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About 116,090 results

Applying Deep Learning to Quantify Empty Lacunae in Histologic Sections of Osteonecrosi...
https://doi.org/10.1002/jor.25201
Journal of Orthopaedic Research : Official Publication Of... Lui E, Maruyama M et. al.

Oct 23rd, 2021 - Osteonecrosis of the femoral head (ONFH) is a disease in which inadequate blood supply to the subchondral bone causes death of cells in the bone marrow. Decalcified histology and assessment of the percentage of empty lacunae are used to quantify the severity of ONFH. However, the current clinical practice of manually counting cells is a tedious and inefficient process. We utilized the power of ...

Pituitary Disease and Pregnancy
https://emedicine.medscape.com/article/127650-print

Oct 22nd, 2021 - The pituitary gland generally undergoes an increase in size during pregnancy, which is mainly due to an increase in blood supply, as it is a highly vascular organ. Some of the volume increase may also occur as a result of estrogen-mediated hyperprolactinemia caused by lactotroph hyperplasia. Despite the increase in size of the pituitary gland during pregnancy, pituitary function usually remains...

Factors associated with low tuberculosis preventive therapy prescription rates among he...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525921
Global Health Action; Ahmed AA, Grammatico M et. al.

Oct 16th, 2021 - Despite extensive rollout of tuberculosis preventive therapy (TPT) in South Africa to reduce the incidence of tuberculosis among people living with HIV (PWH), rates of initiation and completion have remained suboptimal. This study aimed to identify factors associated with low TPT prescription rates among health care workers (HCWs) in rural South Africa. A cross-sectional study was conducted usi...

Protective Immunity after Natural Infection with Severe Acute Respiratory Syndrome Coro...
https://doi.org/10.1016/j.ijid.2021.10.010
International Journal of Infectious Diseases : IJID : Off... Spicer KB, Glick C et. al.

Oct 15th, 2021 - As vaccine supply and access remain limited in many parts of the world, understanding the duration of protection from reinfection after natural infection is important. Distinct individuals testing positive and negative for SARS-CoV-2 between March 6, 2020, and August 31, 2020, in Kentucky, USA, were identified using the Kentucky National Electronic Disease Surveillance System. Individuals were ...

A recessive variant in TFAM causes mtDNA depletion associated with primary ovarian insu...
https://doi.org/10.1007/s00439-021-02380-2 10.1002/path.4809 10.1016/j.tig.2018.05.009 10.1093/humrep/15.suppl_2.189 10.1016/j.cell.2017.12.039 10.1038/ng1095-144 10.3791/4228 10.1016/j.bbagrm.2012.03.002 10.1093/gigascience/gix120 10.2147/IJWH.S37636 10.1210/en.2017-00617 10.1006/jmbi.1995.9889 10.1172/JCI128514 10.1016/j.ajhg.2019.05.007 10.1016/j.bbadis.2017.02.017 10.3791/55630 10.1016/S0021-9258(17)39184-6 10.1042/bj3430281 10.1210/en.2018-00878 10.1073/pnas.1109263108 10.1111/joim.13064 10.1038/ng0398-231 10.1055/s-0036-1585402 10.1093/bioinformatics/btp324 10.1016/j.gene.2005.03.029 10.1093/humrep/deh667 10.1101/gr.107524.110 10.1212/WNL.0000000000001036 10.1038/nsmb.2159 10.1038/ncomms4077 10.3791/50338 10.1016/j.cell.2012.02.035 10.3389/fcell.2020.00381 10.1016/j.cell.2008.06.016 10.1038/35000651 10.1002/cpmo.21 10.1038/nsmb.2160 10.1016/j.autrev.2014.01.003 10.1002/humu.22844 10.1042/EBC20170110 10.1016/j.ebiom.2020.102784 10.1002/jimd.12130 10.1016/j.ymgme.2016.07.001 10.1038/nature10354 10.1016/j.ebiom.2020.102730 10.1210/en.2019-00441 10.1038/nature11707 10.1093/oxfordjournals.humrep.a135954 10.3390/biom10081193 10.1016/j.jdermsci.2017.09.001
Human Genetics; Ullah F, Rauf W et. al.

Oct 15th, 2021 - Mitochondrial disorders are collectively common, genetically heterogeneous disorders in both pediatric and adult populations. They are caused by molecular defects in oxidative phosphorylation, failure of essential bioenergetic supply to mitochondria, and apoptosis. Here, we present three affected individuals from a consanguineous family of Pakistani origin with variable seizures and intellectua...

REBOA in Out-of-hospital Cardiac Arrest
https://clinicaltrials.gov/ct2/show/NCT04373122

Oct 14th, 2021 - Unexpected cardiac arrest is a devastating event with a high mortality and morbidity. Half of the patients who survive to ICU admission ultimately die because of hypoxic-ischemic encephalopathy (HIE). As outcome after cardiac arrest is depending on time and amount of oxygen delivery to heart and brain, preserving myocardial and cerebral perfusion in the event of cardiac arrest by the means of e...

Organizational factors associated with health worker protection during the COVID-19 pan...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504782
BMC Health Services Research; Zungu M, Voyi K et. al.

Oct 13th, 2021 - Health workers, in short supply in many low-and-middle-income countries, are at increased risk of SARS-CoV-2 infection. This study aimed to assess how South Africa, prepared to protect its health workers from SARS-CoV-2 infection. This was a cross-sectional study design applying participatory action research in four provinces of South Africa. A semi-structured questionnaire and a qualitative ob...

Remedial repair of extensive distal muscle secondary necrosis due to high level crush i...
https://doi.org/10.21037/apm-21-2414
Annals of Palliative Medicine; Zhang J, Guo Z et. al.

Oct 12th, 2021 - Extensive necrosis of lower extremity muscles through the clinical practice of limb salvage after a case of high level crushing injury. A case of car accident injury complicated with necrotizing fasciitis, myositis, and septic shock was admitted to our hospital. The pathogenic factors, clinical characteristics, and surgical repair of this case were analyzed. Septic shock, pulmonary infection an...

The Characteristics of Organ Function Damage of Hemorrhagic Shock in Hot Environment an...
https://doi.org/10.1097/SHK.0000000000001873
Shock (Augusta, Ga.); Zhu Y, Ma S et. al.

Oct 11th, 2021 - Hemorrhagic shock is the important factor for causing death of trauma and war injuries. However, pathophysiological characteristics and underlying mechanism in hemorrhagic shock with hot environment remain unclear. Hemorrhagic shock in hot environment rat model was used to explore the changes of mitochondrial and vital organ functions, the variation of the internal environment, stress factors, ...

CADASIL Disease Discovery
https://clinicaltrials.gov/ct2/show/NCT02821780

Oct 11th, 2021 - Small vessel diseases are conditions characterized by the narrowing of small arteries leading to an imbalance of blood supply upon demand. This results in a progressive chronic hypoperfusion with detrimental outcomes for the affected organ system and for the patient. Recent advances in genetic evaluation have identified several genetic variants causing cerebrovascular small vessel diseases. The...

Treatment-Associated Stroke in Patients Undergoing Endovascular Therapy in the ARUBA Tr...
https://doi.org/10.1161/STROKEAHA.120.033743
Stroke Burks JD, Luther EM et. al.

Oct 9th, 2021 - Since the publication of ARUBA trial (A Randomized Trial of Unruptured Brain Arteriovenous Malformations), outcomes in treated and untreated patients with unruptured arteriovenous malformation have been thoroughly compared. However, no prior analysis of ARUBA patients has sought to identify risk factors for perioperative stroke. Improved understanding of risks within the ARUBA cohort will help ...

Protein provision and lower mortality in critically ill patients with COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282450
Clinical Nutrition ESPEN; Silvah JH, de Lima CMM et. al.

Oct 9th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severely impacted the management of critically ill patients, including nutritional therapy. This study aimed to verify an association between mortality and the energy and protein provided to critically ill patients affected by the SARS-CoV-2 and receiving enteral nutrition support. Patients with confirmed COVID-19, with >7 days of sta...

DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis.
https://doi.org/10.1038/s41467-021-26180-4 10.1152/ajpendo.00407.2001 10.1126/science.1160809 10.1097/CCO.0b013e328356da72 10.2353/ajpath.2009.080596 10.1038/s41467-020-18020-8 10.1111/febs.14577 10.1016/0005-2736(94)00272-Q 10.1194/jlr.R600007-JLR200 10.4161/adip.22117 10.1152/physrev.00032.2014 10.1038/nrm2084 10.1111/j.1742-4658.2007.06056.x 10.1074/jbc.M206573200 10.1074/jbc.M504113200 10.1016/j.celrep.2019.10.065 10.1086/513609 10.1002/ajmg.a.38683 10.1038/s41422-018-0124-5 10.1152/ajpendo.00712.2009 10.1111/tra.12281 10.1078/0171-9335-00118 10.1016/j.molcel.2015.04.015 10.1016/j.cell.2018.08.019 10.7150/thno.26550 10.1038/s41556-020-0471-6 10.1038/ncb3338 10.1016/j.molcel.2017.04.026 10.1126/science.aau6391 10.1016/j.molcel.2016.02.009
Nature Communications; Zhang Z, Li X et. al.

Oct 9th, 2021 - Glucose transporter GLUT1 is a transmembrane protein responsible for the uptake of glucose into the cells of many tissues through facilitative diffusion. Plasma membrane (PM) localization is essential for glucose uptake by GLUT1. However, the mechanism underlying GLUT1 PM localization remains enigmatic. We find that GLUT1 is palmitoylated at Cys207, and S-palmitoylation is required for maintain...

Rapid measurement of SARS-CoV-2 spike T cells in whole blood from vaccinated and natura...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409582
The Journal of Clinical Investigation; Tan AT, Lim JM et. al.

Oct 9th, 2021 - Defining the correlates of protection necessary to manage the COVID-19 pandemic requires the analysis of both antibody and T cell parameters, but the complexity of traditional tests limits virus-specific T cell measurements. We tested the sensitivity and performance of a simple and rapid SARS-CoV-2 spike protein-specific T cell test based on the stimulation of whole blood with peptides covering...

Prevalence of SARS-CoV-2 antibodies in the Palestinian population: A primary health cen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500452
PloS One; Maraqa B, Basha W et. al.

Oct 9th, 2021 - This study aimed to assess the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) total antibodies in the north, middle, and south regions of West Bank and the prevalence of SARS-CoV-2 specific antibodies (IgA, IgM, and IgG) in the Palestinian population. This was a cross-sectional study. The serological and epidemiological data of 1269 persons were assessed. Participant...

An ethnographic study of how health system, socio-cultural and individual factors influ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496863
PloS One; Aberese-Ako M, Magnussen P et. al.

Oct 8th, 2021 - Intermittent preventive treatment of malaria among pregnant women with sulfadoxine-pyrimethamine (IPTp-SP), is one of the three recommended interventions for the prevention of malaria in pregnancy (MiP) in sub-Sahara Africa. The World Health Organisation recommended in 2012 that SP be given at each scheduled ANC visit except during the first trimester and can be given a dose every month until t...

WHO Unveils Global Roadmap to Defeat Meningitis by 2030
https://www.medscape.com/viewarticle/960501

Oct 8th, 2021 - The World Health Organization (WHO) and its partners recently released an ambitious plan, the Global Roadmap to Defeat Meningitis by 2030. Their goal is to reduce deaths and disabilities from bacterial meningitis, which kills about 250,000 people annually of the 1.2 million estimated to be infected. This type of infection around the brain and spinal cord also causes long-term disabilities — dea...

Reaching Conclusions From Limited Data Holds Pitfalls
https://www.onclive.com/view/reaching-conclusions-from-limited-data-holds-pitfalls

Oct 6th, 2021 - There are most interesting and complex days in the continuing evolution of the COVID-19 pandemic. On one hand, in the United States and a number of other countries, mass vaccination strategies have finally begun to have a major impact on the incidence and severity of infections, with a substantial proportion of the adult population being fully or at least partially vaccinated. Further, success...

Acute urticaria alone after CoronaVac COVID-19 vaccination should not be contraindicate...
https://doi.org/10.1111/ced.14962
Clinical and Experimental Dermatology; Triwatcharikorn J, Puaratana-Arunkon T et. al.

Oct 6th, 2021 - Patients who developed an immediate allergic reaction within the first 4 hours of COVID-19 vaccine injection are recommended not to receive the same vaccine again. This recommendation mainly focuses on the mRNA and adenoviral vector COVID-19 vaccines, but data for whole virus vaccines are unknown. We report seven patients who developed an immediate reaction within 4 hours (6 generalised urticar...

Humoral response after SARS-CoV-2 mRNA vaccines in dialysis patients: Integrating anti-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491898
PloS One; Bachelet T, Bourdenx JP et. al.

Oct 6th, 2021 - Dialysis patients are both the most likely to benefit from vaccine protection against SARS-CoV-2 and at the highest risk of not developing an immune response. Data from the medical field are thus mandatory. We report our experience with a BNT162b2-mRNA vaccine in a retrospective analysis of 241 dialysis patients including 193 who underwent anti-Spike-Protein-Receptor-Binding-Domain (RBD) IgG an...