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About 72,650 results

Home OCT with AI may be feasible for patients with wet AMD
https://www.healio.com/news/ophthalmology/20210518/holekamp-nm-home-oct-for-monitoring-namd-presented-at-retina-2021-may-814-2021-wailea-hawaii

May 18th, 2021 - WAILEA, Hawaii — The COVID-19 pandemic changed the way physicians monitor age-related macular degeneration, and Nancy M. Holekamp, MD, believes those changes are here to stay. “We all learned that remote monitoring of our patients is desirable, even if there isn’t a pandemic,” she said in her presentation at Retina 2021. “It currently exists with monitoring patients with intermediate AMD, and t...

Gout and Pseudogout
https://emedicine.medscape.com/article/329958-overview

Jul 1st, 2022 - Practice Essentials Gout and pseudogout are the 2 most common crystal-induced arthropathies. Gout (see the image below) is caused by monosodium urate monohydrate crystals; pseudogout is caused by calcium pyrophosphate crystals and is more accurately termed calcium pyrophosphate disease. Gout. Acute podagra due to gout in elderly man. View Media Gallery Signs and symptoms Symptoms of gout or pse...

Gout and Pseudogout
http://emedicine.medscape.com/article/329958-overview

Jul 1st, 2022 - Practice Essentials Gout and pseudogout are the 2 most common crystal-induced arthropathies. Gout (see the image below) is caused by monosodium urate monohydrate crystals; pseudogout is caused by calcium pyrophosphate crystals and is more accurately termed calcium pyrophosphate disease. Gout. Acute podagra due to gout in elderly man. View Media Gallery Signs and symptoms Symptoms of gout or pse...

Phase I Trial of a Novel Anti-HER2 Antibody-Drug Conjugate, ARX788, for the Treatment o...
https://doi.org/10.1158/1078-0432.CCR-22-0456
Clinical Cancer Research : an Official Journal of the Ame... Zhang J, Ji D et. al.

Jun 30th, 2022 - ARX788 is a novel antibody-drug conjugate (ADC) comprised of an anti-HER2 mAb and a potent tubulin inhibitor payload AS269 that is site-specifically conjugated to the antibody via a nonnatural amino acid incorporated into the antibody. Herein, we present the results of a phase I study of the safety, pharmacokinetics, and antitumor activity of ARX788 in patients with HER2-positive metastatic bre...

Logistic Regression-Based Model Is More Efficient Than U-Net Model for Reliable Whole B...
https://doi.org/10.1097/RMR.0000000000000296
Topics in Magnetic Resonance Imaging : TMRI; Dieckhaus H, Meijboom R et. al.

Jun 30th, 2022 - Automated whole brain segmentation from magnetic resonance images is of great interest for the development of clinically relevant volumetric markers for various neurological diseases. Although deep learning methods have demonstrated remarkable potential in this area, they may perform poorly in nonoptimal conditions, such as limited training data availability. Manual whole brain segmentation is ...

Beers Criteria: Considering Diagnoses or Conditions
https://emedicine.medscape.com/article/2172148-overview

Jun 30th, 2022 - Potentially Inappropriate Medication Use in Older Adults Cardiovascular disease (high severity rating [H]) Antiarrhythmic drugs (class Ia, Ic, III): Avoid as first-line agents for atrial fibrillation [1, 2, 3, 4] Disopyramide Dronedarone Digoxin >0.125 mg/day [1] High-sodium-content drugs Hypertension (H) Phenylpropanolamine hydrochloride Pseudoephedrine Diet pills Amphetamines Gastric/duodenal...

Ambulatory fludrocortisone suppression test in the diagnosis of primary aldosteronism: ...
https://doi.org/10.1111/cen.14793
Clinical Endocrinology; Carasel A, Calissendorff J et. al.

Jun 29th, 2022 - The aims of this study were to explore if the ambulatory FST was safe, accurate, and cost-effective. The diagnosis of primary aldosteronism (PA) remains time-consuming and complex. The fludrocortisone suppression test (FST) is used to confirm PA, but it is an in-patient test due to potentially serious complications such as hypokalemia. In Stockholm, FST has been performed since 2005 as an ambul...

Radiological findings of multisystem inflammatory syndrome in children associated with ...
https://doi.org/10.1259/bjr.20220101
The British Journal of Radiology; Kalın S, Sözeri B

Jun 29th, 2022 - To retrospectively evaluate the imaging and clinical findings of patients diagnosed with multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19. The clinical, laboratory and radiological data of 110 patients (74 male and 36 female) diagnosed with COVID-19-related MIS-C between June 2020 and November 2021 were evaluated retrospectively. Cases with a diagnosis of MIS-C bas...

The Association of Human Astrovirus with Extracellular Vesicles Facilitates Cell Infect...
https://doi.org/10.1128/jvi.00848-22
Journal of Virology; Baez-Navarro C, Quevedo IR et. al.

Jun 29th, 2022 - Viral gastroenteritis has a global distribution and represents a high risk for vulnerable population and children under 5 years due to acute diarrhea, fever and dehydration. Human astroviruses (HAstV) have been identified as the third most important cause of viral gastroenteritis in pediatric and immunocompromised patients. Furthermore, HAstV has been reported in biopsies taken from patients wi...

Learning curve and volume outcome relationship of endoscopic trans-oral versus trans-ax...
https://doi.org/10.1016/j.ijsu.2022.106739
International Journal of Surgery (London, England); Dabsha A, Khairallah S et. al.

Jun 29th, 2022 - In the modern era, minimally invasive surgery is rapidly evolving and even replacing conventional open techniques in many surgical fields. Thyroidectomy was not an exception, with the introduction of multiple endoscopic thyroidectomy techniques. Trans-oral endoscopic trans-vestibular thyroidectomy (TOT) is a novel technique with promising outcomes. We conducted this meta-analysis to compare sur...

Postoperative Complications After Total Thyroidectomy for Patients With Graves' Disease.
https://doi.org/10.1177/01945998221108050
Otolaryngology--head and Neck Surgery : Official Journal ... Liang JJ, Irizarry R et. al.

Jun 29th, 2022 - To identify the rates and types of postoperative complications in patients with and without Graves' disease undergoing total thyroidectomy using the National Surgical Quality Improvement Program (NSQIP) database. Retrospective cohort study. All hospitals participating in NSQIP from 2007 to 2017. Thyroidectomy data were abstracted from the NSQIP database from 2007 to 2017 using related Current P...

Exposure-safety relationship for acyclovir in the treatment of neonatal herpes simplex ...
https://doi.org/10.1016/j.earlhumdev.2022.105616
Early Human Development; Ericson JE, Benjamin DK et. al.

Jun 29th, 2022 - Neonatal herpes simplex virus (HSV) disease has been treated with high-dose (20 mg/kg/dose) acyclovir since 1991. Determine the safety of acyclovir in infants with neonatal HSV treated with high-dose acyclovir; examine the association between acyclovir dose and exposure with adverse events (AEs). We obtained demographic information and acyclovir dosing via medical records. Acyclovir exposure wa...

Is anemia frequently recognized in gastroschisis compared to omphalocele? A multicenter...
https://doi.org/10.1007/s00383-022-05150-x
Pediatric Surgery International; Sugita K, Muto M et. al.

Jun 29th, 2022 - We compared cases of anemia in gastroschisis versus omphalocele and investigated this clinical question. A multicenter study of five pediatric surgery departments in southern Japan was planned. Sixty patients were collected between 2011 and 2020, with 33 (gastroschisis: n = 19, omphalocele: n = 14) who met the selection criteria ultimately being enrolled. Anemia was evaluated before discharge a...

IL-2, IL-6 and chitinase 3-like 2 might predict early relapse activity in multiple scle...
https://doi.org/10.1371/journal.pone.0270607
PloS One; Petržalka M, Meluzínová E et. al.

Jun 28th, 2022 - The possibility to better predict the severity of the disease in a patient newly diagnosed with multiple sclerosis would allow the treatment strategy to be personalized and lead to better clinical outcomes. Prognostic biomarkers are highly needed. To assess the prognostic value of intrathecal IgM synthesis, cerebrospinal fluid and serum IL-2, IL-6, IL-10, chitinase 3-like 2 and neurofilament he...

Crosstalk between lysine methyltransferase Smyd2 and TGF-β-Smad3 signaling promotes ren...
https://doi.org/10.1152/ajprenal.00452.2021
American Journal of Physiology. Renal Physiology; Li LX, Agborbesong E et. al.

Jun 28th, 2022 - Autosomal dominant polycystic kidney disease (ADPKD) is an inherited genetic disorder, which is caused by mutations of PKD1 or PKD2 gene and is characterized by renal fluid-filled cyst formation and interstitial fibrosis. PKD1 gene mutation results in the upregulation of SET and MYND domain-containing lysine methyltransferase 2 (SMYD2) in Pkd1 mutant mouse and ADPKD patient kidneys. However, th...

Expression of active B-Raf proto-oncogene in kidney collecting ducts induces cyst forma...
https://doi.org/10.1016/j.kint.2022.05.028
Kidney International; Parnell SC, Raman A et. al.

Jun 28th, 2022 - Polycystic kidney disease (PKD) is characterized by the formation and progressive enlargement of fluid-filled cysts due to abnormal cell proliferation. Cyclic AMP agonists, including arginine vasopressin, stimulate ERK-dependent proliferation of cystic cells, but not normal kidney cells. Previously, B-Raf proto-oncogene (BRAF), a MAPK kinase kinase that activates MEK-ERK signaling, was shown to...

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Prot...
https://doi.org/10.3791/63506
Journal of Visualized Experiments : JoVE; Cabana-Puig X, Luo XM

Jun 28th, 2022 - Systemic lupus erythematosus (SLE) is an autoimmune disorder with no known cure and is characterized by persistent inflammation in many organs, including the kidneys. Under such circumstances, the kidney loses its ability to clean waste from the blood and regulate salt and fluid concentrations, eventually leading to renal failure. Women, particularly those of childbearing age, are diagnosed nin...

X-linked hypophosphatemia, obesity and arterial hypertension: data from the XLH21 study.
https://doi.org/10.1007/s00467-022-05636-9 10.1038/s41581-019-0152-5 10.1016/j.metabol.2019.01.006 10.1002/jbmr.3614 10.1210/clinem/dgab282 10.1530/EJE-15-0661 10.1530/EC-19-0481 10.1055/s-2002-33256 10.1111/joim.12580 10.1210/en.2009-0532 10.3389/fendo.2020.601349 10.1210/jc.2010-0589 10.1111/apa.14907 10.1056/NEJMoa1714641 10.2215/CJN.01640309 10.1111/j.1467-789X.2009.00697.x 10.1515/cclm-2020-0460 10.1210/jc.2015-1551 10.1038/36285 10.1093/gerona/glz061 10.3389/fcvm.2020.617842 10.1016/j.bbrc.2011.09.117 10.1111/pedi.13095 10.1172/JCI46122 10.1002/emmm.201303716 10.1093/ndt/gfy122 10.1002/jbmr.1740 10.1681/ASN.2014101009 10.1111/jnc.13585 10.1016/j.kint.2016.05.019 10.1007/s00467-002-1044-6 10.1507/endocrj.EJ16-0199 10.1210/jcem.82.8.4181 10.1007/s00467-018-4180-3 10.1080/07435800.2016.1242604 10.1097/HJH.0000000000001039
Pediatric Nephrology (Berlin, Germany); Bloudeau L, Linglart A et. al.

Jun 28th, 2022 - The underlying mechanisms of obesity in X-linked hypophosphatemia (XLH) are not known. We aimed to evaluate whether FGF21, an endocrine FGF involved in the regulation of carbohydrate-lipid metabolism, could be involved. We performed a prospective multicenter cross-sectional study comparing FGF23, Klotho, and FGF21 levels in teenagers with XLH compared to healthy controls (VITADOS cohort) after ...

Rare Case of Pediatric Disseminated Choroid Plexus Papilloma: Literature Review and Cal...
https://doi.org/10.1159/000525746
Pediatric Neurosurgery; Mazur-Hart DJ, Yaghi NK et. al.

Jun 28th, 2022 - Choroid plexus tumors are rare neuroectodermal tumors that arise from the choroid plexus. Choroid plexus papillomas (CPP) represent the lowest grade of these types of tumors and have a WHO grade I designation. Despite their typical low grade, some CPPs can exhibit aggressive behaviors including parenchymal invasion and dissemination throughout the neuro-axis. Due to their association with the c...

Caution when using 1,3, β-D-glucan in the CSF as a biomarker of Candida albicans mening...
https://doi.org/10.1016/j.ijid.2022.06.033
International Journal of Infectious Diseases : IJID : Off... Barbolini L, Riat A et. al.

Jun 28th, 2022 - Relying on a biomarker to diagnose or follow-up the treatment of a Candida albicans meningitis would have an impact on patient management. The biomarker 1,3, β-D-glucan (BDG), developed for serum testing, shows inconsistent values when applied on cerebro-spinal fluid (CSF), and its use with the current protocol on CSF samples warrants caution.