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About 233,340 results

Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease.
https://doi.org/10.1002/14651858.CD003733.pub5
The Cochrane Database of Systematic Reviews; Knight-Madden JM, Hambleton IR

Dec 3rd, 2022 - Bronchodilators are used to treat bronchial hyper-responsiveness in asthma. Bronchial hyper-responsiveness may be a component of acute chest syndrome in people with sickle cell disease. Therefore, bronchodilators may be useful in the treatment of acute chest syndrome. This is an update of a previously published Cochrane Review. The aim of the review is to determine whether the use of inhaled, s...

Dental anomalies and their therapeutic implications: retrospective assessment of a freq...
https://doi.org/10.1186/s12903-022-02606-3
BMC Oral Health; Sander AK, Grau E et. al.

Dec 3rd, 2022 - Orofacial clefts are characterized by a frequent occurrence of dental anomalies. Numerous studies demonstrate the high prevalence of dental aplasia, supernumerary teeth, and hypoplastic teeth in patients with cleft lip with/without cleft palate (CL/P), yet the therapeutic consequences are rarely discussed. This study explores prevalence, localization, and association between primary and seconda...

Onset of spondyloarthritis in a patient treated with adalimumab for relapsing anterior ...
https://doi.org/10.1097/MD.0000000000031554
Medicine Raimondo V

Dec 2nd, 2022 - Adalimumab, an inhibitor of tumor necrosis factor-alpha, is a systemic non-corticosteroid agent approved for the treatment of noninfectious uveitis. Secukinumab, a human monoclonal antibody inhibiting interleukin 17A, is also being investigated as a potential treatment for noninfectious uveitis. A 32-year-old Italian woman receiving adalimumab for relapsed anterior uveitis developed axial and p...

Acquired uterine arteriovenous malformation in a patient with cornual pregnancy: A case...
https://doi.org/10.1097/MD.0000000000031629
Medicine Yan Y, Jia Y et. al.

Dec 2nd, 2022 - Acquired uterine arteriovenous malformation (uAVM) is a rare disease and could occur after dilation and curettage, cesarean section, or neoplastic processes. A 29-year-old female presented with acute right lower abdominal pain and positive beta human chorionic gonadotropin (β-hCG). A 6 cm ectopic right cornual pregnancy was found on ultrasound examination. She underwent a laparoscopic resection...

Factors associated with nonadherence to surveillance for hepatocellular carcinoma among...
https://doi.org/10.1097/MD.0000000000031907
Medicine Chang SS, Hu HY et. al.

Dec 2nd, 2022 - Hepatocellular carcinoma (HCC) surveillance can detect the early stage of tumors and lead to improved survival. Adherence to guideline-concordant HCC surveillance is crucial in at-risk populations, including patients with hepatic C virus (HCV) cirrhosis. This study was conducted to identify patient and provider factors associated with nonadherence to HCC surveillance in patients with HCV cirrho...

Ovarian clear cell cancer associated with Trousseau syndrome: A case report and literat...
https://doi.org/10.1097/MD.0000000000032106
Medicine You Y, Chen X et. al.

Dec 2nd, 2022 - Trousseau syndrome is known as patients with tumors have a combination of multiple thrombi with systemic organ infarction. The incidence of ovarian clear cell cancer associated with Trousseau syndrome is relatively low. We report the case of a 41-year-old woman diagnosed with ovarian clear cell cancer with deep vein thrombosis and cerebral infarction who had a poor prognosis. A 41-year-old woma...

m6A reader hnRNPA2B1 drives multiple myeloma osteolytic bone disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706590
Theranostics Liu R, Zhong Y et. al.

Dec 2nd, 2022 - Rationale: Bone destruction is a hallmark of multiple myeloma (MM) and affects more than 80% of patients. Although previous works revealed the roles of N6-methyladenosine (m6A) reader hnRNPA2B1 in the development of tumors, whether hnRNPA2B1 regulates bone destruction in MM is still unknown. Methods: Alizarin red S staining, TRAP staining, ELISA and quantitative real-time PCR assays were used t...

Esophagogastric Junction Outflow Obstruction and Hiatal Hernia: Is Hernia Repair Alone ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673993
JSLS : Journal of the Society of Laparoendoscopic Surgeons; DeLong CG, Liu AT et. al.

Dec 2nd, 2022 - Esophagogastric junction outflow obstruction (EGJOO) is attributed to primary/idiopathic causes or secondary/mechanical causes, including hiatal hernias (HH). While patients with HH and EGJOO (HH+EGJOO) may undergo HH repair without myotomy, it is unclear if an underlying motility disorder is missed by therapy which addresses only the secondary EGJOO cause. The goal of this study was to determi...

Disease Burden in Patients with von Willebrand Disease Potentially Eligible for Prophyl...
https://doi.org/10.1177/10760296221130334
Clinical and Applied Thrombosis/hemostasis : Official Jou... Du P, Morgan G et. al.

Dec 2nd, 2022 - Recent international guidelines conditionally recommend von Willebrand factor (VWF) prophylaxis for von Willebrand disease (VWD) patients with a history of severe/frequent bleeds. This post hoc analysis of the Cost of VWD Across Europe, a Socioeconomic Study (CVESS; conducted in 2018), assessed patient characteristics and disease burden in patients aged >1 year with congenital VWD not receiving...

Clinical characteristics and risk factors for kidney failure in patients with autosomal...
https://doi.org/10.1097/MD.0000000000031838
Medicine Park H, Paek JH et. al.

Dec 2nd, 2022 - Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary and progressive renal disease. By the age of 65 years, 45% to 70% of patients with ADPKD reach end-stage renal disease (ESRD). Although there are various treatments for this condition, no standard therapy exists to delay the progression of ADPKD. Hence, understanding the factors that affect disease progression may be helpful f...

"Is anemia frequently recognized in gastroschisis compared to omphalocele? A multicente...
https://doi.org/10.1007/s00383-022-05288-8
Pediatric Surgery International; Govani DJ, Trambadia RA et. al.

Dec 2nd, 2022 - "Is anemia frequently recognized in gastroschisis compared to omphalocele? A multicenter retrospective study in southern Japan" by Sugita, K et al.|2022|Govani DJ,Trambadia RA,Chhaniara RA,Mirani ZR,Midha PK,|complications,diagnosis,epidemiology,complications,epidemiology,surgery,epidemiology,

Importance of urodynamic evaluation of bladder function after secondary untethering in ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715467
Pediatric Surgery International; Ciesla L, Schneider J et. al.

Dec 2nd, 2022 - A TCS after primary closure of meningomyeloceles is a known complication of the spina bifida disease. Data on the outcome after SSCU surgery is heterogeneous and lacking standardization. Thus we aimed to find a reliable system for assessment of the bladder function before and after SSCU surgery and document postoperative outcome. A retrospective study was performed on a cohort of patients with ...

Bullous Sweet syndrome as a presentation of chronic myelogenous leukaemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716981
BMJ Case Reports; Abbas SW, Shah Z et. al.

Dec 2nd, 2022 - A woman in her 40s presented with a 3-month-long history of fever and tender erythematous bullous skin lesions not responsive to antibiotics. There had been no previous gastrointestinal, respiratory or urinary infection, nor did she have any history of autoimmune disease, drug reaction or vasculitis.Histological evaluation of skin biopsy showed diffuse dense neutrophilic infiltrates located in ...

Asymptomatic pulmonary cryptococcosis presenting with mixed lesions of infiltrative and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716928
BMJ Case Reports; Ito T, Kanai O et. al.

Dec 2nd, 2022 - Pulmonary cryptococcosis (PC) is a rare fungal lung infection that usually occurs in immunocompromised hosts. We report a rare case of PC with asymptomatic and mixed lesions of infiltrative and nodular shadows. A woman in her 50s with a 7-year history of methotrexate treatment for rheumatoid arthritis (RA) presented with abnormal chest shadows on annual examination. Chest CT revealed two tiny n...

The Role of Infection and Inflammation in the Pathogenesis of Pediatric Arterial Ischem...
https://doi.org/10.1016/j.spen.2022.100995
Seminars in Pediatric Neurology; Cornet MC, Grose C et. al.

Dec 2nd, 2022 - Infections play an important role in the pathogenesis of acute ischemic stroke (AIS) in neonates and children. In neonates, chorioamnionitis or intrauterine inflammation has been implicated as a common risk factor for AIS. In infants and children, recent investigations demonstrated that even minor childhood infections are associated with subsequent increased risk for AIS. Post-infectious inflam...

A simple covert hepatic encephalopathy screening model based on blood biochemical param...
https://doi.org/10.1371/journal.pone.0277829
PloS One; Miwa T, Hanai T et. al.

Dec 1st, 2022 - Covert hepatic encephalopathy (CHE) adversely affects clinical outcomes in patients with liver cirrhosis, although its diagnosis is difficult. This study aimed to establish a simple CHE screening model based on blood-related biochemical parameters. This retrospective study enrolled 439 patients who were assessed for CHE using a neuropsychiatric test between January 2011 and June 2019. A simple ...

DEM-TACE as the initial treatment could improve the clinical efficacy of the hepatocell...
https://doi.org/10.1186/s12885-022-10361-5
BMC Cancer; Chen J, Lai L et. al.

Dec 1st, 2022 - Conventional-transarterial chemoembolization (C-TACE) was proven to improve overall survival (OS) in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT), drug-eluting microsphere-TACE (DEM-TACE) was supposed to provide more benefit than C-TACE in this respect. To compare the safety and efficacy between DEM-TACE and C-TACE as the initial treatment in HCC patients with ...

Surgery for chronic arthropathy in people with haemophilia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710191
The Cochrane Database of Systematic Reviews; Chin B, Wee I et. al.

Dec 1st, 2022 - Chronic arthropathy is a potentially debilitating complication for people with haemophilia - a genetic, X-linked, recessive bleeding disorder, characterised by the absence or deficiency of a clotting factor protein. Staging classifications, such as the Arnold-Hilgartner classification for haemophilic arthropathy of the knee, radiologically reflect the extent of knee joint destruction with under...

High intestinal vascular permeability in a murine model for Hirschsprung's disease: imp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713090
Pediatric Surgery International; Suda K, Yamada S et. al.

Dec 1st, 2022 - Intestinal vascular permeability (VP) in a murine model for Hirschsprung's disease (HD) and postoperative Hirschsprung-associated enterocolitis (HAEC) were investigated. Intestinal VP was determined using a Miles assay using 1% Evans blue injected into a superficial temporal vein of newborn endothelin receptor-B KO HD model (KO) and syngeneic wild-type (WT) mice (n = 5, respectively). Extravasa...

Decreased liver damage in rat models of short bowel syndrome through DPP4 inhibition.
https://doi.org/10.1007/s00383-022-05301-0
Pediatric Surgery International; Sueyoshi R, Furuhashi N et. al.

Dec 1st, 2022 - Total parenteral nutrition causes liver damage in patients with short bowel syndrome (SBS), in whom intestinal failure-associated liver disease (IFALD) is the strongest risk factor for mortality. We previously demonstrated the efficacy of dipeptidyl peptidase-4 inhibitors (DPP4-Is) for nutritional absorption and intestinal barrier function enhancement. Herein, we investigated the efficacy of DP...