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About 163,903 results

The Performance of Interferon-gamma Release Assays and Tuberculin Skin Tests in the Dia...
https://doi.org/10.2174/1871526523666221128140615
Infectious Disorders Drug Targets; Abedi F, Farkhondeh T et. al.

Nov 30th, 2022 - Diagnosis and treatment of latent tuberculosis infection (LTBI) in populations under TNF-α antagonists therapy are critical strategies for preventing active tuberculosis (TB). The diagnostic accuracy of IGRAs and the TST for diagnosis of LTBI in patients with IMIDs remains unclear. Accuracy measures of IGRAs and TST were pooled with random effects model. The sensitivity and specificity in IMID ...

Structural Elements Involved in ATP Hydrolysis Inhibition and ATP Synthesis of Tubercul...
https://doi.org/10.1128/aac.01056-22
Antimicrobial Agents and Chemotherapy; Wong CF, Saw WG et. al.

Nov 30th, 2022 - The F1FO-ATP synthase is required for the viability of tuberculosis (TB) and nontuberculous mycobacteria (NTM) and has been validated as a drug target. Here, we present the cryo-EM structures of the Mycobacterium smegmatis F1-ATPase and the F1FO-ATP synthase with different nucleotide occupation within the catalytic sites and visualize critical elements for latent ATP hydrolysis and efficient AT...

High throughput bioluminescent assay to characterize and monitor the activity of SARS-C...
https://doi.org/10.1371/journal.pone.0274343
PloS One; Hsiao K, Zegzouti H et. al.

Nov 30th, 2022 - The fast rate of viral mutations of SARS CoV-2 result in decrease in the efficacy of the vaccines that have been developed before the emergence of these mutations. Thus, it is believed that using additional measures to combat the virus is not only advisable but also beneficial. Two antiviral drugs were authorized for emergency use by the FDA, namely Pfizer's two-drug regimen sold under the bran...

Inhibition of cellular senescence hallmarks by mitochondrial transplantation in senesce...
https://doi.org/10.1016/j.neurobiolaging.2022.11.003
Neurobiology of Aging; Noh SE, Lee SJ et. al.

Nov 29th, 2022 - Retinal pigment epithelium (RPE) damage is a major factor in age-related macular degeneration (AMD). The RPE in AMD shows mitochondrial dysfunction suggesting an association of AMD with mitochondrial function. Therefore, exogenous mitochondrial transplantation for restoring and replacing dysfunctional mitochondria may be an effective therapeutic strategy for AMD. Here, we investigated the effec...

Circulating T-cell receptor diversity as predictive biomarker for PARP inhibitors maint...
https://doi.org/10.1016/j.ygyno.2022.11.013
Gynecologic Oncology; Shu T, Zhou Z et. al.

Nov 29th, 2022 - T-cell receptor (TCR) repertoire diversity is getting increasing attention as a predictive biomarker in cancer patients. However, the characteristics of the TCR together with its predictive significance for high grade serous ovarian cancer (HGSOC) patients receiving poly (ADP-ribose) polymerase inhibitor (PARPi) maintenance therapy remain unknown. Twenty-seven patients with HGSOC were analyzed ...

Virtual screening of phytochemicals by targeting multiple proteins of severe acute resp...
https://doi.org/10.1177/03946320221142793
International Journal of Immunopathology and Pharmacology; Azeem M, Mustafa G et. al.

Nov 29th, 2022 - Medicinal herbs are being investigated for medicationhg development against SARS-CoV-2 as a rich source of bioactive chemicals. One of the finest approaches for finding therapeutically effective drug molecules in real time is virtual screening scheme such as molecular docking in conjunction with molecular dynamics (MD) simulation. These virtual techniques provide an ample opportunity for the sc...

Epigenetic basis for PARP mutagenesis in glioblastoma: A review.
https://doi.org/10.1016/j.ejphar.2022.175424
European Journal of Pharmacology; M A, Xavier J et. al.

Nov 29th, 2022 - Several modifications in the glioblastoma genes are caused by epigenetic modifications, which are crucial in appropriate developmental processes such as self-renewal and destiny determination of neural stem cells. Poly (ADP-ribose)polymerase (PARP) is an essential cofactor involved in DNA repair as well as several other cellular functions such as transcription and chromatin shape modification. ...

Elimusertib (BAY1895344), a novel ATR inhibitor, demonstrates in vivo activity in ATRX ...
https://doi.org/10.1016/j.ygyno.2022.11.014
Gynecologic Oncology; Harold J, Bellone S et. al.

Nov 29th, 2022 - Uterine leiomyosarcoma (uLMS) is a rare, highly aggressive malignancy. Recent data suggest 50% of uLMS may harbor alterations in the ATRX gene and such mutations may confer sensitivity to ataxia-telangiectasia-and-Rad3-related (ATR) kinase inhibitors. We sought to investigate the in vivo activity of Elimusertib (BAY1895344), a novel ATR-inhibitor, against ATRX-mutated uLMS patient-derived xenog...

Potential SARS-CoV-2 RdRp inhibitors of cytidine derivatives: Molecular docking, molecu...
https://doi.org/10.1371/journal.pone.0273256
PloS One; M A Kawsar S, Hosen MA et. al.

Nov 29th, 2022 - The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 is one of the optimum targets for antiviral drug design and development. The hydroxyl groups of cytidine structures were modified with different aliphatic and aromatic groups to obtain 5´-O-acyl and 2´,3´-di-O-acyl derivatives, and then, these derivatives were employed in molecular modeling, antiviral prediction, molecular docking, molecular...

Anti-leishmanial physalins-Phytochemical investigation, in vitro evaluation against cli...
https://doi.org/10.1371/journal.pone.0274543
PloS One; Bano S, Bibi M et. al.

Nov 29th, 2022 - Cutaneous leishmaniasis (CL) is a major health problem in over 98 countries of the world, including Pakistan. The current treatments are associated with a number of adverse effects and availability problem of drugs. Therefore, there is an urgent need of easily available and cost effective treatments of CL- in Pakistan. The bioassay-guided fractionation and purification of crude extract of Physa...

Anti PD-1 Checkpoint Inhibitor As a First-Line Treatment for Advanced Cutaneous Squamou...
https://doi.org/10.1097/SCS.0000000000009112
The Journal of Craniofacial Surgery; Bopota K, Donnelly O et. al.

Nov 29th, 2022 - Immune checkpoint inhibitors (ICI) have become an essential part of cancer treatment. Anti-programmed cell death receptor-1 (PD-1) is a monoclonal antibody that targets PD-1. For patients with inoperable cutaneous squamous cell carcinoma, anti-PD-1 ICI treatment has been approved as monotherapy or in adjunct with other treatment modalities. A patient primarily treated with PD-1 inhibition for l...

Autoimmune and immune-mediated inflammatory diseases after exposure to acid-suppressive...
https://doi.org/10.3233/JRS-220012
The International Journal of Risk & Safety in Medicine; Nevalainen A, Nevalainen O

Nov 29th, 2022 - Pharmacovigilance risk signals have proposed a relationship between the use of acid-suppressive medications and the development of certain autoimmune and immune-mediated inflammatory diseases. A systematic review and a meta-analysis was performed. We reviewed MEDLINE (Ovid) and Scopus for comparative observational studies between these diseases and previous exposure to proton-pump inhibitors (P...

Anti-SARS-CoV-2 antibody decay after vaccination and immunogenicity of the booster dose...
https://doi.org/10.55563/clinexprheumatol/hptln9
Clinical and Experimental Rheumatology; Venerito V, Stefanizzi P et. al.

Nov 29th, 2022 - Scanty data on the anti- SARS-CoV-2 IgG level decay after two-dose BNT162b2 vaccination have been published in patients with psoriatic arthritis (PsA) on TNF inhibitors (TNFi). Similarly, no reports on the immunogenicity of a booster dose in such patients have been provided yet.We aimed to investigate the IgG level decay after two-dose BNT162b2 vaccination and the immunogenicity and safety of t...

18FFluorThanatrace ([18F]FTT) PET Imaging of PARP-inhibitor Drug-Target Engagement as a...
https://doi.org/10.1158/1078-0432.CCR-22-1602
Clinical Cancer Research : an Official Journal of the Ame... Pantel AR, Gitto SB et. al.

Nov 29th, 2022 - Poly(ADP-ribose) polymerase enzyme inhibitors (PARPi) have become the standard-of-care treatment for homologous recombination deficient (HRD) high-grade serous ovarian cancer (HGSOC). However, not all HRD tumors respond to PARPi. Biomarkers to predict response are needed. [18F]FluorThanatrace ([18F]FTT) is a PARPi-analog PET radiotracer that non-invasively measures PARP-1 expression. Herein, we...

Treatment options for unresectable hepatocellular carcinoma with hepatitis virus infect...
https://doi.org/10.1007/s00262-022-03324-z
Cancer Immunology, Immunotherapy : CII; Li X, Ding X et. al.

Nov 29th, 2022 - Currently, there are a few treatment options for unresectable hepatocellular carcinoma (HCC) after progression following sorafenib (SOR) therapy, but with limited benefit. The purpose of this study was to investigate the efficacy and safety of tyrosine kinase inhibitors (TKIs) combined with immune checkpoint inhibitors (ICIs) as second-line treatment. From May 2018 to May 2021, a total of 93 HC...

Second-Line Treatment Options for Hepatocellular Carcinoma: Current State and Challenge...
https://doi.org/10.1080/13543784.2022.2151891
Expert Opinion on Investigational Drugs; Li L, Liu HT et. al.

Nov 29th, 2022 - Since the approval of sorafenib for systemic treatment of advanced hepatocellular carcinoma (HCC), many tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) have shown efficacy and tolerability as first-line treatments. On the other hand, these first-line therapies are associated with low objective response and drug resistance. Many drugs have been successfully tested for s...

The PROTAC selectively degrading Bcl-xL represents a novel Hedgehog pathway inhibitor w...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691367
Theranostics Zhang S, Chen Y et. al.

Nov 29th, 2022 - Rationale: Primary and acquired resistance to Smoothened (Smo) inhibitors largely hampered their clinical efficacy. Given the important functions of hedgehog (Hh) pathway in bone formation and development, the permanent defects in bone growth caused by Smo inhibitors further restrict the use of Smo inhibitors for pediatric tumor patients. Anti-apoptotic Bcl-2 proteins regulate Hh activity by en...

Hippocalcin-Like 1 blunts liver lipid metabolism to suppress tumorigenesis via directly...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691343
Theranostics Chen T, Yuan Z et. al.

Nov 29th, 2022 - Rationale: Hepatocellular carcinoma (HCC) is one of the most severe cancers worldwide, with few effective targeted therapies for HCC. Lipid metabolic reprogramming is emerged as a hallmark of cancer metabolism that guides response to antitumoral therapies. Such lipid metabolic alteration in cancers is critically regulated by the mammalian target of rapamycin mTOR, which is considered as a promi...

N6-methyladenosine-associated prognostic pseudogenes contribute to predicting immunothe...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691354
Theranostics Tan L, Qin Y et. al.

Nov 29th, 2022 - Rationale: N6-methyladenosine (m6A) is involved in critical cancerous processes. Pseudogenes play various roles in carcinogenesis and progression. However, the functional roles of m6A-associated pseudogenes in head and neck squamous cell carcinoma (HNSCC) are largely unknown. Methods: We systematically analyzed the mRNA profile of 24 m6A regulators and 13931 pseudogenes from The Cancer Genome A...

Odevixibat: an investigational inhibitor of the ileal bile acid transporter (IBAT) for ...
https://doi.org/10.1080/13543784.2022.2151890
Expert Opinion on Investigational Drugs; Laue T, Baumann U

Nov 29th, 2022 - Biliary atresia (BA) is a rare, non-curable cholestasis-causing disease in infancy, due to progressive ascending bile duct sclerosis. Even after restoration of bile flow following Kasai portoenterostomy, about half of these children need a liver transplant by their 2nd birthday, due to progressive fibrosis. Toxicity of bile acids may play a central role in disease progression, but drug therapie...