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About 231,848 results

Effect of acetazolamide on visual function in patients with idiopathic intracranial hyp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362615
JAMA , Wall M et. al.

Apr 23rd, 2014 - Acetazolamide is commonly used to treat idiopathic intracranial hypertension (IIH), but there is insufficient information to establish an evidence base for its use. To determine whether acetazolamide is beneficial in improving vision when added to a low-sodium weight reduction diet in patients with IIH and mild visual loss. Multicenter, randomized, double-masked, placebo-controlled study of ace...

The neuropsychiatry of tinnitus: a circuit-based approach to the causes and treatments ...
https://doi.org/10.1136/jnnp-2013-307339
Journal of Neurology, Neurosurgery, and Psychiatry; Minen MT, Camprodon J et. al.

Apr 19th, 2014 - Patients presenting with tinnitus commonly have neuropsychiatric symptoms with which physicians need to be familiar. We provide an overview of tinnitus, including its types and pathophysiology. We discuss how recent methods such as transcranial magnetic stimulation, positron emission tomography, MRI, magnetoencephalography and quantitative EEG improve our understanding of the pathophysiology of...

Rosuvastatin for sepsis-associated acute respiratory distress syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241052
The New England Journal of Medicine; , Truwit JD et. al.

May 19th, 2014 - In the acute respiratory distress syndrome (ARDS), inflammation in the lungs and other organs can cause life-threatening organ failure. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins) can modulate inflammatory responses. Previous observational studies suggested that statins improved clinical outcomes in patients with sepsis. We hypothesized that rosuvastatin therapy woul...

Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698790
JAMA Hsieh MM, Fitzhugh CD et. al.

Jul 24th, 2014 - Myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) is curative for children with severe sickle cell disease, but toxicity may be prohibitive for adults. Nonmyeloablative transplantation has been attempted with degrees of preparative regimen intensity, but graft rejection and graft-vs-host disease remain significant. To determine the efficacy, safety, and outcome on end-orga...

Nonselective β blockers increase risk for hepatorenal syndrome and death in patients wi...
https://doi.org/10.1053/j.gastro.2014.03.005
Gastroenterology Mandorfer M, Bota S et. al.

Mar 18th, 2014 - Nonselective β blockers (NSBBs) reduce portal pressure and the risk for variceal hemorrhage in patients with cirrhosis. However, development of spontaneous bacterial peritonitis (SBP) in these patients could preclude treatment with NSBBs because of their effects on the circulatory reserve. We investigated the effects of NSBBs in patients with cirrhosis and ascites with and without SBP. We perfo...

Actionable diagnosis of neuroleptospirosis by next-generation sequencing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134948
The New England Journal of Medicine; Wilson MR, Naccache SN et. al.

Jun 4th, 2014 - A 14-year-old boy with severe combined immunodeficiency presented three times to a medical facility over a period of 4 months with fever and headache that progressed to hydrocephalus and status epilepticus necessitating a medically induced coma. Diagnostic workup including brain biopsy was unrevealing. Unbiased next-generation sequencing of the cerebrospinal fluid identified 475 of 3,063,784 se...

Clinical picture and treatment of 2212 patients with common variable immunodeficiency.
https://doi.org/10.1016/j.jaci.2013.12.1077
The Journal of Allergy and Clinical Immunology; Gathmann B, Mahlaoui N et. al.

Mar 3rd, 2014 - Common variable immunodeficiency (CVID) is an antibody deficiency with an equal sex distribution and a high variability in clinical presentation. The main features include respiratory tract infections and their associated complications, enteropathy, autoimmunity, and lymphoproliferative disorders. This study analyzes the clinical presentation, association between clinical features, and differen...

Early lung ultrasonography predicts the occurrence of acute respiratory distress syndro...
https://doi.org/10.1007/s00134-014-3382-9
Intensive Care Medicine; Leblanc D, Bouvet C et. al.

Jul 15th, 2014 - Extent of lung contusion on initial computed tomography (CT) scan predicts the occurrence of acute respiratory distress syndrome (ARDS) in blunt chest trauma patients. We hypothesized that lung ultrasonography (LUS) on admission could also predict subsequent ARDS. Forty-five blunt trauma patients were prospectively studied. Clinical examination, chest radiography, and LUS were performed on arri...

Inhibition of the mTORC pathway in the antiphospholipid syndrome.
https://doi.org/10.1056/NEJMoa1312890
The New England Journal of Medicine; Canaud G, Bienaimé F et. al.

Jul 23rd, 2014 - Although thrombosis is considered the cardinal feature of the antiphospholipid syndrome, chronic vascular lesions are common, particularly in patients with life-threatening complications. In patients who require transplantation, vascular lesions often recur. The molecular pathways involved in the vasculopathy of the antiphospholipid syndrome are unknown, and adequate therapies are lacking. We u...

Review article: the management of portal hypertensive gastropathy and gastric antral va...
https://doi.org/10.1111/apt.12824
Alimentary Pharmacology & Therapeutics; Patwardhan VR, Cardenas A

Jun 3rd, 2014 - Portal hypertensive gastropathy (PHG) and gastric antral vascular ectasia (GAVE) are important causes of both acute and chronic gastrointestinal bleeding in patients with cirrhosis. To review the current management of PHG and GAVE. PubMed was searched for English language articles using the key words 'GAVE', 'gastric antral vascular ectasia', 'cirrhosis', 'gastrointestinal bleeding', 'acute', '...

Vulvar cancers in women with vulvar lichen planus: a clinicopathological study.
https://doi.org/10.1016/j.jaad.2014.05.057
Journal of the American Academy of Dermatology; Regauer S, Reich O et. al.

Jul 7th, 2014 - Vulvar squamous cell carcinomas (SCCs) arising in association with vulvar lichen planus (LP) are poorly documented. We sought to present clinicopathological features of 38 patients (median age 61 years, range 39-90 years) with LP-associated vulvar SCCs. Evaluated were location of vulvar SCC and metastases at presentation, recurrences, survival, precursor lesions, presence of human papillomaviru...

Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277680
The New England Journal of Medicine; Gillespie SH, Crook AM et. al.

Sep 9th, 2014 - Early-phase and preclinical studies suggest that moxifloxacin-containing regimens could allow for effective 4-month treatment of uncomplicated, smear-positive pulmonary tuberculosis. We conducted a randomized, double-blind, placebo-controlled, phase 3 trial to test the noninferiority of two moxifloxacin-containing regimens as compared with a control regimen. One group of patients received isoni...

Colonoscopy is associated with a reduced risk for colon cancer and mortality in patient...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297589
Clinical Gastroenterology and Hepatology : the Official C... Ananthakrishnan AN, Cagan A et. al.

Jul 21st, 2014 - Crohn's disease and ulcerative colitis are associated with an increased risk of colorectal cancer (CRC). Surveillance colonoscopy is recommended at 2- to 3-year intervals beginning 8 years after diagnosis of inflammatory bowel disease (IBD). However, there have been no reports of whether colonoscopy examination reduces the risk for CRC in patients with IBD. In a retrospective study, we analyzed...

Reticular erythematous mucinosis: histopathological and immunohistochemical features of...
https://doi.org/10.1111/jdv.12654
Journal of the European Academy of Dermatology and Venere... Cinotti E, Merlo V et. al.

Aug 4th, 2014 - Reticular erythematous mucinosis (REM) and lupus erythematosus tumidus (LET) share similarities. However, to our knowledge no study extensively compared the histological features of these two conditions. The aim of this study is to compare the histological and immunohistochemical features of REM and LET. We evaluated epidermal thickness, hyperkeratosis, dermo-epidermal junction changes, interst...

Dalfampridine may activate latent trigeminal neuralgia in patients with multiple sclero...
https://doi.org/10.1212/WNL.0000000000000931
Neurology Birnbaum G, Iverson J

Sep 27th, 2014 - To determine the effect of dalfampridine (4-aminopyridine), a broad-spectrum, voltage-dependent potassium channel blocker, on patients with trigeminal nerve dysfunction due to multiple sclerosis (MS). We reviewed histories of 71 patients in our clinic with clinically definite MS who were treated with dalfampridine for at least 2 to 3 months. Of the 71 patients, 5 had a history of either trigemi...

Population-Based Surveillance of Birth Defects Potentially Related to Zika Virus Infect...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812309
MMWR. Morbidity and Mortality Weekly Report; Delaney A, Mai C et. al.

Jan 25th, 2018 - Zika virus infection during pregnancy can cause serious birth defects, including microcephaly and brain abnormalities (1). Population-based birth defects surveillance systems are critical to monitor all infants and fetuses with birth defects potentially related to Zika virus infection, regardless of known exposure or laboratory evidence of Zika virus infection during pregnancy. CDC analyzed dat...

Prospective Evaluation of Sunitinib-Induced Cardiotoxicity in Patients with Metastatic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516884
Clinical Cancer Research : an Official Journal of the Ame... Narayan V, Keefe S et. al.

Feb 15th, 2017 - Purpose: To prospectively evaluate cardiotoxicity risk with sunitinib in metastatic renal cell carcinoma (mRCC) routine clinical practice using comprehensive echocardiography and biomarker phenotyping.Experimental Design: In a multicenter prospective study of 90 patients with mRCC, echocardiography and biomarkers of cardiovascular injury and stress were quantified at baseline, 3.5, 15, and 33 w...

The incidence of visual impairment due to retinopathy of prematurity (ROP) and concomit...
https://doi.org/10.1136/bjo.2010.192542
The British Journal of Ophthalmology; van Sorge AJ, Termote JU et. al.

Feb 11th, 2011 - To determine the incidence of visual impairment (VI) caused by retinopathy of prematurity (ROP) and concomitant disabilities in preterm neonates born between 2000 and 2009 in the Netherlands. Data were retrieved from the Dutch institutes for the visually impaired. They were compared with similar Dutch studies conducted in 1975-1987, 1986-1994 and 1994-2000. Records of 42 infants with VI due to ...

Three-dimensional echocardiographic assessment of right ventricular volume and function...
https://doi.org/10.1016/j.echo.2009.11.002
Journal of the American Society of Echocardiography : Off... Grewal J, Majdalany D et. al.

Dec 7th, 2009 - The aim of this study was to evaluate the accuracy of three-dimensional (3D) ultrasound compared with the standard magnetic resonance imaging method in determining right ventricular (RV) volumes and function in adult patients with congenital heart disease and chronic, severe pulmonary regurgitation (PR). Twenty-five patients with severe PR secondary to either pulmonary valvotomy or tetralogy of...

Small bowel bacterial overgrowth in adults: a potential contributor to intestinal failure.
https://www.ncbi.nlm.nih.gov/pubmed/18377796
Current Gastroenterology Reports; Ziegler TR, Cole CR

Apr 1st, 2008 - Small bowel bacterial overgrowth (SBBO), in which colon-derived bacteria colonize the upper small bowel, is found in a wide variety of adult diseases associated with intestinal failure and dysfunction, including short bowel syndrome and other conditions following massive bowel resection, dysmotility disorders, and inflammatory bowel disease. SBBO also appears to be relatively common in the elde...