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About 107,295 results

DNA Sequencing to Detect Residual Disease in Adults With Acute Myeloid Leukemia Prior t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993183
JAMA Dillon LW, Gui G et. al.

Mar 8th, 2023 - Preventing relapse for adults with acute myeloid leukemia (AML) in first remission is the most common indication for allogeneic hematopoietic cell transplant. The presence of AML measurable residual disease (MRD) has been associated with higher relapse rates, but testing is not standardized. To determine whether DNA sequencing to identify residual variants in the blood of adults with AML in fir...

Brown tumor of the cervical spine with primary hyperparathyroidism: A case report and l...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907965
Medicine Liu Z, Yang H et. al.

Feb 24th, 2023 - Brown tumor (BT), an uncommon focal lytic bone tumor, is a non-neoplastic and reactive process caused by increased osteoclastic activity and fibroblastic proliferation in primary or secondary hyperparathyroidism. Vertebral tumor causing neural compression is relatively rare, especially in the cervical spine. A 29-year-old man developed neck pain and arm radicular pain 4 months ago, with the lev...

Reported History of Measles and Long-term Impact on Tetanus Antibody Detected in Childr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990594
The Pediatric Infectious Disease Journal; Ashbaugh HR, Cherry JD et. al.

Feb 17th, 2023 - Recent studies suggest measles-induced immune amnesia could have long-term immunosuppressive effects via preferential depletion of memory CD150+ lymphocytes, and associations with a 2-3 year period of increased mortality and morbidity from infectious diseases other than measles has been shown in children from wealthy and low-income countries. To further examine the associations previous measles...

Prognostic significance of serum CA125 in the overall management for patients with gast...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878806
BMC Gastroenterology; Sui C, Lin C et. al.

Jan 27th, 2023 - Carbohydrate antigen 125 (CA125) is elevated as a tumor marker in many carcinomas, but its association with gastrointestinal stromal tumor (GIST) has received less attention. This study intends to evaluate whether CA125 level can predict tumor progression and overall survival (OS) of GIST patients. We retrospectively analyzed the clinical data and follow-up records of GIST patients who underwen...

Pathogen reduction of monkeypox virus in plasma and whole blood using riboflavin and UV...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857991
PloS One; Ragan IK, Hartson LM et. al.

Jan 21st, 2023 - Monkeypox virus has recently emerged from endemic foci in Africa and, since October 20, 2022, more than 73,000 human infections have been reported by the CDC from over 100 countries that historically have not reported monkeypox cases. The detection of virus in skin lesions, blood, semen, and saliva of infected patients with monkeypox infections raises the potential for disease transmission via ...

Antioxidants, minerals and vitamins in relation to Crohn's disease and ulcerative colit...
https://doi.org/10.1111/apt.17392
Alimentary Pharmacology & Therapeutics; Chen J, Ruan X et. al.

Jan 17th, 2023 - Evidence for antioxidants, minerals and vitamins in relation to the risk of Crohn's disease (CD) and ulcerative colitis (UC) is limited and inconsistent. This mendelian randomization (MR) study aimed to examine the causal associations of circulating levels of antioxidants, minerals and vitamins with CD and UC. Single-nucleotide polymorphisms associated with antioxidants (beta-carotene, lycopene...

Pre- and Post-treatment Serum BAFF Levels and BAFF Gene Polymorphisms in Patients with ...
https://doi.org/10.1080/07435800.2023.2167087
Endocrine Research; Dhaouadi T, Rojbi I et. al.

Jan 14th, 2023 - B cell activating factor (BAFF), a crucial factor for B cell survival and differentiation, has been linked to several autoimmune conditions. The aim of this study was to evaluate the association of BAFF gene's polymorphisms with its serum levels and to assess their effect on Graves' disease (GD) susceptibility and presentation. Sixty-two GD patients and 152 healthy controls have been enrolled t...

The inflammatory cytokine profiles and ocular biometric characteristics of primary angl...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841865
The Journal of International Medical Research; Zeng HB, Jiang JD et. al.

Jan 13th, 2023 - To investigate the pathogenesis of primary angle-closure disease (PACG) by measuring the anatomical structures of the anterior and posterior segments of the eye and inflammatory markers in the peripheral blood. This case-control study enrolled patients diagnosed with acute PACG (APACG) and chronic PACG (CPACG). It also enrolled control subjects without PACG. The anterior and posterior anatomica...

Elevated neurofilament light chain CSF/serum ratio indicates impaired CSF outflow in id...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832777
Fluids and Barriers of the CNS; Engel S, Halcour J et. al.

Jan 12th, 2023 - Impaired cerebrospinal fluid (CSF) homeostasis is central to the pathogenesis of idiopathic intracranial hypertension (IIH), although the precise mechanisms involved are still not completely understood. The aim of the current study was to assess the CSF/serum ratio of neurofilament light chain levels (QNfL) as a potential indicator of functional CSF outflow obstruction in IIH patients. NfL leve...

Total alkaline phosphatase levels by gestational age in a large sample of pregnant women.
https://doi.org/10.1016/j.placenta.2022.12.005
Placenta Titaux C, Ternynck C et. al.

Jan 10th, 2023 - Total alkaline phosphatase (tALP) levels rise physiologically in maternal serum during pregnancy, and excessively so in certain conditions. However, current reference values are dated, nonlinear, and based on small samples. Factors related to variation in tALP remain unexplained. Thus, our goals in this study were to establish a physiological development curve for tALP within low-risk pregnanci...

Associations of genetically predicted fatty acid levels across the phenome: A mendelian...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799317
PLoS Medicine; Zagkos L, Dib MJ et. al.

Dec 30th, 2022 - Fatty acids are important dietary factors that have been extensively studied for their implication in health and disease. Evidence from epidemiological studies and randomised controlled trials on their role in cardiovascular, inflammatory, and other diseases remains inconsistent. The objective of this study was to assess whether genetically predicted fatty acid concentrations affect the risk of...

COMPARATIVE EVALUATION AND PROGNOSTIC UTILITY OF NEURONAL INJURY BIOMARKERS IN COVID-19...
https://doi.org/10.1097/SHK.0000000000002017
Shock (Augusta, Ga.); Vrettou CS, Vassiliou AG et. al.

Dec 23rd, 2022 - Background : COVID-19 disease severity markers include mostly molecules related to not only tissue perfusion, inflammation, and thrombosis, but also biomarkers of neural injury. Clinical and basic research has demonstrated that SARS-COV-2 affects the central nervous system. The aims of the present study were to investigate the role of neural injury biomarkers and to compare them with inflammato...

Quantitative Antibody Levels Against SARS-CoV-2 Spike Protein in COVID-19 and Multisyst...
https://doi.org/10.1089/vim.2022.0089
Viral Immunology; Avcu G, Arslan SY et. al.

Dec 20th, 2022 - The majority of children with coronavirus diseases 2019 (COVID-19) are asymptomatic or develop mild symptoms, and a small number of patients require hospitalization. Multisystem inflammatory syndrome in children (MIS-C) is one of the most severe clinical courses of COVID-19 and is suggested to be a hyperinflammatory condition. This study aimed to compare quantitative antibody levels against SAR...

Role of IL4 and GMCSF in Predicting Survival in Esophageal Cancer.
https://doi.org/10.1097/XCS.0000000000000446
Journal of the American College of Surgeons; Rebernick RJ, Bell HN et. al.

Dec 16th, 2022 - Esophageal cancer (EC) originates in the setting of chronic inflammation. Although previous studies have sought to understand the role of inflammatory signaling in EC, the effect of these immunologic changes on patient outcomes remains understudied. This study's objective was to identify relationships between cytokine levels and prognosis in a mixed cohort of esophageal adenocarcinoma (EAC) and...

Plasma Macrophage Migration Inhibitory Factor Concentration at Each Spectrum of Tubercu...
https://doi.org/10.1089/jir.2022.0197
Journal of Interferon & Cytokine Research : the Official ... -Hidayah N, -Djaharuddin I et. al.

Dec 15th, 2022 - Macrophage migration inhibitory factor (MIF) is an inflammatory mediator in several diseases, including tuberculosis (TB). However, the role of MIF in each stage of TB remains to be further elucidated. Thus, this study aimed to analyze the differences in plasma MIF protein levels in patients with active pulmonary TB, positive and negative interferon-gamma release assay (IGRA) household contacts...

A Win for Women With Symptomatic Uterine Fibroids
https://www.medscape.com/viewarticle/985154

Dec 14th, 2022 - This transcript has been edited for clarity. Uterine leiomyomas or fibroids represent the most common indication for hysterectomy in US women, with the burden of this disease disproportionately born by Black women. Gonadotropin-releasing hormone (GnRH) antagonists comprise a new class of orally active medications which bind to GnRH receptors, thereby rapidly and reversibly suppressing ovarian s...

Happy 200th Birthday, Gregor Mendel and Louis Pasteur
https://www.medscape.com/viewarticle/985304

Dec 13th, 2022 - Louis Pasteur December 27 marks the 200th birthday of Louis Pasteur (1822-1895), the scientist who advanced microbiology and vaccinology and was a main figure bringing germ theory to the forefront of medicine. Earlier in the year, July 20, we also celebrated the 200th birthday of Gregor Mendel (1822-1884), whose contribution — genetics — went unnoticed in his time but is central to modern medic...

How Fitness Trackers Will Help Us Keep an Eye on Disease
https://www.medscape.com/viewarticle/985498

Dec 13th, 2022 - A fitness tracker is like Santa Claus: It knows when you’re sleeping, when you’re awake, and whether you’ve been bad or good – about meeting your daily step goal, that is. It may not bring you presents, but it could provide important insights to help manage chronic disease.  According to Johns Hopkins researchers, fitness tracker metrics, including heart rate and step count, may be closely link...

High-Dose MTX Does Not Reduce CNS Relapse in Pediatric ALL
https://www.medscape.com/viewarticle/985385

Dec 11th, 2022 - NEW ORLEANS — A study with the worthwhile goal of attempting to further improve outcomes and reduce toxicity of treatment for children and young adults with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma found that, contrary to long-held assumptions, high-dose methotrexate does not reduce the risk for central nervous system (CNS) relapse. The same study also addressed two other qu...

International Efforts Needed to Close Regional HSCT Utilization Gap
https://www.medscape.com/viewarticle/985333

Dec 10th, 2022 - NEW ORLEANS — Although acute myeloid leukemia is on the rise worldwide, and the use of hematopoietic stem cell transplants (HSCT) as a treatment has increased overall, in some countries fewer than 5% of patients are offered this option. The use of HSCT, the main curative option for AML, "remains unacceptably low," commented Molly Tokaz, MD, a hematology/oncology fellow at the Fred Hutchinson Ca...