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About 31,113 results

Ring Finger Protein 215 Negatively Regulates Type I IFN Production via Blocking NF-κB p...
https://doi.org/10.4049/jimmunol.2200346
Journal of Immunology (Baltimore, Md. : 1950); Wu Y, Chen D et. al.

Nov 26th, 2022 - Germline-encoded pattern recognition receptors (PRRs) recognize molecules frequently found in pathogens (pathogen-associated molecular patterns [PAMPs]) during viral infection. This process induces production of IFNs, leading to expression of IFN-stimulated genes to establish a cellular antiviral state against viral infection. However, aberrant activation of the IFN system may cause immunopatho...

Sesquiterpenoids from Seriphidium transiliense and Their Melanogenic Activity.
https://doi.org/10.1021/acs.jnatprod.2c00527
Journal of Natural Products; Wu JF, Turak A et. al.

Nov 4th, 2022 - A sesquiterpenoid with an unprecedented 5/5/4 tricyclic skeleton (1), a nor-sesquiterpenoid with a rare 6/7 bicyclic skeleton (2), 10 new sesquiterpenoids (3-12), and six known analogues (13-18) were isolated from the whole plants of Seriphidium transiliense. The structures of compounds 1-12 were elucidated by spectroscopic data analysis. Compound 7 showed melanogenic promotion activity in muri...

An LKB1-mitochondria axis controls TH17 effector function.
https://doi.org/10.1038/s41586-022-05264-1
Nature Baixauli F, Piletic K et. al.

Sep 29th, 2022 - CD4+ T cell differentiation requires metabolic reprogramming to fulfil the bioenergetic demands of proliferation and effector function, and enforce specific transcriptional programmes1-3. Mitochondrial membrane dynamics sustains mitochondrial processes4, including respiration and tricarboxylic acid (TCA) cycle metabolism5, but whether mitochondrial membrane remodelling orchestrates CD4+ T cell ...

Expressional variations of Kaiso: an association with pathological characteristics and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482199
BMC Cancer; Ahmed S, Khan S et. al.

Sep 18th, 2022 - A group of genetically altered cells that have not transformed into a clinical or histologically identifiable state of malignancy but contains a higher risk of transforming into one is known as the field of cancerization. Numerous molecules are being investigated for their significance in the development of this phenomenon. One such protein of this family is Kaiso also known as ZBTB33 (Zinc Fin...

Lactate Dehydrogenase and its clinical significance in pancreatic and thoracic cancers.
https://doi.org/10.1016/j.semcancer.2022.09.001
Seminars in Cancer Biology; Comandatore A, Franczak M et. al.

Sep 13th, 2022 - The energy metabolism of tumor cells is considered one of the hallmarks of cancer because it is different from normal cells and mainly consists of aerobic glycolysis, fatty acid oxidation, and glutaminolysis. It is about one hundred years ago since Warburg observed that cancer cells prefer aerobic glycolysis even in normoxic conditions, favoring their high proliferation rate. A pivotal enzyme d...

Structural insight and characterization of human Twinkle helicase in mitochondrial dise...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371709
Proceedings of the National Academy of Sciences of the Un... Riccio AA, Bouvette J et. al.

Aug 2nd, 2022 - Twinkle is the mammalian helicase vital for replication and integrity of mitochondrial DNA. Over 90 Twinkle helicase disease variants have been linked to progressive external ophthalmoplegia and ataxia neuropathies among other mitochondrial diseases. Despite the biological and clinical importance, Twinkle represents the only remaining component of the human minimal mitochondrial replisome that ...

Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428867
Nature Karagiannis F, Peukert K et. al.

Jul 29th, 2022 - Anorexia and fasting are host adaptations to acute infection, and induce a metabolic switch towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate (BHB)1-6. However, whether ketogenesis metabolically influences the immune response in pulmonary infections remains unclear. Here we show that the production of BHB is impaired in individuals with SARS-CoV-2-induced acut...

A male steroid controls female sexual behaviour in the malaria mosquito.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352575
Nature Peng D, Kakani EG et. al.

Jul 7th, 2022 - Insects, unlike vertebrates, are widely believed to lack male-biased sex steroid hormones1. In the malaria mosquito Anopheles gambiae, the ecdysteroid 20-hydroxyecdysone (20E) appears to have evolved to both control egg development when synthesized by females2 and to induce mating refractoriness when sexually transferred by males3. Because egg development and mating are essential reproductive t...

Expression patterns of uPAR, TF and EGFR and their potential as targets for molecular i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263836
Oncology Reports; Christensen A, Grønhøj C et. al.

Jul 2nd, 2022 - The clinical introduction of molecular imaging for the management of oropharyngeal squamous cell carcinoma (OPSCC) relies on the identification of relevant cancer‑specific biomarkers. The application of three membrane‑bound receptors, namely urokinase‑type plasminogen activator receptor (uPAR), tissue factor (TF) and EGFR have been previously explored for targeted imaging and therapeutic strate...

B cell receptor signaling drives APOBEC3 expression via direct enhancer regulation in c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249768
Blood Cancer Journal; Wang Z, Yan H et. al.

Jul 2nd, 2022 - Constitutively activated B cell receptor (BCR) signaling is a primary biological feature of chronic lymphocytic leukemia (CLL). The biological events controlled by BCR signaling in CLL are not fully understood and need investigation. Here, by analysis of the chromatin states and gene expression profiles of CLL B cells from patients before and after Bruton's tyrosine kinase inhibitor (BTKi) ibru...

Genome-scale CRISPR-Cas9 screen reveals novel regulators of B7-H3 in tumor cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244714
Journal for Immunotherapy of Cancer; Zhao S, Wang Y et. al.

Jun 30th, 2022 - Despite advances in B7 homolog 3 protein (B7-H3) based immunotherapy, the development of drug resistance remains a major clinical concern. The heterogeneity and emerging loss of B7-H3 expression are the main causes of drug resistance and treatment failure in targeted therapies, which reveals an urgent need to elucidate the mechanism underlying the regulation of B7-H3 expression. In this study, ...

Mitochondrial RNA modifications shape metabolic plasticity in metastasis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300468
Nature Delaunay S, Pascual G et. al.

Jun 30th, 2022 - Aggressive and metastatic cancers show enhanced metabolic plasticity1, but the precise underlying mechanisms of this remain unclear. Here we show how two NOP2/Sun RNA methyltransferase 3 (NSUN3)-dependent RNA modifications-5-methylcytosine (m5C) and its derivative 5-formylcytosine (f5C) (refs.2-4)-drive the translation of mitochondrial mRNA to power metastasis. Translation of mitochondrially en...

Caspase-3-Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Choleste...
https://doi.org/10.1158/0008-5472.CAN-21-2934
Cancer Research; Mok EHK, Leung CON et. al.

Jun 30th, 2022 - Accumulating evidence has demonstrated that drug resistance can be acquired in cancer through the repopulation of tumors by cancer stem cell (CSC) expansion. Here, we investigated mechanisms driving resistance and CSC repopulation in hepatocellular carcinoma (HCC) as a cancer model using two drug-resistant, patient-derived tumor xenografts that mimicked the development of acquired resistance to...

Effect of 17β-estradiol on the daily pattern of ACE2, ADAM17, TMPRSS2 and estradiol rec...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239479
PloS One; Herichová I, Jendrisková S et. al.

Jun 29th, 2022 - Covid-19 progression shows sex-dependent features. It is hypothesized that a better Covid-19 survival rate in females can be attributed to the presence of higher 17β-estradiol (E2) levels in women than in men. Virus SARS-CoV-2 is enabled to enter the cell with the use of angiotensin converting enzyme 2 (ACE2). The expression of several renin-angiotensin system components has been shown to exert...

Highly Expressing SCARA5 Promotes Proliferation and Migration of Esophageal Squamous Ce...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232322
Journal of Immunology Research; Jumai K, Zhang T et. al.

Jun 28th, 2022 - Thrombospondin type 1 domain-containing 7A (THSD7A) was reported to play a procancer role in esophageal squamous cell carcinoma (ESCC). The aim of the study was to screen the downstream functional genes of THSD7A and explore their functions in ESCC, based on the reported research into THSD7A function and on gene microarrays. We adopted quantitative reverse-transcription polymerase chain reactio...

Clinicopathological Significance of AKT1 and PLK1 Expression in Oral Squamous Cell Carc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232379
Disease Markers; Sun EC, Dong SS et. al.

Jun 28th, 2022 - Oral squamous cell carcinoma (OSCC) is the sixth leading cause of cancer-related death worldwide and is characterized by metastasis and recurrence. We aimed to evaluate the expression of AKT1 and PLK1 in OSCC and identify their correlation with the clinical and histological features and prognosis of patients with OSCC. Tissue samples were collected from 70 patients with OSCC and 50 patients wit...

Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.
https://doi.org/10.1093/eurheartj/ehac305
European Heart Journal; Perea-Gil I, Seeger T et. al.

Jun 22nd, 2022 - Genetic dilated cardiomyopathy (DCM) is a leading cause of heart failure. Despite significant progress in understanding the genetic aetiologies of DCM, the molecular mechanisms underlying the pathogenesis of familial DCM remain unknown, translating to a lack of disease-specific therapies. The discovery of novel targets for the treatment of DCM was sought using phenotypic sceening assays in indu...

E2F2 enhances the chemoresistance of pancreatic cancer to gemcitabine by regulating the...
https://doi.org/10.1007/s12032-022-01715-x
Medical Oncology (Northwood, London, England); Liu Q, Song C et. al.

Jun 19th, 2022 - Both pro-oncogenic and anti-oncogenic effects of E2F2 have been revealed in different malignancies. However, the precise role of E2F2 in pancreatic cancer, in particular in relation to therapeutic intervention with gemcitabine, remains unclear. In this study, the effect of E2F2 on the proliferation and cell cycle modulation of pancreatic cancer cells, and whether E2F2 plays a role in the treatm...

SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245715
Proceedings of the National Academy of Sciences of the Un... Qin C, Rao Y et. al.

Jun 15th, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolves rapidly under the pressure of host immunity, as evidenced by waves of emerging variants despite effective vaccinations, highlighting the need for complementing antivirals. We report that targeting a pyrimidine synthesis enzyme restores inflammatory response and depletes the nucleotide pool to impede SARS-CoV-2 infection. SARS-...

Cooperation between KDM6B overexpression and TET2 deficiency in the pathogenesis of chr...
https://doi.org/10.1038/s41375-022-01605-1
Leukemia Wei Y, Kanagal-Shamanna R et. al.

Jun 14th, 2022 - Loss-of-function TET2 mutations are recurrent somatic lesions in chronic myelomonocytic leukemia (CMML). KDM6B encodes a histone demethylase involved in innate immune regulation that is overexpressed in CMML. We conducted genomic and transcriptomic analyses in treatment naïve CMML patients and observed that the patients carrying both TET2 mutations and KDM6B overexpression constituted 18% of th...