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About 132,750 results

Monkeypox: Fractional vaccine doses will be piloted as new treatment trial launches
https://www.bmj.com/content/378/bmj.o2080
BMJ Mahase E.

Aug 23rd, 2022 - Smaller doses of the smallpox vaccine, used to provide protection against monkeypox, will be piloted at NHS sites in London and Manchester to maximise supply, the UK Health Security Agency (UKHSA) has announced. In the pilot scheme—which will take place at Chelsea and Westminster NHS Foundation Trust, Central and North West London NHS Foundation Trust, and Locala Health and Wellbeing in Grea...

Maximizing the impact of limited vaccine supply under different early epidemic conditio...
https://doi.org/10.1503/cmaj.221232
CMAJ : Canadian Medical Association Journal = Journal De ... Knight J, Tan DHS et. al.

Nov 29th, 2022 - The current global monkeypox virus (MPXV) outbreak has disproportionately affected gay, bisexual and other men who have sex with men (GBMSM). Given that many jurisdictions have been faced with limited supplies of MPXV vaccine, we aimed to explore optimal vaccine allocation between 2 linked GBMSM transmission networks over a short-term time horizon, across several epidemic conditions. We constru...

ACR Appropriateness Criteria® Osteonecrosis: 2022 Update.
https://doi.org/10.1016/j.jacr.2022.09.009
Journal of the American College of Radiology : JACR; , Ha AS et. al.

Nov 28th, 2022 - Osteonecrosis is defined as bone death due to inadequate vascular supply. It is sometimes also called "avascular necrosis" and "aseptic necrosis" when involving epiphysis, or "bone infarct" when involving metadiaphysis. Common sites include femoral head, humeral head, tibial metadiaphysis, femoral metadiaphysis, scaphoid, lunate, and talus. Osteonecrosis is thought to be a common condition most...

Bone Concentration of Ampicillin/Sulbactam: A Pilot Study in Patients with Osteonecrosi...
https://doi.org/10.3390/ijerph192214917
International Journal of Environmental Research and Publi... Straub A, Stapf M et. al.

Nov 27th, 2022 - Osteonecrosis of the jaw (ONJ) occurs typically after irradiation of the head and neck area or after the intake of antiresorptive agents. Both interventions can lead to compromised bone perfusion and can ultimately result in infection and necrosis. Treatment usually consists of surgical necrosectomy and prolonged antibiotic therapy, usually through beta-lactams such as ampicillin/sulbactam. The...

Does Diabetes Mellitus Increase the Risk of Avascular Osteonecrosis? A Systematic Revie...
https://doi.org/10.3390/ijerph192215219
International Journal of Environmental Research and Publi... Konarski W, Poboży T et. al.

Nov 27th, 2022 - Avascular osteonecrosis (AVN) is caused by the disrupted blood supply to the bone. Most AVN cases occur in the femoral head, but other sites might be affected as well, including the jaw or distal bones of the extremities. Previous studies suggested that diabetes could increase the risk of AVN of the jaw, but the relationship between diabetes and AVN in other bone sites is unclear. This systemat...

Transpositions of the great arteries versus aortic dextropositions. A review of some em...
https://doi.org/10.1002/ar.25129
Anatomical Record (Hoboken, N.J. : 2007); Restivo A, di Gioia C et. al.

Nov 26th, 2022 - This review examines and discusses the morphology and embryology of two main groups of conotruncal cardiac malformations: 1) transposition of the great arteries(complete transposition and incomplete/partial transposition namely double outlet right ventricle , and 2) aortic dextroposition defects (tetralogy of Fallot and Eisenmenger malformation). In both groups, persistent truncus arteriosus wa...

Impact of universal tuberculosis vaccination cessation on the epidemiology of paediatri...
https://doi.org/10.1016/S0140-6736(22)02263-2
Lancet (London, England); Jackson S, Kabir Z et. al.

Nov 26th, 2022 - Universal Bacillus Calmette-Guérin vaccine (BCG) vaccination was discontinued in Ireland in April 2015 due to a lack of vaccine supply. We analysed notifications from the Irish National Tuberculosis Surveillance System from 2011 to 2021 to examine the direct impact of vaccination cessation on active tuberculosis cases among young children. We did a cross-sectional study to compare tuberculosis ...

Study protocol for developing a novel approach for improving supply chain management fo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693879
BMJ Open; Maluleke K, Musekiwa A et. al.

Nov 25th, 2022 - Recent evidence shows that point-of-care (POC) testing is a more feasible alternative for diagnosis of COVID-19 in settings that have poor access to laboratory diagnostic services. Equitable access to POC testing can be optimised through well-established supply chain management (SCM) systems. The proposed study aims to develop a novel approach for improving SCM for COVID-19 POC diagnostic servi...

Fludarabine phosphate - fludarabine injection-Accord Healthcare, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=09b90b67-41e7-4227-bbe9-af5a7289416c

Nov 24th, 2022 - HEALTH CARE PROVIDER LETTER SECTION October 12, 2022 Important Prescribing Information Temporary Importation of Fludarabine Phosphate Injection USP from Canada to Address Drug Shortage Dear Healthcare Professional: Due to the current critical shortage of Fludarabine Phosphate Injection USP products in the United States (U.S.) market, Accord Healthcare Inc., USA (Accord) is coordinating with the...

COVID-19 vaccine acceptance and its socio-demographic and emotional determinants: A mul...
https://doi.org/10.1016/j.vaccine.2022.10.051
Vaccine de Figueiredo A, Simas C et. al.

Nov 23rd, 2022 - Multiple COVID-19 vaccines have now been licensed for human use, with other candidate vaccines in different stages of development. Effective and safe vaccines against COVID-19 have been essential in achieving global reductions in severe disease caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), but multiple factors, including vaccine supply and vaccine confidence, continue to impact...

Adherence of healthcare providers to malaria case management guidelines of the formal p...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682744
Malaria Journal; Argaw MD, Mavundla TR et. al.

Nov 23rd, 2022 - Malaria is an infectious disease which has been globally targeted for elimination in at least 35 of 90 endemic countries by 2030. Most successful malaria elimination country programmes have engaged the private health sector in an effort to identify, document, investigate, provide effective treatment, and follow-up cases. However, there has been limited rigorous research showing evidence of adhe...

Gabapentin, Opioid Prescriptions More Likely to Overlap in Recent Years
https://www.medpagetoday.com/neurology/painmanagement/101854

Nov 21st, 2022 - Overlapping prescriptions of gabapentin and opioids grew over a 12-year period, pharmacy claims data showed. Concurrent prescriptions increased from 1.9% in 2006 to 7.6% in 2018, a relative increase of 344%, reported Evan Peet, PhD, of the RAND Corporation in Washington, D.C., and co-authors, in a research letter published in JAMA Internal Medicine. "As the opioid crisis continues throughout th...

Emergency typhoid immunisation after the fall of Singapore 1942.
https://doi.org/10.1111/imj.15947
Internal Medicine Journal; Shanks GD

Nov 21st, 2022 - Singapore surrendered to the Japanese invasion in February 1942 after its water supply collapsed. At the suggestion of the colonial medical authorities, an emergency typhoid immunisation campaign was then begun using locally manufactured vaccine from extemporary materials; within 3 months, >600 000 had been immunised. Comparison with prewar statistics suggests that a postsurrender typhoid fever...

Banned Blood Donors Welcomed Again as Mad Cow Disease Concerns Fade
https://www.medscape.com/viewarticle/984414

Nov 21st, 2022 - Organizations like the American Red Cross and others are stepping up efforts to recruit previously banned blood donors after the FDA lifted its restrictions on people who had been overseas amid outbreaks of mad cow disease. "This eligibility change will potentially impact hundreds of thousands of individuals who were previously ineligible to give blood or platelets, including many in the milita...

Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing s...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454086
Journal for Immunotherapy of Cancer; Mueller KP, Piscopo NJ et. al.

Nov 17th, 2022 - Chimeric antigen receptor (CAR) T cells have demonstrated high clinical response rates against hematological malignancies (e.g., CD19+ cancers) but have shown limited activity in patients with solid tumors. Recent work showed that precise insertion of a CAR at a defined locus improves treatment outcomes in the context of a CD19 CAR; however, it is unclear if such a strategy could also affect ou...

Neuroinflammation regulates the balance between hippocampal neuron death and neurogenes...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664832
Journal of Neuroinflammation; Cassiano LMG, Oliveira MS et. al.

Nov 16th, 2022 - Thiamine (vitamin B1) is a cofactor for enzymes of central energy metabolism and its deficiency (TD) impairs oxidative phosphorylation, increases oxidative stress, and activates inflammatory processes that can lead to neurodegeneration. Wernicke-Korsakoff syndrome (WKS) is a consequence of chronic TD, which leads to extensive neuronal death, and is associated with neuropathological disorders, i...

Challenges with adherence to the 'test, treat, and track' malaria case management guide...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664683
Malaria Journal; Kolekang AS, Afrane Y et. al.

Nov 16th, 2022 - Despite several efforts at addressing the barriers to adherence to the WHO-supported test, treat and track (T3) malaria case management guideline in Ghana, adherence remains a challenge. This study explored the challenges of prescribers regarding adherence to the T3 guideline. This was an explorative study using key informant interviews amongst prescribers comprising medical doctors, physician ...

Could There Be a Better Treatment for MS Relapses? New Findings From Apheresis Procedures May Trigger a Guideline Update
https://www.medscape.com/viewarticle/984071

Nov 15th, 2022 - What should you do if a patient with multiple sclerosis suffers an acute relapse, but the standard methylprednisolone treatment does not result in any improvement? As it stands, the guidelines recommend a second cycle of the steroid at a double dose. A German study has now shown that visual, motor, and sensory abilities are retained better through immunoadsorption — an important finding for whe...

FDA Warning Letter Cites Abraxane Manufacturing Sterility Issues
https://www.medscape.com/viewarticle/984086

Nov 15th, 2022 - The US Food and Drug Administration (FDA) has sent a warning letter to Abraxis BioScience, which manufactures the chemotherapy drug Abraxane (paclitaxel), citing ongoing contamination hazards since 2021. The warning letter, issued October 31, followed an FDA inspection conducted at the company's Phoenix facility from March 28 to April 6 of this year. The inspection found "significant violations...

Vita-pac - ascorbic acid, cholecalciferol, thiamin hcl, pyridoxal-5-phosphate, folic acid, methylcobalamin, calcium carbonate, ferrous bisglycinate capsule-Trell Pharma
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c671f5f7-6398-45cf-93cd-173a915a9874

Nov 15th, 2022 - STATEMENT OF IDENTITY SECTION Vita-Pac Capsule - Prenatal/Postnatal/Folate Health Dietary Supplement Dispensed by Prescription† Supplement Facts Serving Size: 1 Capsule Servings per Bottle: 30 Amount Per Serving: % Daily Value  Vitamin C (as Ascorbic Acid)   125 mg  104%  Calcium (as Calcium Carbonate from Aquamin Red Algae)  200 mg  15%  Iron (as Ferrous Bisglycinate from Ferrochel Chelate)  1...