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About 32,256 results

Two clinical phenotypes in polycythemia vera.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211877
The New England Journal of Medicine; Spivak JL, Considine M et. al.

Aug 27th, 2014 - Polycythemia vera is the ultimate phenotypic consequence of the V617F mutation in Janus kinase 2 (encoded by JAK2), but the extent to which this mutation influences the behavior of the involved CD34+ hematopoietic stem cells is unknown. We analyzed gene expression in CD34+ peripheral-blood cells from 19 patients with polycythemia vera, using oligonucleotide microarray technology after correctin...

Tailored approach to the treatment of vernal keratoconjunctivitis.
https://doi.org/10.1016/j.ophtha.2009.11.043
Ophthalmology Sacchetti M, Lambiase A et. al.

Apr 12th, 2010 - To develop a standardized clinical grading system for the management of patients with vernal keratoconjunctivitis (VKC) and to identify the risk factors associated with a worsened outcome of the disease, including decrease of visual acuity and ocular complications development. Retrospective cohort study. A total of 207 consecutive patients with VKC, referred to our Cornea and External Diseases ...

The natural history of multiple system atrophy: a prospective European cohort study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581815
The Lancet. Neurology; Wenning GK, Geser F et. al.

Feb 8th, 2013 - Multiple system atrophy (MSA) is a fatal and still poorly understood degenerative movement disorder that is characterised by autonomic failure, cerebellar ataxia, and parkinsonism in various combinations. Here we present the final analysis of a prospective multicentre study by the European MSA Study Group to investigate the natural history of MSA. Patients with a clinical diagnosis of MSA were ...

MRI measurements predict PSP in unclassifiable parkinsonisms: a cohort study.
https://doi.org/10.1212/WNL.0b013e31822e55d0
Neurology Morelli M, Arabia G et. al.

Aug 12th, 2011 - Magnetic resonance parkinsonism index (MRPI) has been proposed as a powerful tool to discriminate patients with progressive supranuclear palsy (PSP) from those with Parkinson disease (PD) or other parkinsonisms, on an individual basis. We investigated the usefulness of MRPI in predicting the clinical evolution in PSP of patients with clinically unclassifiable parkinsonism (CUP), i.e., parkinson...

Prospective multicenter study of a synthetic bioabsorbable anal fistula plug to treat c...
https://doi.org/10.1097/DCR.0000000000000288
Diseases of the Colon and Rectum; Stamos MJ, Snyder M et. al.

Feb 10th, 2015 - Although interest in sphincter-sparing treatments for anal fistulas is increasing, few large prospective studies of these approaches have been conducted. The study assessed outcomes after implantation of a synthetic bioabsorbable anal fistula plug. A prospective, multicenter investigation was performed. The study was conducted at 11 colon and rectal centers. Ninety-three patients (71 men; mean ...

Mycobacterial genotypes are associated with clinical manifestation and progression of l...
https://doi.org/10.1093/cid/cit172
Clinical Infectious Diseases : an Official Publication Of... Shin SJ, Choi GE et. al.

Mar 20th, 2013 - Mycobacterium abscessus and Mycobacterium massiliense, which cause lung disease, are variable in their clinical manifestation and progression. We hypothesized that mycobacterial genotypes represent their pathogenic phenotypes, which would result in particular genotypes being associated with disease progression. Variable number tandem repeat (VNTR) loci were selected to establish a genotype assa...

Hantavirus Pulmonary Syndrome Caused by Maripa Virus in French Guiana, 2008-2016.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621545
Emerging Infectious Diseases; Matheus S, Kallel H et. al.

Sep 20th, 2017 - We report 5 human cases of hantavirus pulmonary syndrome found during surveillance in French Guiana in 2008-2016; of the 5 patients, 4 died. This pathogen should continue to be monitored in humans and rodents in effort to reduce the occurrence of these lethal infections in humans stemming from ecosystem disturbances.

The FIGO systems for nomenclature and classification of causes of abnormal uterine blee...
https://doi.org/10.1016/j.ajog.2012.01.046
American Journal of Obstetrics and Gynecology; Munro MG, Critchley HO et. al.

Mar 5th, 2012 - In November 2010, the International Federation of Gynecology and Obstetrics formally accepted a new classification system for causes of abnormal uterine bleeding in the reproductive years. The system, based on the acronym PALM-COEIN (polyps, adenomyosis, leiomyoma, malignancy and hyperplasia-coagulopathy, ovulatory disorders, endometrial causes, iatrogenic, not classified) was developed in resp...

Prognostic Relevance of Gene-Environment Interactions in Patients With Dilated Cardiomy...
https://doi.org/10.1016/j.jacc.2015.07.023
Journal of the American College of Cardiology; Hazebroek MR, Moors S et. al.

Sep 18th, 2015 - The multifactorial pathogenesis leading to dilated cardiomyopathy (DCM) makes stratification difficult. The recent MOGE(S) (morphofunctional, organ involvement, genetic or familial, etiology, stage) classification addresses this issue. The purpose of this study was to investigate the applicability and prognostic relevance of the MOGE(S) classification in patients with DCM. This study used patie...

Trends of pneumococcal meningitis in children after introduction of the 13-valent pneum...
https://doi.org/10.1097/INF.0000000000000451
The Pediatric Infectious Disease Journal; Levy C, Varon E et. al.

Jul 18th, 2014 - Streptococcus pneumoniae remains an important cause of bacterial meningitis in children younger than 2 years. Here, we analyzed data from an active surveillance network established 12 years ago by the Pediatric Infectious Disease Group and the Pediatric Clinical and Therapeutical Association to analyze the impact of pneumococcal conjugate vaccine (PCV7 implemented in 2002 and PCV13 in 2010) on ...

Systemic therapy for non-clear cell renal cell carcinomas: a systematic review and meta...
https://doi.org/10.1016/j.eururo.2014.05.010
European Urology; Vera-Badillo FE, Templeton AJ et. al.

Jun 2nd, 2014 - Clinical data supporting the use of targeted agents for the treatment of metastatic renal cell carcinoma (RCC) are based predominantly on patients with clear cell histology. Little is known about the efficacy of these drugs in non-clear cell variants. To evaluate the efficacy of different clear cell RCC (ccRCC)-approved targeted agents among patients with non-ccRCC compared with ccRCC. We condu...

A case-control study of hypoxic-ischemic encephalopathy in newborn infants at >36 weeks...
https://doi.org/10.1016/j.ajog.2013.03.023
American Journal of Obstetrics and Gynecology; Hayes BC, McGarvey C et. al.

Mar 25th, 2013 - The purpose of this study was to determine risk factors that are associated with hypoxic ischemic encephalopathy (HIE). This was a case-control study that included newborn infants with HIE who were admitted to the hospital between January 2001 and December 2008. Two control newborn infants were chosen for each case. Logistic regression and classification and regression tree (CART) analysis that...

Unclassified renal cell carcinoma: impact on survival following nephrectomy.
https://doi.org/10.1016/j.urology.2009.12.037
Urology Crispen PL, Tabidian MR et. al.

Mar 12th, 2010 - To evaluate the impact of the category of unclassified renal cell carcinoma (URCC) on survival following nephrectomy. Patients with clear cell RCC (ccRCC, n = 3048) and URCC (n = 38) were identified. Patients with URCC were matched 4:1 with ccRCC patients based on year of surgery, symptoms at presentation, tumor size, stage, regional lymph node involvement, metastases, grade, coagulative tumor ...

The Oxford classification of IgA nephropathy: pathology definitions, correlations, and ...
https://doi.org/10.1038/ki.2009.168
Kidney International; , Roberts IS et. al.

Jul 2nd, 2009 - Pathological classifications in current use for the assessment of glomerular disease have been typically opinion-based and built on the expert assumptions of renal pathologists about lesions historically thought to be relevant to prognosis. Here we develop a unique approach for the pathological classification of a glomerular disease, IgA nephropathy, in which renal pathologists first undertook ...

Is presence of ANCA in crescentic IgA nephropathy a coincidence or novel clinical entit...
https://doi.org/10.1053/j.ajkd.2009.09.031
American Journal of Kidney Diseases : the Official Journa... Bantis C, Stangou M et. al.

Dec 31st, 2009 - There are few anecdotal reports of circulating antineutrophil cytoplasmic autoantibodies (ANCAs) in patients with immunoglobulin A (IgA) nephropathy. Retrospective case series. We studied 8 patients with crescentic IgA nephropathy associated with ANCAs against myeloperoxidase (n = 5) and proteinase 3 (n = 3) followed up for 2.4 +/- 1.7 years. They were compared with 26 patients with IgA nephrop...

Peripartum cardiomyopathy as a part of familial dilated cardiomyopathy.
https://doi.org/10.1161/CIRCULATIONAHA.109.929646
Circulation van Spaendonck-Zwarts KY, van Tintelen JP et. al.

May 11th, 2010 - Anecdotal cases of familial clustering of peripartum cardiomyopathy (PPCM) and familial occurrences of PPCM and idiopathic dilated cardiomyopathy (DCM) together have been observed, suggesting that genetic factors play a role in the pathogenesis of PPCM. We hypothesized that some cases of PPCM are part of the spectrum of familial DCM, presenting in the peripartum period. We reviewed our database...

Paediatric myelodysplastic syndromes and juvenile myelomonocytic leukaemia: molecular c...
https://doi.org/10.1111/j.1365-2141.2007.06958.x
British Journal of Haematology; Niemeyer CM, Kratz CP

Feb 27th, 2008 - Myelodysplastic syndromes (MDS) and the mixed myelodysplastic/myeloproliferative disorder juvenile myelomonocytic leukaemia (JMML) are rare haematopoietic stem cell diseases in children. While MDS-initiating events remain largely obscure, a growing body of clinical, genetic and laboratory evidence suggests that JMML is, at least in part, caused by aberrant signal transduction resulting from mut...

Disseminated superficial actinic porokeratosis co-existing with linear and verrucous po...
https://doi.org/10.1016/j.jaad.2009.07.038
Journal of the American Academy of Dermatology; Murase J, Gilliam AC

May 10th, 2010 - Disseminated superficial actinic porokeratosis (DSAP) is the most common form of porokeratosis, occurring mainly in women on the extremities as atrophic patches rimmed by a ridge of keratin (the cornoid lamella that is diagnostic of porokeratosis histologically and is thought to be a clonal keratinocyte proliferation). DSAP can sometimes coexist with other forms of porokeratosis (Mibelli, linea...

Borrelia miyamotoi infections among wild rodents show age and month independence and co...
https://doi.org/10.1089/vbz.2012.1027
Vector Borne and Zoonotic Diseases (Larchmont, N.Y.); Taylor KR, Takano A et. al.

Dec 5th, 2012 - To clarify how Borrelia miyamotoi is maintained in the environment in Hokkaido, we examined Ixodes persulcatus for its prevalence among wild rodents and its tick vector by detecting a portion of the borrelial flaB gene in rodent urinary bladder and blood samples, and from whole ticks. We compared B. miyamotoi infection rates to Borrelia garinii and Borrelia afzelii, which are human Lyme disease...

Etiology of encephalitis in Australia, 1990-2007.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819877
Emerging Infectious Diseases; Huppatz C, Durrheim DN et. al.

Sep 30th, 2009 - Encephalitis is a clinical syndrome commonly caused by emerging pathogens, which are not under surveillance in Australia. We reviewed rates of hospitalization for patients with encephalitis in Australia's most populous state, New South Wales, from January 1990 through December 2007. Encephalitis was the primary discharge diagnosis for 5,926 hospital admissions; average annual hospitalization ra...