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About 26,305 results

Zika Virus Induces Mitotic Catastrophe in Human Neural Progenitors by Triggering Unsche...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093132
Journal of Virology; Rychlowska M, Agyapong A et. al.

Apr 13th, 2022 - Vertical transmission of Zika virus (ZIKV) leads with high frequency to congenital ZIKV syndrome (CZS), whose worst outcome is microcephaly. However, the mechanisms of congenital ZIKV neurodevelopmental pathologies, including direct cytotoxicity to neural progenitor cells (NPC), placental insufficiency, and immune responses, remain incompletely understood. At the cellular level, microcephaly ty...

Pten heterozygosity restores neuronal morphology in fragile X syndrome mice.
https://doi.org/10.1073/pnas.2109448119
Proceedings of the National Academy of Sciences of the Un... Sathyanarayana SH, Saunders JA et. al.

Apr 9th, 2022 - Genetic studies of hippocampal granule neuron development have been used to elucidate cellular functions of Pten and Fmr1. While mutations in each gene cause neurodevelopmental disorders such as autism and fragile X syndrome, how Pten and Fmr1 function alone or together during normal development is not known. Moreover, Pten mRNA is bound by the fragile X mental retardation protein (FMRP) RNA bi...

Osteoclasts differential-related prognostic biomarker for osteosarcoma based on single ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932072
BMC Cancer; Shao H, Ge M et. al.

Mar 19th, 2022 - Osteosarcoma (OS) is one of the most common primary bone malignant tumors. Osteoclasts have been shown to have a valuable role in OS. In the present study, we analyzed the differentiation states of osteoclasts in OS and their prognostic significance based on integrated scRNA-seq and bulk RNA-seq data. Osteoclasts in distinct differentiation states were characterized, and 661 osteoclasts differe...

Investigating the impact of SARS-CoV-2 infection on basic semen parameters and in vitro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901866
Reproductive Biology and Endocrinology : RB&E; Wang M, Hu J et. al.

Mar 10th, 2022 - This study aimed to evaluate the influences of SARS-CoV-2 infection on semen parameters and investigate the impact of the infection on in vitro fertilization (IVF) outcomes. This retrospective study enrolled couples undergoing IVF cycles between May 2020 and February 2021 at Tongji Hospital, Wuhan. Baseline characteristics were matched using propensity score matching. Participants were categori...

Comparison of transcriptome profiles of nucleated red blood cells in cord blood between...
https://doi.org/10.1080/16078454.2022.2029255
Hematology (Amsterdam, Netherlands); Han Y, Huang L et. al.

Feb 23rd, 2022 - The reactivation of fetal γ-globin expression is an effective strategy for ameliorating the clinical symptoms of β-hemoglobinopathies. However, the mechanism of globin switching, especially the roles of long non-coding RNAs (lncRNAs) in this process, remains elusive. We compared the in vivo transcriptome profiles of nucleated red blood cells (NRBCs) isolated from the umbilical cord blood of pre...

T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854421
Nature Communications; Ravi VM, Neidert N et. al.

Feb 19th, 2022 - Despite recent advances in cancer immunotherapy, certain tumor types, such as Glioblastomas, are highly resistant due to their tumor microenvironment disabling the anti-tumor immune response. Here we show, by applying an in-silico multidimensional model integrating spatially resolved and single-cell gene expression data of 45,615 immune cells from 12 tumor samples, that a subset of Interleukin-...

Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854428
Nature Communications; Li T, Lu D et. al.

Feb 19th, 2022 - Koolen-de Vries syndrome (KdVS) is a rare disorder caused by haploinsufficiency of KAT8 regulatory NSL complex subunit 1 (KANSL1), which is characterized by intellectual disability, heart failure, hypotonia, and congenital malformations. To date, no effective treatment has been found for KdVS, largely due to its unknown pathogenesis. Using siRNA screening, we identified KANSL1 as an essential g...

Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850437
Nature Communications; Lovey A, Verma S et. al.

Feb 18th, 2022 - Mechanisms underlying variability in transmission of Mycobacterium tuberculosis strains remain undefined. By characterizing high and low transmission strains of M.tuberculosis in mice, we show here that high transmission M.tuberculosis strain induce rapid IL-1R-dependent alveolar macrophage migration from the alveolar space into the interstitium and that this action is key to subsequent tempora...

Upregulation of Checkpoint Ligand Programmed Death-Ligand 1 in Patients with Paroxysmal...
https://doi.org/10.4049/jimmunol.2100031
Journal of Immunology (Baltimore, Md. : 1950); Anliker M, Drees D et. al.

Feb 18th, 2022 - Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hemolytic disease driven by impaired complement regulation. Mutations in genes encoding the enzymes that build the GPI anchors are causative, with somatic mutations in the PIG-A gene occurring most frequently. As a result, the important membrane-bound complement regulators CD55 and CD59 are missing on the affected hematopoietic stem cells and ...

Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulm...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872770
Proceedings of the National Academy of Sciences of the Un... Qiu M, Tang Y et. al.

Feb 18th, 2022 - Safe and efficacious systemic delivery of messenger RNA (mRNA) to specific organs and cells in vivo remains the major challenge in the development of mRNA-based therapeutics. Targeting of systemically administered lipid nanoparticles (LNPs) coformulated with mRNA has largely been confined to the liver and spleen. Using a library screening approach, we identified that N-series LNPs (containing a...

Suicide gene therapy by canine mesenchymal stem cell transduced with thymidine kinase i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846542
PloS One; Villatoro AJ, Alcoholado C et. al.

Feb 16th, 2022 - The role played by certain domestic species such as dogs as a translational model in comparative oncology shows great interest to develop new therapeutic strategies in brain tumors. Gliomas are a therapeutic challenge that represents the most common form of malignant primary brain tumors in humans and the second most common form in dogs. Gene-directed enzyme/prodrug therapy using adipose mesenc...

Contribution of Dendritic Cell Subsets to T Cell-Dependent Responses in Mice.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881363
Journal of Immunology (Baltimore, Md. : 1950); Abboud G, Elshikha AS et. al.

Feb 11th, 2022 - BATF3-deficient mice that lack CD8+ dendritic cells (DCs) showed an exacerbation of chronic graft-versus-host disease (cGVHD), including T follicular helper (Tfh) cell and autoantibody responses, whereas mice carrying the Sle2c2 lupus-suppressive locus with a mutation in the G-CSFR showed an expansion of CD8+ DCs and a poor mobilization of plasmacytoid DCs (pDCs) and responded poorly to cGVHD i...

Bacteroides acidifaciens in the gut plays a protective role against CD95-mediated liver...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820816
Gut Microbes; Wang H, Wang Q et. al.

Feb 8th, 2022 - The intestinal flora plays an important role in the development of many human and animal diseases. Microbiome association studies revealed the potential regulatory function of intestinal bacteria in many liver diseases, such as autoimmune hepatitis, viral hepatitis and alcoholic hepatitis. However, the key intestinal bacterial strains that affect pathological liver injury and the underlying fun...

A neomorphic variant in SP7 alters sequence specificity and causes a high-turnover bone...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816926
Nature Communications; Lui JC, Raimann A et. al.

Feb 6th, 2022 - SP7/Osterix is a transcription factor critical for osteoblast maturation and bone formation. Homozygous loss-of-function mutations in SP7 cause osteogenesis imperfecta type XII, but neomorphic (gain-of-new-function) mutations of SP7 have not been reported in humans. Here we describe a de novo dominant neomorphic missense variant (c.926 C > G:p.S309W) in SP7 in a patient with craniosynostosis, c...

hsa_circWDR37_016 Regulates Hypoxia-Induced Proliferation of Pulmonary Arterial Smooth ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786516
Cardiovascular Therapeutics; Li SS, Liang S et. al.

Feb 5th, 2022 - Pulmonary arterial hypertension (PAH) is characterized by abnormal remodeling of pulmonary vessel walls caused by excessive pulmonary arterial smooth muscle cell (PASMC) proliferation. Our previous clinical studies have demonstrated the importance of the downregulated circRNA in PAH. However, the role of upregulated circRNAs is still elusive. Here, we identified the upregulated circRNA in PAH p...

CD4+ICOS+Foxp3+: a sub-population of regulatory T cells contribute to malaria pathogene...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812217
Malaria Journal; Chauhan R, Awasthi V et. al.

Feb 4th, 2022 - Regulatory T cells are known to play a key role to counter balance the protective immune response and immune mediated pathology. However, the role of naturally occurring regulatory cells CD4+CD25+Foxp3+ in malaria infection during the disease pathogenesis is controversial. Beside this, ICOS molecule has been shown to be involved in the development and function of regulatory T cell enhance IL-10...

Autism genes converge on asynchronous development of shared neuron classes.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852827
Nature Paulsen B, Velasco S et. al.

Feb 4th, 2022 - Genetic risk for autism spectrum disorder (ASD) is associated with hundreds of genes spanning a wide range of biological functions1-6. The alterations in the human brain resulting from mutations in these genes remain unclear. Furthermore, their phenotypic manifestation varies across individuals7,8. Here we used organoid models of the human cerebral cortex to identify cell-type-specific developm...

CDK19 regulates the proliferation of hematopoietic stem cells and acute myeloid leukemi...
https://doi.org/10.1038/s41375-022-01512-5
Leukemia Zhang Z, Lu Y et. al.

Feb 4th, 2022 - The cell cycle progression of hematopoietic stem cells (HSCs) and acute myeloid leukemia (AML) cells is precisely controlled by multiple regulatory factors. However, the underlying mechanisms are not fully understood. Here, we find that cyclin-dependent kinase 19 (CDK19), not its paralogue CDK8, is relatively enriched in mouse HSCs, and its expression is more significantly increased than CDK8 a...

The DNA methylome of cervical cells can predict the presence of ovarian cancer.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807742
Nature Communications; Barrett JE, Jones A et. al.

Feb 3rd, 2022 - The vast majority of epithelial ovarian cancer arises from tissues that are embryologically derived from the Müllerian Duct. Here, we demonstrate that a DNA methylation signature in easy-to-access Müllerian Duct-derived cervical cells from women with and without ovarian cancer (i.e. referred to as the Women's risk IDentification for Ovarian Cancer index or WID-OC-index) is capable of identifyin...

PTEN Regulates Dendritic Arborization by Decreasing Microtubule Polymerization Rate.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916761
The Journal of Neuroscience : the Official Journal of The... Getz SA, Tariq K et. al.

Feb 2nd, 2022 - Phosphatase and tensin homolog (PTEN) is a major negative regulator of the phosphatidylinositol-3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) pathway. Loss-of-function mutations in PTEN have been found in a subset of patients with macrocephaly and autism spectrum disorder (ASD). PTEN loss in neurons leads to somal hypertrophy, aberrant migration, dendritic overgrowth, increased spi...