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About 24,480 results

Nuclear hormone receptors in demyelinating diseases.
https://doi.org/10.1111/jne.13171
Journal of Neuroendocrinology; Zorrilla Veloz RI, McKenzie T et. al.

Jun 24th, 2022 - Demyelination results from the pathological loss of myelin and is a hallmark of many neurodegenerative diseases. Despite the prevalence of demyelinating diseases, there are no disease modifying therapies that prevent the loss of myelin or promote remyelination. This review aims to summarize studies in the field that highlight the importance of nuclear hormone receptors in the promotion and main...

Overexpression of p-4EBP1 associates with p-eIF4E and predicts poor prognosis for non-s...
https://doi.org/10.1371/journal.pone.0265465
PloS One; Tang Y, Luo J et. al.

Jun 24th, 2022 - Eukaryotic initiation factor 4E (eIF4E) and its phosphorylated form (p-eIF4E) play a crucial role in the protein synthesis, both are under regulation of eIF4E-binding protein 1 (4EBP1) and mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs). This study aims to explore the potential prognostic significance of p-4EBP1 and p-eIF4E in NSCLC patients. The expression of p-4EBP1 and p-e...

Bergamottin, a bioactive component of bergamot, inhibits SARS-CoV-2 infection in golden...
https://doi.org/10.1016/j.antiviral.2022.105365
Antiviral Research; Zhou M, Liu Y et. al.

Jun 23rd, 2022 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused an ongoing pandemic, coronavirus disease-2019 (COVID-19), which has become a major global public health event. Antiviral compounds remain the predominant means of treating COVID-19. Here, we reported that bergamottin, a furanocoumarin originally found in bergamot, exhibited inhibitory activity against SARS-CoV-2 in vitro, e...

The Microbiota in Eosinophilic esophagitis: a systematic review.
https://doi.org/10.1111/jgh.15921
Journal of Gastroenterology and Hepatology; Angerami Almeida K, de Queiroz Andrade E et. al.

Jun 23rd, 2022 - Eosinophilic esophagitis (EoE) is an atopic disease of the esophagus that has shown a significant increase in incidence and prevalence in the last 20 years. The etiology of EoE is unclear, and few studies explore the esophageal microbiota in EoE. The local microbiome has been implicated in the pathogenesis of several allergic and inflammatory diseases, such as asthma and eczema. In this study, ...

DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Activates YAP Signaling and Confers Che...
https://doi.org/10.1158/0008-5472.CAN-22-0717
Cancer Research; Liu Z, Nan Y et. al.

Jun 23rd, 2022 - Squamous cell carcinomas (SCC) constitute a group of human malignancies that originate from the squamous epithelium. Most SCC patients experience treatment failure and relapse and have a poor prognosis due to de novo and acquired resistance to first-line chemotherapeutic agents. To identify chemoresistance mechanisms and explore novel targets for chemosensitization, we performed whole-transcrip...

Probing O-substituted Nifuroxazide analogues against Leishmania: Synthesis, in vitro ef...
https://doi.org/10.1016/j.ejps.2022.106242
European Journal of Pharmaceutical Sciences : Official Jo... Badenhorst GD, Kannigadu C et. al.

Jun 23rd, 2022 - Leishmaniasis is a neglected tropical disease affecting millions of people worldwide, with 650 000 to 1.1 million new infections reported annually by the World Health Organization. Current antileishmanial treatments are unsatisfactory due to the development of parasitic resistance and the toxicity associated with the drugs used, and this highlights the need for the development of new antileishm...

Psychological interventions for inflammatory bowel disease: a systematic review and com...
https://doi.org/10.1136/bmjopen-2021-056982
BMJ Open; Tiles-Sar N, Neuser J et. al.

Jun 23rd, 2022 - Patients with inflammatory bowel diseases (IBD) often report psychological problems, unemployment, disability, sick leave and compromised quality of life. The effect of psychological interventions on health-related outcomes in IBD is controversial as previous reviews faced the obstacle of high heterogeneity among provided multimodular interventions. The heterogeneity can be addressed with netwo...

Antineutrophil cytoplasmic antibodies in infective endocarditis: a case report and syst...
https://doi.org/10.1007/s10067-022-06240-w 10.1016/S0140-6736(15)00067-7 10.1093/eurheartj/ehv319 10.1001/jama.2015.3656 10.1177/0300060520963990 10.1155/2020/1607141 10.1097/MD.0000000000021358 10.1155/2020/8826956 10.1186/s13256-020-02373-1 10.14503/THIJ-17-6575 10.1093/rheumatology/kez648 10.1186/s12882-020-1694-2 10.1186/s13256-019-2287-1 10.1155/2018/9607582 10.12659/AJCR.909956 10.1002/ccr3.1589 10.1590/0037-8682-0042-2017 10.5414/CNCS109076 10.1016/j.ijscr.2017.01.041 10.1097/IPC.0000000000000384 10.1155/2016/3585860 10.1155/2015/649763 10.1093/ckj/sft165 10.1155/2014/569047 10.1093/ckj/sft030 10.4103/0971-4065.106057 10.1186/1471-2369-13-174 10.1159/000339409 10.1016/j.lpm.2012.07.031 10.2169/internalmedicine.51.8081 10.3109/03009742.2011.648656 10.1053/j.ajkd.2011.06.032 10.3899/jrheum.101322 10.1016/j.revmed.2010.12.017 10.1159/000228645 10.1007/s11255-007-9323-6 10.1007/s10067-005-0176-z 10.1067/mhl.2003.2 10.1093/ndt/13.8.2142 10.1093/clinids/21.4.1004 10.1016/0140-6736(91)91427-v 10.5430/crim.v3n2p29 10.1128/JCM.01095-07 10.1053/j.ajkd.2013.10.058 10.1016/S0140-6736(05)66701-3 10.5414/CN110202 10.5414/CN109495 10.5414/cnp62144 10.1155/2021/9951264 10.2169/internalmedicine.5608-20 10.1093/ndt/12.4.839 10.1097/INF.0000000000001510 10.2169/internalmedicine.55.7331 10.1007/s10165-011-0434-7 10.1097/RHU.0b013e318164187a 10.1002/1529-0131(200001)43:1<226::AID-ANR27>3.0.CO;2-Q 10.1093/ndtplus/sfr030 10.1371/journal.pone.0089777 10.1097/MD.0000000000002564 10.1136/bmjopen-2019-031512 10.1002/art.39046 10.1038/ki.2014.424 10.1007/s10067-010-1424-4 10.2215/CJN.05070516 10.1002/art.38389 10.1007/s10067-019-04636-9 10.1080/0886022X.2020.1803086 10.1097/MD.0000000000005096 10.7326/0003-4819-116-6-488 10.1007/s10067-017-3902-4 10.1002/acr.22723 10.1016/j.nefro.2018.10.014 10.1007/s00296-020-04704-3 10.1093/eurheartj/ehl427 10.1056/NEJM196601272740407 10.1038/s41572-020-0204-y 10.1016/j.kint.2018.01.013 10.1182/blood-2012-03-416156 10.1016/j.autrev.2021.102759 10.7326/0003-4819-120-1-199401010-00003 10.1093/rheumatology/kex001 10.1038/nm968 10.1016/j.berh.2012.12.003 10.1016/S1567-5769(03)00059-6 10.1136/annrheumdis-2016-209507 10.1128/CMR.15.4.613-630.2002
Clinical Rheumatology; Van Gool IC, Kers J et. al.

Jun 23rd, 2022 - Infective endocarditis (IE) may be misdiagnosed as ANCA-associated vasculitis (AAV), especially when antineutrophil cytoplasmic antibodies (ANCA) are detected. Distinguishing IE from AAV is crucial to guide therapy. However, little is known about ANCA positivity in IE patients. We present a case report and systematic review of the literature on patients with ANCA-positive IE, aiming to provide ...

17-Hydroxyprogesterone, Urine
https://emedicine.medscape.com/article/2097997-overview

Jun 23rd, 2022 - Reference Range The reference range of urinary 17-hydroxyprogesterone (17-OHPG) in children is as follows: [1, 2, 3] Age 3 days to 1 year: Up to 50 ng/24 hours Age 1-8 years: Up to 300 ng/24 hours The following is the reference of urinary 17-OHPG in adults: Males: Up to 2 µg/24 hours Females: Up to 4.5 µg/24 hours Next: Interpretation Elevated urinary 17-hydroxyprogesterone (17-OHPG) levels are...

17-Hydroxyprogesterone, Urine
https://emedicine.medscape.com/article/2097997-print

Jun 23rd, 2022 - The reference range of urinary 17-hydroxyprogesterone (17-OHPG) in children is as follows:[1, 2, 3] Age 3 days to 1 year: Up to 50 ng/24 hours Age 1-8 years: Up to 300 ng/24 hours The following is the reference of urinary 17-OHPG in adults: Males: Up to 2 µg/24 hours Females: Up to 4.5 µg/24 hours Elevated urinary 17-hydroxyprogesterone (17-OHPG) levels are associated with the following: Congen...

17-Hydroxyprogesterone, Urine
http://emedicine.medscape.com/article/2097997-overview

Jun 23rd, 2022 - Reference Range The reference range of urinary 17-hydroxyprogesterone (17-OHPG) in children is as follows: [1, 2, 3] Age 3 days to 1 year: Up to 50 ng/24 hours Age 1-8 years: Up to 300 ng/24 hours The following is the reference of urinary 17-OHPG in adults: Males: Up to 2 µg/24 hours Females: Up to 4.5 µg/24 hours Next: Interpretation Elevated urinary 17-hydroxyprogesterone (17-OHPG) levels are...

Psoralea corylifolia L. seed extract attenuates dexamethasone-induced muscle atrophy in...
https://doi.org/10.1016/j.jep.2022.115490
Journal of Ethnopharmacology; Seo E, Truong CS et. al.

Jun 22nd, 2022 - The seeds of Psoralea corylifolia (PCS), also called "Boh-Gol-Zhee" in Korean, have been used in traditional medicine. PCS is effective for the treatment of vitiligo, cancer, inflammatory diseases, neurodegenerative diseases, kidney diseases, and musculoskeletal diseases. In this study, we validated the beneficial effects of PCS extract on dexamethasone (DEX)-induced muscle atrophy in mice. DEX...

Vitamin C (Ascorbic Acid)
https://emedicine.medscape.com/article/2088649-overview

Jun 22nd, 2022 - Reference Range Vitamin C, also known as ascorbic acid, is a water-soluble vitamin. The reference range of vitamin C is 0.6-2 mg/dL. [1] Next: Interpretation Scurvy is caused by prolonged dietary deficiency of vitamin C (ascorbic acid). Vitamin C levels generally reflect recent intake amounts more than body stores. Vitamin C levels of less than 0.3 mg/dL indicate significant deficiency, while l...

Vitamin C (Ascorbic Acid)
https://emedicine.medscape.com/article/2088649-print

Jun 22nd, 2022 - Vitamin C, also known as ascorbic acid, is a water-soluble vitamin. The reference range of vitamin C is 0.6-2 mg/dL.[1] Scurvy is caused by prolonged dietary deficiency of vitamin C (ascorbic acid). Vitamin C levels generally reflect recent intake amounts more than body stores. Vitamin C levels of less than 0.3 mg/dL indicate significant deficiency, while levels that exceed 0.6 mg/dL indicate s...

Vitamin C (Ascorbic Acid)
http://emedicine.medscape.com/article/2088649-overview

Jun 22nd, 2022 - Reference Range Vitamin C, also known as ascorbic acid, is a water-soluble vitamin. The reference range of vitamin C is 0.6-2 mg/dL. [1] Next: Interpretation Scurvy is caused by prolonged dietary deficiency of vitamin C (ascorbic acid). Vitamin C levels generally reflect recent intake amounts more than body stores. Vitamin C levels of less than 0.3 mg/dL indicate significant deficiency, while l...

Moyamoya Disease Associated with a Deficiency of Complement Component 6.
https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106601
Journal of Stroke and Cerebrovascular Diseases : the Offi... Kato M, Kudo Y et. al.

Jun 20th, 2022 - Complement component 6 (C6) deficiency is a very rare genetic defect that leads to significantly diminished synthesis, secretion, or function of C6. In the current report, we demonstrate a previously undescribed, homozygous missense mutation in exon 17 of the C6 gene (c.2545A>G p.Arg849Gly) in a 35-year-old Japanese woman with moyamoya disease and extremely low levels of CH50 (<7.0 U/mL). The c...

The association between ambient UVB dose and ANCA-associated vasculitis relapse and onset.
https://doi.org/10.1186/s13075-022-02834-6 10.1093/ndt/gfv022 10.1056/NEJMoa1108735 10.1681/ASN.2016111260 10.1016/j.autrev.2020.102660 10.1136/ard.60.2.170 10.1136/ard.60.12.1156a 10.1111/j.1445-5994.2006.01297.x 10.1002/art.24790 10.1006/jhev.2000.0403 10.1562/0031-8655(2000)072<0488:AAIBOS>2.0.CO;2 10.1097/BOR.0b013e32835cfc16 10.1212/WNL.0b013e318216715e 10.1371/journal.pone.0222313 10.4049/jimmunol.178.1.145 10.1097/BOR.0b013e3280119842 10.1136/annrheumdis-2016-eular.2768 10.1080/08916930902960347 10.1016/j.msard.2016.10.005 10.3899/jrheum.160066 10.1111/bjd.14296 10.1111/php.13086 10.3945/jn.116.244079 10.1002/art.37715 10.1038/nrrheum.2017.140 10.1136/ard.2006.054593 10.1186/s12882-017-0797-x 10.1136/bmj.h1793 10.1210/jc.2010-2704 10.1002/art.34562 10.3899/jrheum.131038 10.1093/rheumatology/keu321 10.1093/oxfordjournals.aje.a115853 10.3945/ajcn.110.008490
Arthritis Research & Therapy; Scott J, Havyarimana E et. al.

Jun 19th, 2022 - The aetiology of ANCA-associated vasculitis (AAV) and triggers of relapse are poorly understood. Vitamin D (vitD) is an important immunomodulator, potentially responsible for the observed latitudinal differences between granulomatous and non-granulomatous AAV phenotypes. A narrow ultraviolet B spectrum induces vitD synthesis (vitD-UVB) via the skin. We hypothesised that prolonged periods of low...

The promising novel therapies for familial hypercholesterolemia.
https://doi.org/10.1002/jcla.24552
Journal of Clinical Laboratory Analysis; Chen R, Lin S et. al.

Jun 18th, 2022 - The incidence of premature atherosclerotic cardiovascular disease in familial hypercholesterolemia (FH) is high. In recent years, novel therapeutic modalities have shown significant lipid-lowering ability. In this paper, we summarize the recent developments in novel therapies for FH via the treatment of different targets and discuss the characteristics of each targeted therapy. Based on the pro...

PET/CT imaging of CSF1R in a mouse model of tuberculosis.
https://doi.org/10.1007/s00259-022-05862-1 10.1038/s41590-018-0119-x 10.1093/infdis/jit331 10.1021/acsinfecdis.9b00207 10.1007/s11307-015-0836-6 10.2967/jnumed.117.207431 10.1093/infdis/jiy373 10.1371/journal.pone.0039680 10.1016/S1473-3099(20)30148-1 10.1038/s41420-020-00350-7 10.1016/j.it.2018.11.007 10.1186/s40425-017-0257-y 10.1016/j.biopha.2018.04.046 10.1007/s11912-017-0634-1 10.1021/acs.jmedchem.7b00873 10.1016/S1470-2045(18)30143-8 10.1158/1078-0432.CCR-16-3261 10.1038/leu.2017.193 10.1158/1535-7163.MCT-16-0157 10.1073/pnas.1812155116 10.1093/infdis/jir786 10.1038/nature03419 10.1128/AAC.00789-09 10.1371/journal.pone.0006297 10.1021/bc050046n 10.1021/jm200900q 10.1016/bs.ctdb.2016.10.004 10.1186/1465-9921-14-41 10.1021/acsinfecdis.5b00127 10.1097/QAI.0000000000001823 10.1111/j.2041-1014.2010.00582.x 10.1038/s41380-019-0448-7 10.1371/journal.pone.0026317 10.1002/dvg.20219 10.3389/fcell.2019.00250 10.1002/jlcr.3806 10.1093/brain/awz241 10.1016/bs.pmbts.2019.04.005 10.18632/aging.101276 10.1007/s13311-016-0463-1 10.1016/S1474-4422(13)70260-6 10.1172/JCI120444 10.1158/1535-7163.MCT-09-0255 10.2174/1381612053381927 10.1155/2016/9582430 10.1016/j.jot.2017.05.007 10.3389/fonc.2018.00049
European Journal of Nuclear Medicine and Molecular Imaging; Foss CA, Ordonez AA et. al.

Jun 18th, 2022 - Macrophages represent an essential means of sequestration and immune evasion for Mycobacterium tuberculosis. Pulmonary tuberculosis (TB) is characterized by dense collections of tissue-specific and recruited macrophages, both of which abundantly express CSF1R on their outer surface. 4-Cyano-N-(5-(1-(dimethylglycyl)piperidin-4-yl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-2-yl)-1H-imidazole-2-carbo...

Aberrant mesenteric adipose extracellular matrix remodeling is involved in adipocyte dy...
https://doi.org/10.1093/ecco-jcc/jjac087
Journal of Crohn's & Colitis; Zuo L, Li J et. al.

Jun 17th, 2022 - Hypertrophic mesenteric adipose tissue [htMAT] is involved in the disease progression of Crohn's disease [CD] through expressing proinflammatory adipokines from dysfunctional adipocytes with unknown mechanism. Adipocyte function is affected by dynamic adipose tissue extracellular matrix [ECM] remodeling that is mainly mediated by macrophages, and our study aimed to reveal whether aberrant ECM r...