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About 24,798 results

Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490365
Nature Communications; Ferren M, Favède V et. al.

Oct 6th, 2021 - SARS-CoV-2 has caused a global pandemic of COVID-19 since its emergence in December 2019. The infection causes a severe acute respiratory syndrome and may also spread to central nervous system leading to neurological sequelae. We have developed and characterized two new organotypic cultures from hamster brainstem and lung tissues that offer a unique opportunity to study the early steps of viral...

An immune response characterizes early Alzheimer's disease pathology and subjective cog...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476497
Nature Communications; Huang W, Bartosch AM et. al.

Sep 29th, 2021 - Early Alzheimer's disease (AD) pathology can be found in cortical biopsies taken during shunt placement for Normal Pressure Hydrocephalus. This represents an opportunity to study early AD pathology in living patients. Here we report RNA-seq data on 106 cortical biopsies from this patient population. A restricted set of genes correlate with AD pathology in these biopsies, and co-expression netwo...

Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476602
Nature Communications; Volz AK, Frei A et. al.

Sep 29th, 2021 - Primary cilia are microtubule based sensory organelles important for receiving and processing cellular signals. Recent studies have shown that cilia also release extracellular vesicles (EVs). Because EVs have been shown to exert various physiological functions, these findings have the potential to alter our understanding of how primary cilia regulate specific signalling pathways. So far the foc...

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific altera...
https://doi.org/10.1073/pnas.2109123118
Proceedings of the National Academy of Sciences of the Un... Lourda M, Dzidic M et. al.

Sep 23rd, 2021 - Since the outset of the COVID-19 pandemic, increasing evidence suggests that the innate immune responses play an important role in the disease development. A dysregulated inflammatory state has been proposed as a key driver of clinical complications in COVID-19, with a potential detrimental role of granulocytes. However, a comprehensive phenotypic description of circulating granulocytes in seve...

Neglected roles of IgG Fc-binding protein secreted from airway mucin-producing cells in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504265
Innate Immunity; Kobayashi K, Tachibana M et. al.

Sep 16th, 2021 - Both innate immunity and acquired immunity are involved in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The induction of Abs that neutralize the virus has been described, and certain Abs against endemic coronaviruses may cross-react with SARS-CoV-2. Detailed mechanisms to protect against the pandemic of SARS-CoV-2 remain unresolved. We previously reported that IgG Fc-...

Correlation between preoperative inflammatory markers, Ki-67 and the pathological grade...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428732
Medicine Xu G, Li C et. al.

Sep 14th, 2021 - To investigate the correlation between preoperative inflammatory markers, Ki-67 expression and the pathological grade of glioma, and to provide a reference for clinical prediction of glioma prognosis.A total of 45 glioma patients who underwent surgery with complete clinical and pathological data were in our hospital from January 2012 to December 2018 were enrolled. Glioma was divided into WHO g...

Application of CD54 in diagnosing bone marrow involvement by using flow cytometry in pa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431857
BMC Cancer; Wang W, Li Y et. al.

Sep 11th, 2021 - Flow cytometry plays a key role in detecting bone marrow (BM) involvement in patients with diffuse large B-cell lymphoma (DLBCL). To improve its detection sensitivity, we need to explore novel markers. In this study, we detected the expression CD54 on lymphoma cells in BM specimens from DLBCL patients and clarified its diagnostic significance in BM involvement by DLBCL. We collected BM specimen...

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in as...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412261
PLoS Pathogens; Severa M, Diotti RA et. al.

Sep 3rd, 2021 - SARS-CoV-2 fine-tunes the interferon (IFN)-induced antiviral responses, which play a key role in preventing coronavirus disease 2019 (COVID-19) progression. Indeed, critically ill patients show an impaired type I IFN response accompanied by elevated inflammatory cytokine and chemokine levels, responsible for cell and tissue damage and associated multi-organ failure. Here, the early interaction ...

iPSC-Derived Trabecular Meshwork Cells Stimulate Endogenous TM Cell Division Through Ga...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399400
Investigative Ophthalmology & Visual Science; Sui S, Yu H et. al.

Aug 25th, 2021 - Decreased trabecular meshwork (TM) cellularity has been implicated as a major reason for TM dysfunction and aqueous humor (AH) outflow abnormalities in primary open angle glaucoma. We previously found that transplantation of induced pluripotent stem cell (iPSC)-derived TM cells can restore TM function and stimulate endogenous TM cell division. The goal of the present study is to investigate whe...

In situ ultrastructures of two evolutionarily distant apicomplexan rhoptry secretion sy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371170
Nature Communications; Mageswaran SK, Guérin A et. al.

Aug 19th, 2021 - Parasites of the phylum Apicomplexa cause important diseases including malaria, cryptosporidiosis and toxoplasmosis. These intracellular pathogens inject the contents of an essential organelle, the rhoptry, into host cells to facilitate invasion and infection. However, the structure and mechanism of this eukaryotic secretion system remain elusive. Here, using cryo-electron tomography and subtom...

Resveratrol supplementation reduces ACE2 expression in human adipose tissue.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381800
Adipocyte de Ligt M, Hesselink MKC et. al.

Aug 18th, 2021 - Angiotensin converting enzyme-2 (ACE2) is the cell-surface receptor enabling cellular entry of SARS-CoV-2. ACE2 is highly expressed in adipose tissue (AT), rendering AT a potential SARS-CoV-2 reservoir contributing to massive viral spread in COVID-19 patients with obesity. Although rodent and cell studies suggest that the polyphenol resveratrol alters ACE2, human studies are lacking. Here, we i...

CCR6 Expression on B Cells Is Not Required for Clinical or Pathological Presentation of...
https://doi.org/10.4049/jimmunol.2001413
Journal of Immunology (Baltimore, Md. : 1950); Lee DSW, Yam JY et. al.

Aug 18th, 2021 - B cells have been implicated in the pathogenesis of multiple sclerosis, but the mechanisms that guide B cell activation in the periphery and subsequent migration to the CNS remain incompletely understood. We previously showed that systemic inflammation induces an accumulation of B cells in the spleen in a CCR6/CCL20-dependent manner. In this study, we evaluated the role of CCR6/CCL20 in the con...

Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363714
Nature Communications; Skead K, Ang Houle A et. al.

Aug 15th, 2021 - Age-related clonal hematopoiesis (ARCH) is characterized by age-associated accumulation of somatic mutations in hematopoietic stem cells (HSCs) or their pluripotent descendants. HSCs harboring driver mutations will be positively selected and cells carrying these mutations will rise in frequency. While ARCH is a known risk factor for blood malignancies, such as Acute Myeloid Leukemia (AML), why ...

Polyphenylene carboxymethylene (PPCM) microbicide repurposed as antiviral against SARS-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349736
Antiviral Research; Escaffre O, Freiberg AN

Aug 14th, 2021 - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has infected over 200 million people throughout the world as of August 2021. There are currently no approved treatments providing high chance of recovery from a severe case of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, and the beneficial effect of Remdesivir and passive immunization therapies may only be seen when admin...

CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasm...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355313
Nature Communications; Boltryk SD, Passecker A et. al.

Aug 12th, 2021 - The malaria parasite Plasmodium falciparum replicates inside erythrocytes in the blood of infected humans. During each replication cycle, a small proportion of parasites commits to sexual development and differentiates into gametocytes, which are essential for parasite transmission via the mosquito vector. Detailed molecular investigation of gametocyte biology and transmission has been hampered...

The developing mouse coronal suture at single-cell resolution.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355337
Nature Communications; Farmer DT, Mlcochova H et. al.

Aug 12th, 2021 - Sutures separate the flat bones of the skull and enable coordinated growth of the brain and overlying cranium. The coronal suture is most commonly fused in monogenic craniosynostosis, yet the unique aspects of its development remain incompletely understood. To uncover the cellular diversity within the murine embryonic coronal suture, we generated single-cell transcriptomes and performed extensi...

Altered function and differentiation of age-associated B cells contribute to the female...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355159
Nature Communications; Ricker E, Manni M et. al.

Aug 12th, 2021 - Differences in immune responses to viruses and autoimmune diseases such as systemic lupus erythematosus (SLE) can show sexual dimorphism. Age-associated B cells (ABC) are a population of CD11c+T-bet+ B cells critical for antiviral responses and autoimmune disorders. Absence of DEF6 and SWAP-70, two homologous guanine exchange factors, in double-knock-out (DKO) mice leads to a lupus-like syndrom...

Loss of Krüppel-like factor 9 facilitates stemness in ovarian cancer ascites-derived mu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8486214
Cancer Science; Wang K, Liu S et. al.

Aug 8th, 2021 - The ascites that develops in advanced OC, both at diagnosis and upon recurrence, is a rich source of multicellular spheroids/aggregates (MCSs/MCAs), which are the major seeds of tumor cell dissemination within the abdominal cavity. However, the molecular mechanism by which specific ascites-derived tumor cells survive and metastasize remains largely unknown. In this study, we elucidated cancer s...

Development and in vitro characterisation of an induced pluripotent stem cell model of ...
https://doi.org/10.1016/j.biocel.2021.106051
The International Journal of Biochemistry & Cell Biology; Bindhya S, Sidhanth C et. al.

Aug 4th, 2021 - Ovarian cancer recurs despite advances in treatment and is due to drug resistance. The persistence of cancer stem cells (CSCs) is one of the causes. It has been challenging to maintain CSCs long term in culture from primary malignant cells. Reprogramming cancer cells into induced pluripotent stem cells (iPSCs) could be an approach to achieve this. An ovarian cancer cell line, PEO4, was initiall...

Multiomics analyses reveal a critical role of selenium in controlling T cell differenti...
https://doi.org/10.1016/j.immuni.2021.07.004
Immunity Huang LJ, Mao XT et. al.

Aug 4th, 2021 - Inflammatory bowel disease (IBD) mainly includes Crohn's disease (CD) and ulcerative colitis (UC). Immune disorders play an essential role in the pathogenesis of these two IBDs, but the differences in the immune microenvironment of the colon and their underlying mechanisms remain poorly investigated. Here we examined the immunological features and metabolic microenvironment of untreated individ...