×
About 60,423 results

A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma
https://clinicaltrials.gov/ct2/show/NCT04634552

Dec 3rd, 2021 - Multiple myeloma is a malignant plasma cell disorder characterized by osteolytic lesions, increased susceptibility to infections, hypercalcemia, and renal failure. Talquetamab is a humanized immunoglobulin G4 proline, alanine, alanine (IgG4PAA) bispecific antibody designed to target G protein-coupled receptor family C group 5-member D (GPRC5D) and the CD3 molecule found on T lymphocytes (T cell...

Study of Brolucizumab in Adult Patients With Suboptimal Anatomically Controlled Neovascular Age-related Macular Degeneration
https://clinicaltrials.gov/ct2/show/NCT04264819

Dec 3rd, 2021 - Neovascular age-related macular degeneration is characterized by the presence of choroidal neovascularization (CNV), which consists of abnormal blood vessels originating from the choroid that can lead to hemorrhage, fluid exudation, and fibrosis, resulting in photoreceptor damage and vision loss. The safety and efficacy of brolucizumab were assessed in 2 randomized, multicenter, double-masked, ...

Microdialysis and microperfusion electrodes in neurologic disease monitoring.
https://doi.org/10.1186/s12987-021-00292-x
Fluids and Barriers of the CNS; Stangler LA, Kouzani A et. al.

Dec 3rd, 2021 - Contemporary biomarker collection techniques in blood and cerebrospinal fluid have to date offered only modest clinical insights into neurologic diseases such as epilepsy and glioma. Conversely, the collection of human electroencephalography (EEG) data has long been the standard of care in these patients, enabling individualized insights for therapy and revealing fundamental principles of human...

Huge subcutaneous extraperitoneal pseudocyst after migration of the ventriculoperitonea...
https://doi.org/10.1136/bcr-2021-246681
BMJ Case Reports; De Jesus O, Rios-Vicil C et. al.

Dec 3rd, 2021 - The formation of an intraperitoneal pseudocyst as a complication of ventriculoperitoneal shunts is well known. However, the formation of a pseudocyst at the subcutaneous extraperitoneal abdominal space is unusual and likely secondary to the migration of the peritoneal catheter. We present a 53-year-old male who had placement of a ventriculoperitoneal shunt for hydrocephalus secondary to a vesti...

Para-aortic lymphadenopathy associated with adult COVID-19 multisystem inflammatory syn...
https://doi.org/10.1136/bcr-2021-246884
BMJ Case Reports; Carvalho V, Damasco PH et. al.

Dec 3rd, 2021 - A 21-year-old woman arrived at the emergency department with dyspnoea, arterial hypotension and abdominal pain after 5 days with a influenza-like syndrome. SARS-CoV-2 was detected by reverse transcription PCR in a nasopharyngeal swab specimen. CT of the chest and abdomen with contrast demonstrated a minimal amount of free intraperitoneal fluid, gallbladder with wall oedema, multiple para-aortic...

Characterization of Tissue-Specific Immune Responses to Bronchoscopic Instillation of Mycobacterial Antigens Into the Human Lung
https://clinicaltrials.gov/ct2/show/NCT05027958

Dec 3rd, 2021 - We propose a pilot study in which we employ directed bronchoscopic instillation of Mycobacterium tuberculosis (Mtb)-derived Purified Protein Derivative (PPD) to evaluate local airway immune response in adults with or without latent tuberculosis infection (LTBI). Primary Objective: The primary objective of this study is to understand the pulmonary immune response to mycobacterial antigens by det...

Acute Lymphoblastic Leukemia (ALL) Masquerading as Guillain Barre Syndrome.
https://doi.org/10.1097/NRL.0000000000000397
The Neurologist; Al-Chalabi M, Ali N et. al.

Dec 3rd, 2021 - Neurological manifestations of acute lymphoblastic leukemia (ALL) have been reported as cranial neuropathies or meningeal symptoms most common in children. However, ALL can rarely involve the nerve roots causing symmetrical polyradiculopathy which can present with rapid onset paralysis, mimicking Guillain Barre Syndrome (GBS). The symmetrical polyradiculopathy can be the earliest manifestation ...

Treatment of necrotizing enterocolitis by conditioned medium derived from human amnioti...
https://doi.org/10.1371/journal.pone.0260522
PloS One; O'Connell JS, Li B et. al.

Dec 3rd, 2021 - Necrotizing enterocolitis (NEC) is one of the most distressing gastrointestinal emergencies affecting neonates. Amniotic fluid stem cells (AFSC) improve intestinal injury and survival in experimental NEC but are difficult to administer. In this study, we evaluated whether conditioned medium (CM) derived from human AFSC have protective effects. Three groups of C57BL/6 mice were studied: (i) brea...

A pigtailed macaque model of Kyasanur Forest disease virus and Alkhurma hemorrhagic dis...
https://doi.org/10.1371/journal.ppat.1009678
PLoS Pathogens; Broeckel RM, Feldmann F et. al.

Dec 3rd, 2021 - Kyasanur Forest disease virus (KFDV) and the closely related Alkhurma hemorrhagic disease virus (AHFV) are emerging flaviviruses that cause severe viral hemorrhagic fevers in humans. Increasing geographical expansion and case numbers, particularly of KFDV in southwest India, class these viruses as a public health threat. Viral pathogenesis is not well understood and additional vaccines and anti...

Lost in third space: altered tyrosine-kinase inhibitor pharmacokinetics in a patient wi...
https://doi.org/10.1007/s00280-021-04377-0 10.1016/j.ygyno.2010.05.033 10.1016/j.urolonc.2016.10.023 10.1002/jso.25453 10.1038/modpathol.2009.88 10.1007/s00280-019-03952-w 10.1038/bjc.2014.503 10.1007/s00280-009-1170-y 10.1007/s10637-015-0304-9 10.1007/s13277-015-4198-0 10.1007/s11523-014-0306-0 10.1080/0284186X.2017.1311024 10.1177/2054270415585087 10.1007/s13691-012-0039-9 10.1158/1078-0432.CCR-12-2199 10.1007/s00262-020-02621-9
Cancer Chemotherapy and Pharmacology; Krens SD, Mulder SF et. al.

Dec 3rd, 2021 - Pazopanib and sunitinib are oral tyrosine kinase inhibitors (TKI) approved for the treatment of renal cell carcinoma. For both oncolytics, a clear target trough concentration level in plasma has been defined above which improved clinical efficacy can be expected. However, many factors can alter TKI exposure, including disease characteristics. A 79-year old male with metastatic papillary renal c...

Topiramate-induced severe electrolyte abnormalities and hypernatremia leading to centra...
https://doi.org/10.1136/bcr-2021-245870
BMJ Case Reports; Muaddi L, Osman O et. al.

Dec 2nd, 2021 - Central pontine myelinolysis (CPM) develops due to acute hypernatremia from a normal baseline serum sodium in the setting of electrolyte abnormalities induced by topiramate use. Topiramate is a commonly used medication with several indications including migraines, myoclonic jerks and seizures. It has been reported to cause renal tubular acidosis and severe electrolyte abnormalities, which in tu...

Cycloserine and Linezolid for Tuberculosis Meningitis: Pharmacokinetic Evidence of Pote...
https://doi.org/10.1093/cid/ciab992
Clinical Infectious Diseases : an Official Publication Of... Kempker RR, Smith AGC et. al.

Dec 2nd, 2021 - The ability of anti-tuberculosis drugs to cross the blood brain barrier and reach the central nervous system (CNS) is critical to their effectiveness in treating tuberculosis meningitis (TBM). We sought to fill a critical knowledge gap by providing data on the ability of new and repurposed anti-tuberculosis drugs to penetrate into the cerebrospinal fluid (CSF). We conducted a clinical pharmacol...

Study of cerebrospinal fluid levels of lactate, lactate dehydrogenase and adenosine dea...
https://doi.org/10.1080/01616412.2021.2004366
Neurological Research; Singh L, Javali M et. al.

Dec 2nd, 2021 - Meningitis is a serious clinical health issue in most developing countries. Late diagnosis and treatment result in significant morbidity and mortality. This research aims to study the utility of CSF lactate, lactate dehydrogenase (LDH), and adenosine deaminase (ADA) as diagnostic markers in acute meningitis, and to differentiate among varied aetiologies of acute meningitis and their outcomes. A...

Assessing the utility of the Xpert Mycobacterium tuberculosis/rifampin assay for analys...
https://doi.org/10.1002/jcla.24154
Journal of Clinical Laboratory Analysis; Bai W, Liu L et. al.

Dec 2nd, 2021 - There is limited research assessing the utility of the Xpert Mycobacterium tuberculosis/rifampin (MTB/RIF) assay for the analysis of bronchoalveolar lavage fluid (BALF) in Chinese patients with suspected pulmonary tuberculosis (PTB). Thus, our objective was to determine the diagnostic accuracy of the Xpert MTB/RIF assay and evaluate its utility for the determination of rifampicin resistance. We...

WDHA Syndrome Treatment & Management
https://emedicine.medscape.com/article/183189-treatment

Dec 2nd, 2021 - Approach Considerations A multispecialty team composed of gastroenterologists, surgeons, radiologists, and oncologists should evaluate patients with WDHA syndrome. Because of the rarity of VIPomas, most treatment recommendations are based on experience with pancreatic endocrine tumors. Most experts agree, however, that chemotherapy and interferon are indicated for patients with extensive metast...

Medulloblastoma Pathology
http://emedicine.medscape.com/article/1743856-overview

Dec 2nd, 2021 - Definition Medulloblastoma is defined by the World Health Organization (WHO) as "an embryonal neuroepithelial tumor arising in the cerebellum or dorsal brainstem, presenting mainly in childhood and consisting of densely packed small round undifferentiated cells with mild to moderate nuclear pleomorphism and high mitotic count." [1] These tumors display considerable clinical and biologic heterog...

Effects of Intraoperative GDFT on the Postoperative Brain Edema
https://clinicaltrials.gov/ct2/show/NCT03323580

Dec 2nd, 2021 - Whether a fluid protocol aiming for cardiac output augmentation or fluid restriction is favorable to post-craniotomy outcomes such as brain edema remains uncertain. To our knowledge, there has been no extensive and quantitative analysis of brain edema following SVV-based GDFT in neurosurgical patients with malignant supratentorial glioma. So the study aima to observe the effect of the stroke vo...

Evaluating LINFU™: A Noninvasive Method for Collecting Pancreatic Cells for the Early Detection of Pancreatic Cancer
https://clinicaltrials.gov/ct2/show/NCT04793633

Dec 2nd, 2021 - Patients will undergo collection of pancreatic fluid by the LINFU™ Technique as part of this study. This procedure takes about 30-45 minutes. This procedure will be done in the beginning of the participant's standard of care endoscopic ultrasound procedure (EUS). The details for the procedure are listed below. LINFU™ Technique Once the participant is sedated or under anesthesia, low intensity n...

Gastroschisis Outcomes of Delivery (GOOD) Study
https://clinicaltrials.gov/ct2/show/NCT02774746

Dec 2nd, 2021 - Gastroschisis is the most common congenital abdominal wall abnormality in which the intestines are outside of body floating in the amniotic fluid. This is diagnosed by prenatal ultrasound at 18-20 weeks gestation. Gastroschisis occurs in 1 out of every 4000 births and the incidence is increasing. The majority of patients with gastroschisis have an uncomplicated neonatal course and recover well ...

Prolonged corrected QT interval in hospitalized patients with coronavirus disease 2019 ...
https://doi.org/10.1177/03000605211056834
The Journal of International Medical Research; Mohamed Ali S, Musa A et. al.

Dec 2nd, 2021 - To evaluate the association of a prolonged corrected QT (QTc) interval in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its association with in-patient mortality. A cohort of 745 patients were recruited from a single center between 1 March 2020 and 31 May 2020. We analyzed the factors associated with a prolonged QTc and mortality. A prolonged QTc interval >450 ms wa...