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About 127,008 results

Review of 2022 WHO guidelines on the control and elimination of schistosomiasis.
https://doi.org/10.1016/S1473-3099(22)00221-3
The Lancet. Infectious Diseases; Lo NC, Bezerra FSM et. al.

May 21st, 2022 - Schistosomiasis is a helminthiasis infecting approximately 250 million people worldwide. In 2001, the World Health Assembly (WHA) 54.19 resolution defined a new global strategy for control of schistosomiasis through preventive chemotherapy programmes. This resolution culminated in the 2006 WHO guidelines that recommended empirical treatment by mass drug administration with praziquantel, predomi...

FDA Roundup: May 20, 2022 | FDA
https://www.fda.gov/news-events/press-announcements/fda-roundup-may-20-2022

May 20th, 2022 - For Immediate Release: May 20, 2022 Today, the U.S. Food and Drug Administration is providing an at-a-glance summary of news from around the agency: On May 19, the FDA issued responses to two food additive petitions and a citizen petition requesting agency action on phthalates in food contact applications. The FDA amended its food additive regulations to no longer provide for most phthalates to...

Siga Gets Requests for Smallpox Drug in Europe as Monkeypox Spreads
https://www.medscape.com/viewarticle/974283

May 20th, 2022 - (Reuters) - Siga Technologies Inc has received requests for the use of its smallpox drug to treat monkeypox, its chief executive officer told Reuters on Thursday, as cases spread in parts of Europe. There had been no deliveries yet but the company was "well-positioned" in terms of supply, CEO Phil Gomez said. The drug, tecovirimat (TPOXX; ST-246), was approved in 2018 to treat smallpox in the U...

Right ventricular myocardial energetic model for evaluating right heart function in pul...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115705
Physiological Reports; Scott JV, Tembulkar TU et. al.

May 19th, 2022 - Pulmonary arterial hypertension (PAH) increases right ventricular (RV) workload and decreases myocardial oxygen reserve, eventually leading to poor cardiac output. This study created and assessed a novel model of RV work output based on RV hemodynamics and oxygen supply, allowing new insight into causal mechanisms of RV dysfunction. The RV function model was built upon an earlier, left ventricu...

Microfluidic chain reaction of structurally programmed capillary flow events.
https://doi.org/10.1038/s41586-022-04683-4 10.1101/SQB.1986.051.01.032 10.1126/science.2448875 10.1073/pnas.0407024101 10.1038/nature13118 10.1016/0925-4005(90)80209-I 10.1126/science.1076996 10.1146/annurev-anchem-062011-143028 10.1039/C4CS00371C 10.1073/pnas.0604663103 10.1039/C8LC00458G 10.1039/C6LC00764C 10.1039/c3lc50691f 10.1146/annurev-anchem-061318-114845 10.1063/1.4790819 10.1039/C4LC00920G 10.1016/j.aca.2017.11.026 10.1002/adma.202008712 10.1016/j.sna.2005.12.011 10.1093/infdis/jiaa273 10.1128/JCM.02204-20 10.1038/s41598-021-83108-0 10.1373/clinchem.2015.248625 10.1097/MOH.0000000000000074 10.1111/jth.15538 10.1136/jcp.6.1.3 10.1136/jcp.6.1.9 10.1159/000073575 10.1097/00001721-200403000-00006 10.1038/nature07226 10.1038/s41586-019-1635-z
Nature Yafia M, Ymbern O et. al.

May 19th, 2022 - Chain reactions, characterized by initiation, propagation and termination, are stochastic at microscopic scales and underlie vital chemical (for example, combustion engines), nuclear and biotechnological (for example, polymerase chain reaction) applications1-5. At macroscopic scales, chain reactions are deterministic and limited to applications for entertainment and art such as falling dominoes...

When Africans Asked for COVID Shots, They Didn't Get Them. Now They Don't Want Them
https://www.medscape.com/viewarticle/974184

May 19th, 2022 - DAKAR/ACCRA (Reuters) - It's noisy inside the Mamprobi clinic in Accra as kids clamber over their mothers while they wait to get their measles vaccines. Outside, an area reserved for COVID-19 shots is empty. A health worker leans back in his chair and scrolls on a tablet. One woman, waiting to get her daughter inoculated, is fully aware of the dangers of measles: the high fever, the rash, the r...

Can lymphovascular invasion be predicted by contrast-enhanced CT imaging features in pa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116049
BMC Medical Imaging; Li Y, Su H et. al.

May 18th, 2022 - To investigate the value of contrast-enhanced CT (CECT)-derived imaging features in predicting lymphovascular invasion (LVI) status in esophageal squamous cell carcinoma (ESCC) patients. One hundred and ninety-seven patients with postoperative pathologically confirmed esophageal squamous cell carcinoma treated in our hospital between January 2017 and January 2019 were enrolled in our study, inc...

Addressing Inequities in SARS-CoV-2 Vaccine Uptake: The Boston Medical Center Health Sy...
https://doi.org/10.7326/M22-0028
Annals of Internal Medicine; Assoumou SA, Peterson A et. al.

May 17th, 2022 - Academic medical centers could play an important role in increasing access to and uptake of SARS-CoV-2 vaccines, especially in Black and Latino communities that have been disproportionately affected by the pandemic. This article describes the vaccination program developed by the Boston Medical Center (BMC) health system (New England's largest safety-net health system), its affiliated community ...

Self Tonometry and Transfer of Glaucoma Patients' Data for Improving the Supply Situation
https://clinicaltrials.gov/ct2/show/NCT04698876

May 17th, 2022 - The SALUS project is developing an outpatient, intersectoral form of care in which patients measure their intraocular pressure in their home environment with a so-called self-tonometer. The measured intraocular pressure values are incorporated into daily pressure profiles, which can be viewed via an electronic case file together with further examination data both by the treating ophthalmologist...

Fast Five Quiz: Chronic Thromboembolic Pulmonary Hypertension
https://www.medscape.com/viewarticle/969947

May 17th, 2022 - Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and late complication of acute pulmonary embolism (PE) that has not resolved despite adequate anticoagulation. In most patients with PE, resolution of the embolus and restoration of blood flow occur. However, for unknown reasons, in a small subset of patients, undissolved blood clots in the pulmonary arteries result in the formatio...

Low Butyrylcholinesterase: A Possible Biomarker of SIDS Risk?
https://www.medscape.com/viewarticle/974072

May 16th, 2022 - Reduced levels of the cholinergic-system enzyme butyrylcholinesterase (BChE) may provide another piece of the puzzle for sudden infant death syndrome (SIDS), preliminary data from Australian researchers suggested. A small case-control study led by Carmel T. Harrington, PhD, a sleep medicine expert and honorary research fellow at the Children"s Hospital at Westmead (Australia), found that measur...

The prognostic role of extended preoperative hypercoagulability work-up in high-risk mi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107705
BMC Surgery; Falkner F, Thomas B et. al.

May 16th, 2022 - Hypercoagulability is associated with an increased risk of microvascular complications and free flap failures. The authors present their experience and approach to diagnosing and treating patients with heterozygotic factor V Leiden (hFVL) thrombophilia undergoing free flap reconstruction. Between November 2009 and June 2018, 23 free flap surgeries were performed in 15 hypercoagulable patients w...

Seasonal variation in water use for hygiene in Oromia, Ethiopia, and its implications f...
https://doi.org/10.1371/journal.pntd.0010424
PLoS Neglected Tropical Diseases; Greenland K, Czerniewska A et. al.

May 14th, 2022 - If facial hygiene practices vary seasonally this could have important implications for the design of interventions for trachoma control. This observational study was conducted to explore seasonal variation in hygiene behaviours in 9 households with at least one child aged 1-9 years-of-age in the West Arsi zone in rural Oromia, Ethiopia. Sixty-one household members were observed intensively over...

Outpatient treatment options to address the SARS-CoV-2 variant Omicron.
https://doi.org/10.1080/14787210.2022.2077191
Expert Review of Anti-infective Therapy; McCarthy MW

May 14th, 2022 - On 26 November 2021, the World Health Organization's Technical Advisory Group on SARS-CoV-2 Virus Evolution designated PANGO lineage B.1.1.529 a variant of concern and gave it the designation Omicron. The following day, the United Kingdom reported its first two cases of Omicron, a novel variant that was thought to be more transmissible than other variants such as Delta, Beta, and Alpha. Omicron...

Effects of optic nerve head-related parameters on retinal vessel calibers measurement r...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097128
BMC Ophthalmology; Iwase A, Tsutsumi T et. al.

May 14th, 2022 - Although relationship between the retinal vessel caliber (RVC) and glaucoma is well known, there has been a paucity of information on the effects of glaucoma-related optic nerve head (ONH) structural factors on the RVC. Information on this relationship should be useful in studying possible roles of ocular circulation in the development and progression of glaucoma. Subjects were from Kumejima St...

First report of whole-genome analysis of an extensively drug-resistant Mycobacterium tu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102340
Antimicrobial Resistance and Infection Control; Kabahita JM, Kabugo J et. al.

May 14th, 2022 - Uganda remains one of the countries with the highest burden of TB/HIV. Drug-resistant TB remains a substantial challenge to TB control globally and requires new strategic effective control approaches. Drug resistance usually develops due to inadequate management of TB patients including improper treatment regimens and failure to complete the treatment course which may be due to an unstable supp...

SARS-CoV-2 RT-qPCR testing of pooled saliva samples: A case study of 824 asymptomatic i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098043
PloS One; Oba J, Taniguchi H et. al.

May 14th, 2022 - From the beginning of the COVID-19 pandemic, the demand for diagnostic and screening tests has exceeded supply. Although the proportion of vaccinated people has increased in wealthier countries, breakthrough infections have occurred amid the emergence of new variants. Pooled-sample COVID-19 testing using saliva has been proposed as an efficient, inexpensive, and non-invasive method to allow lar...

Castleman Disease Misdiagnosed as Pancreatic Neuroendocrine Tumor by Fine Needle Aspira...
https://doi.org/10.1177/00031348221102606
The American Surgeon; Gou H, Fan J et. al.

May 12th, 2022 - Castleman disease (CD) is a lymphoproliferative disorder that rarely occurs in the pancreas. We reported a 46-year-old man was admitted to our hospital due to recurrent minor epigastric pain for 7 days. The abdominal enhanced CT showed irregular foci in the body of the pancreas with abundant blood supply considered a neuroendocrine tumor. The patient was subsequently diagnosed with pancreatic n...

Safety and Efficacy of Daily CF101 Administered Orally in Subjects With Elevated Intraocular Pressure
https://clinicaltrials.gov/ct2/show/NCT01033422

May 12th, 2022 - This is a Phase 2, randomized, double-masked, placebo-controlled, parallel-group study in adult males and females, aged 18 years and over, with a diagnosis of glaucoma or ocular hypertension. This trial will be performed in 2 segments. In Segment 1, subjects will be randomized to receive either CF101 1.0 mg, or matching placebo, given orally every 12 hours for 16 weeks. Segment 1 will enroll ap...

Transmission Dynamics of Residual and Re-emerging Malaria in the Amazon: Defining a Roadmap to Malaria Elimination
https://clinicaltrials.gov/ct2/show/NCT03689036

May 12th, 2022 - Cross-sectional surveys will be carried out in order to identify risk factors for residual malaria infection and disease at both the individual and household level, to supply parasite samples for detailed population-level molecular analyses and to supply epidemiological data for parameterization of new mathematical models of malaria transmission. SPECIFIC AIMS: Aim 1: Longitudinally determine m...