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About 54,555 results

Clear cell stromal tumor of the lung with multinucleated giant cells: a report of a cas...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881279
Diagnostic Pathology; Jakša R, Stružinská I et. al.

Jan 29th, 2023 - Clear cell (hemangioblastoma-like) stromal tumor of the lung (CCSTL) is a rare pulmonary neoplasm. Recently, 9 cases of CCSTL harboring the YAP1-TFE3 gene fusion have been described, and it has been suggested that this aberration could be a characteristic feature of this tumor. We here report another case of CCSTL in a 57-year-old male, which presented as a solitary lung nodule 45 mm in the gre...

Insights into the drug screening approaches in leishmaniasis.
https://doi.org/10.1016/j.intimp.2022.109591
International Immunopharmacology; Gopu B, Kour P et. al.

Jan 27th, 2023 - Leishmaniasis, a tropically neglected disease, is responsible for the high mortality and morbidity ratio in poverty-stricken areas. Currently, no vaccine is available for the complete cure of the disease. Current chemotherapeutic regimens face the limitations of drug resistance and toxicity concerns indicating a great need to develop better chemotherapeutic leads that are orally administrable, ...

Product Quality Research for Developing and Assessing Regulatory Submissions for Generi...
https://doi.org/10.1208/s12248-023-00781-x
The AAPS Journal; Belenos A, Wood EL et. al.

Jan 27th, 2023 - Approval of the first generic 0.05% cyclosporine ophthalmic emulsion (COE) in the U.S. represents a milestone achievement of the science and research program in the U.S. Food and Drug Administration's Center for Drug Evaluation and Research (CDER). COE is a locally acting complex drug product indicated to increase tear production in patients whose production is presumed to be suppressed due to ...

Solubility Enhancement and Inhalation Delivery of Cyclodextrin-Based Inclusion Complex ...
https://doi.org/10.1208/s12249-023-02510-1
AAPS PharmSciTech; Patil SM, Barji DS et. al.

Jan 27th, 2023 - Tuberculosis (TB) is a contiguous airborne disease caused by Mycobacterium tuberculosis (M.tb), primarily affecting the human lungs. The progression of drug-susceptible TB to drug-resistant strains, MDR-TB and XDR-TB, has become a global challenge toward eradicating TB. Conventional TB treatment involves frequent dosing and prolonged treatment regimens predominantly by an oral or invasive route...

Clear-cell Variant of Mucoepidermoid Carcinoma Presenting as a Palatal Mass in a 10-Yea...
https://doi.org/10.21873/anticanres.16238
Anticancer Research; Han SH, O'Toole TR et. al.

Jan 26th, 2023 - The clear-cell variant of mucoepidermoid carcinoma (MEC) involving minor salivary glands is extremely rare in children. We report a case of clear-cell variant MEC in the minor salivary gland in a 10-year-old boy who presented with a mass of the right hard palate. Fine-needle aspiration showed features suggestive of clear-cell variant of MEC. Microscopically, the tumor cells showed predominant c...

Variants in KLK11, affecting signal peptide cleavage of kallikrein-related peptidase 11...
https://doi.org/10.1093/bjd/ljac029
The British Journal of Dermatology; Gong Z, Dai S et. al.

Jan 24th, 2023 - Mendelian disorders of cornification (MeDOC) are a group of heterogeneous genodermatoses with different genetic bases. The pathogenesis of a substantial group of MeDOC remains to be elucidated. To identify a new causative gene and the pathogenesis of a previously undescribed autosomal-dominant cornification disorder. Whole-exome sequencing was performed in three families with the novel cornific...

Euclasta condylotricha flowers essential oils: A new source of juvenile hormones and it...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870135
PloS One; Bohounton RB, Djihinto OY et. al.

Jan 24th, 2023 - The essential oil (EO) of plants of the Poaceae family has diverse chemical constituents with several biological properties. But, data on the chemical constituents and toxicity are still unavailable for some species belonging to this family, such as Euclasta condylotricha Steud (Eu. condylotricha). In this study, the chemical composition of the EOs of Eu. condylotricha flowers was evaluated by ...

Parkin coregulates glutathione metabolism in adult mammalian brain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869535
Acta Neuropathologica Communications; El Kodsi DN, Tokarew JM et. al.

Jan 24th, 2023 - We recently discovered that the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis. To further examine the protective effects of parkin in an oxidative stress model, we first combined the loss of prkn with Sod2 haploinsufficiency in mice. Although adult prkn-/-//Sod2± animals did not develop dopamine cell loss in the S. nigra, they had more reactive oxida...

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for differ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9854196
Parasites & Vectors; Ebersbach JC, Sato MO et. al.

Jan 20th, 2023 - Schistosomiasis is a major neglected tropical disease that affects up to 250 million individuals worldwide. The diagnosis of human schistosomiasis is mainly based on the microscopic detection of the parasite's eggs in the feces (i.e., for Schistosoma mansoni or Schistosoma japonicum) or urine (i.e., for Schistosoma haematobium) samples. However, these techniques have limited sensitivity, and mi...

Cryo-EM reveals the molecular basis oflaminin polymerization and LN-lamininopathies.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852560
Nature Communications; Kulczyk AW, McKee KK et. al.

Jan 20th, 2023 - Laminin polymerization is the major step in basement membranes assembly. Its failures cause laminin N-terminal domain lamininopathies including Pierson syndrome. We have employed cryo-electron microscopy to determine a 3.7 Å structure of the trimeric laminin polymer node containing α1, β1 and γ1 subunits. The structure reveals the molecular basis of calcium-dependent formation of laminin lattic...

D614G SARS-CoV-2 Pseudovirus Infectivity and Binding of Spike Protein to the ACE2 Recep...
https://doi.org/10.1089/vim.2022.0117
Viral Immunology; McCullagh L, Sheehy N et. al.

Jan 18th, 2023 - Understanding the functional characteristics of antibodies produced against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will assist in the determination of disease outcomes for this virus. In this study, the ability of antibodies to inhibit viral entry into the host cell through the interaction of the receptor binding domain of the viral spike protein and the angiotensin-conver...

Ethanol extract from Artemisia argyi leaves inhibits HSV-1 infection by destroying the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841929
Virology Journal; Liu P, Zhong L et. al.

Jan 17th, 2023 - Herpes simplex virus type 1 (HSV-1) is a widely disseminated virus that establishes latency in the brain and causes occasional but fatal herpes simplex encephalitis. Currently, acyclovir (ACV) is the main clinical drug used in the treatment of HSV-1 infection, and the failure of therapy in immunocompromised patients caused by ACV-resistant HSV-1 strains necessitates the requirement to develop n...

Formulation for the Targeted Delivery of a Vaccine Strain of Oncolytic Measles Virus (O...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838128
International Journal of Nanomedicine; Naseer F, Ahmad T et. al.

Jan 17th, 2023 - Oncolytic viruses are reported as dynamite against cancer treatment nowadays. In the present work, a live attenuated oral measles vaccine (OMV) strain was used to formulate a polymeric surface-functionalized ligand-based nanoformulation (NF). OMV (half dose: not less than 500 TCID units; 0.25 mL) was encapsulated in thiolated chitosan and outermost coating with hyaluronic acid by ionic gelation...

Extraction, structure and bioactivities of polysaccharides from Rehmannia glutinosa: A ...
https://doi.org/10.1016/j.jep.2022.116132
Journal of Ethnopharmacology; Bian Z, Zhang R et. al.

Jan 13th, 2023 - Rehmannia glutinosa (Gaertn.) DC. (RG) is a widely used herb for clearing heat and cooling the blood. Polysaccharides from Rehmannia glutinosa (Gaertn.) DC. (RGPs) have a variety of biological activities, including antioxidation, hypoglycemia, immune enhancement, hematopoiesis promotion, and antianxiety. This review provides up-to-date and comprehensive information on the extraction and separat...

Unravelling the enigma of siRNA and aptamer mediated therapies against pancreatic cancer.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835391
Molecular Cancer; Liu Z, Parveen N et. al.

Jan 13th, 2023 - Pancreatic cancer (PC) is a fatal disease that has a poor 5-year survival rate. The poor prognosis can be attributed to both troublesome detections at the initial stage, which makes the majority of the treatment options largely unsuccessful and leads to extensive metastasis, as well as to its distinct pathophysiological characteristics, such as rich desmoplastic tumours bounded by dysplastic an...

DDQ/Fe(NO3)3-Catalyzed Aerobic Synthesis of 3-Acyl Indoles and an In Silico Study for t...
https://doi.org/10.1021/acs.joc.2c02009
The Journal of Organic Chemistry; Rana G, Kar A et. al.

Jan 10th, 2023 - In the present study, we herein report a DDQ-catalyzed new protocol for the synthesis of substituted 3-acylindoles. Being a potential system for virtual hydrogen storage, introduction of catalytic DDQ in combination with Fe(NO3)3·9H2O and molecular oxygen as co-catalysts offers a regioselective oxo-functionalization of C-3 alkyl-/aryllidine indolines even with scale-up investigations. Intermedi...

Investigation of anti-galectin-8 levels in patients with multiple sclerosis: A consort-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829274
Medicine Cinkir U, Bir LS et. al.

Jan 7th, 2023 - Galectins are a family of endogenous mammalian lectins involved in pathogen recognition, killing, and facilitating the entry of microbial pathogens and parasites into the host. They are the intermediators that decipher glycan-containing information about the host immune cells and microbial structures to modulate signaling events that cause cellular proliferation, chemotaxis, cytokine secretion,...

Long noncoding RNA FAM157C contributes to clonal proliferation in paroxysmal nocturnal ...
https://doi.org/10.1007/s00277-022-05055-8
Annals of Hematology; Wang H, Liu H et. al.

Jan 7th, 2023 - Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal disease of hematopoietic stem cells (HSCs). Long noncoding RNAs (lncRNAs) perform a wide range of biological functions, including the regulation of gene expression, cell differentiation, and proliferation, but their role in PNH remains unclear.CD59- and CD59+ granulocytes and monocytes from 35 PNH patients were sorted. High-throughput s...

Fasciola gigantica vaccine construct: an in silico approach towards identification and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813462
BMC Immunology; Das KC, Konhar R et. al.

Jan 6th, 2023 - Continuous attempts have been made to pinpoint candidate vaccine molecules and evaluate their effectiveness in order to commercialise such vaccines for the treatment of tropical fascioliasis in livestock. The pathophysiology of fascioliasis can be related to liver damage brought on by immature flukes that migrate and feed, as well as immunological reactions to chemicals produced by the parasite...

Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M β-Lact...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872677
Antimicrobial Agents and Chemotherapy; Alsenani TA, Rodríguez MM et. al.

Jan 6th, 2023 - Design of novel β-lactamase inhibitors (BLIs) is one of the currently accepted strategies to combat the threat of cephalosporin and carbapenem resistance in Gram-negative bacteria. Boronic acid transition state inhibitors (BATSIs) are competitive, reversible BLIs that offer promise as novel therapeutic agents. In this study, the activities of two α-amido-β-triazolylethaneboronic acid transition...