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About 26,415 results

Alteration of the gut microbiota following SARS-CoV-2 infection correlates with disease...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726722
Gut Microbes; Sencio V, Machelart A et. al.

Dec 30th, 2021 - Mounting evidence suggests that the gut-to-lung axis is critical during respiratory viral infections. We herein hypothesized that disruption of gut homeostasis during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may associate with early disease outcomes. To address this question, we took advantage of the Syrian hamster model. Our data confirmed that this model recapitu...

MFmap: A semi-supervised generative model matching cell lines to tumours and cancer sub...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675718
PloS One; Zhang X, Kschischo M

Dec 17th, 2021 - Translating in vitro results from experiments with cancer cell lines to clinical applications requires the selection of appropriate cell line models. Here we present MFmap (model fidelity map), a machine learning model to simultaneously predict the cancer subtype of a cell line and its similarity to an individual tumour sample. The MFmap is a semi-supervised generative model, which compresses h...

Culicoides Latreille (Diptera: Ceratopogonidae) as potential vectors for Leishmania mar...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673663
PLoS Neglected Tropical Diseases; Sunantaraporn S, Thepparat A et. al.

Dec 16th, 2021 - Biting midges of genus Culicoides (Diptera: Ceratopogonidae) are the vectors of several pathogenic arboviruses and parasites of humans and animals. Several reports have suggested that biting midges might be a potential vector of Leishmania parasites. In this study, we screened for Leishmania and Trypanosoma DNA in biting midges collected from near the home of a leishmaniasis patient in Lamphun ...

Estimating the strength of selection for new SARS-CoV-2 variants.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671537
Nature Communications; Dorp CHV, Goldberg EE et. al.

Dec 16th, 2021 - Controlling the SARS-CoV-2 pandemic becomes increasingly challenging as the virus adapts to human hosts through the continual emergence of more transmissible variants. Simply observing that a variant is increasing in frequency is relatively straightforward, but more sophisticated methodology is needed to determine whether a new variant is a global threat and the magnitude of its selective advan...

Metabolic drug survey highlights cancer cell dependencies and vulnerabilities.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671470
Nature Communications; Pemovska T, Bigenzahn JW et. al.

Dec 16th, 2021 - Interrogation of cellular metabolism with high-throughput screening approaches can unravel contextual biology and identify cancer-specific metabolic vulnerabilities. To systematically study the consequences of distinct metabolic perturbations, we assemble a comprehensive metabolic drug library (CeMM Library of Metabolic Drugs; CLIMET) covering 243 compounds. We, next, characterize it phenotypic...

Local occurrence and fast spread of B.1.1.7 lineage: A glimpse into Friuli Venezia Giulia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670677
PloS One; Mio C, Dal Secco C et. al.

Dec 15th, 2021 - In-depth study of the entire SARS-CoV-2 genome has uncovered many mutations, which have replaced the lineage that characterized the first wave of infections all around the world. In December 2020, the outbreak of variant of concern (VOC) 202012/01 (lineage B.1.1.7) in the United Kingdom defined a turning point during the pandemic, immediately posing a worldwide threat on the Covid-19 vaccinatio...

Laboratory diagnostic, epidemiological, and clinical characteristics of human leptospir...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670671
PLoS Neglected Tropical Diseases; Kakita T, Okano S et. al.

Dec 15th, 2021 - Leptospirosis is considered an endemic disease among agricultural workers in Okinawa Prefecture, which is the southernmost part of Japan and has a subtropical climate, but data on the current status and trend of this disease are scarce. We conducted a retrospective study of clinically suspected leptospirosis patients whose sample and information were sent to the Okinawa Prefectural Institute of...

Safety and Efficacy of Acetyl-DL-Leucine in Certain Types of Cerebellar Ataxia: The ALC...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672236
JAMA Network Open; Feil K, Adrion C et. al.

Dec 15th, 2021 - Cerebellar ataxia is a neurodegenerative disease impairing motor function characterized by ataxia of stance, gait, speech, and fine motor disturbances. To investigate the efficacy, safety, and tolerability of the modified essential amino acid acetyl-DL-leucine in treating patients who have cerebellar ataxia. The Acetyl-DL-leucine on Cerebellar Ataxia (ALCAT) trial was an investigator-initiated,...

The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725892
Emerging Microbes & Infections; Wang Y, Zhang L et. al.

Dec 11th, 2021 - The emergence of Omicron/BA.1 has brought new challenges to fight against SARS-CoV-2. A large number of mutations in the Spike protein suggest that its susceptibility to immune protection elicited by the existing COVID-19 infection and vaccines may be altered. In this study, we constructed the pseudotyped SARS-CoV-2 variant Omicron. The sensitivity of 28 serum samples from COVID-19 convalescent...

Perianal Fistula After Ileoanal Pouch in Patients With Ulcerative Colitis: A Review of ...
https://doi.org/10.1097/DCR.0000000000002114
Diseases of the Colon and Rectum; Heimann TM, Swaminathan S et. al.

Dec 10th, 2021 - Ileoanal pouch anastomosis is the surgical treatment of choice for patients with intractable ulcerative colitis. Perianal disease is a feature that is often present in Crohn's disease and infrequently in ulcerative colitis. The aim of this study is to identify the incidence and factors associated with the development of postoperative perianal fistula in patients undergoing ileoanal pouch anasto...

Variable expression of eighteen common housekeeping genes in human non-cancerous kidney...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659319
PloS One; Strauss P, Mikkelsen H et. al.

Dec 10th, 2021 - Housekeeping, or reference genes (RGs) are, by definition, loci with stable expression profiles that are widely used as internal controls to normalize mRNA levels. However, due to specific events, such as pathological changes, or technical procedures, their expression might be altered, failing to fulfil critical normalization pre-requisites. To identify RG genes suitable as internal controls in...

The emergence, genomic diversity and global spread of SARS-CoV-2.
https://doi.org/10.1038/s41586-021-04188-6
Nature Li J, Lai S et. al.

Dec 10th, 2021 - Since the first cases of COVID-19 were documented in Wuhan, China in 2019, the world has witnessed a devastating global pandemic, with more than 238 million cases, nearly 5 million fatalities and the daily number of people infected increasing rapidly. Here we describe the currently available data on the emergence of the SARS-CoV-2 virus, the causative agent of COVID-19, outline the early viral ...

Mutational landscape of SARS-CoV-2 genome in Turkey and impact of mutations on spike pr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648120
PloS One; Hatirnaz Ng O, Akyoney S et. al.

Dec 7th, 2021 - The Coronavirus Disease 2019 (COVID-19) was declared a pandemic in March 2020 by the World Health Organization (WHO). As of May 25th, 2021 there were 2.059.941 SARS-COV2 genome sequences that have been submitted to the GISAID database, with numerous variations. Here, we aim to analyze the SARS-CoV-2 genome data submitted to the GISAID database from Turkey and to determine the variant and clade ...

Effect of preventive chemotherapy with praziquantel on schistosomiasis among school-age...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695385
The Lancet. Infectious Diseases; Kokaliaris C, Garba A et. al.

Dec 6th, 2021 - Over the past 20 years, schistosomiasis control has been scaled up. Preventive chemotherapy with praziquantel is the main intervention. We aimed to assess the effect of preventive chemotherapy on schistosomiasis prevalence in sub-Saharan Africa, comparing 2000-10 with 2011-14 and 2015-19. In this spatiotemporal modelling study, we analysed survey data from school-aged children (aged 5-14 years)...

Comparison of Clinical Findings in SARS-CoV-2 with Other Respiratory Viruses in Critica...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690266
Journal of Tropical Pediatrics; Perk O, Ozcan S et. al.

Dec 6th, 2021 - The aim of this study was to compare the clinical and laboratory findings in SARS-CoV-2 (COVID-19) with those of other respiratory viruses in critically ill children. It is a single center retrospective descriptive study conducted in a 32-bed pediatric intensive care unit (PICU). Our study was performed in Ankara City Hospital, Ankara, Turkey, between 1 March 2020, and 1 March 2021. Demographic...

Genetic population of Plasmodium knowlesi during pre-malaria elimination in Thailand.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641246
Malaria Journal; Sugaram R, Boondej P et. al.

Dec 5th, 2021 - Thailand is committed to eliminating malaria by 2024. From 2013 to 2020, the total number of malaria cases have decreased, from 37,741 to 4474 (an 88.1% reduction). However, infections with Plasmodium knowlesi, a monkey malarial pathogen that can also infect humans, have been increasingly observed. This study focused on the molecular analysis of P. knowlesi parasites causing malaria in Thailand...

Altered cervicovaginal microbiota in premenopausal ovarian cancer patients.
https://doi.org/10.1016/j.gene.2021.146083
Gene Morikawa A, Kawabata A et. al.

Dec 3rd, 2021 - Nearly three hundred thousand female patients are diagnosed with ovarian cancer in the world annually, and this number shows an increasing trend. However, characteristic symptoms caused by ovarian cancer are so few that early diagnosis remains challenging, and an effective screening method has not yet been established. Here, we conducted a case-control study in Japan to analyze the association ...

IQ in Autism Spectrum Disorder: A Population-Based Birth Cohort Study.
https://doi.org/10.1542/peds.2020-049899
Pediatrics Katusic MZ, Myers SM et. al.

Dec 2nd, 2021 - We aimed to describe the intellectual ability and ratio of boys to girls with average or higher IQ within autism spectrum disorder (ASD) cases identified in a population-based birth cohort. We hypothesized that research-identified individuals with ASD would be more likely to have average or higher IQ, compared to clinically diagnosed ASD. We also hypothesized the male to female ratio would decr...

Molecular identification of two newly identified human pathogens causing leishmaniasis ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631652
PLoS Neglected Tropical Diseases; Jariyapan N, Bates MD et. al.

Dec 1st, 2021 - PCR-based methods to amplify the 3' untranslated region (3'-UTR) of the heat shock protein 70 (type I) gene (HSP70-I) have previously been used for typing of Leishmania but not with Leishmania (Mundinia) martiniquensis and L. (Mundinia) orientalis, newly identified human pathogens. Here, the 3'-UTRs of HSP70-I of L. martiniquensis, L. orientalis, and 10 other species were sequenced and analyzed...

Bacterial variation in the oral microbiota in multiple sclerosis patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631616
PloS One; Zangeneh Z, Abdi-Ali A et. al.

Dec 1st, 2021 - Microorganisms in oral cavity are called oral microbiota, while microbiome consists of total genome content of microorganisms in a host. Interaction between host and microorganisms is important in nervous system development and nervous diseases such as Autism, Alzheimer, Parkinson and Multiple Sclerosis (MS). Bacterial infections, as an environmental factor in MS pathogenesis play role in T hel...