifestation of systemic lupus erythematosus (SLE) which contributes to significant morbidity and mortality. It is unclear whether the timing of LN onset influences renal outcome. This study aimed to investigate differences in clinical features-particularly the relapse-free rate-in remission duration from induction therapies for LN and the onset timing of LN aft...

Fetal akinesia deformation sequence and massive perivillous fibrin deposition resulting...
https://doi.org/10.1002/mgg3.1827
Molecular Genetics & Genomic Medicine; Tjon JK, Lakeman P et. al.

Oct 13th, 2021 - Massive perivillous fibrin deposition (MPFD) is associated with adverse pregnancy outcomes and is mainly caused by maternal factors with limited involvement of fetal or genetic causes. We present one consanguineous couple with six fetuses developing Fetal Akinesia Deformation Sequence (FADS) and MPFD, with a possible underlying genetic cause. This prompted a literature review on prevalence of F...

Diagnostic accuracy of in vivo early tumor imaging from probe-based confocal laser endo...
https://doi.org/10.1007/s00784-021-04156-4 10.3322/caac.21590 10.1586/14737140.6.7.1111 10.1067/mhn.2001.112311 10.1017/S0022215118001718 10.1002/wsbm.1412 10.1111/jgh.13267 10.1155/2016/4638683 10.1002/lary.25646 10.1177/0194599814528660 10.14639/0392-100X-2121 10.1002/hed.24303 10.1002/lsm.23223 10.1148/radiol.12120509 10.1007/s11548-018-1836-1 10.1002/hed.24253 10.1097/SLA.0000000000002127 10.1016/j.anl.2021.01.005 10.1007/s00405-021-06659-y 10.1016/j.gie.2016.05.011 10.1007/s00405-021-06954-8 10.1159/000445368 10.1002/hed.21735 10.1039/c7an02106b 10.1111/odi.12430 10.1055/s-0030-1256632 10.5858/arpa.2014-0549-ED
Clinical Oral Investigations; Abbaci M, Casiraghi O et. al.

Oct 13th, 2021 - Probe-based confocal laser endomicroscopy (pCLE) is a noninvasive and real-time imaging technique allowing acquisition of in situ images of the tissue microarchitecture during oral surgery. We aimed to assess the diagnostic performance of pCLE combined with patent blue V (PB) in improving the management of early oral cavity, oro/hypopharyngeal, and laryngeal cancer by imaging squamous cell carc...

Mitosis-Karyorrhexis Index evaluation by digital image visual analysis for application ...
https://doi.org/10.1002/cncy.22520
Cancer Cytopathology; Bhardwaj N, Rohilla M et. al.

Oct 12th, 2021 - The Mitosis-Karyorrhexis Index (MKI) score is important in neuroblastoma evaluation and in the application of the International Neuroblastoma Pathology Classification (INPC). Currently, it is not standardized for smears. Hence, the aim of this study was to devise and validate methods for MKI evaluation in fine-needle aspiration biopsy (FNAB) of neuroblastoma. A total of 50 cases of neuroblastom...

Low-pressure hydrodistension induces bladder glomerulations in female patients with int...
https://doi.org/10.1002/nau.24818
Neurourology and Urodynamics; Hsu LN, Tsai YS et. al.

Oct 12th, 2021 - The role of hydrodistension in the diagnosis of interstitial cystitis/bladder pain syndrome (IC/BPS) is controversial. This study evaluated the effect of low-pressure hydrodistension on glomerulation formation in female patients diagnosed with the disease. Sixty female patients with the clinical diagnosis of IC/BPS and 30 female controls without the disease underwent cystoscopy and hydrodistens...

Emerging molecular alterations leading to histology-specific targeted therapies in ovar...
https://doi.org/10.1016/j.ctrv.2021.102298
Cancer Treatment Reviews; Bartoletti M, Musacchio L et. al.

Oct 12th, 2021 - After more than 30 years of a one-size-fits-all approach in the management of advanced ovarian cancer, in 2018 the SOLO1 trial results have introduced a new era of personalized medicine. A deeper knowledge of ovarian cancer biology and the development of new drugs targeting specific molecular pathways have led to biomarker-driven phase 3 trials with practice changing results. Thereafter, platin...

Dr. McGregor Discusses Ongoing Trials in Non-Clear Cell RCC
https://www.onclive.com/view/dr-mcgregor-discusses-ongoing-trials-in-non-clear-cell-rcc

Oct 11th, 2021 - Bradley McGregor, MD, senior physician, Dana-Farber Cancer Center, clinical director, Lank Center for Genitourinary Oncology, Instructor of Medicine, Harvard Medical School, discusses ongoing trials in patients with non-clear cell renal cell carcinoma (RCC).  Recent advances have been made with therapeutic approaches in non-clear cell RCC, including further understanding the role of atezolizum...

HEPATIC STEATOSIS IN THE MOUSE MODEL OF WILSON DISEASE COINCIDES WITH A MUTED INFLAMMAT...
https://doi.org/10.1016/j.ajpath.2021.09.010
The American Journal of Pathology; Gottlieb A, Dev S et. al.

Oct 11th, 2021 - Wilson disease (WND) is caused by inactivation of the copper (Cu) transporter ATP7B and Cu accumulation in tissues. WND presentations vary from liver steatosis to inflammation, fibrosis, and liver failure. Diets influence the liver phenotype in WND, but findings are inconsistent. To better understand the impact of excess calories on liver phenotype in WND, we compared C57BL/6J Atp7b-/- and C57B...

Advances in Diagnosis and Risk Stratification of Acute Myeloid Leukemia and Myelodyspla...
https://doi.org/10.1007/978-3-030-78311-2_1 10.1182/blood-2018-10-844621 10.1016/j.beha.2019.02.006 10.1056/NEJMoa0810069 10.1056/NEJMoa1005143 10.1038/ng.620 10.1056/NEJMoa1103283 10.1073/pnas.1000834107 10.1016/j.cell.2012.06.023 10.1056/NEJMoa1408617 10.1182/blood-2015-03-631747 10.1182/blood-2015-08-667063 10.1080/10428194.2018.1433298 10.3324/haematol.2012.064667 10.1038/leu.2011.44 10.1200/JCO.2011.40.7379 10.3324/haematol.2010.025494 10.1182/blood-2009-04-215814 10.1056/NEJMoa1013343 10.1080/1042819031000067620 10.1200/JCO.2013.52.3381 10.1182/blood-2015-07-604496 10.1056/NEJMoa1516192 10.1182/blood-2016-08-733196 10.1182/blood-2013-05-503847 10.1182/bloodadvances.2018019398 10.1038/leu.2017.30 10.1182/blood-2012-09-399725 10.1186/s12943-015-0353-x 10.1056/NEJMoa1403088 10.1200/JCO.2007.15.2058 10.1182/blood-2017-09-801498 10.3324/haematol.2018.188094 10.1182/blood-2018-08-868752
Cancer Treatment and Research; Pillai RK, Afkhami M

Oct 10th, 2021 - Advances in high-throughput DNA sequencing technology in the past decade have made a tremendous impact on basic science and clinical practice. Methods using the latest next generation sequencing technology can sequence an entire human genome within a few hours. Diagnosis and prognostication of hematologic neoplasms have moved from traditional histology and immunophenotyping to integration of cy...

Whole genome copy number analyses reveal a highly aberrant genome in TP53 mutant lung a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501630
BMC Cancer; Bjaanæs MM, Nilsen G et. al.

Oct 10th, 2021 - Genetic alterations are common in non-small cell lung cancer (NSCLC), and DNA mutations and translocations are targets for therapy. Copy number aberrations occur frequently in NSCLC tumors and may influence gene expression and further alter signaling pathways. In this study we aimed to characterize the genomic architecture of NSCLC tumors and to identify genomic differences between tumors strat...

The meningioma surface factor: a novel approach to quantify shape irregularity on preop...
https://doi.org/10.3171/2021.5.JNS204223
Journal of Neurosurgery; Popadic B, Scheichel F et. al.

Oct 9th, 2021 - Atypical and anaplastic meningiomas account for 20% of all meningiomas. An irregular tumor shape on preoperative MRI has been associated with WHO grade II-III histology. However, this subjective allocation does not allow quantification or comparison. An objective parameter of irregularity could substantially influence resection strategy toward a more aggressive approach. Therefore, the aim of t...

The natural history of ampullary adenomas in familial adenomatous polyposis: a long-ter...
https://doi.org/10.1016/j.gie.2021.09.036
Gastrointestinal Endoscopy; Singh AD, Bhatt A et. al.

Oct 9th, 2021 - Ampullary adenomas (AAs), common in familial adenomatous polyposis (FAP), are precursors to ampullary carcinoma. We assessed the natural history of AA and factors associated with clinically significant progression (CSP). Consecutive FAP patients with AAs and ≥2 esophagogastroduodenoscopies (EGD) were identified from a hereditary gastrointestinal cancer registry. We assessed the incidence of CSP...