×
About 52,573 results

HDAC6 modulates myofibril stiffness and diastolic function of the heart.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106344
The Journal of Clinical Investigation; Lin YH, Major JL et. al.

May 17th, 2022 - Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD), while augmented titin compliance appears to impair systolic performance in dilated cardiomyopathy. We found that myofibril stiffness was elevated in mice lacking histone...

Interaction of Pelargonium sidoides Compounds with Lactoferrin and SARS-CoV-2: Insights...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101775
International Journal of Environmental Research and Publi... Iacovelli F, Costanza G et. al.

May 15th, 2022 - (1) Background: Pelargonium sidoides extracts and lactoferrin are two important natural, anti-inflammatory, and antiviral agents, which can interfere with the early stages of SARS-CoV-2 infection. Molecular docking and molecular dynamics simulation approaches have been applied to check for the occurrence of interactions of the Pelargonium sidoides compounds with lactoferrin and with SARS-CoV-2 ...

Substrate recognition and cryo-EM structure of the ribosome-bound TAC toxin of Mycobact...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098466
Nature Communications; Mansour M, Giudice E et. al.

May 14th, 2022 - Toxins of toxin-antitoxin systems use diverse mechanisms to control bacterial growth. Here, we focus on the deleterious toxin of the atypical tripartite toxin-antitoxin-chaperone (TAC) system of Mycobacterium tuberculosis, whose inhibition requires the concerted action of the antitoxin and its dedicated SecB-like chaperone. We show that the TAC toxin is a bona fide ribonuclease and identify exa...

The monoterpene 1,8-cineole prevents cerebral edema in a murine model of severe malaria.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098050
PloS One; Santos ECD, Silva LS et. al.

May 14th, 2022 - 1,8-Cineole is a naturally occurring compound found in essential oils of different plants and has well-known anti-inflammatory and antimicrobial activities. In the present work, we aimed to investigate its potential antimalarial effect, using the following experimental models: (1) the erythrocytic cycle of Plasmodium falciparum; (2) an adhesion assay using brain microvascular endothelial cells;...

Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal ant...
https://doi.org/10.1073/pnas.2120976119
Proceedings of the National Academy of Sciences of the Un... Torres JL, Ozorowski G et. al.

May 14th, 2022 - SignificanceClinical candidate monoclonal antibody J08 binds the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S-protein independent of known escape mutations and is able to potently neutralize most variants of concern (VoCs). Here, we explore these properties using cell-based assays and structural studies. A relatively small epitope footprint high on the receptor binding domain ...

Bendamustine: A review of pharmacology, clinical use and immunological effects (Review).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100486
Oncology Reports; Lalic H, Aurer I et. al.

May 5th, 2022 - Bendamustine is an alkylating agent classified into the group of nitrogen mustard analogues, synthesized almost sixty years ago. It was registered in former East Germany in 1971 and approved by the US Food and Drug Administration in 2008 for treatment of chronic lymphocytic leukemia and indolent B‑cell non‑Hodgkin lymphoma. Considering its beneficial properties in the therapy of relapsed or ref...

Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes...
https://doi.org/10.1158/1940-6207.CAPR-21-0529
Cancer Prevention Research (Philadelphia, Pa.); Vageli DP, Doukas PG et. al.

May 4th, 2022 - Tobacco smoking is the most known risk factor for hypopharyngeal cancer. Bile reflux has recently been documented as an independent risk factor for NFκB-mediated hypopharyngeal squamous cell carcinoma. However, the carcinogenic effect of tobacco smoke on the hypopharynx and its combination with bile has not yet been proven by direct evidence. We investigated whether in vivo chronic exposure (12...

Involvement of IL-26 in bronchiolitis obliterans syndrome but not in acute rejection af...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063324
Respiratory Research; Magnusson JM, Ericson P et. al.

May 4th, 2022 - The main long-term complication after lung transplantation is bronchiolitis obliterans syndrome (BOS), a deadly condition in which neutrophils may play a critical pathophysiological role. Recent studies show that the cytokine interleukin IL-26 can facilitate neutrophil recruitment in response to pro-inflammatory stimuli in the airways. In this pilot study, we characterized the local involvement...

Crystal structures of BMPRII extracellular domain in binary and ternary receptor comple...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064986
Nature Communications; Guo J, Liu B et. al.

May 4th, 2022 - Heterozygous mutations in BMPR2 (bone morphogenetic protein (BMP) receptor type II) cause pulmonary arterial hypertension. BMPRII is a receptor for over 15 BMP ligands, but why BMPR2 mutations cause lung-specific pathology is unknown. To elucidate the molecular basis of BMP:BMPRII interactions, we report crystal structures of binary and ternary BMPRII receptor complexes with BMP10, which contai...

Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main prote...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046211
Nature Communications; Kneller DW, Li H et. al.

Apr 29th, 2022 - Emerging SARS-CoV-2 variants continue to threaten the effectiveness of COVID-19 vaccines, and small-molecule antivirals can provide an important therapeutic treatment option. The viral main protease (Mpro) is critical for virus replication and thus is considered an attractive drug target. We performed the design and characterization of three covalent hybrid inhibitors BBH-1, BBH-2 and NBH-2 cre...

Surface-enhanced Raman scattering from an electromagnetic induced transparency substrat...
https://doi.org/10.1364/OE.455350
Optics Express; Ren S, Zhao Y et. al.

Apr 28th, 2022 - Surface-enhanced Raman scattering (SERS) is a powerful analytical method that is especially suitable for the detection of protein molecules. Detection sensitivity of SERS is directly related to the enhancement factor of the substrate, which is dependent on the strength of a local surface electric field generated by surface plasmonic resonance from substrate. In this study, an electromagnetic in...

Designing and characterization of a SARS-CoV-2 immunogen with receptor binding motif gr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033297
International Journal of Biological Macromolecules; Khatri R, Parray HA et. al.

Apr 27th, 2022 - The COVID-19 pandemic caused by SARS-CoV-2 has a significant burden on the economy and healthcare around the world. Vaccines are the most effective tools to fight infectious diseases by containing the spread of the disease. The current vaccines against SARS-CoV-2 are mostly based on the spike protein of SARS-CoV-2, which is large and has many immune-dominant non-neutralizing epitopes that may e...

Effect of Ramadan intermittent fasting on inflammatory markers, disease severity, depre...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036734
BMC Gastroenterology; Negm M, Bahaa A et. al.

Apr 26th, 2022 - Intermittent fasting (IF) during the month of Ramadan is part of the religious rituals of Muslims. The effect of intermittent fasting on disease activity in inflammatory bowel diseases (IBD) is still unknown. This is the first study to assess the effect of IF during Ramadan on inflammatory markers in patients diagnosed with IBD. The effects on clinical disease activity, quality of life, and lev...

Isolation, characterization, and structure-based engineering of a neutralizing nanobody...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020654
International Journal of Biological Macromolecules; Li T, Zhou B et. al.

Apr 24th, 2022 - SARS-CoV-2 engages with human cells through the binding of its Spike receptor-binding domain (S-RBD) to the receptor ACE2. Molecular blocking of this engagement represents a proven strategy to treat COVID-19. Here, we report a single-chain antibody (nanobody, DL4) isolated from immunized alpaca with picomolar affinity to RBD. DL4 neutralizes SARS-CoV-2 pseudoviruses with an IC50 of 0.101 μg mL-...

Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimet...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015912
Drug Design, Development and Therapy; Zhu J, Zhang H et. al.

Apr 23rd, 2022 - Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently poses a threat to human health. 3C-like proteinase (3CLpro) plays an important role in the viral life cycle. Hence, it is considered an attractive antiviral target protein. Whole-genome sequencing showed that the sequence homology between SARS-CoV-2 3CLpro and SARS-CoV 3CLpro is ...

Structural basis of protein substrate processing by human mitochondrial high-temperatur...
https://doi.org/10.1073/pnas.2203172119
Proceedings of the National Academy of Sciences of the Un... Toyama Y, Harkness RW et. al.

Apr 23rd, 2022 - SignificanceProtein aggregates are often toxic, leading to impaired cellular activities and disease. The human HtrA2 trimeric enzyme cleaves such aggregates, and mutations in HtrA2 are causative for various neurodegenerative disorders, such as Parkinson's disease and essential tremor. The mechanism by which cleavage occurs has been studied using small peptides, but little information is availab...

Computational prediction of potential inhibitors for SARS-COV-2 main protease based on ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032443
PloS One; Gomes IS, Santana CA et. al.

Apr 23rd, 2022 - The development of new drugs is a very complex and time-consuming process, and for this reason, researchers have been resorting heavily to drug repurposing techniques as an alternative for the treatment of various diseases. This approach is especially interesting when it comes to emerging diseases with high rates of infection, because the lack of a quickly cure brings many human losses until th...

An in-silico study of the mutation-associated effects on the spike protein of SARS-CoV-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022835
PloS One; Shishir TA, Jannat T et. al.

Apr 22nd, 2022 - The emergence of Omicron (B.1.1.529), a new Variant of Concern in the COVID-19 pandemic, while accompanied by the ongoing Delta variant infection, has once again fueled fears of a new infection wave and global health concern. In the Omicron variant, the receptor-binding domain (RBD) of its spike glycoprotein is heavily mutated, a feature critical for the transmission rate of the virus by intera...

Occurrence of a novel cleavage site for cathepsin G adjacent to the polybasic sequence ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015119
PloS One; Mustafa Z, Kalbacher H et. al.

Apr 19th, 2022 - The serine proteases neutrophil elastase (NE), proteinase 3 (PR3), cathepsin G (CatG), and neutrophil serine protease 4 (NSP4) are secreted by activated neutrophils as a part of the innate immune response against invading pathogens. However, these serine proteases might be adopted by viruses to mediate viral surface protein priming resulting in host cell entrance and productive infection. Indee...

The relationship among integrin alpha 7, CD133 and Nestin as well as their correlation ...
https://doi.org/10.1016/j.clineuro.2022.107198
Clinical Neurology and Neurosurgery; Li C, Liu J et. al.

Apr 18th, 2022 - Integrin alpha 7 (ITGA7), a potential glioma stem cell marker, regulates several other stem cell markers including CD133 and Nestin in several cancers, meanwhile its high expression is related to poor prognosis in multiple solid tumor patients. However, few studies report correlation of ITGA7 with prognosis in astrocytoma patients. Hence, this study aimed to determine the astrocytoma-tissue ITG...