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About 10,915 results

South Korea Approves First Domestically Developed COVID Vaccine
https://www.medscape.com/viewarticle/976355

Jun 30th, 2022 - SEOUL (Reuters) - South Korea approved its first domestically developed COVID-19 vaccine, manufactured by SK bioscience Co Ltd, for general public use following positive clinical data, authorities said on Wednesday. The SKYCovione vaccine was authorised for a two-dose regimen on people aged 18 or older, with shots given four weeks apart, according to the Ministry of Food and Drug Safety. In a p...

Severe COVID-19 in Chronic Liver Disease Linked With Cholestasis and Secondary Sclerosing Cholangitis
https://www.medscape.com/viewarticle/976382

Jun 30th, 2022 - NEW YORK (Reuters Health) - Severe COVID-19 increases the risk for cholestasis and secondary sclerosing cholangitis (SSC) in patients with chronic liver disease (CLD), researchers say. Among 65 patients with preexisting CLD who were hospitalized for COVID-19, 23% developed cholestatic liver failure (cholestasis plus bilirubin at least 6mg/dL) and 15.4% developed SSC on the basis of cross-sectio...

The Next COVID Booster Shots Will Likely Be Updated for Omicron
https://www.medscape.com/viewarticle/976166

Jun 27th, 2022 - NEW YORK (Reuters) - COVID-19 vaccines this fall are likely to be based on the Omicron variant of the coronavirus rather than the original strain, although some experts suggest they may only offer significant benefits for older and immunocompromised people. Moderna, Pfizer and Novavax have been testing vaccines based on the first Omicron variant that became dominant last winter, BA.1, driving a...

Some Long COVID Patients Still Have Virus in Blood
https://www.medscape.com/viewarticle/976197

Jun 27th, 2022 - (Reuters) - Some cases of long COVID may be the immune system's response to a SARS-CoV-2 infection lurking somewhere in the body, new findings from a small study suggest. Researchers analyzed multiple plasma samples collected over time from 63 patients with COVID-19, including 37 who went on to develop long COVID. In the majority of those with long COVID, the spike protein from the surface of t...

Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health
https://clinicaltrials.gov/ct2/show/NCT04573062

Jun 24th, 2022 - Study Description: In late 2019, the novel coronavirus SARS/CoV2 appeared in Wuhan, China. The various ways that humans will recover from COVID-19 is just starting to be observed and it is clear there will be a wide range of convalescent experiences. A year into the pandemic, the post-acute sequelae of SARS/CoV2 infection (PASC) is known to be common and includes a broad range of symptoms and p...

An Observational Study of Neurologic Function After COVID-19 Infection
https://clinicaltrials.gov/ct2/show/NCT04564287

Jun 24th, 2022 - Study Description: This study will characterize ongoing neurologic abnormalities in those who recovered from acute COVID-19 infection yet have persistent neurologic symptoms. Despite clinical recovery from the acute infection, some individuals continue to experience ongoing symptoms, at times several months after recovery (Post-Acute Sequelae of SARS CoV-2 Infection, PASC), and many of these sy...

Identification and Characterization of SARS-CoV-2 Specific CD8 T Cells in Humans
https://clinicaltrials.gov/ct2/show/NCT04565067

Jun 24th, 2022 - Study Description: This study is to identify epitopes of SARS-CoV-2 that are recognized by CD8 T cells in the blood of healthy young and old participants as well as COVID-19 recovered. We will also measure general health factors using blood, saliva and urine samples. By analyzing the frequency, differentiation, and expansion of these SARS-CoV-2 recognizing CD8 T cells, we hope to shed light int...

COVID-19 Associated Lymphopenia Pathogenesis Study in Blood
https://clinicaltrials.gov/ct2/show/NCT04401436

Jun 24th, 2022 - Coronavirus disease 2019 (COVID-19) is an acute respiratory syndrome caused by the novel coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The emergence of SARS-CoV-2 has led to a pandemic with a wide range of manifestations. One of the hallmarks of severe illness is the presence of elevated levels of inflammatory biomarkers, coagulopathy, and lymphopenia. Lymphopenia is...

Serological Surveillance for COVID-19 in Central North Carolina
https://clinicaltrials.gov/ct2/show/NCT04490174

Jun 24th, 2022 - It has been demonstrated that respiratory virus outbreaks and pandemics, such as influenza, SARS, MERS, and now the newly emerged SARS-CoV-2 virus, have a major impact on morbidity and mortality worldwide, as well as having devastating global economic and societal impact. During these outbreaks it is critical to gain a rapid understanding of the exposures and immunity in the general population....

Role of the Microbiota in the Evolution of the SARS-CoV-2 Disease,COVID-19, in Hospitalized Patients
https://clinicaltrials.gov/ct2/show/NCT04669938

Jun 24th, 2022 - Patients hospitalized for COVID-19 may need intensive care (e.g. mechanical ventilation) during hospitalization. Some risk factors are already known (e.g. sex, comorbidities, initial clinical presentation inflammatory cytokines), but better targeting of such patients is still needed, at least because existing risk factors are not strong enough to provide an accurate prediction. Care organizatio...

Ocular Findings and Viral Persistence in Ocular Fluids in COVID-19 Survivors
https://clinicaltrials.gov/ct2/show/NCT04665752

Jun 24th, 2022 - Study Description: The objective of this study is to understand the rate and extent of ocular involvement in COVID-19 patients and whether SARS-COV-2 can be detected in ocular fluids or tissue in convalescent phase. Objectives: Primary Objective: To investigate if COVID survivors show signs of anterior or posterior segment inflammation or other retinochoroidal changes after recovery. Secondary ...

Mental Health Impact of the COVID-19 Pandemic on Amish and Mennonite Participants in AMBiGen
https://clinicaltrials.gov/ct2/show/NCT04684615

Jun 24th, 2022 - This protocol leverages existing NIMH studies and participants to accomplish time-sensitive research on the mental health impact of environmental stressors imposed by the COVID-19 pandemic. The study will describe the relationship between stressors related to COVID-19 and self-rated measures of mental health symptoms and distress among Amish and Mennonite participants in an ongoing study of bip...

Natural History of Systemic and Nasal Mucosal Immunity to Influenza and SARS-CoV-2 in Adults After Vaccination
https://clinicaltrials.gov/ct2/show/NCT04794829

Jun 24th, 2022 - Title: Natural History of Systemic and Nasal Mucosal Immunity to Influenza and SARS-CoV-2 in Adults after Vaccination Study Description: Yearly influenza vaccination is necessary due to short-lasting influenza immunity and changing strains of circulating influenza. With limited effectiveness of yearly influenza vaccines and the ongoing potential for an influenza pandemic, there is a need for a ...

A Clinical Observational Study of SARS-CoV-2 Specific CD8 T-Cell Responses to COVID-19 Vaccines in Humans
https://clinicaltrials.gov/ct2/show/NCT04852289

Jun 24th, 2022 - STUDY DESCRIPTION: This study is to identify SARS-CoV-2 S protein specific CD8 T cells in the blood of COVID-19 vaccinated participants. Pfizer and Moderna made vaccines will be used in this study. As both vaccines are mRNA based encoding S protein of SARS-CoV-2 and require two doses, the CD8 T cell response is expected to be comparable. We will also measure general health factors using blood s...

Send-In Sample Collection for Comprehensive Analyses of Innate and Adaptive Immune Responses During Acute COVID-19 and Convalescence
https://clinicaltrials.gov/ct2/show/NCT04582903

Jun 24th, 2022 - In response to the public health emergency posed by the coronavirus disease 2019 (COVID-19) pandemic, researchers at the National Institute of Allergy and Infectious Diseases (NIAID) are leading a large international collaboration to characterize the innate and adaptive immune responses to acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and convalescence. This proto...

A Longitudinal Study of COVID-19 Sequelae and Immunity
https://clinicaltrials.gov/ct2/show/NCT04411147

Jun 24th, 2022 - Title: A Longitudinal Study of COVID-19 Sequelae and Immunity Study Description: This is a longitudinal cohort study to evaluate the clinical sequelae of acute COVID-19 and characterize the immune response to SARS-CoV-2. Household contacts of the COVID-19 cohort will also be recruited and serve as a control group. Objectives: Characterize the medical sequalae and persistent symptoms following r...

SARS-COV2 Pandemic Serosurvey in a Rare Disease Population
https://clinicaltrials.gov/ct2/show/NCT04609085

Jun 24th, 2022 - It has been demonstrated that respiratory virus outbreaks and pandemics, such as influenza, SARS, MERS, and now the newly emerged SARS-COV2 virus, have a major impact on morbidity and mortality worldwide, as well as having devastating global economic and societal impact. During these outbreaks it is critical to gain a rapid understanding of the exposures and immunity in the general population. ...

Respiratory Physiotherapy and Neurorehabilitation in Patients With Post-covid19 Sequelae.
https://clinicaltrials.gov/ct2/show/NCT05195099

Jun 24th, 2022 - The objectives are to reduce dyspnoea, increase exertional capacity, increase vital capacity and respiratory muscle strength. vital capacity and respiratory muscle strength. In addition to increasing the sensibility of smell and taste, observing if there is a relationship between the decrease of these senses with the senses with appetite and whether appetite has normalised in post-SARS-CoV-2 pa...

Within Household Transmission of COVID-19 Infections
https://clinicaltrials.gov/ct2/show/NCT05430516

Jun 24th, 2022 - In the absence of a vaccine, the spread of SARS-CoV-2 can only be mitigated via non-pharmaceutical interventions that reduce the risks of forward transmission. Currently, European policymakers are implementing combinations of fierce pandemic control measures. However, there is substantial uncertainty on the transmission dynamics of SARS-CoV-2 and, consequently, the effect of each specific mitig...

Post Covid-19 Vaccination Development or Flare of ARD
https://clinicaltrials.gov/ct2/show/NCT05160428

Jun 24th, 2022 - -In this study: patients with known diagnosed rheumatic diseases who are vaccinated (one or full doses) of any type of COVID-19 vaccines will be enrolled. new ARD and prevalence of different MSK manifestations after covid-19 vaccinations also will be reported. The prevalence of flare of ARD after covid-19 vaccinations will be dteremined. Also we will compare between different types and doses of...