×
About 97,265 results

Prevalence of SARS-CoV-2 antibodies in the Palestinian population: A primary health cen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500452
PloS One; Maraqa B, Basha W et. al.

Oct 9th, 2021 - This study aimed to assess the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) total antibodies in the north, middle, and south regions of West Bank and the prevalence of SARS-CoV-2 specific antibodies (IgA, IgM, and IgG) in the Palestinian population. This was a cross-sectional study. The serological and epidemiological data of 1269 persons were assessed. Participant...

Rapid measurement of SARS-CoV-2 spike T cells in whole blood from vaccinated and natura...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409582
The Journal of Clinical Investigation; Tan AT, Lim JM et. al.

Oct 9th, 2021 - Defining the correlates of protection necessary to manage the COVID-19 pandemic requires the analysis of both antibody and T cell parameters, but the complexity of traditional tests limits virus-specific T cell measurements. We tested the sensitivity and performance of a simple and rapid SARS-CoV-2 spike protein-specific T cell test based on the stimulation of whole blood with peptides covering...

Humoral response after SARS-CoV-2 mRNA vaccines in dialysis patients: Integrating anti-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491898
PloS One; Bachelet T, Bourdenx JP et. al.

Oct 6th, 2021 - Dialysis patients are both the most likely to benefit from vaccine protection against SARS-CoV-2 and at the highest risk of not developing an immune response. Data from the medical field are thus mandatory. We report our experience with a BNT162b2-mRNA vaccine in a retrospective analysis of 241 dialysis patients including 193 who underwent anti-Spike-Protein-Receptor-Binding-Domain (RBD) IgG an...

Systemic lupus erythematosus presenting as hyponatremia-associated rhabdomyolysis: A ca...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483824
Medicine Lee IH, Cho S et. al.

Oct 2nd, 2021 - Systemic lupus erythematosus (SLE) is an autoimmune disease that involves multiple organs and causes various clinical manifestations. Cases of rhabdomyolysis as the initial presentation of SLE are rare, and there are no reported cases of SLE presenting hyponatremia-associated rhabdomyolysis as the first manifestation. Herein, we report a case of SLE with lupus nephritis in a patient with acute ...

Enhanced liver fibrosis score as a surrogate of liver-related complications and mortali...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483841
Medicine Fujinaga Y, Namisaki T et. al.

Oct 2nd, 2021 - The presence of bridging fibrosis predicts survival of primary biliary cholangitis (PBC). This study aimed to compare serum parameters for the estimation of liver fibrosis and prediction of clinical outcomes in PBC.Out of 392 patients with PBC, 102 who underwent liver biopsy and in whom fibrosis indices, platelet count, hyaluronic acid, type IV collagen 7 second domain, procollagen type III ami...

Dysregulated expression of circular RNAs serve as diagnostic and prognostic markers in ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483828
Medicine Liu F, Wu X et. al.

Oct 2nd, 2021 - Recent studies have reported a connection between non-coding RNAs such as circular RNAs (circRNAs) and the prognosis of various cancers. However, the mechanism of circRNA in ovarian cancer and cervical cancer has not been consistent. We evaluated the diagnostic and prognostic roles of circRNAs in ovarian and cervical cancer by meta-analysis. Pooled hazard ratios with 95% confidence intervals we...

Association of total cholesterol and atherosclerotic cardiovascular disease in patients...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483838
Medicine Huang G, Lu H et. al.

Oct 2nd, 2021 - The association between serum total cholesterol (TC) level and incident atherosclerotic cardiovascular disease (ASCVD) in patients with follicular thyroid cancer postthyroidectomy is unknown.This was a retrospective study and patients (n = 384) were divided into low and high TC groups according to the median TC level. Incidence of composite ASCVD (myocardial infarction, ischemic stroke, and car...

The value of complete blood count for the prognosis analysis of preoperative esophageal...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485493
BMC Cancer; Lv X, Han S et. al.

Oct 2nd, 2021 - To investigate the predictive value of preoperative complete blood count for the survival of patients with esophageal squamous cell carcinoma. A total of 1587 patients with pathologically confirmed esophageal squamous cell carcinoma who underwent esophagectomy in the Cancer Hospital Affiliated to Xinjiang Medical University from January 2010 to December 2019 were collected by retrospective stud...

Prevalence and risk factors for SARS-CoV-2 infection and seroprevalence among clinical ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483404
PloS One; Alishaq M, Jeremijenko A et. al.

Oct 1st, 2021 - While many studies have reported the rate and risk of SARS-CoV-2 infection among healthcare workers (HCWs), there are scant data regarding the impact of employment type and job grades upon such risk. We determined the rate of SARS-CoV-2 infection based on a positive nasopharyngeal swab (NPS) PCR among employees of a large national healthcare system. Antibody testing was performed on those who a...

An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specif...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483319
PloS One; Mangsbo SM, Havervall S et. al.

Oct 1st, 2021 - Numerous assays evaluating serological and cellular responses have been developed to characterize immune responses against SARS-CoV-2. Serological assays are both cost- and time-effective compared to cellular assays, but cellular immune responses may provide a diagnostic value to determine previous SARS-CoV-2 infection in seronegative individuals. However, potential cross-reactive T cell respon...

Association of neutrophil-to-lymphocyte ratio with severe radiation-induced mucositis i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480102
BMC Cancer; Kawashita Y, Kitamura M et. al.

Sep 30th, 2021 - The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that informs clinical decisions regarding recurrence and overall survival in most epithelial cancers. Radiotherapy for head and neck cancer leads to mucositis in almost all patients and severe radiation-mucositis affects their quality of life (QOL). However, little is known about the NLR for severe mucositis. Therefor...

Overweight with HBV infection limited the efficacy of TACE in hepatocellular carcinoma ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480082
BMC Cancer; Sun YD, Zhang H et. al.

Sep 30th, 2021 - Transarterial chemoembolization (TACE) is an effective treatment for patients with hepatocellular carcinoma (HCC). However, the impact of hepatitis B viral (HBV) infection and body mass index (BMI) on TACE is controversial. The present study aimed to compare the influence of HBV and high BMI on TACE outcomes in advanced HCC. Based on HBV infection history and BMI, patients were assigned to diff...

Case report: a 5-year-old with new onset nephrotic syndrome in the setting of COVID-19 ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476119
BMC Nephrology; Morgan KM, Imani PD

Sep 29th, 2021 - This is a case report of an asymptomatic SARS-CoV-2 infection associated with new-onset nephrotic syndrome in a pediatric patient. This is the third case of new-onset nephrotic syndrome in children associated with SARS-CoV-2 infection, but is the first case report describing a new-onset nephrotic syndrome presentation in a patient who had asymptomatic COVID-19 infection. This is a case of a pre...

SARS-CoV-2 mucosal antibody development and persistence and their relation to viral loa...
https://doi.org/10.1038/s41467-021-25949-x 10.1016/j.cmi.2020.04.040 10.1056/NEJMe2009758 10.1056/NEJMoa2008457 10.3201/eid2702.203517 10.1038/s41467-020-19545-8 10.1056/NEJMoa2034577 10.1038/s41586-020-2639-4 10.1128/JVI.00647-20 10.1172/jci.insight.142386 10.4049/jimmunol.180.2.948 10.1128/JVI.80.8.4079-4087.2006 10.1038/s41591-020-0868-6 10.1016/j.cell.2020.05.042 10.1038/s41564-020-00813-8 10.1371/journal.pone.0240205 10.1093/infdis/jis033 10.1016/j.jcv.2014.04.017 10.1038/s41467-020-16256-y 10.1093/infdis/jiaa479 10.18637/jss.v082.i13
Nature Communications; Fröberg J, Gillard J et. al.

Sep 25th, 2021 - Although serological studies have shown that antibodies against SARS-CoV-2 play an important role in protection against (re)infection, the dynamics of mucosal antibodies during primary infection and their potential impact on viral load and the resolution of disease symptoms remain unclear. During the first pandemic wave, we assessed the longitudinal nasal antibody response in index cases with m...

Neuromyelitis optica spectrum disorder with active replication of hepatitis B virus and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462564
Medicine Lei J, Wang H

Sep 25th, 2021 - Neuromyelitis optica spectrum disorder (NMOSD) associated with active replication of hepatitis B virus (HBV) is rare. High-dose corticosteroids are the mainstay treatment of NMOSD; however, these may cause reactivation of viral replication in patients with stable HBV which may lead to liver damage. Therefore, care should be placed in corticosteroid use in patients with NMOSD and HBV infection. ...

eARDS: A multi-center validation of an interpretable machine learning algorithm of earl...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462682
PloS One; Singhal L, Garg Y et. al.

Sep 25th, 2021 - We present an interpretable machine learning algorithm called 'eARDS' for predicting ARDS in an ICU population comprising COVID-19 patients, up to 12-hours before satisfying the Berlin clinical criteria. The analysis was conducted on data collected from the Intensive care units (ICU) at Emory Healthcare, Atlanta, GA and University of Tennessee Health Science Center, Memphis, TN and the Cerner® ...

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific altera...
https://doi.org/10.1073/pnas.2109123118
Proceedings of the National Academy of Sciences of the Un... Lourda M, Dzidic M et. al.

Sep 23rd, 2021 - Since the outset of the COVID-19 pandemic, increasing evidence suggests that the innate immune responses play an important role in the disease development. A dysregulated inflammatory state has been proposed as a key driver of clinical complications in COVID-19, with a potential detrimental role of granulocytes. However, a comprehensive phenotypic description of circulating granulocytes in seve...

Cytokine Signaling and Matrix Remodeling Pathways Associated with Cardiac Sarcoidosis D...
https://doi.org/10.1536/ihj.21-164
International Heart Journal; Young BD, Moreland H et. al.

Sep 22nd, 2021 - While cardiac imaging has improved the diagnosis and risk assessment for cardiac sarcoidosis (CS), treatment regimens have consisted of generalized heart failure therapies and non-specific anti-inflammatory regimens. The overall goal of this study was to perform high-sensitivity plasma profiling of specific inflammatory pathways in patients with sarcoidosis and with CS.Specific inflammatory/pro...

Most Fully Vaccinated Patients With Cancer Have SARS-CoV-2 Antibodies.
https://doi.org/10.1001/jama.2021.14707
JAMA Slomski A

Sep 22nd, 2021 - Most Fully Vaccinated Patients With Cancer Have SARS-CoV-2 Antibodies.|2021|Slomski A,|blood,immunology,immunology,immunology,

Preclinical evaluation of a synthetic peptide vaccine against SARS-CoV-2 inducing multi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480813
Emerging Microbes & Infections; Aparicio B, Casares N et. al.

Sep 21st, 2021 - Identification of relevant epitopes is crucial for the development of subunit peptide vaccines inducing neutralizing and cellular immunity against SARS-CoV-2. Our aim was the characterization of epitopes in the receptor-binding domain (RBD) of SARS-CoV-2 spike (S) protein to generate a peptide vaccine. Epitope mapping using a panel of 10 amino acid overlapped 15-mer peptides covering region 401...