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About 169,830 results

The Omicron variant is highly resistant against antibody-mediated neutralization – implications for control of the COVID-19 pandemic
https://www.cell.com/cell/fulltext/S0092-8674(21)01495-1
Cell Hoffmann M, .

Dec 23rd, 2021 - The rapid spread of the SARS-CoV-2 Omicron variant suggests that the virus might become globally dominant. Further, the high number of mutations in the viral spike-protein raised concerns that the virus might evade antibodies induced by infection or vaccination. Here, we report that the Omicron spike was resistant against most therapeutic antibodies but remained susceptible to inhibition by Sot...

Novel biomarkers for acute respiratory distress syndrome: genetics, epigenetics and tra...
https://doi.org/10.2217/bmm-2021-0749
Biomarkers in Medicine; Zheng F, Pan Y et. al.

Jan 15th, 2022 - Acute respiratory distress syndrome (ARDS) can be induced by multiple clinical factors, including sepsis, acute pancreatitis, trauma, intestinal ischemia/reperfusion and burns. However, these factors alone may poorly explain the risk and outcomes of ARDS. Emerging evidence suggests that genomic-based or transcriptomic-based biomarkers may hold the promise to establish predictive or prognostic s...

MicroRNA-625-3p improved proliferation and involved chemotherapy resistance via targeti...
https://doi.org/10.1186/s13048-021-00939-1 10.1016/j.bbagen.2018.11.005 10.3390/ijerph16091510 10.1016/j.biopha.2018.03.043 10.1186/s13048-019-0484-6 10.1016/j.molmed.2014.06.005 10.1097/JTO.0b013e3182572e83 10.1038/srep41330 10.3892/ijmm_00000530 10.1186/s12943-016-0536-0 10.15252/embr.201948483 10.1016/j.molonc.2013.02.016 10.1038/bjc.2013.795 10.3389/fgene.2018.00555 10.1186/s13148-018-0587-8 10.1016/j.bbrc.2016.11.037 10.1097/PAP.0b013e3181b4fffa 10.1186/s13048-019-0482-8 10.1038/s41419-018-0390-7 10.1186/s13046-019-1171-6 10.7150/jca.41135 10.1016/j.omto.2018.12.002 10.1186/s13048-019-0576-3 10.1158/0008-5472.CAN-07-2488
Journal of Ovarian Research; Zhong L, Liu X et. al.

Jan 15th, 2022 - High-grade serous ovarian cancer (HGSOC) is an aggressive gynaecological malignancy and associated with poor prognosis. Here we examined the effects of miR-625-3p on proliferation, treatment, migration and invasion in HGSOC. The proliferation of HGSOC cells was evaluated by MTT assay. Transwell assay was performed to examine migration and matrigel assay were used to assess invasion. The effect ...

Additional heterologous versus homologous booster vaccination in immunosuppressed patie...
https://doi.org/10.1136/annrheumdis-2021-221558
Annals of the Rheumatic Diseases; Bonelli M, Mrak D et. al.

Jan 15th, 2022 - SARS-CoV-2-induced COVID-19 has led to exponentially rising mortality, particularly in immunosuppressed patients, who inadequately respond to conventional COVID-19 vaccination. In this blinded randomised clinical trial, we compare the efficacy and safety of an additional booster vaccination with a vector versus mRNA vaccine in non-seroconverted patients. We assigned 60 patients under rituximab ...

BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell ...
https://doi.org/10.1038/s41556-021-00821-8
Nature Cell Biology; Samelson AJ, Tran QD et. al.

Jan 15th, 2022 - SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to its cell-surface receptor ACE2. We conducted a targeted CRISPRi screen to uncover druggable pathways controlling Spike protein binding to human cells. Here we show that the protein BRD2 is required for ACE2 transcription in human lung epithelial cells and cardiomyocytes, and BRD2 inhibitors currently e...

Iron Deficiency in Inflammatory Bowel Disease Is Associated With Low Levels of Vitamin ...
https://doi.org/10.14309/ctg.0000000000000450 10.7754/Clin.Lab.2019.190918
Clinical and Translational Gastroenterology; Stallhofer J, Veith L et. al.

Jan 15th, 2022 - Iron deficiency and vitamin D deficiency are common comorbidities in inflammatory bowel disease (IBD). Accumulating evidence indicates that active 1,25-dihydroxyvitamin D (1,25(OH)D) may enhance iron absorption by suppressing hepcidin. We investigated the influence of vitamin D on iron metabolism in patients with IBD and on the expression of genes facilitating intestinal epithelial iron absorpt...

Immune checkpoint inhibitor-induced refractory polyarthritis rapidly improved by sarilu...
https://doi.org/10.1097/MD.0000000000028428
Medicine Abe K, Ishikawa Y et. al.

Jan 15th, 2022 - Immune checkpoint inhibitors (ICIs) have shown efficacy for the treatment of various kinds of malignant tumors. However, ICIs can cause immune-related adverse events, such as arthritis. Nevertheless, the treatment of ICI-induced arthritis has not been established yet. Here we report a case of ICI-induced polyarthritis successfully treated using sarilumab and monitored using joint ultrasonograph...

Detection of traumatic internal carotid artery pseudoaneurysm by postmortem imaging: A ...
https://doi.org/10.1097/MD.0000000000028544
Medicine Wan L, Song Y et. al.

Jan 15th, 2022 - Postmortem imaging (PMI), including computed tomography (PMCT), postmortem computed tomography angiography (PMCTA), and postmortem magnetic resonance imaging (PMMRI), is rapidly becoming effective and a practical method in forensic medicine. This study aimed to present a specific forensic case in which the PMI approach and its applications were used. A 40-year-old male patient had moderate unil...

Levofloxacin prophylaxis for pediatric leukemia patients: Longitudinal follow-up for im...
https://doi.org/10.1002/pbc.29525
Pediatric Blood & Cancer; Davis A, Stevens AM et. al.

Jan 15th, 2022 - Bloodstream infections (BSIs) cause morbidity and mortality in pediatric patients with leukemia. Antibiotic prophylaxis during periods of chemotherapy-induced neutropenia may reduce the incidence of BSIs. A levofloxacin prophylaxis guideline was implemented for pediatric patients with acute myeloid leukemia and relapsed acute lymphoblastic leukemia. We conducted a retrospective cohort study ove...

Disease-specific complications and multidisciplinary interventions in achondroplasia.
https://doi.org/10.1007/s00774-021-01298-z 10.1038/s41436-021-01287-7
Journal of Bone and Mineral Metabolism; Kitoh H, Matsushita M et. al.

Jan 15th, 2022 - Achondroplasia (ACH) is the most common skeletal dysplasia and characterized by a disproportionate short stature, macrocephaly with frontal bossing, exaggerated lumbar lordosis, and trident hands. It is induced by activated mutations in the fibroblast growth factor receptor 3 (FGFR3) gene. In addition to short stature, patients with ACH have a high prevalence of medical complications, including...

Cholinergic Receptor Imaging in Dystonia
https://clinicaltrials.gov/ct2/show/NCT02689466

Jan 14th, 2022 - Dystonia is a heterogeneous group of movement disorders characterized by abnormal muscle contractions resulting in abnormal postures and movements. The spectrum of dystonia includes focal, segmental, multifocal, and generalized presentations with a broad range of age of onset. An example of a focal dystonia is cervical dystonia. The pathophysiology of dystonia is unclear, but prior neuroimaging...

The Safety and Efficacy of Induced Hypertension and Hypervolemia in Preventing Neurolog...
https://doi.org/10.1016/j.wneu.2022.01.017
World Neurosurgery; Li Y, Wang AR et. al.

Jan 14th, 2022 - Perioperative management of blood pressure in patients undergoing surgical revascularization for moyamoya disease (MMD) remains a controversial topic. We evaluated the safety and efficacy of induced hypertension and hypervolemia (IHH) in preventing neurological complications during the perioperative period after direct surgical revascularization in a large hemorrhagic onset moyamoya disease (HO...

Glucose fluxes in glycolytic and oxidative pathways detected in vivo by deuterium magne...
https://doi.org/10.1016/j.nicl.2021.102932
NeuroImage. Clinical; Simões RV, Henriques RN et. al.

Jan 14th, 2022 - Glioblastoma multiforme (GBM), the most aggressive glial brain tumors, can metabolize glucose through glycolysis and mitochondrial oxidation pathways. While specific dependencies on those pathways are increasingly associated with treatment response, detecting such GBM subtypes in vivo remains elusive. Here, we develop a dynamic glucose-enhanced deuterium spectroscopy (DGE 2H-MRS) approach for d...

Inhibiting mitochondrial fission rescues degeneration in hereditary spastic paraplegia ...
https://doi.org/10.1093/brain/awab488
Brain : a Journal of Neurology; Chen Z, Chai E et. al.

Jan 14th, 2022 - Hereditary spastic paraplegias (HSPs) are characterized by lower limb spasticity resulting from degeneration of long corticospinal axons. SPG11 is one of the most common autosomal recessive HSPs, and the SPG11 protein spatacsin forms a complex with the SPG15 protein spastizin and heterotetrameric AP5 adaptor protein complex, which includes the SPG48 protein AP5Z1. Using the integration-free epi...

Analysis of the clinical characteristics of lamotrigine-induced haemophagocytic lymphoh...
https://doi.org/10.1111/jcpt.13602
Journal of Clinical Pharmacy and Therapeutics; Wang C, Fan Z et. al.

Jan 14th, 2022 - Lamotrigine is currently known to be related to haemophagocytic lymphohistiocytosis (HLH). Knowledge regarding the association between HLH and lamotrigine is mainly based on case reports. The purpose of this study was to evaluate the clinical characteristics of lamotrigine-induced HLH. We collected literature from 1994 to 31 August 2020 in Chinese and English on HLH induced by lamotrigine for r...

Ajmaline-Induced Abnormalities in Brugada Syndrome: Evaluation With ECG Imaging.
https://doi.org/10.1161/JAHA.121.024001
Journal of the American Heart Association; Pannone L, Monaco C et. al.

Jan 14th, 2022 - Background The rate of sudden cardiac death (SCD) in Brugada syndrome (BrS) is ≈1%/y. Noninvasive electrocardiographic imaging is a noninvasive mapping system that has a role in assessing BrS depolarization and repolarization abnormalities. This study aimed to analyze electrocardiographic imaging parameters during ajmaline test (AJT). Methods and Results All consecutive epicardial maps of the r...

Early and Very Early GRIM19 and MCL1 Expression Are Correlated to Late Acquired Prednis...
https://doi.org/10.1007/978-3-030-78787-5_20 10.1016/j.leukres.2009.04.018 10.1055/s-2001-16848 10.1001/jamaoncol.2019.5582 10.31557/apjcp.2019.20.9.2619 10.1002/ajh.25619 10.1007/s12185-019-02703-0 10.1007/s12185-019-02678-y 10.1182/blood.V70.3.860.860 10.1182/blood-2006-11-056366 10.1158/1078-0432.CCR-04-2097 10.1186/s10020-019-0106-1 10.2174/2589977512666200220122650 10.22034/apjcp.2018.19.8.2319 10.1038/cddis.2017.344 10.1016/S1567-5769(02)00081-4 10.2174/1389450003349056 10.1016/j.mce.2012.01.003 10.1177/1010428317694308 10.1371/journal.pone.0072326 10.1016/j.leukres.2015.04.012 10.1002/1097-0142(196611)19:11<1725::aid-cncr2820191142>3.0.co;2-t 10.1002/humu.20533 10.1097/00008571-200011000-00006 10.1093/nar/gki475 10.1093/nar/gkt439 10.1093/nar/gkx356 10.1002/cyto.990080101 10.1002/cyto.990080617 10.1007/s00432-004-0659-3 10.1074/jbc.M411767200 10.3324/haematol.10543 10.1038/s41419-018-0625-7 10.1038/s41375-018-0201-2 10.3390/cancers11111779 10.1016/j.bbrc.2020.02.165 10.3324/haematol.2013.093823 10.1016/j.ejca.2014.03.011 10.1016/S0960-0760(00)00161-8
Advances in Experimental Medicine and Biology; G L, Adamaki M et. al.

Jan 14th, 2022 - Glucocorticoids (GCs) are still first-line drugs for the treatment of childhood acute lymphoblastic leukemia (ALL). Prednisolone is a corticosteroid and one of the most important agents in the treatment of ALL. We report here a study of Prednisolone treatment using as a model a leukemia cell line with subsequent investigation of resistance-related gene expression. Gene silencing has been used i...

Inhibition of CXCR4 in Spinal Cord and DRG with AMD3100 Attenuates Colon-Bladder Cross-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747645
Drug Design, Development and Therapy; Zhang H, Dong X et. al.

Jan 14th, 2022 - Cross-sensitization of pelvic organs is one theory for why symptoms of gut sickness and interstitial cystitis/bladder pain syndrome overlap. Experimental colitis has been shown to trigger bladder hyperactivity and hyperalgesia in rats. The chemokine receptor CXCR4 plays a key role in bladder function and central sensitization. We aim to study the role of CXCR4 and its inhibitor AMD3100 in colon...

Boosting NAD+ blunts toll-like receptor-4 induced type-I interferon in control and syst...
https://doi.org/10.1172/JCI139828
The Journal of Clinical Investigation; Wu J, Singh K et. al.

Jan 14th, 2022 - Fasting and NAD+-boosting compounds including NAD+ precursor nicotinamide riboside (NR) confer anti-inflammatory effects. However, the underlying mechanisms and therapeutic potential are incompletely defined. We explored the underlying biology in myeloid cells from healthy volunteers following in-vivo placebo or NR administration and subsequently tested the findings in-vitro in monocytes extrac...

Diagnosis of Pulmonary Embolism on 99mTc-Labeled Macroaggregated Albumin Lung Imaging A...
https://doi.org/10.1097/RLU.0000000000004026
Clinical Nuclear Medicine; Frazzitta AE, Kay MD et. al.

Jan 14th, 2022 - A 54-year-old man with hepatocellular carcinoma from alcohol-induced cirrhosis presented with hepatic encephalopathy and refractory ascites related to decompensated liver disease. MRI confirmed disease progression adjacent the site of prior radiofrequency ablation, performed 2 years prior, with associated right hepatic vein tumor thrombus. 99mTc-labeled macroaggregated albumin lung shunt imagin...