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Germline Variants Identified in Patients with Early-onset Renal Cell Carcinoma Referred for Germline Genetic Testing
https://pubmed.ncbi.nlm.nih.gov/34654685/
European Urology Oncology; Truong H

Oct 12th, 2021 - Despite guidelines recommending genetic counseling for patients with early-onset renal cell carcinoma (RCC), studies interrogating the spectrum of germline mutations and clinical associations in patients with early-onset RCC are lacking.

Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants
https://www.biorxiv.org/content/10.1101/2021.07.19.452771v1
BioRxiv Tada T, Zhou H et. al.

Jul 19th, 2021 - The increasing prevalence of SARS-CoV-2 variants has raised concerns regarding possible decreases in vaccine efficacy. Here, neutralizing antibody titers elicited by mRNA-based and an adenoviral vector-based vaccine against variant pseudotyped viruses were compared.

DSHS Statement on Monkeypox Investigation
https://www.dshs.texas.gov/news/releases/2021/20210716.aspx
Texas Health and Human Services

Jul 16th, 2021 - The Texas Department of State Health Services is working with Dallas County Health and Human Services and the CDC to investigate a single case of monkeypox virus infection in a Dallas County resident who recently returned from Nigeria. The patient is isolated in the hospital, and the public health investigation has identified a few people who may have been exposed in Dallas and are monitoring t...

CDC and Texas Confirm Monkeypox In U.S. Traveler
https://www.cdc.gov/media/releases/2021/s0716-confirm-monkeypox.html
Centers for Disease Control and Prevention (CDC)

Jul 16th, 2021 - The Centers for Disease Control and Prevention (CDC) and the Texas Department of State Health Services confirmed on July 15 a case of human monkeypox in a U.S. resident who recently traveled from Nigeria to the United States. The person is currently hospitalized in Dallas. CDC is working with the airline and state and local health officials to contact airline passengers and others who may have ...

Levetiracetam - levetiracetam tablet, film coated-Solco Healthcare US, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd713e60-478c-43cd-b680-ff594a0b3864

Jan 8th, 2022 - Levetiracetam is indicated for the treatment of partial-onset seizures in patients 1 month of age and older (1.1) Levetiracetam is indicated for adjunctive therapy for the treatment of: •Myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy (1.2) •Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilep...

Heterologous SARS-CoV-2 Booster Vaccinations – Preliminary Report
https://www.medrxiv.org/content/10.1101/2021.10.10.21264827v1.full.pdf
Medrxiv Atmar RL, .

Oct 13th, 2021 - Background: While Coronavirus disease 2019 (Covid-19) vaccines are highly effective, breakthrough infections are occurring. Booster vaccinations have recently received emergency use authorization (EUA) for certain populations but are restricted to homologous mRNA vaccines. We evaluated homologous and heterologous booster vaccination in persons who had received an EUA Covid-19 vaccine regimen.

Fauci in the Doghouse; SCOTUS to Review Texas Abortion Law; Public Health's Downfall
https://www.medpagetoday.com/infectiousdisease/covid19/95235

Oct 25th, 2021 - Note that some links may require registration or subscription. NIH officials admitted that they funded research to the Wuhan Institute of Virology that enhanced bat coronaviruses, but insisted there were too many genetic differences for one of those viruses to have led to the origin of the COVID pandemic. (Vanity Fair) Meanwhile, 24 legislators sent a letter to NIAID Director Anthony Fauci, MD,...

Psoriasis patients with more severe disease at higher risk of developing PsA
https://www.mdedge.com/dermatology/article/247833/psoriatic-arthritis/psoriasis-patients-more-severe-disease-higher-risk

Oct 24th, 2021 - Key clinical point: Patients with psoriasis with the most severe disease were at highest risk of developing psoriatic arthritis (PsA), highlighting the need for regular screening for signs and symptoms of PsA. Major finding: Overall incidence of PsA in patients with mild, moderate, and severe psoriasis was 2.

PsA: Phase 3 confirms rapid and significant response of secukinumab on synovitis
https://www.mdedge.com/dermatology/article/247831/psoriatic-arthritis/psa-phase-3-confirms-rapid-and-significant-response

Oct 24th, 2021 - Key clinical point: Evaluation with power Doppler ultrasound revealed a rapid and significant reduction of synovitis in patients with psoriatic arthritis (PsA) upon treatment with secukinumab. Major finding : At week 12, the adjusted mean change in the global European League Against Rheumatism (EULAR) and the Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) (EULAR-OMERACT) syn.

Risk classification at diagnosis predicts post-HCT outcomes in AML
https://www.mdedge.com/hematology-oncology/article/247827/aml/risk-classification-diagnosis-predicts-post-hct-outcomes-aml

Oct 24th, 2021 - Key clinical point: Risk classification at acute myeloid leukemia (AML) diagnosis predicted clinical outcomes in patients with or without KMT2A-rearranged AML who underwent allogeneic hematopoietic cell transplant (HCT) in the first complete remission (CR1). Major finding: Transplanted patients with KMT2A-rearranged and adverse-risk AML had worse overall survival (hazard ratio [HR] 1.

Using Neural Networks in Order to Analyze Telework Adaptability across the European Uni...
https://doi.org/10.3390/ijerph182010586
International Journal of Environmental Research and Publi... Iordache AMM, Dura CC et. al.

Oct 24th, 2021 - Our study addresses the issue of telework adoption by countries in the European Union and draws up a few feasible scenarios aimed at improving telework's degree of adaptability in Romania. We employed the dataset from the 2020 Eurofound survey on Living, Working and COVID-19 (Round 2) in order to extract ten relevant determinants of teleworking on the basis of 24,123 valid answers provided by r...

Impact of Life Stressors on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Symptoms...
https://doi.org/10.3390/ijerph182010614
International Journal of Environmental Research and Publi... Balinas C, Eaton-Fitch N et. al.

Oct 24th, 2021 - (1) Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, multifaceted illness. The pathomechanism, severity and progression of this illness is still being investigated. Stressors have been implicated in symptom exacerbation for ME/CFS, however, there is limited information for an Australian ME/CFS cohort. The aim of this study was to assess the potential effect ...

Differences in the Prevalence of SARS-CoV-2 Infection and Access to Care between Italia...
https://doi.org/10.3390/ijerph182010621
International Journal of Environmental Research and Publi... Pagani G, Conti F et. al.

Oct 24th, 2021 - The northern Italian region of Lombardy has been severely affected by the COVID-19 pandemic since its arrival in Europe. However, there are only a few published studies of the possible influence of social and cultural factors on its prevalence in the general population. This cross-sectional study of the San Siro social-housing neighbourhood of Milan, which was carried about between 23 December ...

Regional Characteristics of the Second Wave of SARS-CoV-2 Infections and COVID-19 Death...
https://doi.org/10.3390/ijerph182010663
International Journal of Environmental Research and Publi... Doblhammer G, Kreft D et. al.

Oct 24th, 2021 - (1) Background: In the absence of individual level information, the aim of this study was to identify the regional key features explaining SARS-CoV-2 infections and COVID-19 deaths during the upswing of the second wave in Germany. (2) Methods: We used COVID-19 diagnoses and deaths from 1 October to 15 December 2020, on the county-level, differentiating five two-week time periods. For each perio...

Tuberculosis Treatment Outcome and Predictors in Africa: A Systematic Review and Meta-A...
https://doi.org/10.3390/ijerph182010678
International Journal of Environmental Research and Publi... Teferi MY, El-Khatib Z et. al.

Oct 24th, 2021 - This review aimed to summarize and estimate the TB treatment success rate and factors associated with unsuccessful TB treatment outcomes in Africa. Potentially eligible primary studies were retrieved from PubMed and Google Scholar. The risk of bias and quality of studies was assessed using The Joanna Briggs Institute's (JBI) appraisal criteria, while heterogeneity across studies was assessed us...

Leveraging HIV Care Infrastructures for Integrated Chronic Disease and Pandemic Managem...
https://doi.org/10.3390/ijerph182010751
International Journal of Environmental Research and Publi... Brault MA, Vermund SH et. al.

Oct 24th, 2021 - In Sub-Saharan Africa, communicable and other tropical infectious diseases remain major challenges apart from the continuing HIV/AIDS epidemic. Recognition and prevalence of non-communicable diseases have risen throughout Africa, and the reimagining of healthcare delivery is needed to support communities coping with not only with HIV, tuberculosis, and COVID-19, but also cancer, cardiovascular ...

The Quality of Life of Children with Myelomeningocele: A Cross-Sectional Preliminary St...
https://doi.org/10.3390/ijerph182010756
International Journal of Environmental Research and Publi... Rozensztrauch A, Iwańska M et. al.

Oct 24th, 2021 - To investigate the relationship between the defects and symptoms caused by myelomeningocele (MMC) and quality of life. A cross-sectional questionnaire survey. The subjects were 52 parents of children with MMC. Structured questionnaires were used: the Pediatric Quality of Life Inventory 4.0 Generic Core Scales (PedsQLTM 4.0) and a Study-Specific Questionnaire (SSQ). The overall PedsQLTM 4.0 scor...

Not Just a 'Breath of Death': Indirect Consequences of Working in a COVID-19 Unit.
https://doi.org/10.3390/ijerph182010802
International Journal of Environmental Research and Publi... Guha A, Schalek P et. al.

Oct 24th, 2021 - We carried out a survey in the Czech Republic between January and February 2021 to evaluate the impact of COVID-19 on doctors working in the COVID-19 unit. A rise in 250,000 cases were seen in the Czech Republic during the time of the survey. The indirect impact of the disease on doctors working in COVID-19 units and strategies to control the situation in the Czech Republic were evaluated here....

Multi-Task Learning-Based Immunofluorescence Classification of Kidney Disease.
https://doi.org/10.3390/ijerph182010798
International Journal of Environmental Research and Publi... Pan S, Fu Y et. al.

Oct 24th, 2021 - Chronic kidney disease is one of the most important causes of mortality worldwide, but a shortage of nephrology pathologists has led to delays or errors in its diagnosis and treatment. Immunofluorescence (IF) images of patients with IgA nephropathy (IgAN), membranous nephropathy (MN), diabetic nephropathy (DN), and lupus nephritis (LN) were obtained from the General Hospital of Chinese PLA. The...

Prevalence of Asymptomatic SARS-CoV-2 Infection in the General Population of the Veneto...
https://doi.org/10.3390/ijerph182010838
International Journal of Environmental Research and Publi... Cocchio S, Nicoletti M et. al.

Oct 24th, 2021 - The aim of our study was to ascertain the prevalence of SARS-CoV-2 infection in the general population during a period of moderate risk, just before Italy started to implement its vaccination campaign. A third-generation antigenic nasal swab sample was collected by a healthcare provider, and all individuals testing positive subsequently had a nasopharyngeal swab for molecular testing; the resul...