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About 23,413 results

FRUCTOSE-1,6-BISPHOSPHATASE DEFICIENCY CAUSES FATTY LIVER DISEASE AND REQUIRES LONG-TER...
https://doi.org/10.1002/jimd.12452
Journal of Inherited Metabolic Disease; Gorce M, Lebigot E et. al.

Oct 24th, 2021 - Liver disease, occurring during pediatric or adult age, is often of undetermined cause. Some cases are probably related to undiagnosed inherited metabolic disorders. Hepatic disorders associated with fructose-1,6-bisphosphatase deficiency, a gluconeogenesis defect, are not reported in the literature. These symptoms are mainly described during acute crises, and many reports don't mention them be...

Prevalence and factors associated with diabetes mellitus among tuberculosis patients in...
https://doi.org/10.1136/bmjopen-2021-050542
BMJ Open; Rajaa S, Krishnamoorthy Y et. al.

Oct 24th, 2021 - To determine the prevalence and determinants of diabetes mellitus (DM) among tuberculosis (TB) patients and to assess the additional yield and number needed to screen (NNS) to obtain a newly diagnosed DM among TB patients. We undertook a cross-sectional analysis of the cohort data under Regional Prospective Observational Research for Tuberculosis-India consortium. Newly diagnosed TB patients re...

Bariatric surgery-what the ophthalmologist needs to know.
https://doi.org/10.1038/s41433-021-01811-8 10.1111/j.1750-3841.2008.00766.x 10.1007/s11695-014-1472-y 10.1056/NEJM199511023331803 10.1016/j.gassur.2003.09.020 10.1016/j.soard.2010.02.044 10.1016/j.ophtha.2004.12.045 10.1159/000485235 10.1590/s0004-2803.2017v54n1-13 10.1177/0004563220939604 10.1007/s11695-018-3262-4 10.1097/SLA.0000000000002079 10.1097/SLA.0b013e3181884308 10.1016/j.jns.2021.117482 10.3390/ijms19061816 10.3949/ccjm.77a.09135 10.2337/dc11-s254 10.1056/NEJMoa1600869 10.1111/aos.13555 10.2337/db13-1619 10.1016/j.soard.2016.10.002 10.1111/dom.13538 10.1111/dme.12727 10.1016/j.jdiacomp.2013.10.006 10.1038/eye.2017.119 10.1016/j.ajo.2020.12.033 10.1097/WNO.0000000000000684 10.1007/s00464-015-4458-5 10.1038/s41433-018-0238-5 10.1001/jamaneurol.2021.0659 10.1016/j.soard.2021.03.020 10.1016/j.soard.2020.03.032 10.4103/2152-7806.171230 10.5935/0004-2749.20200030 10.1007/s11695-019-03806-7 10.1371/journal.pone.0216351 10.4103/ijo.IJO_295_20 10.1007/s11695-020-04904-7 10.1038/s41366-018-0242-7 10.1111/aos.13087 10.1097/IJG.0000000000000573 10.1111/aos.13826 10.1111/aos.13722 10.1152/japplphysiol.00587.2005 10.1097/MCP.0000000000000322 10.1016/j.surg.2006.08.012 10.1007/s11695-020-05080-4 10.1097/ICO.0000000000002286 10.1007/s11695-019-04310-8 10.1016/j.jaapos.2010.01.015 10.1097/WNO.0000000000000332 10.1097/WNO.0b013e3182269910
Eye (London, England); Hari T, Elsherbiny S

Oct 23rd, 2021 - The incidence of bariatric surgery is increasing due to obesity being one of our top public health challenges. As such, bariatric-related ophthalmic changes are a potentially new clinical area of knowledge, with increasing published evidence on post-bariatric complications experienced by patients and identified by clinicians. We reviewed the available literature and summarised the different com...

Disease burden and treatment sequence of polymyositis and dermatomyositis patients in J...
https://doi.org/10.1007/s10067-021-05939-6 10.1002/mus.24566 10.1038/nrrheum.2018.41 10.1056/NEJMra1402225 10.1016/j.autrev.2011.06.007 10.1016/j.jtauto.2019.100018 10.3109/14397595.2013.844308 10.3109/s10165-012-0733-7 10.1111/ncn3.12223 10.1016/S0140-6736(03)14368-1 10.1002/art.37754 10.4103/0028-3886.60386 10.4103/0019-5154.100479 10.1007/s10067-012-1940-5 10.1111/1346-8138.14604 10.12688/f1000research.13585.1 10.3109/14397595.2015.1091137 10.1002/pds.1082 10.1001/jama.2013.281053 10.1016/j.jval.2017.08.3018 10.1097/01.mlr.0000182534.19832.83 10.1111/j.1524-4733.2007.00213.x 10.1093/rheumatology/keq279 10.21037/atm.2020.01.56 10.1371/journal.pone.0098824 10.1136/heartjnl-2019-315511 10.1371/journal.pone.0094128 10.1515/folmed-2017-0003 10.3111/13696998.2016.1151433 10.1046/j.1525-1497.1999.00324.x 10.1016/j.jbspin.2020.03.002 10.1007/s00296-019-04248-1 10.1016/S0140-6736(04)17670-8 10.1370/afm.516
Clinical Rheumatology; Miyazaki C, Ishii Y et. al.

Oct 23rd, 2021 - Since new consensus on polymyositis (PM) and dermatomyositis (DM) were released in Japan, an updated evidence on treatment landscape and PM/DM burden was essential. This study evaluates treatment burden and overall treatment cost of PM/DM-related inpatient and outpatient visits, treatments, and procedures/patient/year. This retrospective, observational study analyzed insurance claims from Japan...

Coronavirus disease 2019 (Covid-19) vaccination recommendations in special populations ...
https://doi.org/10.1002/rmv.2309
Reviews in Medical Virology; Mohseni Afshar Z, Babazadeh A et. al.

Oct 23rd, 2021 - Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a crucial step in ending the current worldwide pandemic. However, several particularly vulnerable groups in the population were not included in sufficient numbers in coronavirus disease 2019 (Covid-19) vaccine trials. Therefore, as science advances, the advice for vaccinating these special populations against Co...

Utility of 18FDOPA PET/MRI for Focal Hyperinsulinism
https://clinicaltrials.gov/ct2/show/NCT05088798

Oct 22nd, 2021 - Congenital hyperinsulinism (CHI) is a clinically and genetically heterogeneous disorder that is the most common cause of permanent hypoglycemia in infants and children. More than 50% of the medically-unresponsive patients have focal disease. Which is characterized by a distinct region of Beta-cell hyperplasia in the pancreas, due to a somatic loss of a gene that regulates cell proliferation. Re...

National Eye Institute Biorepository for Retinal Diseases
https://clinicaltrials.gov/ct2/show/NCT01496625

Oct 22nd, 2021 - This protocol establishes a clinical database and biospecimen repository for potential use in subsequent research projects approved by the NIH IRB, such as the identification of novel factors relevant to the pathogenesis, progression, and response to treatment of a variety of retinal conditions, particularly age-related macular degeneration (AMD) and diabetic retinopathy and their associated sy...

Efficacy and safety of sirolimus therapy in familial hypoinsulinemic hypoglycemia cause...
https://doi.org/10.1016/j.ejmg.2021.104368
European Journal of Medical Genetics; Dushar M, Nowaczyk J et. al.

Oct 22nd, 2021 - Activating mutation in the insulin signal-transducing kinase AKT2 results in severe hypoinsulinemic hypoketotic hypoglycemia and a characteristic phenotype of possible overgrowth and, sometimes, acanthosis nigricans. Herein, we describe a metabolic and hormonal profile before and during treatment with sirolimus in two brothers with AKT2 mutation inherited from the mosaic father, who showed low-...

SARS-CoV-2 infection and cardiovascular or pulmonary complications in ambulatory care: ...
https://doi.org/10.1371/journal.pone.0258914
PloS One; Karapetyan S, Schneider A et. al.

Oct 22nd, 2021 - Risk factors of severe COVID-19 have mainly been investigated in the hospital setting. We investigated pre-defined risk factors for testing positive for SARS-CoV-2 infection and cardiovascular or pulmonary complications in the outpatient setting. The present cohort study makes use of ambulatory claims data of statutory health insurance physicians in Bavaria, Germany, with polymerase chain react...

Valproate Toxicity Workup
https://emedicine.medscape.com/article/819315-workup

Oct 21st, 2021 - Approach Considerations Determination of the valproate (valproic acid [VPA]) level is obviously warranted. Reviews have shown that nearly 20% of VPA overdose patients may present with initial VPA concentrations that are in the therapeutic range, or even undetectable; accordingly, serial levels should be obtained until a peak level has been reached and the levels are clearly trending downward. D...

Beta-Blocker Toxicity
https://emedicine.medscape.com/article/813342-overview

Oct 21st, 2021 - Practice Essentials Beta-adrenergic antagonist (ie, beta-blocker) toxicity can produce clinical manifestations including bradycardia, hypotension, arrhythmias, hypothermia, hypoglycemia, and seizures (see the images below). The presentation may range from asymptomatic to shock. Beta-blocker toxicity. Bradycardia is evident on a rhythm strip from a 48-year-old man who presented to the emergency ...

Deciphering the link between Diabetes mellitus and SARS-CoV-2 infection through differe...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527307
Journal of Endocrinological Investigation; Bhavya , Pathak E et. al.

Oct 21st, 2021 - Coronavirus Disease 2019 (COVID-19) severity and Diabetes mellitus affect each other bidirectionally. However, the cause of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection on the incidence of diabetes is unclear. In the SARS-CoV-2-infected cells, host microRNAs (miRNAs) may target the native gene transcripts as well as the viral genomic and subgenomic RNAs. Here, we invest...

Investigation of blood leptin and adropin levels in patients with multiple sclerosis: A...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448068
Medicine Cinkir U, Bir LS et. al.

Oct 20th, 2021 - The effects of adipokines have been investigated in multiple sclerosis (MS) in the literature. Results are uncertain, and subgroups like adropin have not been previously studied. We primarily aimed to determine leptin and adropin levels in MS and their potential use as a biomarker. This study was an experimental research. While 44 MS patients diagnosed according to McDonald criteria were includ...

Associations between Diabetes Mellitus and Nontuberculous Mycobacterium-Caused Diseases...
https://doi.org/10.4269/ajtmh.20-1441
The American Journal of Tropical Medicine and Hygiene; Wang JY, Lin HC et. al.

Oct 19th, 2021 - Patients with diabetes mellitus (DM) are at greater risk of developing active tuberculosis and other intracellular bacterial infections, although the risk of acquiring infections from nontuberculous Mycobacterium (NTM) remains undefined. This study evaluated associations between DM and incidence of NTM infection-caused pulmonary and cutaneous diseases. Data for DM patients were extracted from t...

Updates in deep learning research in ophthalmology.
https://doi.org/10.1042/CS20210207
Clinical Science (London, England : 1979); Ng WY, Zhang S et. al.

Oct 19th, 2021 - Ophthalmology has been one of the early adopters of artificial intelligence (AI) within the medical field. Deep learning (DL), in particular, has garnered significant attention due to the availability of large amounts of data and digitized ocular images. Currently, AI in Ophthalmology is mainly focused on improving disease classification and supporting decision-making when treating ophthalmic d...

Zyvox - linezolid injection, solution-Pharmacia & Upjohn Company LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3e5e9975-6f36-42e4-ab46-0e75dda83592

Oct 19th, 2021 - ZYVOX is an oxazolidinone-class antibacterial indicated in adults and children for the treatment of the following infections caused by susceptible Gram-positive bacteria: Nosocomial pneumonia (1.1); Community-acquired pneumonia (1.2); Complicated skin and skin structure infections, including diabetic foot infections, without concomitant osteomyelitis (1.3); Uncomplicated skin and skin structure...

Role of Volume in Small Abdominal Aortic Aneurysm Surveillance.
https://doi.org/10.1016/j.jvs.2021.09.046
Journal of Vascular Surgery; Olson SL, Panthofer AM et. al.

Oct 17th, 2021 - Current management of small abdominal aortic aneurysm (AAA) primarily involves serial imaging surveillance of maximum transverse diameter (MTD) to estimate rupture risk. Other measurements, such as volume and tortuosity, are less well-studied and may help characterize and predict AAA progression. This study evaluated predictors of AAA volume growth and discusses the role of volume in clinical p...

Diabetes-Related Foot Infections: Diagnosis and Treatment.
https://www.ncbi.nlm.nih.gov/pubmed/34652105
American Family Physician; Matheson EM, Bragg SW et. al.

Oct 16th, 2021 - Diabetes-related foot infections occur in approximately 40% of diabetes-related foot ulcers and cause significant morbidity. Clinicians should consider patient risk factors (e.g., presence of foot ulcers greater than 2 cm, uncontrolled diabetes mellitus, poor vascular perfusion, comorbid illness) when evaluating for a foot infection or osteomyelitis. Indicators of infection include erythema, in...

Osteomyelitis: Diagnosis and Treatment.
https://www.ncbi.nlm.nih.gov/pubmed/34652112
American Family Physician; Bury DC, Rogers TS et. al.

Oct 16th, 2021 - Osteomyelitis is an inflammatory condition of bone secondary to an infectious process. Osteomyelitis is usually clinically diagnosed with support from imaging and laboratory findings. Bone biopsy and microbial cultures offer definitive diagnosis. Plain film radiography should be performed as initial imaging, but sensitivity is low in the early stages of disease. Magnetic resonance imaging with ...

Sorbitol is a severity biomarker for PMM2-CDG with therapeutic implications.
https://doi.org/10.1002/ana.26245
Annals of Neurology; Ligezka AN, Radenkovic S et. al.

Oct 16th, 2021 - Epalrestat, an aldose reductase inhibitor increases PMM enzyme activity in a PMM2-CDG worm-model. Epalrestat also decreases sorbitol level in diabetic neuropathy. We evaluated the genetic, biochemical and clinical characteristics including the Nijmegen Progression CDG Rating Scale, urine polyol levels and fibroblast glycoproteomics in PMM2-CDG patients. We performed PMM enzyme measurements, mul...