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About 53,645 results

Traditional herbs against COVID-19: back to old weapons to combat the new pandemic.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510171
European Journal of Medical Research; Al-Kuraishy HM, Al-Fakhrany OM et. al.

Sep 27th, 2022 - Recently, the coronavirus (COVID-19) pandemic is a chief public health disaster caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There are no established effective preventive or therapeutic anti-COVID-19 drugs available except for some recently approved vaccines. Still, countless recent studies recommend various alternative and complementary approaches against COVID-19, w...

Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509318
Nature Communications; Ko KT, Lennartz F et. al.

Sep 25th, 2022 - An effective malaria vaccine remains a global health priority and vaccine immunogens which prevent transmission of the parasite will have important roles in multi-component vaccines. One of the most promising candidates for inclusion in a transmission-blocking malaria vaccine is the gamete surface protein Pfs48/45, which is essential for development of the parasite in the mosquito midgut. Indee...

Estimation of the Frequency and Time of Human Exposure to Arsenic by Single Hair Analysis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517363
International Journal of Environmental Research and Publi... Li B, Xu W et. al.

Sep 24th, 2022 - Arsenic (As) and its compounds are widely used in many applications. Long-term exposure to As can cause acute and chronic poisoning. In severe cases, it can lead to adverse effects, such as gene mutation, cell cancer and fetal malformation. The objective of this study was to accurately estimate As exposure frequency and time. Quantitative analysis of As in single hairs obtained from APL (acute ...

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the pre...
https://doi.org/10.1073/pnas.2210990119
Proceedings of the National Academy of Sciences of the Un... Yang K, Wang C et. al.

Sep 20th, 2022 - Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge currently available coronavirus disease 2019 vaccines and monoclonal antibody therapies through epitope change on the receptor binding domain of the viral spike glycoprotein. Hence, there is a specific urgent need for alternative antivirals that target processes less likely to be affected by mutation, such as the...

Identification of Drug Combination Therapies for SARS-CoV-2: A Molecular Dynamics Simul...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469804
Drug Design, Development and Therapy; Abdel-Halim H, Hajar M et. al.

Sep 17th, 2022 - The development of effective treatments for coronavirus infectious disease 19 (COVID-19) caused by SARS-Coronavirus-2 was hindered by the little data available about this virus at the start of the pandemic. Drug repurposing provides a good strategy to explore approved drugs' possible SARS-CoV-2 antiviral activity. Moreover, drug synergism is essential in antiviral treatment due to improved effi...

DOTAREM (DOTA)-Gold-Nanoparticles: Design, Spectroscopic Evaluation to Build Hybrid Con...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469803
International Journal of Nanomedicine; Khan M, Liu H et. al.

Sep 17th, 2022 - The realization of MRI contrast agents through chemical protocols of functionalization is a strong domain of research. In this work, we developed and formulated a novel hybrid gold nanoparticle system in which a gold salt (HAuCl4) is combined with dotarem, an MRI contrast agent (DOTA) by chelation (Method IN) and stabilized by a lactose-modified chitosan polymer (CTL; Chitlac) to form DOTA IN-C...

ALS mutations in the TIA-1 prion-like domain trigger highly condensed pathogenic struct...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499527
Proceedings of the National Academy of Sciences of the Un... Sekiyama N, Takaba K et. al.

Sep 17th, 2022 - T cell intracellular antigen-1 (TIA-1) plays a central role in stress granule (SG) formation by self-assembly via the prion-like domain (PLD). In the TIA-1 PLD, amino acid mutations associated with neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) or Welander distal myopathy (WDM), have been identified. However, how these mutations affect PLD self-assembly properties has r...

A self-assembled bilayer polypeptide-engineered hydrogel for spatiotemporal modulation ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479290
Journal of Nanobiotechnology; Xie X, Wei J et. al.

Sep 16th, 2022 - Drug resistance of pathogens and immunosuppression are the main causes of clinical stagnation of osteomyelitis. The ideal treatment strategy for osteomyelitis is to achieve both efficient antibacterial and bone healing through spatiotemporal modulation of immune microenvironment. In this study, a bilayer hydrogel based on genetically engineered polypeptide AC10A and AC10ARGD was prepared by sel...

Formulating Ternary Inclusion Complex of Sorafenib Tosylate Using β-Cyclodextrin and Hy...
https://doi.org/10.1208/s12249-022-02406-6
AAPS PharmSciTech; Donthi MR, Munnangi SR et. al.

Sep 16th, 2022 - Sorafenib tosylate (SFNT) is the first-line drug for hepatocellular carcinoma. It exhibits poor solubility leading to low oral bioavailability subsequently requiring intake of large quantities of drug to exhibit desired efficacy. The present investigation was aimed at enhancing the solubility and dissolution rate of SFNT using complexation method. The binary inclusion complex was prepared with ...

Design and development of a self-assembling protein nanoparticle displaying PfHAP2 anti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467374
PloS One; Zahedi F, Abouie Mehrizi A et. al.

Sep 13th, 2022 - In order to move towards the elimination and eradication of malaria in the world, the development of vaccines is inevitable. Many modern vaccines are based on recombinant technology; however, they may not provide a fully protective, long-lasting immune response. One of the strategies to improve recombinant vaccines is designing the nanovaccines such as self-assembling protein nanoparticles (SAP...

In vivo Detection of Macromolecule Free Radicals in Mouse Sepsis-Associated Encephalopa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444031
International Journal of Nanomedicine; Liu H, Ma C et. al.

Sep 9th, 2022 - Free radicals in oxidative stress are known to play a pathogenic role in sepsis. A major clinical challenge associated with sepsis is sepsis-associated encephalopathy (SAE). The rapid increase of free radicals in the brain promotes SAE progression. Here, macromolecule free radicals in the mouse brain were uniquely detected by immunospin trapping (IST) and magnetic resonance imaging (MRI). The n...

Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481167
PLoS Pathogens; Thébault S, Lejal N et. al.

Sep 7th, 2022 - The binding of the SARS-CoV-2 spike to angiotensin-converting enzyme 2 (ACE2) promotes virus entry into the cell. Targeting this interaction represents a promising strategy to generate antivirals. By screening a phage-display library of biosynthetic protein sequences build on a rigid alpha-helicoidal HEAT-like scaffold (named αReps), we selected candidates recognizing the spike receptor binding...

Clinical characteristics and outcomes in those with primary extrahepatic malignancy and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446745
BMC Gastroenterology; Alshuwaykh O, Cheung A et. al.

Sep 6th, 2022 - Malignancy-related ascites accounts for approximately 10% of causes of ascites. Our AIM was to characterize the ascites fluid and correlate clinical outcomes in those with extrahepatic malignancy and ascites. 241 subjects with extrahepatic solid tumors and ascites were reviewed from 1/1/2000 to 12/31/2019, 119 without liver metastasis and 122 with liver metastasis. Ascites fluid consistent with...

Novel eIF4A1 inhibitors with anti-tumor activity in lymphoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441068
Molecular Medicine (Cambridge, Mass.); Kayastha F, Herrington NB et. al.

Sep 5th, 2022 - Deregulated translation initiation is implicated extensively in cancer initiation and progression. It is actively pursued as a viable target that circumvents the dependency on oncogenic signaling, a significant factor in current strategies. Eukaryotic translation initiation factor (eIF) 4A plays an essential role in translation initiation by unwinding the secondary structure of messenger RNA (m...

In silico designing of a novel epitope-based candidate vaccine against Streptococcus pn...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440865
Journal of Translational Medicine; Bahadori Z, Shafaghi M et. al.

Sep 5th, 2022 - Streptococcus pneumoniae is the leading reason for invasive diseases including pneumonia and meningitis, and also secondary infections following viral respiratory diseases such as flu and COVID-19. Currently, serotype-dependent vaccines, which have several insufficiency and limitations, are the only way to prevent pneumococcal infections. Hence, it is plain to need an alternative effective stra...

X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cle...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440467
Nature Communications; Lee J, Kenward C et. al.

Sep 4th, 2022 - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the pathogen that causes COVID-19, produces polyproteins 1a and 1ab that contain, respectively, 11 or 16 non-structural proteins (nsp). Nsp5 is the main protease (Mpro) responsible for cleavage at eleven positions along these polyproteins, including at its own N- and C-terminal boundaries, representing essential processing events for...

A Selective Reduction of Osteosarcoma by Mitochondrial Apoptosis Using Hydroxyapatite N...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423115
International Journal of Nanomedicine; Wu H, Liu S et. al.

Sep 2nd, 2022 - In recent years, using hydroxyapatite nanoparticles (HANPs) for tumor therapy attracted increasing attention because HANPs were found to selectively suppress the growth of tumor cells but exhibit ignorable toxicity to normal cells. This study aimed to investigate the capacities of HANPs with different morphologies and particle sizes against two kinds of osteosarcoma (OS) cells, human OS 143B ce...

SARS-CoV-2 requires acidic pH to infect cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499588
Proceedings of the National Academy of Sciences of the Un... Kreutzberger AJB, Sanyal A et. al.

Sep 2nd, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry starts with membrane attachment and ends with spike (S) protein-catalyzed membrane fusion depending on two cleavage steps, namely, one usually by furin in producing cells and the second by TMPRSS2 on target cells. Endosomal cathepsins can carry out both. Using real-time three-dimensional single-virion tracking, we show that...

Peptidomimetic Small-Molecule Inhibitors of 3CLPro Activity and Spike-ACE2 Interaction:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454270
The Journal of Organic Chemistry; Tedesco F, Calugi L et. al.

Aug 31st, 2022 - The development of molecules able to target protein-protein interactions (PPIs) is of interest for the development of novel therapeutic agents. Since a high percentage of PPIs are mediated by α-helical structure at the interacting surface, peptidomimetics that reproduce the essential conformational components of helices are useful templates for the development of PPIs inhibitors. In this work, ...

Missense mutations in spike protein of SARS-CoV-2 delta variant contribute to the alter...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382871
Immunity, Inflammation and Disease; Mahmood TB, Hossan MI et. al.

Aug 31st, 2022 - Many of the global pandemics threaten human existence over the decades among which coronavirus disease (COVID-19) is the newest exposure circulating worldwide. The RNA encoded severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is referred as the pivotal agent of this deadly disease that induces respiratory tract infection by interacting host ACE2 receptor with its spike glycopro...