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About 105,365 results

Fast Five Quiz: Chronic Thromboembolic Pulmonary Hypertension
https://www.medscape.com/viewarticle/969947

May 17th, 2022 - Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and late complication of acute pulmonary embolism (PE) that has not resolved despite adequate anticoagulation. In most patients with PE, resolution of the embolus and restoration of blood flow occur. However, for unknown reasons, in a small subset of patients, undissolved blood clots in the pulmonary arteries result in the formatio...

Low Butyrylcholinesterase: A Possible Biomarker of SIDS Risk?
https://www.medscape.com/viewarticle/974072

May 16th, 2022 - Reduced levels of the cholinergic-system enzyme butyrylcholinesterase (BChE) may provide another piece of the puzzle for sudden infant death syndrome (SIDS), preliminary data from Australian researchers suggested. A small case-control study led by Carmel T. Harrington, PhD, a sleep medicine expert and honorary research fellow at the Children"s Hospital at Westmead (Australia), found that measur...

Serum β-catenin changes vary among different stages of osteonecrosis of the femoral hea...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088107
BMC Musculoskeletal Disorders; Huang J, Zhou Y et. al.

May 11th, 2022 - Wnt/β-catenin signaling pathway is closely related to the pathogenesis Osteonecrosis of the femoral head (ONFH). β-catenin, as a major component of Wnt signaling pathway, plays a vital role in the proliferation of osteoblasts. But the effect of altering β-catenin level on the early diagnosis and staging of ONFH has not been studied. Our purpose is to investigate the role of β-catenin level in t...

Apolipoprotein C-III in patients with systemic lupus erythematosus.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088095
Arthritis Research & Therapy; Martín-González C, Ferrer-Moure C et. al.

May 11th, 2022 - Systemic lupus erythematosus (SLE) has been associated with atherosclerotic cardiovascular disease (CV) and an altered lipid profile. High levels of apolipoprotein C-III (ApoC3) are associated with elevated triglyceride levels and an increased risk of CV. In the present study, we aimed to study circulating ApoC3 in patients with SLE and describe its relationship with the manifestations of the d...

Safety and serum distribution of anti-SARS-CoV-2 monoclonal antibody MAD0004J08 after i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046195
Nature Communications; Lanini S, Milleri S et. al.

Apr 29th, 2022 - The emerging threat represented by SARS-CoV-2 variants, demands the development of therapies for better clinical management of COVID-19. MAD0004J08 is a potent Fc-engineered monoclonal antibody (mAb) able to neutralize in vitro all current SARS-CoV-2 variants of concern (VoCs) including the omicron variant even if with significantly reduced potency. Here we evaluated data obtained from the firs...

Effect of Ramadan intermittent fasting on inflammatory markers, disease severity, depre...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036734
BMC Gastroenterology; Negm M, Bahaa A et. al.

Apr 26th, 2022 - Intermittent fasting (IF) during the month of Ramadan is part of the religious rituals of Muslims. The effect of intermittent fasting on disease activity in inflammatory bowel diseases (IBD) is still unknown. This is the first study to assess the effect of IF during Ramadan on inflammatory markers in patients diagnosed with IBD. The effects on clinical disease activity, quality of life, and lev...

Polymorphisms of potential drug resistant molecular markers in Plasmodium vivax from Ch...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036727
Infectious Diseases of Poverty; Wang Z, Wei C et. al.

Apr 26th, 2022 - Plasmodium vivax remains the predominant species at the China-Myanmar border, imposing a major challenge to the recent gains in regional malaria elimination. To closely supervise the emerging of drug resistance in this area, we surveyed the variations in genes potentially correlated with drug resistance in P. vivax parasite and the possible drug selection with time. A total of 235 P. vivax samp...

Malaria: Testing Parasite DNA in Travelers' Blood May Help Predict Drug Resistance
https://www.medscape.com/viewarticle/972715

Apr 25th, 2022 - Testing the DNA of antimicrobial-resistant Plasmodium falciparum in the blood of travelers from malaria-endemic regions may help researchers monitor how drug resistance changes over time, a study from Canada reports. "Malaria remains the deadliest vector-borne infectious disease worldwide. Plasmodium spp., most commonly P. falciparum, are responsible for [approximately] 229 million cases and 50...

Impact of serum interleukin-22 as a biomarker for the differential use of molecular tar...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011943
Arthritis Research & Therapy; Miyagawa I, Nakayamada S et. al.

Apr 17th, 2022 - We explored whether serum cytokines could be used as biomarkers for optimal use of tumor necrosis factor inhibitors (TNF-i) and interleukin (IL)-17 inhibitors (IL-17-i) in patients with psoriatic arthritis (PsA). In cohort 1 (47 patients treated with IL-17-i [n=23] or TNF-i [n=24] for ≥1 year), we identified serum cytokines that predicted the achievement of Disease Activity in Psoriatic Arthrit...

Circulating IL-6, IL-10, and TNF-alpha and IL-10/IL-6 and IL-10/TNF-alpha ratio profile...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041759
PLoS Neglected Tropical Diseases; M'Bondoukwé NP, Moutongo R et. al.

Apr 15th, 2022 - Malaria, blood-borne filarial worms and intestinal parasites are all endemic in Gabon. This geographical co-distribution leads to polyparasitism and, consequently, the possibility of immune-mediated interactions among different parasite species. Intestinal protozoa and helminths could modulate antimalarial immunity, for example, thereby potentially increasing or reducing susceptibility to malar...

Single Immunization with Recombinant ACAM2000 Vaccinia Viruses Expressing the Spike and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093096
Journal of Virology; Deschambault Y, Lynch J et. al.

Apr 13th, 2022 - Increasing cases of SARS-CoV-2 breakthrough infections from immunization with current spike protein-based COVID-19 vaccines highlight the need to develop alternative vaccines using different platforms and/or antigens. In this study, we expressed SARS-CoV-2 spike and nucleocapsid proteins based on a novel vaccinia virus (VACV) ACAM2000 platform (rACAM2000). In this platform, the vaccinia virus h...

Run Into a Rabid Animal? What to Know
https://www.medscape.com/viewarticle/971878

Apr 11th, 2022 - News of rabid foxes or other animals doesn't make quite as much of a stir here in Western Maryland as it did on Capitol Hill. Here, it seems to be more regarded as a hazard of country living. https://twitter.com/thecapitolfox/status/1511407331661262861?s=20&t=PgQSZc3O9K1HF8Ez1hDXHA Admittedly, my enthusiasm for seeing the beautiful creatures has waned over the years. And I don't dissect dead an...

Up-regulated serum levels of interleukin (IL)-17A and IL-22 in Egyptian pediatric patie...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977483
Cytokine Ahmed Mostafa G, Mohamed Ibrahim H et. al.

Apr 11th, 2022 - Both IL-17A and IL-22 share cellular sources and signaling pathways. They have synergistic action on epithelial cells to stimulate their production of antimicrobial peptides which are protective against infections. However, both interleukins may contribute to ARDS pathology if their production is not controlled. This study aimed to investigate serum levels of IL-17A and IL-22 in relation to the...

Pro-inflammatory immune profile mediated by TNF and IFN-γ and regulated by IL-10 is ass...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977499
Cytokine Chaves DG, de Oliveira LC et. al.

Apr 10th, 2022 - The SARS-CoV-2 virus has infected and killed millions of people, but little is known about the risk factors that lead to the development of severe, mild or asymptomatic conditions after infection. The individual immune response and the balance of cytokines and chemokines have been shown to be important for the prognosis of patients. Additionally, it is essential to understand how the production...

Serum miRNAs as biomarkers for the rare types of muscular dystrophy.
https://doi.org/10.1016/j.nmd.2022.03.003
Neuromuscular Disorders : NMD; Koutsoulidou A, Koutalianos D et. al.

Apr 9th, 2022 - Muscular dystrophies are a group of disorders that cause progressive muscle weakness. There is an increasing interest for the development of biomarkers for these disorders and specifically for Duchene Muscular Dystrophy. Limited research however, has been performed on the biomarkers' development for the most rare muscular dystrophies, like the Facioscapulohumeral Muscular Dystrophy, Limb-Girdle...

Some Leukemias Detectable Up to 16 Years Before Diagnosis?
https://www.medscape.com/viewarticle/971835

Apr 8th, 2022 - The preclinical phase of chronic lymphocytic leukemia (CLL) may be exist longer than previously thought, even in adverse-prognostic cases, as suggested by a sequencing analysis of blood samples obtained up to 22 years prior to CLL diagnosis. Previous analyses showed that monoclonal B-cell lymphocytosis (MBL), a CLL precursor state, has been detected up to 6 years before CLL diagnosis, the inves...

CCL21 and IP10 as serum biomarkers for pulmonary involvement in systemic lupus erythema...
https://doi.org/10.1177/09612033221093493
Lupus Osman HM, Omar GM et. al.

Apr 6th, 2022 - Although the significance of inflammatory cytokines and chemokines in the pathogenesis of SLE is well established, the findings showed diversity and implied that combining different biomarkers could be useful in monitoring disease activity or organ involvement. Despite the potentially high prevalence of lung involvement in SLE, only a few studies have investigated for lung biomarkers. The aim o...

Validation of a quantitative lateral flow immunoassay (LFIA)-based point-of-care (POC) ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977564
Archives of Virology; Pieri M, Nicolai E et. al.

Apr 5th, 2022 - With the widespread use of coronavirus disease 2019 (COVID-19) vaccines, a rapid and reliable method to detect SARS-CoV-2 neutralizing antibodies (NAbs) is extremely important for monitoring vaccine effectiveness and immunity in the population. The purpose of this study was to evaluate the performance of the RapiRead™ reader and the TestNOW™ COVID-19 NAb rapid point-of-care (POC) test for quant...

T cell response against SARS-CoV-2 persists after one year in patients surviving severe...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957405
EBioMedicine Venet F, Gossez M et. al.

Mar 30th, 2022 - In critically ill COVID-19 patients, the initial response to SARS-CoV-2 infection is characterized by major immune dysfunctions. The capacity of these severe patients to mount a robust and persistent SARS-CoV-2 specific T cell response despite the presence of severe immune alterations during the ICU stay is unknown. Critically ill COVID-19 patients were sampled five times during the ICU stay an...

Novel Small Molecule Fibroblast Growth Factor 23 Inhibitors Increase Serum Phosphate an...
https://doi.org/10.1124/molpharm.121.000471
Molecular Pharmacology; Xiao Z, Liu J et. al.

Mar 28th, 2022 - Excess fibroblast growth factor (FGF) 23 causes hereditary hypophosphatemic rickets, such as X-linked hypophosphatemia (XLH) and tumor-induced osteomalacia (TIO). A small molecule that specifically binds to FGF23 to prevent activation of the fibroblast growth factor receptor/α-Klotho complex has potential advantages over the currently approved systemically administered FGF23 blocking antibody. ...