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About 30,915 results

SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesis.
https://doi.org/10.1073/pnas.2122897119
Proceedings of the National Academy of Sciences of the Un... Qin C, Rao Y et. al.

Jun 15th, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolves rapidly under the pressure of host immunity, as evidenced by waves of emerging variants despite effective vaccinations, highlighting the need for complementing antivirals. We report that targeting a pyrimidine synthesis enzyme restores inflammatory response and depletes the nucleotide pool to impede SARS-CoV-2 infection. SARS-...

TNF-α/IFN-γ synergy amplifies senescence-associated inflammation and SARS-CoV-2 recepto...
https://doi.org/10.1111/acel.13646
Aging Cell; Kandhaya-Pillai R, Yang X et. al.

Jun 2nd, 2022 - Older age and underlying conditions such as diabetes/obesity or immunosuppression are leading host risk factors for developing severe complications from COVID-19 infection. The pathogenesis of COVID-19-related cytokine storm, tissue damage, and fibrosis may be interconnected with fundamental aging processes, including dysregulated immune responses and cellular senescence. Here, we examined effe...

RNA binding protein RALY activates the cholesterol synthesis pathway through an MTA1 sp...
https://doi.org/10.1016/j.canlet.2022.215711
Cancer Letters; Qiao Y, Shi Q et. al.

May 2nd, 2022 - Alternative splicing is an important RNA processing event that contributes to RNA complexity and protein diversity in cancer. Accumulating evidence demonstrates the essential roles of some alternatively spliced genes in carcinogenesis. However, the potential roles of alternatively spliced genes in hepatocellular carcinoma (HCC) are still largely unknown. Here we showed that the HnRNP Associated...

Targeted inhibition of the expression of both MCM5 and MCM7 by miRNA-214 impedes DNA re...
https://doi.org/10.1016/j.canlet.2022.215677
Cancer Letters; Wang J, Amin A et. al.

May 2nd, 2022 - MicroRNAs are noncoding RNAs with a typical length of 22 nucleotides that post-transcriptionally suppress gene expression by inducing target mRNA degradation and/or impairing translation in eukaryotes. Thousands of miRNA genes in the human genome are involved in various physiological and pathological processes. Each miRNA targets many different mRNAs, while each mRNA may be targeted by various ...

Prognostic impact of PRDM16 expression in acute myeloid leukemia with normal cytogenetics.
https://doi.org/10.1080/16078454.2022.2066306
Hematology (Amsterdam, Netherlands); Xiang X, Lu Q et. al.

Apr 28th, 2022 - Cytogenetically normal acute myeloid leukemia (CN-AML) is a heterogeneous disease with variable clinical outcomes. The identification of potential biomarkers to better classify the patients with unfavorable prognoses who may require more aggressive therapies is an emergent demand. PRDM16 is a transcriptional cofactor and histone methyltransferase, playing a critical role in maintaining hematopo...

Single Ascending Dose Study of a Short Interfering RNA Targeting Lipoprotein(a) Product...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978050
JAMA Nissen SE, Wolski K et. al.

Apr 4th, 2022 - Lipoprotein(a) (Lp[a]) is an important risk factor for atherothrombotic cardiovascular disease and aortic stenosis, for which there are no treatments approved by regulatory authorities. To assess adverse events and tolerability of a short interfering RNA (siRNA) designed to reduce hepatic production of apolipoprotein(a) and to assess associated changes in plasma concentrations of Lp(a) at diffe...

Increased expression of Nrf2 and elevated glucose uptake in pheochromocytoma and paraga...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931959
BMC Cancer; Kamai T, Murakami S et. al.

Mar 19th, 2022 - Pheochromocytomas (PCC) and paragangliomas (PGL) are catecholamine-producing neuroendocrine tumors. According to the World Health Organization Classification 2017, all PCC/PGL are considered to have malignant potential. There is growing evidence that PCC/PGL represent a metabolic disease that leads to aerobic glycolysis. Cellular energy metabolism involves both transcription factor nuclear fact...

The Expression and Prognostic Value of ILK and YAP1 in Glioma.
https://doi.org/10.1097/PAI.0000000000000984
Applied Immunohistochemistry & Molecular Morphology : AIMM; Wang Q, Sang W et. al.

Mar 10th, 2022 - Integrin-linked kinase (ILK) is a widely expressed serine/threonine-protein kinase that has been implicated in cancer development, progression, and metastasis. Yes-associated protein (YAP), as the most important effector of Hippo signaling pathway, which is considered to be a tumor suppressor pathway, acts as an oncogene in a variety of human cancers. The present study aimed to explore the expr...

Integrated Multiomic Profiling Identifies the Epigenetic Regulator PRC2 as a Therapeuti...
https://doi.org/10.1158/2159-8290.CD-21-0980
Cancer Discovery; Gambacorta V, Beretta S et. al.

Mar 8th, 2022 - Immune escape represents a major driver of acute myeloid leukemia (AML) reemergence after allogeneic hematopoietic cell transplantation (allo-HCT), with up to 40% of relapses prompted by nongenomic loss of HLA class II expression in leukemia cells. By integrative analysis of gene expression, DNA methylation, and chromatin accessibility in paired diagnosis/relapse primary samples and in the resp...

Identification of diagnostic markers and immune cell infiltration characteristics in an...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897842
European Journal of Medical Research; Xia M, Zhao F et. al.

Mar 6th, 2022 - Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a group of life-threatening systemic autoimmune diseases. The aim of this study was to determine the relationship between the AAV hub gene and immune cell infiltration, and its value for clinical disease treatment. We downloaded the microarray information of 37 AAV patients and 27 controls from Gene Expression Omnibus (GEO). Gen...

ΔNp63-Senataxin circuit controls keratinocyte differentiation by promoting the transcri...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915885
Proceedings of the National Academy of Sciences of the Un... Gatti V, Fierro C et. al.

Mar 3rd, 2022 - SignificanceΔNp63 is a master regulator of skin homeostasis since it finely controls keratinocyte differentiation and proliferation. Here, we provide cellular and molecular evidence demonstrating the functional role of a ΔNp63 interactor, the R-loop-resolving enzyme Senataxin (SETX), in fine-tuning keratinocyte differentiation. We found that SETX physically binds the p63 DNA-binding motif prese...

Development of DG9 peptide-conjugated single- and multi-exon skipping therapies for the...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892351
Proceedings of the National Academy of Sciences of the Un... Lim KRQ, Woo S et. al.

Feb 24th, 2022 - Duchenne muscular dystrophy (DMD) is primarily caused by out-of-frame deletions in the dystrophin gene. Exon skipping using phosphorodiamidate morpholino oligomers (PMOs) converts out-of-frame to in-frame mutations, producing partially functional dystrophin. Four single-exon skipping PMOs are approved for DMD but treat only 8 to 14% of patients each, and some exhibit poor efficacy. Alternativel...

BCL-2 expression promotes immunosuppression in chronic lymphocytic leukemia by enhancin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862474
Molecular Cancer; Liu L, Cheng X et. al.

Feb 24th, 2022 - Chronic lymphocytic leukemia (CLL) results in increased susceptibility to infections. T cell dysfunction is not associated with CLL in all patients; therefore, it is important to identify CLL patients with T cell defects. The role of B-cell lymphoma-2 (BCL-2) in CLL has been explored; however, few studies have examined its role in T cells in CLL patients. Herein, we have investigated the regula...

HLA-E and HLA-F Are Overexpressed in Glioblastoma and HLA-E Increased After Exposure to...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865046
Cancer Genomics & Proteomics; Hrbac T, Kopkova A et. al.

Feb 20th, 2022 - Glioblastoma (GBM) is one of the deadliest human cancers responding very poorly to therapy. Although the central nervous system has been traditionally considered an immunologically privileged site with an enhanced immune response, GBM appears to benefit from this immunosuppressive milieu. Immunomodulatory molecules play an important role in immune tumor-host interactions. Non-classical human le...

PERK activation by SB202190 ameliorates amyloidogenesis via the TFEB-induced autophagy-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876914
Aging Do M, Park J et. al.

Feb 16th, 2022 - The protein kinase R (PKR)-like endoplasmic reticulum (ER) kinase (PERK), a key ER stress sensor of the unfolded protein response (UPR), can confer beneficial effects by facilitating the removal of cytosolic aggregates through the autophagy-lysosome pathway (ALP). In neurodegenerative diseases, the ALP ameliorates the accumulation of intracellular protein aggregates in the brain. Transcription ...

SELPLG Expression Was Potentially Correlated With Metastasis and Prognosis of Osteosarc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825369
Pathology Oncology Research : POR; Wang B, Sun Y

Feb 15th, 2022 - Background: Osteosarcoma (OS) is the most prevalent malignant primary bone tumor in children. Selectin P ligand gene (SELPLG) has been studied in several cancers. Our research aimed to explore the role of SELPLG in OS. Methods: All OS patient data was obtained from TARGET and GEO databases. Differential expression analyses were conducted in limma package of R. Functional analyses included GO an...

Overexpression of BACH1 mediated by IGF2 facilitates hepatocellular carcinoma growth an...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771560
Theranostics Xie M, Sun M et. al.

Feb 15th, 2022 - Background: Accumulating studies manifest that BTB and CNC homology 1 (BACH1) facilitates multiple malignancies progression and metastasis, and targeting the BACH1 pathway enhances antitumor efficacy. Nevertheless, the exact mechanism of BACH1 promoting growth and metastasis and its therapeutic significance in hepatocellular carcinoma (HCC) remain unclear. Methods: The expression of BACH1 in hu...

Contribution of Dendritic Cell Subsets to T Cell-Dependent Responses in Mice.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881363
Journal of Immunology (Baltimore, Md. : 1950); Abboud G, Elshikha AS et. al.

Feb 11th, 2022 - BATF3-deficient mice that lack CD8+ dendritic cells (DCs) showed an exacerbation of chronic graft-versus-host disease (cGVHD), including T follicular helper (Tfh) cell and autoantibody responses, whereas mice carrying the Sle2c2 lupus-suppressive locus with a mutation in the G-CSFR showed an expansion of CD8+ DCs and a poor mobilization of plasmacytoid DCs (pDCs) and responded poorly to cGVHD i...

Identification of targetable kinases in idiopathic pulmonary fibrosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822646
Respiratory Research; Higo H, Ohashi K et. al.

Feb 9th, 2022 - Tyrosine kinase activation plays an important role in the progression of pulmonary fibrosis. In this study, we analyzed the expression of 612 kinase-coding and cancer-related genes using next-generation sequencing to identify potential therapeutic targets for idiopathic pulmonary fibrosis (IPF). Thirteen samples from five patients with IPF (Cases 1-5) and eight samples from four patients withou...

HER2 Overexpression and Amplification in Uterine Carcinosarcomas With Serous Morphology.
https://doi.org/10.1097/PAS.0000000000001870
The American Journal of Surgical Pathology; Jenkins TM, Cantrell LA et. al.

Feb 8th, 2022 - Uterine carcinosarcoma (UCS) is an aggressive malignancy with few treatment options. A recent clinical trial has shown an increase in progression-free survival in patients with human epidermal growth factor receptor 2 (HER2)-positive serous endometrial carcinomas treated with anti-HER2-targeted therapies. Few studies have evaluated HER2 expression/amplification in UCS. Similar to serous endomet...