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About 26,418 results

A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia e...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499540
Proceedings of the National Academy of Sciences of the Un... Wang L, Park JY et. al.

Sep 13th, 2022 - The neocortex, the center for higher brain function, first emerged in mammals and has become massively expanded and folded in humans, constituting almost half the volume of the human brain. Primary microcephaly, a developmental disorder in which the brain is smaller than normal at birth, results mainly from there being fewer neurons in the neocortex because of defects in neural progenitor cells...

The Effect of Yes-Associated Protein on the Interaction Between the MEK/Extracellular S...
https://doi.org/10.1097/SCS.0000000000008115
The Journal of Craniofacial Surgery; Dong X, Zhang M et. al.

Aug 31st, 2022 - C342Y (Cys342Tyr) point mutation of FGFR2 (fibroblast growth factor receptor 2) is closely associated with the pathogenesis of Crouzon syndrome. The dura mater plays an important role in mediating the closure of cranial sutures. However, the underlying mechanisms of these pathological processes have been rarely investigated. in this study, the authors analyzed the effects of dura cells with FGF...

Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and pro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403751
Disease Models & Mechanisms; Pfeifer K, Wolfstetter G et. al.

Aug 17th, 2022 - Activating anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK) mutations occur in pediatric neuroblastoma and are associated with poor prognosis. To study ALK-activating mutations in a genetically controllable system, we employed CRIPSR/Cas9, incorporating orthologs of the human oncogenic mutations ALKF1174L and ALKY1278S in the Drosophila Alk locus. AlkF1251L and AlkY1355S mutant D...

Secreted fungal virulence effector triggers allergic inflammation via TLR4.
https://doi.org/10.1038/s41586-022-05005-4
Nature Dang EV, Lei S et. al.

Jul 28th, 2022 - Invasive fungal pathogens are major causes of human mortality and morbidity1,2. Although numerous secreted effector proteins that reprogram innate immunity to promote virulence have been identified in pathogenic bacteria, so far, there are no examples of analogous secreted effector proteins produced by human fungal pathogens. Cryptococcus neoformans, the most common cause of fungal meningitis a...

Persistent Maintenance of Intermediate Memory B Cells Following SARS-CoV-2 Infection an...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364791
Journal of Virology; Pušnik J, König J et. al.

Jul 22nd, 2022 - Robust population-wide immunity will help to curb the SARS-CoV-2 pandemics. To maintain the immunity at protective levels, the quality and persistence of the immune response elicited by infection or vaccination must be determined. We analyzed the dynamics of B cell response during 12 months following SARS-CoV-2 infection on an individual level. In contrast to antibodies, memory B cells specific...

Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303934
Proceedings of the National Academy of Sciences of the Un... van Zyl T, Yan W et. al.

Jul 21st, 2022 - The anterior segment of the eye consists of the cornea, iris, ciliary body, crystalline lens, and aqueous humor outflow pathways. Together, these tissues are essential for the proper functioning of the eye. Disorders of vision have been ascribed to defects in all of them; some disorders, including glaucoma and cataract, are among the most prevalent causes of blindness in the world. To character...

The administration of amnion-derived multipotent cell secretome ST266 protects against ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448291
American Journal of Physiology. Gastrointestinal and Live... Sodhi CP, Ahmad R et. al.

Jul 13th, 2022 - Necrotizing enterocolitis (NEC) is the leading cause of death from gastrointestinal disease in premature infants and is steadily rising in frequency. Patients who develop NEC have a very high mortality, illustrating the importance of developing novel prevention or treatment approaches. We and others have shown that NEC arises in part from exaggerated signaling via the bacterial receptor, Toll-l...

Deciphering the immunopeptidome in vivo reveals new tumour antigens.
https://doi.org/10.1038/s41586-022-04839-2
Nature Jaeger AM, Stopfer LE et. al.

Jun 16th, 2022 - Immunosurveillance of cancer requires the presentation of peptide antigens on major histocompatibility complex class I (MHC-I) molecules1-5. Current approaches to profiling of MHC-I-associated peptides, collectively known as the immunopeptidome, are limited to in vitro investigation or bulk tumour lysates, which limits our understanding of cancer-specific patterns of antigen presentation in viv...

Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175369
Acta Neuropathologica Communications; Utagawa EC, Moreno DG et. al.

Jun 9th, 2022 - Although Down syndrome (DS), the most common developmental genetic cause of intellectual disability, displays proliferation and migration deficits in the prenatal frontal cortex (FC), a knowledge gap exists on the effects of trisomy 21 upon postnatal cortical development. Here, we examined cortical neurogenesis and differentiation in the FC supragranular (SG, II/III) and infragranular (IG, V/VI...

Carbonic anhydrase IX proteoglycan-like and intracellular domains mediate pulmonary mic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255709
American Journal of Physiology. Lung Cellular and Molecul... Stevens RP, Alexeyev MF et. al.

Jun 8th, 2022 - The lungs of patients with acute respiratory distress syndrome (ARDS) have hyperpermeable capillaries that must undergo repair in an acidic microenvironment. Pulmonary microvascular endothelial cells (PMVECs) have an acid-resistant phenotype, in part due to carbonic anhydrase IX (CA IX). CA IX also facilitates PMVEC repair by promoting aerobic glycolysis, migration, and network formation. Molec...

Brain motor and fear circuits regulate leukocytes during acute stress.
https://doi.org/10.1038/s41586-022-04890-z
Nature Poller WC, Downey J et. al.

Jun 1st, 2022 - The nervous and immune systems are intricately linked1. Although psychological stress is known to modulate immune function, mechanistic pathways linking stress networks in the brain to peripheral leukocytes remain poorly understood2. Here we show that distinct brain regions shape leukocyte distribution and function throughout the body during acute stress in mice. Using optogenetics and chemogen...

Zika Virus Induces Mitotic Catastrophe in Human Neural Progenitors by Triggering Unsche...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093132
Journal of Virology; Rychlowska M, Agyapong A et. al.

Apr 13th, 2022 - Vertical transmission of Zika virus (ZIKV) leads with high frequency to congenital ZIKV syndrome (CZS), whose worst outcome is microcephaly. However, the mechanisms of congenital ZIKV neurodevelopmental pathologies, including direct cytotoxicity to neural progenitor cells (NPC), placental insufficiency, and immune responses, remain incompletely understood. At the cellular level, microcephaly ty...

Pten heterozygosity restores neuronal morphology in fragile X syndrome mice.
https://doi.org/10.1073/pnas.2109448119
Proceedings of the National Academy of Sciences of the Un... Sathyanarayana SH, Saunders JA et. al.

Apr 9th, 2022 - Genetic studies of hippocampal granule neuron development have been used to elucidate cellular functions of Pten and Fmr1. While mutations in each gene cause neurodevelopmental disorders such as autism and fragile X syndrome, how Pten and Fmr1 function alone or together during normal development is not known. Moreover, Pten mRNA is bound by the fragile X mental retardation protein (FMRP) RNA bi...

Osteoclasts differential-related prognostic biomarker for osteosarcoma based on single ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932072
BMC Cancer; Shao H, Ge M et. al.

Mar 19th, 2022 - Osteosarcoma (OS) is one of the most common primary bone malignant tumors. Osteoclasts have been shown to have a valuable role in OS. In the present study, we analyzed the differentiation states of osteoclasts in OS and their prognostic significance based on integrated scRNA-seq and bulk RNA-seq data. Osteoclasts in distinct differentiation states were characterized, and 661 osteoclasts differe...

Investigating the impact of SARS-CoV-2 infection on basic semen parameters and in vitro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901866
Reproductive Biology and Endocrinology : RB&E; Wang M, Hu J et. al.

Mar 10th, 2022 - This study aimed to evaluate the influences of SARS-CoV-2 infection on semen parameters and investigate the impact of the infection on in vitro fertilization (IVF) outcomes. This retrospective study enrolled couples undergoing IVF cycles between May 2020 and February 2021 at Tongji Hospital, Wuhan. Baseline characteristics were matched using propensity score matching. Participants were categori...

Comparison of transcriptome profiles of nucleated red blood cells in cord blood between...
https://doi.org/10.1080/16078454.2022.2029255
Hematology (Amsterdam, Netherlands); Han Y, Huang L et. al.

Feb 23rd, 2022 - The reactivation of fetal γ-globin expression is an effective strategy for ameliorating the clinical symptoms of β-hemoglobinopathies. However, the mechanism of globin switching, especially the roles of long non-coding RNAs (lncRNAs) in this process, remains elusive. We compared the in vivo transcriptome profiles of nucleated red blood cells (NRBCs) isolated from the umbilical cord blood of pre...

T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854421
Nature Communications; Ravi VM, Neidert N et. al.

Feb 19th, 2022 - Despite recent advances in cancer immunotherapy, certain tumor types, such as Glioblastomas, are highly resistant due to their tumor microenvironment disabling the anti-tumor immune response. Here we show, by applying an in-silico multidimensional model integrating spatially resolved and single-cell gene expression data of 45,615 immune cells from 12 tumor samples, that a subset of Interleukin-...

Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854428
Nature Communications; Li T, Lu D et. al.

Feb 19th, 2022 - Koolen-de Vries syndrome (KdVS) is a rare disorder caused by haploinsufficiency of KAT8 regulatory NSL complex subunit 1 (KANSL1), which is characterized by intellectual disability, heart failure, hypotonia, and congenital malformations. To date, no effective treatment has been found for KdVS, largely due to its unknown pathogenesis. Using siRNA screening, we identified KANSL1 as an essential g...

Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850437
Nature Communications; Lovey A, Verma S et. al.

Feb 18th, 2022 - Mechanisms underlying variability in transmission of Mycobacterium tuberculosis strains remain undefined. By characterizing high and low transmission strains of M.tuberculosis in mice, we show here that high transmission M.tuberculosis strain induce rapid IL-1R-dependent alveolar macrophage migration from the alveolar space into the interstitium and that this action is key to subsequent tempora...

Upregulation of Checkpoint Ligand Programmed Death-Ligand 1 in Patients with Paroxysmal...
https://doi.org/10.4049/jimmunol.2100031
Journal of Immunology (Baltimore, Md. : 1950); Anliker M, Drees D et. al.

Feb 18th, 2022 - Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hemolytic disease driven by impaired complement regulation. Mutations in genes encoding the enzymes that build the GPI anchors are causative, with somatic mutations in the PIG-A gene occurring most frequently. As a result, the important membrane-bound complement regulators CD55 and CD59 are missing on the affected hematopoietic stem cells and ...