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About 189,128 results

Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from th...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00327-0/fulltext
The Lancet; Menni C, .

Apr 7th, 2022 - On Nov 26, 2021, WHO designated the SARS-CoV-2 variant B.1.1.529 (omicron), first seen in South Africa, as a new variant of concern.1 Of the many mutations detected in omicron, more than 30 are in the spike protein and 15 are in the receptor-binding domain, which could affect transmission, disease presentation, and natural or vaccine-induced protective immunity.1 In the subsequent weeks, omicro...

Ambient air pollution and COVID-19 risk: Evidence from 35 observational studies
https://www.sciencedirect.com/science/article/pii/S0013935121013608?via=ihub
Environmental Research; Zang ST, .

Mar 30th, 2022 - Coronavirus disease 2019 (COVID-19) is induced by a previously undiscovered coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Lu et al., 2020). Since SARS-CoV-2 was first discovered in December 2019, as of April 25, 2021, more than four million fatalities have been attributed to COVID-19, accounting for approximately 2% of the infected cases (>214 million)...

Simultaneous Cases of Carfilzomib-Induced Thrombotic Microangiopathy in 2 Patients With Multiple Myeloma
https://www.mdedge.com/fedprac/avaho/article/255829/multiple-myeloma/simultaneous-cases-carfilzomib-induced-thrombotic
Nathaniel J. Myall, MD, Samantha X. Wang, MD et. al.

Jun 28th, 2022 - As a class of drugs, proteasome inhibitors are known to rarely cause drug-induced thrombotic microangiopathy (DITMA). In particular, carfilzomib is a second-generation, irreversible proteasome inhibitor approved for the treatment of relapsed, refractory multiple myeloma (MM) in combination with other therapeutic agents.

Tumor Necrosis Factor α Inhibitor–Induced Lupuslike Syndrome in a Patient Prescribed Certolizumab Pegol
https://www.mdedge.com/dermatology/article/255803/dermatopathology/tumor-necrosis-factor-inhibitor-induced-lupuslike
David Walton Crasto Jr, DO, Loren Touma, DO et. al.

Jun 28th, 2022 - To the Editor: Tumor necrosis factor α (TNF-α) inhibitor–induced lupuslike syndrome (TAILS) is a newly described entity that refers to the onset of subacute cutaneous lupus erythematosus (SCLE) during drug therapy with TNF-α antagonists. The condition is unique because it is thought to occur via a separate pathophysiologic mechanism than all other agents implicated in the development of drug-in.

Epigenetic rewiring of pathways related to odour perception in immune cells exposed to ...
https://doi.org/10.1080/15592294.2022.2089471
Epigenetics Huoman J, Sayyab S et. al.

Jun 28th, 2022 - A majority of SARS-CoV-2 recoverees develop only mild-to-moderate symptoms, while some remain completely asymptomatic. Although viruses, including SARS-CoV-2, may evade host immune responses by epigenetic mechanisms including DNA methylation, little is known about whether these modifications are important in defence against and healthy recovery from COVID-19 in the host. To this end, epigenome-...

A case of congenital fiber-type disproportion syndrome presenting dilated cardiomyopath...
https://doi.org/10.1002/mgg3.2008
Molecular Genetics & Genomic Medicine; Matsumoto A, Tsuda H et. al.

Jun 28th, 2022 - Actin, alpha, skeletal muscle 1 (ACTA1) is one of the causative genes of nemaline myopathy (NM) and congenital fiber-type disproportion (CFTD). CFTD is characterized by type 1 fiber atrophy and distinguished from NM in the absence of rods. Eight patients with CFTD, including one patient with dilated cardiomyopathy (DCM), have previously been reported. Herein, we report the case of a 10-year-old...

Biocompatibility of Human Induced Pluripotent Stem Cell-Derived Retinal Progenitor Cell...
https://doi.org/10.1177/09636897221104451
Cell Transplantation; Han IC, Bohrer LR et. al.

Jun 28th, 2022 - Loss of photoreceptor cells is a primary feature of inherited retinal degenerative disorders including age-related macular degeneration and retinitis pigmentosa. To restore vision in affected patients, photoreceptor cell replacement will be required. The ideal donor cells for this application are induced pluripotent stem cells (iPSCs) because they can be derived from and transplanted into the s...

Case report: hypoglycemia secondary to methimazole-induced insulin autoimmune syndrome ...
https://doi.org/10.1097/MD.0000000000029337
Medicine Wu HY, Chen IH et. al.

Jun 28th, 2022 - Hypoglycemia is an emergent condition with many causes, including underlying diabetes mellitus either with the use of insulin or oral anti-diabetic medications for glucose control, and organ (heart, hepatic, or renal) failure. Insulin autoimmune syndrome (IAS) can also cause hypoglycemia, however it is relatively difficult to diagnose as it is rare clinically. Although uncommon, IAS can be life...

Echinacoside Ameliorates Cyclophosphamide-Induced Bladder Damage in Mice.
https://doi.org/10.1089/jmf.2021.K.0194
Journal of Medicinal Food; Shao Y, Liu Y et. al.

Jun 28th, 2022 - Interstitial cystitis (IC) is featured by apoptosis and chronic inflammation in bladder tissue. We aimed to evaluate the effect of echinacoside (ECH), which is known to modulate inflammation and apoptosis on IC using relevant models. We established a mouse model of cystitis using cyclophosphamide (CYP) and treated human urothelium cells (SV-HUC-1) with lipopolysaccharide (LPS) + ATP as in vitro...

Immunogenicity and Safety of SpikoGen®, an Adjuvanted Recombinant SARS-CoV-2 Spike Prot...
https://doi.org/10.1111/imm.13540
Immunology Tabarsi P, Anjidani N et. al.

Jun 28th, 2022 - SpikoGen® is a subunit recombinant spike protein vaccine combined with Advax-CpG55.2™ adjuvant. This COVID-19 vaccine was shown to be safe, immunogenic, and efficacious in previous clinical trials. This study aimed to assess the safety and immunogenicity of SpikoGen® vaccine as a homologous and heterologous booster vaccination. This double-blind and randomized placebo-controlled (5:1) trial was...

Differential IL-12 signaling induces human natural killer cell activating receptor-medi...
https://doi.org/10.1084/jem.20212434
The Journal of Experimental Medicine; Shemesh A, Pickering H et. al.

Jun 28th, 2022 - IL-12 is an essential cytokine involved in the generation of memory or memory-like NK cells. Mouse cytomegalovirus infection triggers NK receptor-induced, ligand-specific IL-12-dependent NK cell expansion, yet specific IL-12 stimulation ex vivo leading to NK cell proliferation and expansion is not established. Here, we show that IL-12 alone can sustain human primary NK cell survival without pro...

Possible levetiracetam-induced aseptic meningitis versus viral meningitis: Case report ...
https://doi.org/10.1097/01.NPR.0000843216.79693.7e
The Nurse Practitioner; Vickery SB, Roach JK et. al.

Jun 28th, 2022 - Possible levetiracetam-induced aseptic meningitis versus viral meningitis: Case report and literature review.|2022|Vickery SB,Roach JK,Parsons C,Vickery PB,|

Circ_0000523 regulates miR-1184/COL1A1/PI3K/Akt pathway to promote nasopharyngeal carci...
https://doi.org/10.1007/s10495-022-01743-y 10.1093/jnci/djz044 10.1259/bjr.20190209 10.1371/journal.pgen.1008325 10.3389/fonc.2021.654871 10.7150/thno.42174 10.1038/onc.2017.361 10.1016/j.cca.2020.05.029 10.2147/OTT.S249202 10.1371/journal.pbio.2004880 10.1186/s13046-019-1023-4 10.1002/cam4.2650 10.1016/j.canlet.2021.10.003 10.3389/fcell.2022.841017 10.1016/j.prp.2022.153820 10.12659/MSM.915624 10.1016/S0140-6736(19)30956-0 10.7150/jca.30757 10.1038/nrc.2017.99 10.1007/s12282-017-0793-9 10.18632/aging.103963 10.1016/j.yexmp.2019.104288 10.1590/1414-431x20187811 10.1007/s11010-020-03835-2 10.1016/j.mcp.2020.101625 10.1111/jcmm.15590 10.2147/OTT.S259033 10.3892/ol.2020.11594 10.2147/OTT.S249667
Apoptosis : an International Journal on Programmed Cell D... Huang P, Li M et. al.

Jun 28th, 2022 - The present study is to investigate the biological functions and mechanisms of circular RNA_0000523 (circ_0000523) in nasopharyngeal carcinoma (NPC). Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was conducted to examine the expression levels of circ_0000523 and microRNA-1184 (miR-1184) in NPC tissues and cells. Collagen type 1 alpha 1 chain (COL1A1) expression was asse...

mTOR pathway mediates endoplasmic reticulum stress-induced CD4+ T cell apoptosis in sep...
https://doi.org/10.1007/s10495-022-01740-1 10.1016/S1473-3099(19)30567-5 10.1097/SHK.0000000000000234 10.1056/NEJMra021333 10.1038/nri3552 10.1159/000135631 10.1096/fj.06-6805com 10.1016/j.bbadis.2017.02.015 10.1038/srep01142 10.1101/cshperspect.a013169 10.1016/j.bbamcr.2013.06.028 10.1016/j.tibs.2015.01.002 10.1016/j.joca.2014.04.025 10.1161/CIRCRESAHA.110.227819 10.1038/nrd2755 10.1016/j.cell.2017.02.004 10.1038/nrm3025 10.1038/cdd.2011.98 10.1016/j.molcel.2007.12.023 10.1038/nrdp.2016.35 10.1080/21505594.2019.1685151 10.1038/nprot.2008.214 10.1155/2018/4798209 10.1016/j.intimp.2019.106049 10.1093/infdis/jit036 10.1155/2015/591572 10.1093/mutage/ges080 10.18632/oncotarget.5492 10.1001/jama.2016.0287 10.1097/00003246-199907000-00002 10.1016/j.phrs.2016.07.019 10.1038/sj.cdd.4401817 10.1038/sj.embor.7400779 10.1016/j.fob.2014.07.006 10.1038/s41598-017-16662-1 10.3389/fcell.2021.695041 10.1126/science.1226191 10.1016/j.cell.2009.07.017 10.1016/j.mce.2015.02.016 10.1074/jbc.M114.594028 10.1097/SHK.0000000000000367 10.1111/ajt.12711 10.1097/SHK.0000000000000373 10.1158/2326-6066.CIR-17-0081 10.1189/jlb.6A0214-097R 10.3389/fphys.2021.653601
Apoptosis : an International Journal on Programmed Cell D... Bai G, Wang H et. al.

Jun 28th, 2022 - Endoplasmic reticulum stress (ERS) has been well documented to participate in the pathophysiological processes of apoptosis in many diseases. Inhibition of ERS ameliorates pathological organ injury. However, the upstream signaling pathways and molecular regulatory mechanisms of which are still unknown. mTOR, an evolutionarily conserved protein kinase, is a key regulator of apoptosis. Hence, in ...

RNF213 loss of function reshapes vascular transcriptome and spliceosome leading to disr...
https://doi.org/10.1177/0271678X221110679
Journal of Cerebral Blood Flow and Metabolism : Official ... Zhang L, Rashad S et. al.

Jun 28th, 2022 - RNF213 gene mutations are the cause behind Moyamoya disease, a rare cerebrovascular occlusive disease. However, the function of RNF213 in the vascular system and the impact of its loss of function are not yet comprehended. To understand RNF23 function, we performed gene knockdown (KD) in vascular cells and performed various phenotypical analysis as well as extensive transcriptome and epitranscr...

Mesenchymal Stem Cell-derived Extracellular Vesicles Prevent Experimental Bronchopulmon...
https://doi.org/10.1093/stcltm/szac041
Stem Cells Translational Medicine; Sharma M, Bellio MA et. al.

Jun 28th, 2022 - Mesenchymal stem cell (MSC) extracellular vesicles (EVs) have beneficial effects in preclinical bronchopulmonary dysplasia and pulmonary hypertension (BPD-PH) models. The optimal source, dosing, route, and duration of effects are however unknown. The objectives of this study were to (a) compare the efficacy of GMP-grade EVs obtained from Wharton's Jelly MSCs (WJ-MSCs) and bone marrow (BM-MSCs),...

An alternative way of SARS-COV-2 to induce cell stress and elevated DNA damage risk in ...
https://doi.org/10.1002/iid3.638
Immunity, Inflammation and Disease; Zhou H, Ren X et. al.

Jun 28th, 2022 - The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in 2020 has led to millions of deaths worldwide. Case reports suggested that infection of SARS-CoV-2 is potentially associated with occurrences of cardiovascular pathology. However, the mode of action and mechanisms of SARS-CoV-2 influencing cardiomyocytes still remain largely unclear. To explore the mechanisms underly...

A Limited Role for AMD3100 Induced Stem Cell Mobilization for Modulation of Thoracic Tr...
https://doi.org/10.1097/SHK.0000000000001933
Shock (Augusta, Ga.); Vogel M, Möhrle B et. al.

Jun 28th, 2022 - Thoracic trauma is a major cause of mortality due to the associated inflammatory acute respiratory distress syndrome and morbidity due to impaired tissue regeneration. Trauma-induced lung inflammation is characterized by the early recruitment of cells with pro- or anti-inflammatory activity to the lung. Therapeutic interventions reducing the level of tissue inflammation may result in decreased ...

Bilateral Emphysematous Pyelonephritis Associated with COVID Pneumonia: A Case Report.
https://doi.org/10.12659/AJCR.936370
The American Journal of Case Reports; Savić S, Pejović T et. al.

Jun 28th, 2022 - BACKGROUND 0ptviral pneumonia and bilateral emphysematous pyelonephritis create a rapid acute respiratory distress syndrome. CASE REPORT A 59-year-old diabetic man with altered awareness was admitted as an emergency due to fever, shivering, and pain in the lap. Based on the accurate diagnosis, we concluded that the patient had bilateral emphysematous pyelonephritis, as well as inflammatory chan...

Male Marfan mice are predisposed to high fat diet induced obesity, diabetes, and fatty ...
https://doi.org/10.1152/ajpcell.00062.2022
American Journal of Physiology. Cell Physiology; Tiedemann K, Muthu ML et. al.

Jun 28th, 2022 - Gene mutations in the extracellular matrix protein fibrillin-1 cause connective tissue disorders including Marfan syndrome (MFS) with clinical symptoms in the cardiovascular, skeletal, and ocular systems. MFS patients also exhibit alterations in adipose tissues, which in some individuals leads to lipodystrophy, whereas in others to obesity. We have recently demonstrated that fibrillin-1 regulat...