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About 205,608 results

Natural History and Development of Spondyloarthritis
https://clinicaltrials.gov/ct2/show/NCT01422694

Oct 14th, 2022 - The purpose of this protocol is to study the natural history of spondyloarthritis (SpA) in children and adults. Spondyloarthritis encompasses a spectrum of immune-mediated inflammatory diseases that exhibit overlapping features, but differ from other types of inflammatory arthritis in genetic predisposition, pathogenesis, and outcome. Ankylosing spondylitis (AS), the most common form of SpA, fr...

Antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot
https://www.biorxiv.org/content/10.1101/2022.10.22.513349v1
BioRxiv Wang Q, .

Oct 24th, 2022 - The SARS-CoV-2 Omicron variant and its numerous sub-lineages have exhibited a striking ability to evade humoral immune responses induced by prior vaccination or infection. The Food and Drug Administration (FDA) has recently granted Emergency Use Authorizations (EUAs) to new bivalent formulations of the original Moderna and Pfizer mRNA SARS-CoV-2 vaccines that target both the ancestral strain as...

Posttetanic potentiation improves neuromuscular efficiency of mouse muscle in vitro.
https://doi.org/10.14814/phy2.15529
Physiological Reports; Laidlaw R, Vandenboom R

Dec 4th, 2022 - Neuromuscular efficiency is defined as the ratio of work output to stimulation rate. The purpose of these experiments was to test the hypothesis that neuromuscular efficiency would be increased in proportion to posttetanic potentiation, that is, the stimulation-induced increase in work output displayed by rodent fast-twitch muscle. To this end, extensor digitorum longus muscles from wild-type a...

Tacrolimus ameliorates bleomycin-induced pulmonary fibrosis by inhibiting M2 macrophage...
https://doi.org/10.1016/j.intimp.2022.109424
International Immunopharmacology; Liu B, Jiang Q et. al.

Dec 4th, 2022 - Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown cause and characterized by excessive proliferation of fibroblasts and the irregular remodeling of extracellular matrix (ECM), which ultimately cause the severe distortion of the alveolar architecture. The median survival of IPF patients is 2-5 years. IPF patients are predominantly infiltrated by M2 macrophages...

Polycyclic Polyprenylated Acylphloroglucinols Bearing a Lavandulyl-Derived Substituent ...
https://doi.org/10.1021/acs.jnatprod.2c00888
Journal of Natural Products; Xu ZH, Grossman RB et. al.

Dec 4th, 2022 - Many type B polycyclic polyprenylated acylphloroglucinols (PPAPs) bear a lavandulyl-derived substituent, and the configurational assignment of this side chain can be difficult and sometimes leads to erroneous conclusions. In this study, 21 PPAPs, including the new xanthochymusones A-I (1-9), have been isolated from the fruits of Garcinia xanthochymus and structurally characterized. The relative...

Oxidative DNA damage by N4-hydroxycytidine, a metabolite of the SARS-CoV-2 antiviral mo...
https://doi.org/10.1093/infdis/jiac477
The Journal of Infectious Diseases; Kobayashi H, Mori Y et. al.

Dec 4th, 2022 - Molnupiravir is an antiviral agent recently used for treating COVID-19. Here, we demonstrate that N4-hydroxycytidine (NHC), a molnupiravir metabolite, treated with cytidine deaminase (CDA) induced Cu(II)-mediated oxidative DNA damage in isolated DNA. A colorimetric assay revealed hydroxylamine generation from CDA-treated NHC. The site specificity of DNA damage also suggested involvement of hydr...

Wnt inhibitors reduce the unfolded protein response and enhance bortezomib-induced cell...
https://doi.org/10.1182/bloodadvances.2022008442
Blood Advances; Spaan I, van Nieuwenhuijzen N et. al.

Dec 3rd, 2022 - Wnt inhibitors reduce the unfolded protein response and enhance bortezomib-induced cell death in multiple myeloma.|2022|Spaan I,van Nieuwenhuijzen N,Kimman T,Rockx-Brouwer D,Tieland RG,|

Durable medication-free remission of sarcoidosis following discontinuation of anti-tumo...
https://doi.org/10.1016/j.rmed.2022.107055
Respiratory Medicine; Yee AMF

Dec 3rd, 2022 - Monoclonal antibodies against tumor necrosis factor-alpha (TNF-α) have been used successfully in the treatment of sarcoidosis, but optimal duration of their use is unclear. Published studies have consistently suggested that withdrawal of therapy typically results in prompt disease relapse. The aim of this study is to identify and characterize patients with sarcoidosis in whom medication-free di...

Deciphering clinical abbreviations with a privacy protecting machine learning system.
https://doi.org/10.1038/s41467-022-35007-9
Nature Communications; Rajkomar A, Loreaux E et. al.

Dec 3rd, 2022 - Physicians write clinical notes with abbreviations and shorthand that are difficult to decipher. Abbreviations can be clinical jargon (writing "HIT" for "heparin induced thrombocytopenia"), ambiguous terms that require expertise to disambiguate (using "MS" for "multiple sclerosis" or "mental status"), or domain-specific vernacular ("cb" for "complicated by"). Here we train machine learning mode...

STMN2 overexpression promotes cell proliferation and EMT in pancreatic cancer mediated ...
https://doi.org/10.1038/s41417-022-00568-w
Cancer Gene Therapy; Shao M, Wang L et. al.

Dec 3rd, 2022 - STMN2, as a key regulator in microtubule disassembly and dynamics, has recently been shown to participate in cancer development. However, the corresponding role in pancreatic ductal adenocarcinoma (PC), to our knowledge, has not been reported yet. In the current study, we systematically investigate the potential role of STMN2 in the progression of PC in vitro and vivo. Overexpression of STMN2 w...

Cellular and Molecular Responses to Ethyl-Parathion in Undifferentiated SH-SY5Y Cells P...
https://doi.org/10.1093/toxsci/kfac125
Toxicological Sciences : an Official Journal of the Socie... Amar SK, Donohue KB et. al.

Dec 3rd, 2022 - High-fidelity non-animal screening methods are needed that can rapidly and accurately characterize organophosphorus compound (OP)-induced neurotoxicity. Herein, the efficacy of human neuroblastoma cell line (SH-SY5Y) to provide molecular and cellular responses characteristic of the OP neurotoxicity pathway was investigated in response to the OP-model compound, ethyl-parathion. Undifferentiated ...

Safety and potential efficacy of selective dorsal rhizotomy in adults with spinal cord ...
https://doi.org/10.1016/j.wneu.2022.11.127
World Neurosurgery; Oraee-Yazdani S, Tavanaei R et. al.

Dec 3rd, 2022 - Despite the abundant literature on the use of selective dorsal rhizotomy (SDR) in spastic cerebral palsy, no investigation has evaluated its use in adult patients with chronic spinal cord injury (SCI)-induced spasticity. The present investigation aimed to evaluate the safety and potential efficacy of SDR in chronic SCI-induced spasticity for the first time. In this open-label, single-arm, non-r...

Uncommon presentations of common variable immunodeficiency.
https://doi.org/10.1136/bcr-2022-250570
BMJ Case Reports; Alok A, Aslam S et. al.

Dec 3rd, 2022 - Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder that causes decreased immunity and increased susceptibility to infections. It affects B lymphocyte differentiation, resulting in predominantly bacterial and less frequently viral, fungal, and protozoal infections. The respiratory and gastrointestinal tracts where antibody defences are essential are usually affected. ...

Effect of the third dose of BNT162b2 COVID-19 mRNA vaccine on anti-SARS-CoV-2 antibody ...
https://doi.org/10.1016/j.vaccine.2022.11.049
Vaccine Tanaka H, Mukai J et. al.

Dec 3rd, 2022 - Administration of three doses of Pfizer-BioNTech BNT162b2 COVID-19 mRNA vaccine was completed in Japan in the spring of 2022. This study aimed to evaluate the antibody responses, and kinetics of three doses of vaccine in healthcare workers (HCWs). We conducted a longitudinal cohort study with HCWs, who had no history of COVID-19 or serologic evidence of SARS-CoV-2 infection, from a single hospi...

A randomized phase 3 trial to assess the immunogenicity and safety of 3 consecutively p...
https://doi.org/10.1016/j.vaccine.2022.10.056
Vaccine Turner Overton E, Schmidt D et. al.

Dec 3rd, 2022 - Since vaccination remains the only effective protection against orthopox virus-induced diseases such as smallpox or monkeypox, the strategic use and stockpiling of these vaccines remains of significant public health importance. The approved liquid-frozen formulation of Bavarian Nordic's Modified Vaccinia Ankara (MVA-BN) smallpox vaccine has specific cold-chain requirements, while the freeze-dri...

Eribulin normalizes pancreatic cancer-associated fibroblasts by simulating selected fea...
https://doi.org/10.1186/s12885-022-10330-y
BMC Cancer; Luong T, Cukierman E

Dec 3rd, 2022 - Less than 11% of pancreatic cancer patients survive 5-years post-diagnosis. The unique biology of pancreatic cancer includes a significant expansion of its desmoplastic tumor microenvironment, wherein cancer-associated fibroblasts (CAFs) and their self-produced extracellular matrix are key components. CAF functions are both tumor-supportive and tumor-suppressive, while normal fibroblastic cells...

Relationships between biological age, distance from aquatic habitats and pyrethroid res...
https://doi.org/10.1186/s12936-022-04389-y
Malaria Journal; Pinda PG, Msaky DS et. al.

Dec 3rd, 2022 - Malaria transmission can be highly heterogeneous between and within localities, and is influenced by factors such as survival and biting frequencies of Anopheles mosquitoes. This study investigated the relationships between the biological age, distance from aquatic habitats and pyrethroid resistance status of Anopheles funestus mosquitoes, which currently dominate malaria transmission in south-...

Glutamine promotes the proliferation of epithelial cells via mTOR/S6 pathway in oral li...
https://doi.org/10.1111/jop.13391
Journal of Oral Pathology & Medicine : Official Publicati... Hu J, Ling Z et. al.

Dec 3rd, 2022 - Although abnormal cell proliferation and apoptosis are associated with the pathogenesis of OLP, the exactly mechanism of which is not yet known. It has been reported that glutamine (Gln) can promote cell proliferation and inhibit apoptosis of various tumor cells. This study aims to evaluate the effect of Gln metabolism on the balance of proliferation and apoptosis in epithelial cells of OLP. 30...

Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis i...
https://doi.org/10.1371/journal.pgen.1010515
PLoS Genetics; Kang L, Dai J et. al.

Dec 3rd, 2022 - Millions of patients suffer from silicosis, but it remains an uncurable disease due to its unclear pathogenic mechanisms. Though the Nlrp3 inflammasome is involved in silicosis pathogenesis, inhibition of its classic downstream factors, Caspase-1 and Gsdmd, fails to block pyroptosis and cytokine release. To clarify the molecular mechanism of silicosis pathogenesis for new therapy, we examined s...

Discovery of STRO-002, a Novel Homogeneous ADC Targeting Folate Receptor Alpha, for the...
https://doi.org/10.1158/1535-7163.MCT-22-0322
Molecular Cancer Therapeutics; Li X, Zhou S et. al.

Dec 3rd, 2022 - STRO-002 is a novel homogeneous FolRα targeting antibody drug conjugate (ADC), currently being investigated in the clinic as a treatment for ovarian and endometrial cancers. Here we describe the discovery, optimization, and anti-tumor properties of STRO-002. STRO-002 was generated by conjugation of a novel cleavable 3-aminophenyl hemiasterlin linker-warhead (SC239) to the non-natural amino acid...