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About 26,875 results

Incidence and survival of patients with oligometastatic esophagogastric cancer: a multi...
https://doi.org/10.1016/j.radonc.2022.06.012
Radiotherapy and Oncology : Journal of the European Socie... Kroese TE, Christ SM et. al.

Jun 27th, 2022 - This multicenter study assessed the incidence and survival of patients with esophagogastric cancer and oligometastatic disease (OMD) in two tertiary referral cancer centers in The Netherlands and Switzerland. Between 2010-2021, patients with metastatic esophagogastric cancer were identified. Patients with de-novo OMD were included (first-time diagnosis of ≤5 distant metastases on 18F-FDG-PET/CT...

Changes in HPV prevalence in Danish women with vulvar cancer during 28 years - A nation...
https://doi.org/10.1016/j.ygyno.2022.06.014
Gynecologic Oncology; Rasmussen CL, Thomsen LT et. al.

Jun 25th, 2022 - A substantial proportion of vulvar cancers are caused by high-risk human papillomavirus (hrHPV), but hrHPV prevalence in vulvar cancer has mainly been investigated in smaller studies which did not evaluate time trends. Our aim was to assess hrHPV prevalence in >1300 Danish vulvar cancers diagnosed during 1990-2017, including changes in hrHPV prevalence over time. In a nationwide pathology regis...

Utility of frozen section in pediatric and adolescent malignant ovarian nonseminomatous...
https://doi.org/10.1016/j.ygyno.2022.06.013
Gynecologic Oncology; Dicken BJ, Billmire DF et. al.

Jun 25th, 2022 - In adult women, most malignant ovarian tumors are epithelial in origin. The use of intra-operative frozen section to distinguish between benign and malignant histology is reliable in guiding operative decision-making to determine the extent of surgical staging required. Pediatric and adolescent patients with ovarian masses have a much different spectrum of pathology with most tumors arising fro...

Natural History of Familial Carcinoid Tumor
https://clinicaltrials.gov/ct2/show/NCT00646022

Jun 24th, 2022 - Study Description: This study is designed as a prospective evaluation for diagnostic screening, genotyping and natural history of participants belonging to kindreds with familial carcinoid tumor. Objectives: Primary Objective: Study the natural history of familial carcinoid tumors: incidence, age of onset, symptoms, the appropriate diagnostic (biochemical and imaging) modalities, location, hist...

Individualized Response Assessment to Heated Intraperitoneal Chemotherapy (HIPEC) for the Treatment of Peritoneal Carcinomatosis From Ovarian, Colorectal, Appendiceal, or Peritoneal Mesothelioma Hi...
https://clinicaltrials.gov/ct2/show/NCT04847063

Jun 24th, 2022 - Background: Peritoneal carcinomatosis is uniformly fatal if untreated; improved outcomes are seen with aggressive cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC). The selection of chemotherapeutic agent for HIPEC is largely based on primary tumor histology and provider preference as opposed to knowledge of the potential efficacy of a specific agent for an individual ...

BRCA Mutations in Latinas
https://clinicaltrials.gov/ct2/show/NCT01251900

Jun 24th, 2022 - BACKGROUND: Mutations in the BRCA1 and BRCA2 genes predispose to breast and ovarian cancer, and are increasingly recognized in prostate and pancreatic cancers. Basal/ Triple negative breast cancer is associated with BRCA mutations in some ethnicities.However the link between BRCA gene mutations and Basil/ triple negative disease in Hispanic/ Latino women is not known. Common recurrent mutations...

Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal Cancer
https://clinicaltrials.gov/ct2/show/NCT00050752

Jun 24th, 2022 - Background: Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) is a rare autosomal dominantly inherited disorder which confers susceptibility to develop cutaneous and uterine leiomyomas and renal cell carcinoma. HLRCC is caused by mutations in the Krebs cycle enzyme, fumarate hydratase localized on chromosome 1q42.3-q43. Objectives: Define the risk of developing renal cancer, cutaneous lei...

Trial to Determine the Efficacy and Safety of JCAR017 in Adult Participants With Aggressive B-Cell Non-Hodgkin Lymphoma
https://clinicaltrials.gov/ct2/show/NCT03484702

Jun 24th, 2022 - This is a study to determine the efficacy and safety of JCAR017 in adult participants with aggressive B-cell NHL. The study will enroll participants in Europe and Japan with diffuse large B-cell lymphoma (DLBCL) not otherwise specified (NOS; de novo or transformed follicular lymphoma [tFL]), high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements with DLBCL histology (HGBL), fol...

Venetoclax With Obinutuzumab and Magrolimab (VENOM) in Relapsed and Refractory Indolent B-cell Malignancies
https://clinicaltrials.gov/ct2/show/NCT04599634

Jun 24th, 2022 - Background: Indolent B-cell malignancies are associated with frequent disease relapse Standard frontline therapy includes a monoclonal anti-CD20 antibody with or without chemotherapy; novel targeted therapies have changed the treatment landscape and are preferred therapy for some patients with high-risk molecular features Targeted therapies given indefinitely add to drug resistance, treatment-e...

Effective therapy of polymyositis in mice via selective inhibition of the immunoproteas...
https://doi.org/10.1002/eji.202249851
European Journal of Immunology; Del Rio Oliva M, Kirk CJ et. al.

Jun 24th, 2022 - Polymyositis (PM) is a chronic autoimmune inflammatory myopathy resulting in muscle weakness. The limited approved therapies and their poor efficacy contribute to its comorbidity. We investigated the therapeutic use of ONX 0914 and KZR-616, selective inhibitors of the immunoproteasome, in C protein-induced myositis (CIM), a mouse model of PM that closely resembles the human disease. Diseased mi...

The Arginine Methyltransferase Carm1 is Necessary for Heart Development.
https://doi.org/10.1093/g3journal/jkac155
G3 (Bethesda, Md.); Jamet S, Ha S et. al.

Jun 24th, 2022 - To discover genes implicated in human congenital disorders, we performed ENU mutagenesis in the mouse and screened for mutations affecting embryonic development. In this work we report defects of heart development in mice homozygous for a mutation of Coactivator-associated Arginine Methyltransferase 1 (Carm1). While Carm1 has been extensively studied, it has never been previously associated wit...

Bone Marrow Histology in Hemophagocytic Lymphohistiocytosis.
https://doi.org/10.5858/arpa.2021-0381-OA
Archives of Pathology & Laboratory Medicine; Yu SC, Cheng CL et. al.

Jun 24th, 2022 - Bone marrow (BM) samples are obtained through aspiration and trephine biopsy. Hemophagocytic lymphohistiocytosis (HLH) has been largely studied in BM aspirate smears. To investigate the histologic features of HLH in trephine biopsy. Patients with hemophagocytosis in BM aspirate smears were assigned to HLH (n = 127) and non-HLH (n = 203) groups. We quantified hematoxylin-eosin and CD68 immunohis...

Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery
https://clinicaltrials.gov/ct2/show/NCT03533582

Jun 23rd, 2022 - PRIMARY OBJECTIVES: I. To reduce therapy associated toxicity for patients with non-metastatic hepatoblastoma (HB) and hepatocellular carcinoma (HCC) without adversely affecting long term outcomes. II. To determine the event-free survival (EFS) in patients with HB whose tumor is completely resected at diagnosis and either receive no adjuvant chemotherapy (completely resected well differentiated ...

Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma
https://clinicaltrials.gov/ct2/show/NCT02176967

Jun 23rd, 2022 - PRIMARY OBJECTIVES: I. To eliminate therapy as the initial approach for infants < 12 months of age with small International Neuroblastoma Risk Group (INRG) stage L1 neuroblastoma while maintaining an overall survival (OS) of 99%. II. To eliminate therapy as the initial approach for non-high-risk patients < 18 months of age with localized neuroblastoma and favorable biology (histologic and genom...

Everolimus targeted nanotherapy reduces inflammation and fibrosis in scleroderma-relate...
https://doi.org/10.1111/bph.15898
British Journal of Pharmacology; González-Sánchez E, Muñoz-Callejas A et. al.

Jun 22nd, 2022 - Interstitial lung disease (ILD) is the main cause of mortality in systemic sclerosis (SSc) and current therapies available are of low efficacy or high toxicity. Thus, the identification of innovative less toxic and high efficacy therapeutic approaches to ILD treatment is a crucial point. P-selectin Glycoprotein Ligand-1 (PSGL-1) interaction with P-selectin initiates leukocyte extravasation and ...

Polatuzumab vedotin in relapsed / refractory aggressive B-cell lymphoma.
https://doi.org/10.1080/14737140.2022.2093191
Expert Review of Anticancer Therapy; Varma G, Wang J et. al.

Jun 22nd, 2022 - Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive lymphoma histology. Outcomes for patients with relapsed or refractory (R/R) disease remain suboptimal. Polatuzumab vedotin (polatuzumab) is a recently approved antibody drug conjugate that targets CD79b, with a tubulin toxin payload, that has demonstrated significant clinical activity and an acceptable toxicity profile when adm...

Thymomectomy vs complete thymectomy in early-stage non myasthenic thymomas: a multicent...
https://doi.org/10.1093/icvts/ivac167
Interactive Cardiovascular and Thoracic Surgery; Voulaz E, Perroni G et. al.

Jun 21st, 2022 - Thymomectomy is gaining consensus over complete thymectomy in early-stage thymoma without myasthenia gravis. This is due both to the difficulty of establishing prospective and randomized controlled studies and to the lack of well defined selection criteria. This bicentric, retrospective propensity-score matched study aims at comparing oncological outcomes, measured in terms of overall survival ...

Pelvic soft tissue sarcomas.
https://doi.org/10.1016/j.ejso.2022.06.003
European Journal of Surgical Oncology : the Journal of Th... Sarre-Lazcano C, Dumitra S et. al.

Jun 21st, 2022 - Pelvic soft tissue sarcomas (PSTS) are a rare, heterogeneous group of tumors. They have been usually analyzed with retroperitoneal sarcomas (RPS), but actually have key differences. Due to their unique anatomic location, symptomatic presentation of PSTS may be more common than RPS. Adequate imaging approach is paramount for guiding differential diagnosis, while preoperative biopsy is mandatory,...

Papulonecrotic tuberculid.
https://doi.org/10.1111/ced.15302
Clinical and Experimental Dermatology; Palaniappan V, Sadhasivamohan A et. al.

Jun 21st, 2022 - Papulonecrotic tuberculid (PNT) is an uncommon form of id eruption that occur in association with tuberculosis infections, in patients with a high degree of immunity and allergic sensitivity to mycobacterial organisms. It commonly presents as recurrent crops of papulonecrotic lesions which crust or ulcerate and heals with atrophic varioliform scars over a period of time. The differential diagno...

Intraoperative indocyanine green fluorescence navigation in a robot-assisted partial ne...
https://doi.org/10.1136/bcr-2021-248323
BMJ Case Reports; Holmes A, Tissot S et. al.

Jun 21st, 2022 - A man in his 60s was referred to the urology department with an incidental finding of large 75 mm mass within a horseshoe kidney. CT imaging highlighted the well-known aberrant arterial anatomy seen in horseshoe kidney which often causes significant surgical challenges.After careful preoperative planning, the mass was resected successfully during a robot-assisted partial nephrectomy. Intraopera...