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About 120,878 results

Rosuvastatin for sepsis-associated acute respiratory distress syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241052
The New England Journal of Medicine; , Truwit JD et. al.

May 19th, 2014 - In the acute respiratory distress syndrome (ARDS), inflammation in the lungs and other organs can cause life-threatening organ failure. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins) can modulate inflammatory responses. Previous observational studies suggested that statins improved clinical outcomes in patients with sepsis. We hypothesized that rosuvastatin therapy woul...

A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depres...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200497
Neuropsychopharmacology : Official Publication of the Ame... Brown ES, Park J et. al.

Jun 11th, 2014 - Depression in bipolar disorder (BPD) is challenging to treat. Therefore, additional medication options are needed. In the current report, the effect of the neurosteroid pregnenolone on depressive symptoms in BPD was examined. Adults (n=80) with BPD, depressed mood state, were randomized to pregnenolone (titrated to 500 mg/day) or placebo, as add-on therapy, for 12 weeks. Outcome measures includ...

Transplantation outcomes for severe combined immunodeficiency, 2000-2009.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183064
The New England Journal of Medicine; Pai SY, Logan BR et. al.

Jul 30th, 2014 - The Primary Immune Deficiency Treatment Consortium was formed to analyze the results of hematopoietic-cell transplantation in children with severe combined immunodeficiency (SCID) and other primary immunodeficiencies. Factors associated with a good transplantation outcome need to be identified in order to design safer and more effective curative therapy, particularly for children with SCID diag...

Surveillance for stage I nonseminoma testicular cancer: outcomes and long-term follow-u...
https://doi.org/10.1200/JCO.2013.53.5831
Journal of Clinical Oncology : Official Journal of the Am... Daugaard G, Gundgaard MG et. al.

Sep 30th, 2014 - To describe treatment results in a large cohort with stage I nonseminoma germ cell cancer (NSGCC) treated in a surveillance program. From January 1, 1984, to December 31, 2007, 1,226 patients with stage I NSGCC, including high-risk patients with vascular invasion, were observed in a surveillance program. The relapse rate after orchiectomy alone was 30.6% at 5 years. Presence of vascular invasio...

Ten-year follow-up after initiation of statin therapy in children with familial hyperch...
https://doi.org/10.1001/jama.2014.8892
JAMA Kusters DM, Avis HJ et. al.

Sep 9th, 2014 - Ten-year follow-up after initiation of statin therapy in children with familial hypercholesterolemia.|2014|Kusters DM,Avis HJ,de Groot E,Wijburg FA,Kastelein JJ,|therapeutic use,blood,drug therapy,blood,therapeutic use,

Prospective evaluation of ursodeoxycholic acid withdrawal in patients with primary scle...
https://doi.org/10.1002/hep.27074
Hepatology (Baltimore, Md.); Wunsch E, Trottier J et. al.

Feb 12th, 2014 - Ursodeoxycholic acid (UDCA) is no longer recommended for management of adult patients with primary sclerosing cholangitis (PSC). We undertook a prospective evaluation of UDCA withdrawal in a group of consecutive patients with PSC. Twenty six patients, all treated with UDCA (dose range: 10-15 mg/kg/day) were included. Paired blood samples for liver biochemistry, bile acids, and fibroblast growth...

Chimeric antigen receptor T cells for sustained remissions in leukemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267531
The New England Journal of Medicine; Maude SL, Frey N et. al.

Oct 15th, 2014 - Relapsed acute lymphoblastic leukemia (ALL) is difficult to treat despite the availability of aggressive therapies. Chimeric antigen receptor-modified T cells targeting CD19 may overcome many limitations of conventional therapies and induce remission in patients with refractory disease. We infused autologous T cells transduced with a CD19-directed chimeric antigen receptor (CTL019) lentiviral v...

Eosinophilic esophagitis in adults is associated with IgG4 and not mediated by IgE.
https://doi.org/10.1053/j.gastro.2014.05.036
Gastroenterology Clayton F, Fang JC et. al.

Jun 7th, 2014 - Eosinophilic esophagitis is usually triggered by foods, by unclear mechanisms. We evaluated the roles of IgE and IgG4 in the development of eosinophilic esophagitis. We performed a prospective, randomized, double-blind, placebo-controlled trial of adults with eosinophilic esophagitis given an antibody against IgE (omalizumab, n = 16) or placebo (n = 14) every 2-4 weeks for 16 weeks, based on we...

Lymphoma Remissions Caused by Anti-CD19 Chimeric Antigen Receptor T Cells Are Associate...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455597
Journal of Clinical Oncology : Official Journal of the Am... Kochenderfer JN, Somerville RPT et. al.

Mar 15th, 2017 - Purpose T cells genetically modified to express chimeric antigen receptors (CARs) targeting CD19 (CAR-19) have potent activity against acute lymphoblastic leukemia, but fewer results supporting treatment of lymphoma with CAR-19 T cells have been published. Patients with lymphoma that is chemotherapy refractory or relapsed after autologous stem-cell transplantation have a grim prognosis, and new...

Long-term results and recurrence patterns from SCALOP: a phase II randomised trial of g...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482737
British Journal of Cancer; Hurt CN, Falk S et. al.

Apr 4th, 2017 - SCALOP, a randomised, phase II trial, tested the activity and safety of gemcitabine (GEM)-based and capecitabine (CAP)-based chemoradiation (CRT) for locally advanced pancreatic cancer (LAPC). Here we present the long-term outcomes. Eligibility: histologically proven LAPC ⩽7 cm. Following 12 weeks of induction GEMCAP chemotherapy (three cycles: GEM 1000 mg m-2 days 1, 8, 15; CAP 830 mg m-2 days...

Subcutaneous immunoglobulin in myasthenia gravis exacerbation: A prospective, open-labe...
https://doi.org/10.1212/WNL.0000000000004365
Neurology Beecher G, Anderson D et. al.

Aug 17th, 2017 - To investigate the efficacy, tolerability, and safety of subcutaneous immunoglobulin (SCIg) in patients with mild to moderate myasthenia gravis (MG) exacerbation. We performed a prospective, open-label, phase 3 trial in patients with MG aged 18 years or older and mild to moderate worsening (transition from Myasthenia Gravis Foundation of America class I to II/III or class II to III), treated wi...

Prospective Evaluation of Sunitinib-Induced Cardiotoxicity in Patients with Metastatic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516884
Clinical Cancer Research : an Official Journal of the Ame... Narayan V, Keefe S et. al.

Feb 15th, 2017 - Purpose: To prospectively evaluate cardiotoxicity risk with sunitinib in metastatic renal cell carcinoma (mRCC) routine clinical practice using comprehensive echocardiography and biomarker phenotyping.Experimental Design: In a multicenter prospective study of 90 patients with mRCC, echocardiography and biomarkers of cardiovascular injury and stress were quantified at baseline, 3.5, 15, and 33 w...

Repression of osteocyte Wnt/β-catenin signaling is an early event in the progression of...
https://doi.org/10.1002/jbmr.1630
Journal of Bone and Mineral Research : the Official Journ... Sabbagh Y, Graciolli FG et. al.

Apr 11th, 2012 - Chronic kidney disease-mineral bone disorder (CKD-MBD) is defined by abnormalities in mineral and hormone metabolism, bone histomorphometric changes, and/or the presence of soft-tissue calcification. Emerging evidence suggests that features of CKD-MBD may occur early in disease progression and are associated with changes in osteocyte function. To identify early changes in bone, we utilized the ...

CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia.
https://doi.org/10.1002/ana.21628
Annals of Neurology; Berrih-Aknin S, Ruhlmann N et. al.

Oct 22nd, 2009 - Myasthenia gravis (MG), a neuromuscular disease mediated by anti-acetylcholine receptor (AChR) autoantibodies, is associated with thymic hyperplasia characterized by ectopic germinal centers that contain pathogenic antibody-producing B cells. Our thymic transcriptome study demonstrated increased expression of CCL21, a recruiter of immune cells. Accordingly, we are investigating its implication ...

Update on rapid diagnostic testing for malaria.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223842
Clinical Microbiology Reviews; Murray CK, Gasser RA et. al.

Jan 18th, 2008 - To help mitigate the expanding global impact of malaria, with its associated increasing drug resistance, implementation of prompt and accurate diagnosis is needed. Malaria is diagnosed predominantly by using clinical criteria, with microscopy as the current gold standard for detecting parasitemia, even though it is clearly inadequate in many health care settings. Rapid diagnostic tests (RDTs) h...

An inactivated cell-culture vaccine against yellow fever.
https://doi.org/10.1056/NEJMoa1009303
The New England Journal of Medicine; Monath TP, Fowler E et. al.

Apr 7th, 2011 - Yellow fever is a lethal viral hemorrhagic fever occurring in Africa and South America. A highly effective live vaccine (17D) is widely used for travelers to and residents of areas in which yellow fever is endemic, but the vaccine can cause serious adverse events, including viscerotropic disease, which is associated with a high rate of death. A safer, nonreplicating vaccine is needed. In a doub...

Overweight/Obese adults with pituitary disorders require lower peak growth hormone cuto...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255132
The Journal of Clinical Endocrinology and Metabolism; Dichtel LE, Yuen KC et. al.

Sep 11th, 2014 - Obesity is associated with diminished GH secretion, which may result in the overdiagnosis of adult GH deficiency (GHD) in overweight/obese pituitary patients. However, there are no body mass index (BMI)-specific peak GH cutoffs for the glucagon stimulation test (GST), the favored dynamic test for assessing adult GHD in the United States. The objective of the study was to determine a peak GH cut...

Podocyte effacement closely links to suPAR levels at time of posttransplantation focal ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026282
Transplantation Alachkar N, Wei C et. al.

Jul 11th, 2013 - Focal segmental glomerulosclerosis (FSGS) recurs after kidney transplantation in more than 30% of cases and can lead to allograft loss. Serum soluble urokinase-type plasminogen activator receptor (suPAR) is implicated in the pathogenesis of native and recurrent FSGS. We conducted a retrospective study of 25 adults with posttransplantation FSGS. We investigated the relationship between suPAR lev...

Fibroblast Growth Factor 23 and Kidney Disease Progression in Autosomal Dominant Polycy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586583
Clinical Journal of the American Society of Nephrology : ... Chonchol M, Gitomer B et. al.

Jul 14th, 2017 - Increases in fibroblast growth factor 23 precede kidney function decline in autosomal dominant polycystic kidney disease; however, the role of fibroblast growth factor 23 in autosomal dominant polycystic kidney disease has not been well characterized. We measured intact fibroblast growth factor 23 levels in baseline serum samples from 1002 participants in the HALT-PKD Study A (n=540; mean eGFR ...

How I manage neonatal thrombocytopenia.
https://doi.org/10.1111/j.1365-2141.2011.08892.x
British Journal of Haematology; Chakravorty S, Roberts I

Sep 28th, 2011 - Although neonatal thrombocytopenia (platelet count < 150×10(9) /l) is a common finding in hospital practice, a careful clinical history and examination of the blood film is often sufficient to establish the diagnosis and guide management without the need for further investigations. In preterm neonates, early-onset thrombocytopenia (<72h) is usually secondary to antenatal causes, has a character...