×
About 27,815 results

Changing the name of diabetes insipidus: a position statement of The Working Group for ...
https://doi.org/10.1507/endocrj.EJ20220831
Endocrine Journal; , Arima H et. al.

Oct 17th, 2022 - "What's in a name? That which we call a rose/By any other name would smell as sweet." (Juliet, from Romeo and Juliet by William Shakespeare). Shakespeare's implication is that a name is nothing but a word and it therefore represents a convention with no intrinsic meaning. Whilst this may be relevant to romantic literature, disease names do have real meanings, and consequences, in medicine. Henc...

Unified rhombic lip origins of group 3 and group 4 medulloblastoma.
https://doi.org/10.1038/s41586-022-05208-9
Nature Smith KS, Bihannic L et. al.

Sep 22nd, 2022 - Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into biologically distinct subgroups, suggesting that a personalized approach to therapy would be beneficial1. Mouse modelling and cross-species genomics have provided increasing evidence of discrete, subgroup-specific developmental origins2. However, the anatomical and cellular complexity of developing human tissu...

Failure of human rhombic lip differentiation underlies medulloblastoma formation.
https://doi.org/10.1038/s41586-022-05215-w
Nature Hendrikse LD, Haldipur P et. al.

Sep 22nd, 2022 - Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain1-4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the upper rhombic lip (RL) granule cell lineage5-8. By contrast, mutations that activate WNT signalling lead to WNT MB in the lower RL9,10. However, littl...

SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477415
Proceedings of the National Academy of Sciences of the Un... McGrath ME, Xue Y et. al.

Aug 31st, 2022 - The ongoing COVID-19 pandemic is a major public health crisis. Despite the development and deployment of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pandemic persists. The continued spread of the virus is largely driven by the emergence of viral variants, which can evade the current vaccines through mutations in the spike protein. Although these difference...

Helminth species dependent effects on Th1 and Th17 cytokines in active tuberculosis pat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423606
PLoS Neglected Tropical Diseases; Bewket G, Kiflie A et. al.

Aug 18th, 2022 - Despite that the impact of different helminth species is not well explored, the current dogma states that helminths affect the Th1/Th2 balance which in turn affects the risk of tuberculosis (TB) reactivation and severity of disease. We investigated the influence of helminth species on cytokine profiles including IL-17A in TB patients and healthy community controls (CCs). In total, 104 newly dia...

Loss of Pfizer (BNT162b2) Vaccine-Induced Antibody Responses against the SARS-CoV-2 Omi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472620
Journal of Virology; Gupta SL, Mantus G et. al.

Aug 18th, 2022 - Emerging variants, especially the recent Omicron variant, and gaps in vaccine coverage threaten mRNA vaccine mediated protection against SARS-CoV-2. While children have been relatively spared by the ongoing pandemic, increasing case numbers and hospitalizations are now evident among children. Thus, it is essential to better understand the magnitude and breadth of vaccine-induced immunity in chi...

Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Per...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9423911
Emerging Infectious Diseases; Munnink BBO, Nijhuis RHT et. al.

Aug 5th, 2022 - We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identified several potential immune escape mutations in the spike protein.

Risk of covid-19 related deaths for SARS-CoV-2 omicron (B.1.1.529) compared with delta ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344192
BMJ (Clinical Research Ed.); Ward IL, Bermingham C et. al.

Aug 3rd, 2022 - To assess the risk of covid-19 death after infection with omicron BA.1 compared with delta (B.1.617.2). Retrospective cohort study. England, United Kingdom, from 1 December 2021 to 30 December 2021. 1 035 149 people aged 18-100 years who tested positive for SARS-CoV-2 under the national surveillance programme and had an infection identified as omicron BA.1 or delta compatible. The main outcome ...

Local-scale virome depiction in Medellín, Colombia, supports significant differences be...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328524
PloS One; Calle-Tobón A, Pérez-Pérez J et. al.

Jul 28th, 2022 - Aedes spp. comprise the primary group of mosquitoes that transmit arboviruses such as dengue, Zika, and chikungunya viruses to humans, and thus these insects pose a significant burden on public health worldwide. Advancements in next-generation sequencing and metagenomics have expanded our knowledge on the richness of RNA viruses harbored by arthropods such as Ae. aegypti and Ae. albopictus. Inc...

Shared N417-Dependent Epitope on the SARS-CoV-2 Omicron, Beta, and Delta Plus Variants.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364786
Journal of Virology; Moyo-Gwete T, Madzivhandila M et. al.

Jul 23rd, 2022 - As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve, several variants of concern (VOCs) have arisen which are defined by multiple mutations in their spike proteins. These VOCs have shown variable escape from antibody responses and have been shown to trigger qualitatively different antibody responses during infection. By studying plasma from individuals infected w...

A Virion-Based Combination Vaccine Protects against Influenza and SARS-CoV-2 Disease in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364787
Journal of Virology; Chaparian RR, Harding AT et. al.

Jul 22nd, 2022 - Vaccines targeting SARS-CoV-2 have been shown to be highly effective; however, the breadth against emerging variants and the longevity of protection remains unclear. Postimmunization boosting has been shown to be beneficial for disease protection, and as new variants continue to emerge, periodic (and perhaps annual) vaccination will likely be recommended. New seasonal influenza virus vaccines c...

The Glycan-Binding Trait of the Sarbecovirus Spike N-Terminal Domain Reveals an Evoluti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364788
Journal of Virology; Guo H, Li A et. al.

Jul 20th, 2022 - The spike protein on sarbecovirus virions contains two external, protruding domains: an N-terminal domain (NTD) with unclear function and a C-terminal domain (CTD) that binds the host receptor, allowing for viral entry and infection. While the CTD is well studied for therapeutic interventions, the role of the NTD is far less well understood for many coronaviruses. Here, we demonstrate that the ...

Major Changes in 2021 World Health Organization Classification of Central Nervous Syste...
https://doi.org/10.1148/rg.210236
Radiographics : a Review Publication of the Radiological ... Kurokawa R, Kurokawa M et. al.

Jul 9th, 2022 - The World Health Organization (WHO) published the fifth edition of the WHO Classification of Tumors of the Central Nervous System (WHO CNS5) in 2021, as an update of the WHO central nervous system (CNS) classification system published in 2016. WHO CNS5 was drafted on the basis of recommendations from the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT-NOW)...

Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433318
Nature Karthikeyan S, Levy JI et. al.

Jul 8th, 2022 - As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical for public health interventions. Inferring lineage prevalence by clinical testing is infeasible at scale, especially in areas with limited resources, participation, or testing and/or sequencing capacity, which can also introduce biases1-3. SARS-CoV-2 RNA concentration in wastewater successfully tracks re...

Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385487
Nature Wang Q, Guo Y et. al.

Jul 6th, 2022 - SARS-CoV-2 Omicron subvariants BA.2.12.1 and BA.4/5 have surged notably to become dominant in the United States and South Africa, respectively1,2. These new subvariants carrying further mutations in their spike proteins raise concerns that they may further evade neutralizing antibodies, thereby further compromising the efficacy of COVID-19 vaccines and therapeutic monoclonals. We now report fin...

Grey wolf genomic history reveals a dual ancestry of dogs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279150
Nature Bergström A, Stanton DWG et. al.

Jun 30th, 2022 - The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when and where the wolf progenitors of the present-day dog lineage (Canis familiaris) lived1-8. Here we ...

Characterization of a thermostable Cas13 enzyme for one-pot detection of SARS-CoV-2.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282225
Proceedings of the National Academy of Sciences of the Un... Mahas A, Marsic T et. al.

Jun 29th, 2022 - Type VI CRISPR-Cas systems have been repurposed for various applications such as gene knockdown, viral interference, and diagnostics. However, the identification and characterization of thermophilic orthologs will expand and unlock the potential of diverse biotechnological applications. Herein, we identified and characterized a thermostable ortholog of the Cas13a family from the thermophilic or...

Range Expansion of Ixodes scapularis and Borrelia burgdorferi in Ontario, Canada, from ...
https://doi.org/10.1089/vbz.2022.0015
Vector Borne and Zoonotic Diseases (Larchmont, N.Y.); Robinson EL, Jardine CM et. al.

Jun 22nd, 2022 - Range expansion of the vector tick species, Ixodes scapularis, has been detected in Ontario over the last two decades. This has led to elevated risk of exposure to Borrelia burgdorferi, the bacterium that causes Lyme disease. Previous research using passive surveillance data suggests that I. scapularis populations establish before the establishment of B. burgdorferi transmission cycles, with a ...

BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385493
Nature Cao Y, Yisimayi A et. al.

Jun 18th, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages BA.2.12.1, BA.4 and BA.5 exhibit higher transmissibility than the BA.2 lineage1. The receptor binding and immune-evasion capability of these recently emerged variants require immediate investigation. Here, coupled with structural comparisons of the spike proteins, we show that BA.2.12.1, BA.4 and BA.5 (BA.4 and BA....

The source of the Black Death in fourteenth-century central Eurasia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217749
Nature Spyrou MA, Musralina L et. al.

Jun 16th, 2022 - The origin of the medieval Black Death pandemic (AD 1346-1353) has been a topic of continuous investigation because of the pandemic's extensive demographic impact and long-lasting consequences1,2. Until now, the most debated archaeological evidence potentially associated with the pandemic's initiation derives from cemeteries located near Lake Issyk-Kul of modern-day Kyrgyzstan1,3-9. These sites...