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About 604,653 results

Levetiracetam - levetiracetam tablet, film coated-Solco Healthcare US, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd713e60-478c-43cd-b680-ff594a0b3864

Jan 8th, 2022 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older (1.1) Levetiracetam is indicated for adjunctive therapy for the treatment of: •Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy (1.2) •Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilep...

A second functional furin site in the SARS-CoV-2 spike protein.
https://doi.org/10.1080/22221751.2021.2014284
Emerging Microbes & Infections; Zhang Y, Zhang L et. al.

Dec 4th, 2021 - The ubiquitously-expressed proteolytic enzyme furin is closely related to the pathogenesis of SARS-CoV-2, and therefore represents a key target for antiviral therapy. Based on bioinformatic analysis and pseudovirus tests, we discovered a second functional furin site located in the spike protein. Furin still increased the infectivity of mutated SARS-CoV-2 pseudovirus in 293T-ACE2 cells when the ...

Mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome): defining and measuring functio...
https://doi.org/10.1186/s13023-021-02113-8 10.2741/4490 10.1002/humu.23613 10.1186/s13023-016-0503-2 10.1186/s13023-019-1080-y 10.1016/j.jpeds.2004.03.018 10.1016/j.ymgme.2013.02.013 10.1002/ajmg.a.36584 10.1097/00019052-199612000-00011 10.1186/s12969-019-0375-9 10.3390/ijms19103063 10.1016/j.ejpain.2009.08.006 10.1097/j.pain.0000000000001377 10.1016/S0304-3959(01)00314-1 10.1002/ajmg.a.30579 10.1097/AJP.0b013e318192bfb1 10.1016/j.jval.2018.01.015 10.1136/adc.2007.123653 10.1016/j.jpeds.2006.12.052 10.1016/j.physio.2021.03.002 10.1016/j.ymgme.2014.10.015 10.1007/s10545-014-9715-6 10.1186/s13023-017-0634-0 10.1016/j.ymgme.2021.03.006 10.1590/S0021-75572008000200007 10.1016/j.ymgmr.2017.08.007 10.1002/jmd2.12043 10.1097/00004694-199809000-00001 10.1002/acr.20635 10.1097/BPO.0000000000000168 10.1002/art.1780371209 10.1186/1750-1172-8-101 10.1097/00005650-199902000-00003 10.1007/s10897-014-9791-7 10.1155/2006/197616
Orphanet Journal of Rare Diseases; Leiro B, Phillips D et. al.

Dec 4th, 2021 - Research about pediatric patients' perspective on mucopolysaccharidosis type VI (MPS VI) and its impact on daily life is limited. We aimed to identify the disease concepts of interest that most impact function and day-to-day life of pediatric patients with MPS VI, and to consider clinical outcome assessments (COAs) that may potentially measure meaningful improvements in these concepts. Potentia...

The clinical features of pulmonary artery involvement in Takayasu arteritis and its rel...
https://doi.org/10.1186/s13075-021-02675-9 10.1161/CIRCULATIONAHA.114.012547 10.3899/jrheum.140664 10.1111/1756-185X.13354 10.5152/eurjrheum.2018.17052 10.3899/jrheum.190045 10.1186/s13075-020-02203-1 10.1007/s10067-020-05271-5 10.1016/j.ijcard.2018.08.047 10.1253/circj.CJ-88-0007 10.1164/rccm.200604-571ST 10.1093/eurheartj/ehv317 10.3899/jrheum.140436 10.1002/acr.24055 10.1378/chest.67.1.69 10.2214/ajr.159.2.1352939 10.1002/art.1780350419 10.1007/s002590100648 10.1186/s12890-018-0755-9 10.1253/circj.CJ-09-0905 10.1161/01.CIR.80.3.429 10.31138/mjr.30.3.171 10.1016/j.rdc.2013.10.006 10.21037/jtd-20-267 10.1007/s11748-016-0723-3 10.1159/000029490 10.1097/00124743-200210000-00006 10.2169/internalmedicine.45.1686 10.1007/s00408-010-9241-8 10.2169/internalmedicine.53.2558
Arthritis Research & Therapy; Mukoyama H, Shirakashi M et. al.

Dec 4th, 2021 - Pulmonary artery involvement (PAI) in Takayasu arteritis (TAK) can lead to severe complications, but the relationship between the two has not been fully clarified. We retrospectively investigated 166 consecutive patients with TAK who attended Kyoto University Hospital from 1997 to 2018. The demographic data, clinical symptoms and signs, comorbidities, treatments, and imaging findings were compa...

Inflammatory breast cancer, trimodal treatment, and mortality: Does where you live matter?
https://doi.org/10.1016/j.surg.2021.08.061
Surgery Relation T, Li Y et. al.

Dec 4th, 2021 - The objective of this study is to examine the associations among neighborhood socioeconomic status, trimodal treatment, and disease-specific mortality among inflammatory breast cancer patients using data from the Surveillance, Epidemiology, and End Results program. Patients diagnosed with inflammatory breast cancer (T4d) from 2010 to 2016 were identified in the Surveillance, Epidemiology, and E...

Time to regain birth weight - a marker to predict the severity of retinopathy of premat...
https://doi.org/10.1186/s12887-021-03027-x 10.1016/j.jpeds.2012.12.038 10.1001/archophthalmol.2012.243 10.3345/kjp.2015.58.2.52 10.1016/S0140-6736(13)60178-6 10.1001/archopht.1996.01100140419009 10.1542/peds.112.5.1016 10.1073/pnas.101113998 10.1203/00006450-200112000-00017 10.1159/000087587 10.1038/70963 10.1093/humrep/13.5.1389 10.1203/00006450-199103000-00001 10.1016/0378-3782(86)90096-4 10.1203/01.PDR.0000155950.67503.BC 10.1016/j.clp.2013.02.004 10.3109/14767058.2013.764407 10.1001/archophthalmol.2009.244 10.1542/peds.2004-1309 10.1001/archopht.124.12.1711 10.1007/s00417-008-1012-3 10.1136/archdischild-2014-306816 10.1080/14767058.2017.1381902 10.1001/archopht.121.12.1684 10.1542/peds.2018-3061 10.21037/aes.2017.03.05 10.2223/JPED.1870 10.1067/mpa.2000.110342 10.1067/mpa.2003.S1091853102420150 10.1080/14767058.2021.1940937 10.1016/j.anpede.2020.05.016 10.3928/01913913-20190208-01 10.20471/acc.2020.59.03.03 10.1038/eye.2011.29 10.3980/j.issn.2222-3959.2015.06.23 10.1080/20469047.2019.1631588 10.1038/s41598-020-74600-0 10.1136/archdischild-2019-316976
BMC Pediatrics; Anvekar A, Athikarisamy S et. al.

Dec 4th, 2021 - Poor weight gain in the first few weeks of life has been studied as a predictor of retinopathy of prematurity (ROP). Our aim was to assess whether time taken to regain birthweight (BW) be used as an additional marker to identify infants with type 1 ROP. In this retrospective study, preterm infants (< 27 weeks gestational age at birth) born during the period from 1/1/2010-31/12/2015 at a tertiar...

Prevalence of potential mediators of artemisinin resistance in African isolates of Plas...
https://doi.org/10.1186/s12936-021-03987-6
Malaria Journal; Owoloye A, Olufemi M et. al.

Dec 4th, 2021 - The devastating public health impact of malaria has prompted the need for effective interventions. Malaria control gained traction after the introduction of artemisinin-based combination therapy (ACT). However, the emergence of artemisinin (ART) partial resistance in Southeast Asia and emerging reports of delayed parasite sensitivity to ACT in African parasites signal a gradual trend towards tr...

CircRNAs in lung adenocarcinoma: diagnosis and therapy.
https://doi.org/10.2174/1566523221666211202095258
Current Gene Therapy; Su L, Zhao J et. al.

Dec 4th, 2021 - Lung adenocarcinoma (LUAD) is the common histological subtype of non-small-cell lung carcinoma (NSCLC). Circular RNAs (circRNAs) represent a new class of non-coding RNAs (ncRNAs) involved in the development of cancer. Accumulating evidence indicated that a large number of circular RNAs were found to be involved in many biological processes, including tumor initiation, proliferation and progress...

Prognostic significance of ethnicity and age in advanced stage epithelial ovarian cance...
https://doi.org/10.1016/j.ygyno.2021.11.013
Gynecologic Oncology; duPont NC, Enserro D et. al.

Dec 4th, 2021 - Age and ethnicity are among several factors that influence overall survival (OS) in ovarian cancer. The study objective was to determine whether ethnicity and age were of prognostic significance in women enrolled in a clinical trial evaluating the addition of bevacizumab to front-line therapy. Women with advanced stage ovarian, primary peritoneal, or fallopian tube cancer were enrolled in a pha...

Association of site of treatment with clinical outcomes following intravenous antimicro...
https://doi.org/10.1016/j.jcf.2021.11.009
Journal of Cystic Fibrosis : Official Journal of the Euro... Sanders DB, Khan U et. al.

Dec 4th, 2021 - In the STOP2 (Standardized Treatment of Pulmonary Exacerbations-2) study, intravenous (IV) antimicrobial treatment duration for adults with cystic fibrosis (CF) experiencing pulmonary exacerbations (PEx) was determined based on initial treatment response. The impact of home vs hospital care remains an important clinical question in CF. Our hypothesis was that STOP2 participants treated at home ...

Centromere protein F promotes progression of hepatocellular carcinoma through ERK and c...
https://doi.org/10.1038/s41417-021-00404-7 10.3322/caac.21551 10.20517/2394-5079.2018.18 10.21147/j.issn.1000-9604.2018.06.01 10.1016/S0140-6736(18)30010-2 10.1038/nrc.2016.138 10.1038/nrm3107 10.1158/0008-5472.CAN-05-3389 10.1242/dev.129.7.1715 10.3892/or.2016.5009 10.1002/pmic.201900038 10.1016/j.bbrc.2013.06.021 10.1186/s12935-019-0986-8 10.1080/15384101.2019.1661173 10.7717/peerj.7436 10.1016/j.semcancer.2015.02.006 10.1371/journal.pone.0017794 10.1200/jco.2010.28.15_suppl.3012 10.18632/oncotarget.4879 10.1186/1476-4598-9-237 10.1186/s13046-019-1202-3 10.1038/ncomms11418 10.1002/hep.25900 10.1002/hep.23882 10.1002/1878-0261.12846 10.18632/aging.100296 10.3892/ol.2017.5557 10.1002/cam4.1228
Cancer Gene Therapy; Chen H, Wu F et. al.

Dec 4th, 2021 - Hepatocellular carcinoma (HCC) is one of the deadliest cancer types worldwide. The centromere proteins (CENPs) are critical for the mitosis-related protein complex and are involved in kinetochore assembly and spindle checkpoint signaling during mitosis. However, the clinical significance of CENPs in the recurrence and progression of HCC remains poorly understood. Here, we examined the expressio...

Propofol induces apoptosis and ameliorates 5‑fluorouracil resistance in OSCC cells by r...
https://doi.org/10.3892/mmr.2021.12552
Molecular Medicine Reports; Yang KS, Che PC et. al.

Dec 4th, 2021 - Among the different types of oral cancer, >90% of cases are oral squamous cell carcinoma (OSCC). 5‑fluorouracil (5‑FU) is a commonly used treatment for OSCC, but cells typically display resistance to the drug. Propofol, an intravenous anesthetic agent, exhibits certain anticancer effects, including the inhibition of cancer cell proliferation, migration and invasion. Secreted proteins, such as g...

Health-related quality of life, obesity, fragmented sleep, fatigue, and psychosocial pr...
https://doi.org/10.1002/pon.5862
Psycho-oncology Klages KL, Berlin KS et. al.

Dec 4th, 2021 - Youth with craniopharyngioma experience weight gain, fragmented sleep, excessive daytime sleepiness (EDS), fatigue, and psychosocial problems that negatively impact their overall health-related quality of life (HRQoL). Greater hypothalamic tumor involvement (HI) may be associated with higher rates or severity of these impairments; however, the direct and indirect impact of HI on the physical an...

Retrospective evaluation of an observational cohort by the Central and Eastern Europe N...
https://doi.org/10.1111/hiv.13214
HIV Medicine; Lakatos B, Kowalska J et. al.

Dec 4th, 2021 - The aim of this international multicentre study was to review potential drug-drug interactions (DDIs) for real-life coadministration of combination antiretroviral therapy (cART) and coronavirus disease 2019 (COVID-19)-specific medications. The Euroguidelines in Central and Eastern Europe Network Group initiated a retrospective, observational cohort study of HIV-positive patients diagnosed with ...

Platycodin D inhibits the malignant progression of papillary thyroid carcinoma by NF-κB...
https://doi.org/10.1002/ddr.21902
Drug Development Research; Deng B, Sun M

Dec 4th, 2021 - Papillary thyroid carcinoma (PTC) is the most common pathological type of thyroid cancer. Studies have shown that platycodin D has several pharmacological effects like anti-inflammatory, immunomodulatory, and anti-tumor effects, while the effect and mechanism of platycodin D on PTC are still unclear. This study was designed to investigate the effects of platycodin D on PTC by a series of in vit...

Repository corticotropin injection improves quality metrics in an observational study o...
https://doi.org/10.2217/nmt-2021-0030
Neurodegenerative Disease Management; Kaplan J, Miller T et. al.

Dec 4th, 2021 - Aim: To determine whether clinicians evaluate American Academy of Neurology (AAN) quality metrics for patients with multiple sclerosis (MS) relapse and whether repository corticotropin injection (RCI) improves clinical and patient-reported outcomes associated with these metrics at 2 and 6 months after treatment. Methods: A multicenter, prospective, observational registry evaluating patients rec...

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630469
Journal of Hepatocellular Carcinoma; Deldar Abad Paskeh M, Mirzaei S et. al.

Dec 4th, 2021 - Liver cancers cause a high rate of death worldwide and hepatocellular carcinoma (HCC) is considered as the most common primary liver cancer. HCC remains a challenging disease to treat. Wnt/β-catenin signaling pathway is considered a tumor-promoting factor in various cancers; hence, the present review focused on the role of Wnt signaling in HCC, and its association with progression and therapy r...

Clinical Outcomes of COVID-19 and Impact on Disease Course in Patients with Inflammator...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632463
Canadian Journal of Gastroenterology & Hepatology; Wetwittayakhlang P, Albader F et. al.

Dec 4th, 2021 - The impact of COVID-19 has been of great concern in patients with inflammatory bowel disease (IBD) worldwide, including an increased risk of severe outcomes and/or possible flare of IBD. This study aims to evaluate prevalence, outcomes, the impact of COVID-19 in patients with IBD, and risk factors associated with severe COVID-19 or flare of IBD activity. A consecutive cohort of IBD patients who...

Liver Transplantation for intrahepatic cholangiocarcinoma: ready for prime time?
https://doi.org/10.1002/hep.32258
Hepatology (Baltimore, Md.); Sapisochin G, Ivanics T et. al.

Dec 4th, 2021 - Cholangiocarcinoma (CCA) represents the second most common primary liver malignancy after hepatocellular carcinoma and has risen in incidence globally in the past decades. Intrahepatic cholangiocarcinoma (iCCA) comprises 20% of all CCAs, with the rest being extrahepatic (including perihilar [pCCA] and distal CCA). Though long representing an absolute contraindication for liver transplantation (...

Efficiency of high cumulative cisplatin dose in high- and low-risk patients with locore...
https://doi.org/10.1002/cam4.4477
Cancer Medicine; Jiang YT, Chen KH et. al.

Dec 4th, 2021 - The optimal cumulative cisplatin dose (CCD) during radiation therapy for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients receiving induction chemotherapy (IC) plus CCRT remains controversial. This study aimed to explore the treatment efficiency of CCD for high-and low-risk patients with LA-NPC. Data from 472 LA-NPC patients diagnosed from 2014 to 2018 and treated with IC plus...